Hepatitis research and treatment最新文献_第5页

Deficient knowledge on hepatitis B infection in pregnant women and prevalence of hepatitis B surface antigen carriage in an endemic area: a review. 一个流行地区对孕妇乙型肝炎感染和乙型肝炎表面抗原携带流行的认识不足:综述。

Hepatitis research and treatment Pub Date : 2012-01-01 Epub Date: 2012-09-28 DOI: 10.1155/2012/317451

Oi Ka Chan, Terence T Lao, Stephen S H Suen, Tak Yeung Leung

引用次数: 21

Seroprevalence and Risk Factors for Hepatitis C Virus Infection among General Population in Central Region of Yemen. 也门中部地区普通人群丙型肝炎病毒感染的血清阳性率和危险因素

Hepatitis research and treatment Pub Date : 2012-01-01 Epub Date: 2012-12-18 DOI: 10.1155/2012/689726

Rajesh N Gacche, Sadiq K Al-Mohani

{"title":"Seroprevalence and Risk Factors for Hepatitis C Virus Infection among General Population in Central Region of Yemen.","authors":"Rajesh N Gacche, Sadiq K Al-Mohani","doi":"10.1155/2012/689726","DOIUrl":"10.1155/2012/689726","url":null,"abstract":"Background. Hepatitis C virus (HCV) represents a major worldwide public health problem. Though several studies from Yemen have provided an estimate of the prevalence of this viral infection, there exist only few studies which reflect the status in the general population. Aim. The present study was designed to investigate the prevalence of hepatitis C infection among general population in central region of Yemen. Methods. The study population comprised 2,379 apparently healthy subjects who were screened for hepatitis C antibodies (HCV Abs) status using ELISA quantitative technique. Seroprevalence rate of seropositive subjects was calculated and stratified by age, sex, educational level, and monthly income. Results. The study showed that out of 2,379 subjects, 31 (1.3%) were HCV Abs positive. Higher prevalence of HCV Abs was found among females, 24 (1.01%), than males, 7 (0.29%). The age specific prevalence rose from 00 (0.00%) in subjects aged ≤14 years to a maximum of 9 (0.38%) in subjects aged ≥55 years. The prevalence of HCV Abs was more prevalent in illiterate subjects and increased with decreasing monthly income. Conclusion. It was found that variables including age and educational level were significantly associated with HCV Ab positivity and not associated with gender and monthly income.","PeriodicalId":73232,"journal":{"name":"Hepatitis research and treatment","volume":"2012 ","pages":"689726"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/689726","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31162006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 41

Hepatitis C virus core antigen test in monitoring of dialysis patients. 监测透析患者的丙型肝炎病毒核心抗原检测。

Hepatitis research and treatment Pub Date : 2012-01-01 Epub Date: 2012-12-04 DOI: 10.1155/2012/832021

Gioacchino Li Cavoli, Carmela Zagarrigo, Onofrio Schillaci, Francesca Servillo, Angelo Tralongo, Mario Coglitore, Filippo Spadaro, Concetta Scimeca, Natalia Li Destri, Ugo Rotolo

{"title":"Hepatitis C virus core antigen test in monitoring of dialysis patients.","authors":"Gioacchino Li Cavoli, Carmela Zagarrigo, Onofrio Schillaci, Francesca Servillo, Angelo Tralongo, Mario Coglitore, Filippo Spadaro, Concetta Scimeca, Natalia Li Destri, Ugo Rotolo","doi":"10.1155/2012/832021","DOIUrl":"10.1155/2012/832021","url":null,"abstract":"Hepatitis C virus infection is a persistent worldwide public health concern. The prevalence of HCV infection is much higher in patients on chronic haemodialysis (HD) than in the general population. HCV infection can detrimentally affect patients throughout the spectrum of chronic kidney disease. Despite the control of blood products, hepatitis C virus transmission is still being observed among patients undergoing dialysis. Detection systems for serum HCV antibodies are insensitive in the acute phase because of the long serological window. Direct detection of HCV depends on PCR test but this test is not suitable for routine screening. Recent studies have highlighted the importance of HCV core antigen detection as an alternative to PCR. Few studies exist about the efficacy of HCV core antigen test in dialysis population. We studied the utility of HCV core antigen test in routine monitoring of virological status of dialysis patients. We screened 92 patients on long-term dialysis both by PCR HCV-RNA and HCV core antigen test. The sensitivity of HCVcAg test was 90%, the specificity 100%, the positive predictive power 100%, the negative predictive power 97%, and the accuracy 97%. We think serological detection of HCV core antigen may be an alternative to NAT techniques for routine monitoring of patients on chronic dialysis.","PeriodicalId":73232,"journal":{"name":"Hepatitis research and treatment","volume":"2012 ","pages":"832021"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31151834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of occult hepatitis C virus in egyptian patients with chronic lymphoproliferative disorders. 埃及慢性淋巴细胞增生性疾病患者中隐性丙型肝炎病毒的流行情况。

Hepatitis research and treatment Pub Date : 2012-01-01 Epub Date: 2012-12-12 DOI: 10.1155/2012/429784

Samar Samir Youssef, Aml S Nasr, Taher El Zanaty, Rasha Sayed El Rawi, Mervat M Mattar

{"title":"Prevalence of occult hepatitis C virus in egyptian patients with chronic lymphoproliferative disorders.","authors":"Samar Samir Youssef, Aml S Nasr, Taher El Zanaty, Rasha Sayed El Rawi, Mervat M Mattar","doi":"10.1155/2012/429784","DOIUrl":"10.1155/2012/429784","url":null,"abstract":"Background. Occult hepatitis C virus infection (OCI) was identified as a new form of Hepatitis C virus (HCV), characterized by undetectable HCV antibodies and HCV RNA in serum, while HCV RNA is detectable in liver and peripheral blood cells only. Aim. The aim of this study was to investigate the occurrence of OCI in Egyptian patients with lymphoproliferative disorders (LPDs) and to compare its prevalence with that of HCV in those patients. Subjects and Methods. The current study included 100 subjects, 50 of them were newly diagnosed cases having different lymphoproliferative disorders (patients group), and 50 were apparently healthy volunteers (controls group). HCV antibodies were detected by ELISA, HCV RNA was detected in serum and peripheral blood mononuclear cells (PBMCs) by reverse transcription polymerase chain reaction(RT-PCR), and HCV genotype was detected by INNO-LiPA. Results. OCI was detected in 20% of patients group, compared to only 4% OCI in controls group. HCV was detected in 26% of patients group with a slightly higher prevalence. There was a male predominance in both HCV and OCI. All HCV positive patients were genotype 4. Conclusion. Our data revealed occurrence of occult HCV infection in Egyptian LPD patients at a prevalence of 20% compared to 26% of HCV.","PeriodicalId":73232,"journal":{"name":"Hepatitis research and treatment","volume":"2012 ","pages":"429784"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31151832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interleukin 28B Gene Polymorphism and Association with Chronic Hepatitis C Therapy Results in Latvia. 白细胞介素28B基因多态性与拉脱维亚慢性丙型肝炎治疗结果的关系

Hepatitis research and treatment Pub Date : 2012-01-01 Epub Date: 2012-04-24 DOI: 10.1155/2012/324090

Ieva Tolmane, Baiba Rozentale, Jazeps Keiss, Ludmila Ivancenko, Nadezda Subnikova, Zaiga Reinholde, Ieva Kozlovska, Nina Sumlaninova, Sniedze Laivacuma, Raimonds Simanis

{"title":"Interleukin 28B Gene Polymorphism and Association with Chronic Hepatitis C Therapy Results in Latvia.","authors":"Ieva Tolmane, Baiba Rozentale, Jazeps Keiss, Ludmila Ivancenko, Nadezda Subnikova, Zaiga Reinholde, Ieva Kozlovska, Nina Sumlaninova, Sniedze Laivacuma, Raimonds Simanis","doi":"10.1155/2012/324090","DOIUrl":"https://doi.org/10.1155/2012/324090","url":null,"abstract":"Introduction. With the standard treatment of chronic hepatitis C, sustained virological response (SVR) can be achieved only in half of all patients. Interleukin-28B appears to be involved in the control of HCV infection, and the genetic polymorphism of the encoding IL-28B gene may determine the efficacy of clearance of HCV. The aim of this paper was to detect IL-28B gene polymorphism in Latvia and to analyze therapy results. This is the first study on IL-28B gene polymorphism in Latvia. Material and Methods. There were 159 chronic viral hepatitis C patients included in the study. In order to detect IL-28B gene polymorphism, we used molecular biology techniques and methods: classical DNA separation, amplification by PCR, and standard sequencing. Genotype was defined as CC, CT, TC, or TT type. 142 patients were treated with the standard of care treatment. Results were analyzed according to IL-28B polymorphism. Results. There were 53 patients (33%) with CC genotype, 84 patients (53%) with CT/TC genotype, and 22 patients (14%) with TT genotype. 34 patients (74%) in CC genotype subgroup achieved SVR versus 50 patients (52%) in non-CC subgroups. In patients with genotype 1, SVR was achieved in 16 patients (84%) in CC subgroup versus 30 patients (47.6%) in non-CC subgroups, P = 0.007. Conclusions. The most common genotype of IL28B in Latvia is CT/TC, with an incidence of 53%. Patients with CC genotype achieved SVR more often than CT or TT subgroups. IL28B gene polymorphism therefore is a strong predictor of treatment result.","PeriodicalId":73232,"journal":{"name":"Hepatitis research and treatment","volume":"2012 ","pages":"324090"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/324090","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30637461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Hepatitis C virus: a critical appraisal of new approaches to therapy. 丙型肝炎病毒:对治疗新方法的关键评价。

Hepatitis research and treatment Pub Date : 2012-01-01 Epub Date: 2012-10-08 DOI: 10.1155/2012/138302

David R Nelson, Donald M Jensen, Mark S Sulkowski, Greg Everson, Michael W Fried, Stuart C Gordon, Ira Jacobson, Nancy S Reau, Kenneth Sherman, Nora Terrault, David Thomas

引用次数: 6

Antioxidant therapy in nonalcoholic steatohepatitis. 非酒精性脂肪性肝炎的抗氧化治疗

Hepatitis research and treatment Pub Date : 2012-01-01 Epub Date: 2012-11-22 DOI: 10.1155/2012/947575

Said A Al-Busafi, Mamatha Bhat, Philip Wong, Peter Ghali, Marc Deschenes

引用次数: 48

Compliance of healthcare professionals with safety measures for control of hepatitis viruses in hemodialysis centers: an experience from southeast iran. 卫生保健专业人员在血液透析中心遵守控制肝炎病毒的安全措施:来自伊朗东南部的经验。

Hepatitis research and treatment Pub Date : 2012-01-01 Epub Date: 2012-11-08 DOI: 10.1155/2012/415841

Sodaif Darvish Moghaddam, Mohammad Javad Zahedi, Mahdieh Dalili, Mostafa Shokoohi

{"title":"Compliance of healthcare professionals with safety measures for control of hepatitis viruses in hemodialysis centers: an experience from southeast iran.","authors":"Sodaif Darvish Moghaddam, Mohammad Javad Zahedi, Mahdieh Dalili, Mostafa Shokoohi","doi":"10.1155/2012/415841","DOIUrl":"https://doi.org/10.1155/2012/415841","url":null,"abstract":"Introduction. Noncompliance with the recommended infection control measures by the healthcare professionals (HCPs) plays a major role in transmission of hepatitis B (HBV) and hepatitis C (HCV) viruses in hemodialysis (HD) wards. This study aimed to determine the compliance rate of the HCP with safety measures in the HD wards in southeast Iran. Patients and Methods. A total of 208 patients were enrolled. Adherence of HCPs with standard infection control measures was assessed. Results. Sixty-one HCPs with a mean age of 32.4 ± 11.2 years old were responsible for healthcare services. Compliance with the following items was weak: not sharing medications trolley (29.8%), disinfecting the shared instruments (46.2%), using single use materials for many patients (52.4%), carrying used materials in disposable containers (51.9%), not returning of unused materials to the clean room (55.3%), and adherence to hand washing (58.7%). Periodic monitoring for HBV and HCV was performed on 100% and 69.7% of the patients, respectively. Less than 2/3 of HCPs participated in the retraining courses. Conclusion. Compliance of HCPs with safety measures for viral hepatitis prevention was partly inadequate in HD wards. Emphasis on retraining of HCPs and official supervision would be effective steps in the reduction of viral dissemination.","PeriodicalId":73232,"journal":{"name":"Hepatitis research and treatment","volume":"2012 ","pages":"415841"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/415841","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31088065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Association of interferon-alpha and ribavirin-induced thyroid dysfunction with severity of disease and response to treatment in pakistani asian patients of chronic hepatitis C. 干扰素- α和利巴韦林诱导的甲状腺功能障碍与巴基斯坦亚裔慢性丙型肝炎患者疾病严重程度和治疗反应的关系

Hepatitis research and treatment Pub Date : 2012-01-01 Epub Date: 2012-09-02 DOI: 10.1155/2012/864315

Amina Nadeem, Muhammad Aslam

{"title":"Association of interferon-alpha and ribavirin-induced thyroid dysfunction with severity of disease and response to treatment in pakistani asian patients of chronic hepatitis C.","authors":"Amina Nadeem, Muhammad Aslam","doi":"10.1155/2012/864315","DOIUrl":"https://doi.org/10.1155/2012/864315","url":null,"abstract":"Objective. To determine the association of thyroid dysfunction with the severity of the disease and response to treatment in patients of chronic hepatitis C. Design. Cohort study. Patients. One hundred and sixty seven noncirrhotic chronic hepatitis C patients were grouped into treatment group (n = 107) and control group (n = 60). Measurements. Baseline S. ALT and S. AST by IFCC and S. TSH, S. free T4, and S.T3 level were measured by chemiluminescence method. The severity of the disease was measured by Knodell histopathological index (HPI) on liver biopsy. Study group patients underwent 24-weeks IFN and ribavirin therapy and thyroid functions were determined at weeks 0, 12, and 24. Response to therapy was determined by PCR-HCV test. Results. 20 treated patients (18.69%) developed thyroid dysfunction with relative risk (RR) of 11.25 and attributable risk (AR) of 91%. Females were at higher risk. Hypothyroidism was common than hyperthyroidism. There was no significant association between thyroid dysfunction and severity of the disease (P = 0.81) and response to therapy (P = 0.79). Conclusion. Interferon-alpha and ribavirin therapy induces thyroid dysfunction in chronic hepatitis C patients. There is no association between severity of disease and response to therapy with interferon-induced thyroid dysfunction.","PeriodicalId":73232,"journal":{"name":"Hepatitis research and treatment","volume":"2012 ","pages":"864315"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/864315","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30901917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Neopterin as a marker of response to antiviral therapy in hepatitis C virus patients. 新蝶呤作为丙型肝炎病毒患者抗病毒治疗反应的标志物。

Hepatitis research and treatment Pub Date : 2012-01-01 Epub Date: 2012-06-28 DOI: 10.1155/2012/619609

Gregory F Oxenkrug, Pura J Requintina, Dennis L Mikolich, Robin Ruthazer, Kathleen Viveiros, Hannah Lee, Paul Summergrad

{"title":"Neopterin as a marker of response to antiviral therapy in hepatitis C virus patients.","authors":"Gregory F Oxenkrug, Pura J Requintina, Dennis L Mikolich, Robin Ruthazer, Kathleen Viveiros, Hannah Lee, Paul Summergrad","doi":"10.1155/2012/619609","DOIUrl":"https://doi.org/10.1155/2012/619609","url":null,"abstract":"Predicting the efficacy of antiviral treatment of hepatitis C virus (HCV) is of importance for both patient well-being and health care expense. The expression of interferon-stimulated genes (IFN-SGs) in the liver was suggested as a marker of response to anti-viral therapy. IFN-SGs encode the guanosine triphosphate cyclohydrolase 1 (GTPCH), a rate-limiting enzyme of pteridines biosynthesis. Neopterin, a stable byproduct of GTPCH-catalyzed reaction, is used as a marker of interferon-induced GTPCH activation. We hypothesized that assessment of neopterin concentrations might predict the response to antiviral therapy. Neopterin concentrations were evaluated in 260 HCV patients treated by pegylated interferon combined with ribavirin. Mean and median pretreatment neopterin concentrations were lower in patients with sustained virological response than in nonresponders. The rate of response was twofold higher among patients with pretreatment neopterin levels <16 nmol/L than in patients with neopterin levels ≥16 nmol/L, even after controlling for HCV genotype status. Our study suggests that the pretreatment level of neopterin might be used in routine clinical practice as rapid and cost-effective marker to predict the response to antiviral therapy in HCV patients.","PeriodicalId":73232,"journal":{"name":"Hepatitis research and treatment","volume":"2012 ","pages":"619609"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2012/619609","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"30774779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13