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Soluble chemokine binding proteins are also encoded by herpesviruses 可溶性趋化因子结合蛋白也可由疱疹病毒编码
Immunology today Pub Date : 2000-10-01 DOI: 10.1016/S0167-5699(00)01632-7
Antonio Alcami, Stacey Efstathiou
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引用次数: 10
Bacterial vaccines for the treatment of multiple sclerosis and other autoimmune diseases 细菌疫苗用于治疗多发性硬化症和其他自身免疫性疾病
Immunology today Pub Date : 2000-10-01 DOI: 10.1016/S0167-5699(00)01700-X
Graham A.W Rook , Giovanni Ristori , Marco Salvetti , Gavin Giovannoni , Edward J Thompson , John L Stanford
{"title":"Bacterial vaccines for the treatment of multiple sclerosis and other autoimmune diseases","authors":"Graham A.W Rook ,&nbsp;Giovanni Ristori ,&nbsp;Marco Salvetti ,&nbsp;Gavin Giovannoni ,&nbsp;Edward J Thompson ,&nbsp;John L Stanford","doi":"10.1016/S0167-5699(00)01700-X","DOIUrl":"https://doi.org/10.1016/S0167-5699(00)01700-X","url":null,"abstract":"<div><p>In animal models it is often possible to block Th1-mediated autoimmunity by deviating the response to Th2. In this article, Graham Rook and colleagues argue that this might prove a dangerous strategy in humans, and that we should distinguish between potentially pathogenic Th2 effector cells, and Th2-like physiological regulators of Th1 responses. The regulators might be triggered by appropriate Th1-inducing bacterial vaccines.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 10","pages":"Pages 503-508"},"PeriodicalIF":0.0,"publicationDate":"2000-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01700-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"92140557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 35
Transcriptional regulation of Th1/Th2 polarization Th1/Th2极化的转录调控
Immunology today Pub Date : 2000-10-01 DOI: 10.1016/S0167-5699(00)01712-6
Jyothi Rengarajan, Susanne J Szabo, Laurie H Glimcher
{"title":"Transcriptional regulation of Th1/Th2 polarization","authors":"Jyothi Rengarajan,&nbsp;Susanne J Szabo,&nbsp;Laurie H Glimcher","doi":"10.1016/S0167-5699(00)01712-6","DOIUrl":"10.1016/S0167-5699(00)01712-6","url":null,"abstract":"<div><p>The two polarized T helper (Th) subsets Th1 and Th2 are identified by their signature cytokines, interferon γ (IFN-γ) and interleukin 4 (IL-4) respectively. Understanding the transcriptional regulation of cytokine expression is therefore critical for elucidating the process of Th cell differentiation. Ubiquitous and tissue-specific transcription factors, as well as chromatin remodeling of genomic loci have been implicated in IL-4 and IFN-γ regulation. We propose a model of Th1/Th2 polarization based on the balance between Th1- and Th2-specific transcription factors.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 10","pages":"Pages 479-483"},"PeriodicalIF":0.0,"publicationDate":"2000-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01712-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21897586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 458
Causing a commotion in the blood: immunotherapy progresses from bacteria to bacterial DNA 在血液中引起骚动:免疫疗法从细菌发展到细菌DNA
Immunology today Pub Date : 2000-10-01 DOI: 10.1016/S0167-5699(00)01719-9
Arthur M Krieg , Hermann Wagner
{"title":"Causing a commotion in the blood: immunotherapy progresses from bacteria to bacterial DNA","authors":"Arthur M Krieg ,&nbsp;Hermann Wagner","doi":"10.1016/S0167-5699(00)01719-9","DOIUrl":"10.1016/S0167-5699(00)01719-9","url":null,"abstract":"<div><p>The vertebrate immune system recognizes bacterial DNA as foreign based on its content of unmethylated CpG motifs. The detection of CpG motifs by the innate immune system induces immune responses that are strongly Th1-biased. These responses can be mimicked using synthetic oligonucleotides, which have shown significant effects as vaccine adjuvants and as immunotherapeutics for treatment of cancer and allergic conditions in model systems.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 10","pages":"Pages 521-526"},"PeriodicalIF":0.0,"publicationDate":"2000-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01719-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21897593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 138
Follicular dendritic cells: a license to tangle with scrapie 滤泡树突状细胞:与痒病纠缠在一起的许可证
Immunology today Pub Date : 2000-10-01 DOI: 10.1016/S0167-5699(00)01737-0
Marie H Kosco-Vilbois
{"title":"Follicular dendritic cells: a license to tangle with scrapie","authors":"Marie H Kosco-Vilbois","doi":"10.1016/S0167-5699(00)01737-0","DOIUrl":"10.1016/S0167-5699(00)01737-0","url":null,"abstract":"","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 10","pages":"Page 468"},"PeriodicalIF":0.0,"publicationDate":"2000-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01737-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21923138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Controlling the controllers of death 控制死亡的控制者
Immunology today Pub Date : 2000-10-01 DOI: 10.1016/S0167-5699(00)01738-2
Shane T Grey
{"title":"Controlling the controllers of death","authors":"Shane T Grey","doi":"10.1016/S0167-5699(00)01738-2","DOIUrl":"10.1016/S0167-5699(00)01738-2","url":null,"abstract":"","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 10","pages":"Page 469"},"PeriodicalIF":0.0,"publicationDate":"2000-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01738-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21923141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ageing of lymphocytes and lymphocytes in the aged 衰老的淋巴细胞和老年淋巴细胞
Immunology today Pub Date : 2000-10-01 DOI: 10.1016/S0167-5699(00)01714-X
Amiela Globerson , Rita B Effros
{"title":"Ageing of lymphocytes and lymphocytes in the aged","authors":"Amiela Globerson ,&nbsp;Rita B Effros","doi":"10.1016/S0167-5699(00)01714-X","DOIUrl":"10.1016/S0167-5699(00)01714-X","url":null,"abstract":"<div><p>Immunosenescence is a complex process involving multiple reorganizational and developmentally regulated changes, rather than simple unidirectional decline in all functions. Here, these compensatory modulations are reviewed with reference to the importance of integrating information on cellular alterations identified <em>in vitro</em> with data on global physiological changes in the aged environment with which these cells interact <em>in vivo</em>.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 10","pages":"Pages 515-521"},"PeriodicalIF":0.0,"publicationDate":"2000-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01714-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21897592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 312
TNF is here to stay! TNF就在这里!
Immunology today Pub Date : 2000-10-01 DOI: 10.1016/S0167-5699(00)01722-9
Fran Balkwill , Brian Foxwell , Fionula Brennan
{"title":"TNF is here to stay!","authors":"Fran Balkwill ,&nbsp;Brian Foxwell ,&nbsp;Fionula Brennan","doi":"10.1016/S0167-5699(00)01722-9","DOIUrl":"10.1016/S0167-5699(00)01722-9","url":null,"abstract":"<div><p>A recent conference<span>*</span> on tumour necrosis factor (TNF) and related molecules highlighted the many recent advances, from intracellular signalling to clinical applications, in our knowledge of this fascinating molecule.</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 10","pages":"Pages 470-471"},"PeriodicalIF":0.0,"publicationDate":"2000-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01722-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21897583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
New Trends at Immunology Today…. 免疫学今日新趋势....
Immunology today Pub Date : 2000-10-01 DOI: 10.1016/S0167-5699(00)01721-7
Elaine Bell (Editor)
{"title":"New Trends at Immunology Today….","authors":"Elaine Bell (Editor)","doi":"10.1016/S0167-5699(00)01721-7","DOIUrl":"10.1016/S0167-5699(00)01721-7","url":null,"abstract":"<div><p>‘<em>It is not the strongest of the species that survives, nor the most intelligent; it is the one that is most adaptable to change.</em>’</p><p>Charles Robert Darwin (1809–1882)</p></div>","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 10","pages":"Page 467"},"PeriodicalIF":0.0,"publicationDate":"2000-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01721-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21923136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Marginal zones matter 边缘地带很重要
Immunology today Pub Date : 2000-10-01 DOI: 10.1016/S0167-5699(00)01740-0
John Pound
{"title":"Marginal zones matter","authors":"John Pound","doi":"10.1016/S0167-5699(00)01740-0","DOIUrl":"10.1016/S0167-5699(00)01740-0","url":null,"abstract":"","PeriodicalId":73346,"journal":{"name":"Immunology today","volume":"21 10","pages":"Page 469"},"PeriodicalIF":0.0,"publicationDate":"2000-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0167-5699(00)01740-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21923139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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