Graham A.W Rook , Giovanni Ristori , Marco Salvetti , Gavin Giovannoni , Edward J Thompson , John L Stanford
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Bacterial vaccines for the treatment of multiple sclerosis and other autoimmune diseases
In animal models it is often possible to block Th1-mediated autoimmunity by deviating the response to Th2. In this article, Graham Rook and colleagues argue that this might prove a dangerous strategy in humans, and that we should distinguish between potentially pathogenic Th2 effector cells, and Th2-like physiological regulators of Th1 responses. The regulators might be triggered by appropriate Th1-inducing bacterial vaccines.
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