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Acta gastro-enterologica Belgica最新文献

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Bile acid malabsorption investigated by selenium-75-homocholic acid taurine (75SeHCAT) scans, a retrospective single-centre experience. 通过硒-75-高胆酸牛磺酸（75SeHCAT）扫描检查胆汁酸吸收不良，这是一项回顾性单中心经验。
IF 1.3 4区 医学
Acta gastro-enterologica Belgica Pub Date : 2024-07-01 DOI: 10.51821/87.3.13036
F Vulsteke, R De Gersem, J Arts, T Vanuytsel
{"title":"Bile acid malabsorption investigated by selenium-75-homocholic acid taurine (75SeHCAT) scans, a retrospective single-centre experience.","authors":"F Vulsteke, R De Gersem, J Arts, T Vanuytsel","doi":"10.51821/87.3.13036","DOIUrl":"https://doi.org/10.51821/87.3.13036","url":null,"abstract":"<p><strong>Background: </strong>Bile acid malabsorption (BAM) is a common entity in patients experiencing chronic watery diarrhea. However, literature suggests that BAM is underdiagnosed and undertreated. In many countries 75SeHCAT is the gold standard for diagnosing BAM (1-5). The aim of this retrospective study was to investigate the frequency of BAM using 75SeHCAT scintigraphy and the response to treatment with bile acid sequestrants.</p><p><strong>Methods: </strong>We retrospectively evaluated the clinical data of 420 patients who had a 75SeHCAT scan from January 2016 to January 2023. Electronic medical records were investigated for risk factors of BAM. BAM was defined as a 75SeHCAT retention of less than 15%. Response to bile acid sequestrants was evaluated based on outpatient clinical reports.</p><p><strong>Results: </strong>Median age at the time of 75SeHCAT test was 47 years (range 14-87). Out of 420 patients, 192 (46%) had a positive result for BAM. Cholecystectomy and ileal resection were significant predictors for BAM (p<0.001). BAM type 1 is statistically more likely to be more severe compared to type 2 (p<0.0001) and compared to type 3 (p=0.0021). In patients who fulfilled Rome IV criteria for IBS-D or functional diarrhea, 75 out of 121 (38%) tested positive for BAM. Overall, treatment with bile acid binders was effective in 76%.</p><p><strong>Conclusions: </strong>This retrospective study of patients who underwent SeHCAT scanning confirms that about 1/3 patients presenting with therapy-resistant chronic diarrhea in secondary care suffer from BAM. Including the test in clinical management protocols of chronic diarrhea allows early and quantitative diagnosis and treatment of BAM.</p>","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":"87 3","pages":"381-387"},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of metabolic dysfunction-associated fatty liver disease after pancreatic surgery in a historical Belgian cohort and review of the literature. 比利时历史群组中胰腺手术后代谢功能障碍相关脂肪肝的发病率及文献综述。
IF 1.3 4区 医学
Acta gastro-enterologica Belgica Pub Date : 2024-07-01 DOI: 10.51821/87.3.10078
V D'Cruz, A De Zutter, M Van den Broecke, S Ribeiro, L Abreu de Carvalho, P Smeets, C Lecluyse, E Pape, E Callebout, F Berrevoet, K Geboes
{"title":"Prevalence of metabolic dysfunction-associated fatty liver disease after pancreatic surgery in a historical Belgian cohort and review of the literature.","authors":"V D'Cruz, A De Zutter, M Van den Broecke, S Ribeiro, L Abreu de Carvalho, P Smeets, C Lecluyse, E Pape, E Callebout, F Berrevoet, K Geboes","doi":"10.51821/87.3.10078","DOIUrl":"10.51821/87.3.10078","url":null,"abstract":"<p><strong>Background and objectives: </strong>Metabolic dysfunction-associated fatty liver disease (MAFLD) has been reported as a complication after pancreatic surgery. The aim of this study is to assess this phenomenon in a Belgian population, specifically in a period in time when less perioperative chemotherapy was given.</p><p><strong>Methods: </strong>We performed a retrospective monocentric cohort study with 124 selected patients who underwent pancreatic surgery - pancreaticoduodenectomy (PD), distal pancreatectomy (DP) or total pancreatectomy - between 2005 and 2014. Steatosis was assessed radiologically, using Hounsfield units on liver and spleen. Data on imaging, liver function, weight and other relevant parameters were gathered preoperatively as well as 2 and 6 months, 1 and 2 years after surgery.</p><p><strong>Results: </strong>Thirty-eight (31%) out of 124 patients developed liver steatosis at least at one point in time in the two years following surgery, with a prevalence of 21.0% at 2 months, 28.6% at 6 months, 16.4% at 1 year and 20.8 % at 2 years. A statistically significant association with preoperative AST and ALT values, administration of pancreatic enzyme supplementation as a surrogate for pancreatic exocrine insufficiency (PEI) and weight loss at 2 years was detected.</p><p><strong>Conclusion: </strong>MAFLD is seen in 31% of patients with PD or DP pancreatic resection in this retrospective analysis of a monocentric Belgian cohort. Both early and late onset of MAFLD was observed, implying that long-term follow-up is necessary. Clinical impact as well as a direct correlation with patients' weight and oral enzyme supplements needs to be further investigated.</p>","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":"87 3","pages":"373-380"},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An uncommon indication for liver transplantation: toxic epidermal necrolysis. 肝脏移植的罕见适应症：中毒性表皮坏死症。
IF 1.3 4区 医学
Acta gastro-enterologica Belgica Pub Date : 2024-07-01 DOI: 10.51821/87.3.13045
B Uzakgider, D Kayar Calili, Y Genc, I Ozkocak Turan
{"title":"An uncommon indication for liver transplantation: toxic epidermal necrolysis.","authors":"B Uzakgider, D Kayar Calili, Y Genc, I Ozkocak Turan","doi":"10.51821/87.3.13045","DOIUrl":"10.51821/87.3.13045","url":null,"abstract":"","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":"87 3","pages":"433-434"},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation of the prevalence of functional constipation and its related factors for in older outpatients. 老年门诊患者功能性便秘发病率及其相关因素调查。
IF 1.3 4区 医学
Acta gastro-enterologica Belgica Pub Date : 2024-07-01 DOI: 10.51821/87.3.12949
M Esra Bozkurt, T Erdogan, Z Fetullahoglu, S Ozkok, C Kilic, G Bahat, M Akif Karan
{"title":"Investigation of the prevalence of functional constipation and its related factors for in older outpatients.","authors":"M Esra Bozkurt, T Erdogan, Z Fetullahoglu, S Ozkok, C Kilic, G Bahat, M Akif Karan","doi":"10.51821/87.3.12949","DOIUrl":"https://doi.org/10.51821/87.3.12949","url":null,"abstract":"<p><strong>Background: </strong>Functional constipation (FC) is a geriatric syndrome that is common in the older adult's population and can seriously affect the quality of life and may be a frequent cause of hospital visits. In this study, we planned to investigate the relationship between FC and its related factors for in older outpatients.</p><p><strong>Patients and methods: </strong>Participants aged 65 and over who applied to the geriatrics outpatient were included in the study. The diagnosis of FC was made according to the presence of the Rome IV criteria. Frailty was screened by the using FRAIL scale, ≥ 3 a score of were evaluated as frail. Participants quality of life was evaluated by Euro-Quality of Life Visual Analog Scale (EQ-VAS).</p><p><strong>Results: </strong>The study included 602 participants. FC prevalence was found 28.7%. In univariate analyses, FC was found related to age, having a diagnosis of depression or Parkinson diseases, frailty, urinary incontinence, sleep disorders, number of chronic diseases, and EQ-VAS. In multivariate analyses, FC was not found to be associated by the frailty while the number of chronic diseases [OR=1.212, 95%CI (1.084-1.355), p=0.001] and EQ-VAS were found to be related [OR=0.988, 95%CI (0.978-0.997), p=0.012].</p><p><strong>Conclusion: </strong>In the results of this study, FC was not found to be associated by frailty in older outpatients but it emerged as a syndrome that should be screened frequently in patients with a high number of chronic diseases and a low general quality of life.</p>","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":"87 3","pages":"361-365"},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An unusual case of high gastrointestinal bleeding after Whipple surgery. 一例不寻常的 Whipple 手术后消化道大出血病例。
IF 1.3 4区 医学
Acta gastro-enterologica Belgica Pub Date : 2024-07-01 DOI: 10.51821/87.3.12803
E Dubois, R Geelen
{"title":"An unusual case of high gastrointestinal bleeding after Whipple surgery.","authors":"E Dubois, R Geelen","doi":"10.51821/87.3.12803","DOIUrl":"https://doi.org/10.51821/87.3.12803","url":null,"abstract":"<p><p>Pancreatic cancer is an aggressive malignancy with poor survival rates. Pancreatic surgery has improved outcomes in the last few decades, but still contains high morbidity rates. Pancreatic fistula, delayed gastric emptying, intra-abdominal infections and bleeding are well-known complications. We report a case of a 57-year old woman with a portogastric fistula complicated with high gastrointestinal bleeding and septic thrombophlebitis after pancreaticoduodenectomy for pancreatic adenocarcinoma.</p>","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":"87 3","pages":"430-432"},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New onset inflammatory bowel disease after initiation of anti-IL-17a treatment: a case series. 抗IL-17a治疗后新发炎症性肠病：一个病例系列。
IF 1.3 4区 医学
Acta gastro-enterologica Belgica Pub Date : 2024-07-01 DOI: 10.51821/87.3.12874
J Geldof, M Truyens, B Strubbe, S Claeys, G Dewitte, E Glorieus, A Hoorens, T Lobaton
{"title":"New onset inflammatory bowel disease after initiation of anti-IL-17a treatment: a case series.","authors":"J Geldof, M Truyens, B Strubbe, S Claeys, G Dewitte, E Glorieus, A Hoorens, T Lobaton","doi":"10.51821/87.3.12874","DOIUrl":"https://doi.org/10.51821/87.3.12874","url":null,"abstract":"<p><p>Immune mediated inflammatory diseases (IMIDs) are a heterogenous group of inflammatory disorders of joint, skin, and gut characterized by both shared and distinct pathological pathways. This complexity has therapeutic implications, as not all IMIDs exhibit responsiveness to available biologicals. Moreover, cases have been documented where patients undergoing biologic therapy experience paradoxical occurrences of either a new IMID or a flare-up of a previously asymptomatic one. Treatment with anti- IL-17a has been approved for ankylosing spondylitis, psoriasis, and psoriatic arthritis, but was not found effective for the treatment of inflammatory bowel disease (IBD). This case series describes four patients with new onset IBD under treatment with an IL-17a inhibitor for a rheumatological or dermatological indication.</p>","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":"87 3","pages":"413-417"},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Statin therapy: improving survival in patients with hepatocellular carcinoma and portal hypertension is possible? 他汀类药物治疗：改善肝细胞癌和门静脉高压症患者的生存率可行吗？
IF 1.3 4区 医学
Acta gastro-enterologica Belgica Pub Date : 2024-07-01 DOI: 10.51821/87.3.13018
G Dispinzieri, C Becchetti, C Mazzarelli, A Airoldi, F Aprile, L Cesarini, M Cucco, G Perricone, R Stigliano, M Vangeli, R Viganò, L S Belli
{"title":"Statin therapy: improving survival in patients with hepatocellular carcinoma and portal hypertension is possible?","authors":"G Dispinzieri, C Becchetti, C Mazzarelli, A Airoldi, F Aprile, L Cesarini, M Cucco, G Perricone, R Stigliano, M Vangeli, R Viganò, L S Belli","doi":"10.51821/87.3.13018","DOIUrl":"https://doi.org/10.51821/87.3.13018","url":null,"abstract":"<p><p>Statins are generally known for their lipid-lowering properties and protection against cardiovascular events. However, growing evidence suggests that statins are a promising treatment for patients with chronic liver disease. Specifically, there is data supporting their role in reducing portal pressure and having a chemopreventive effect on hepatocellular carcinoma (HCC). Treatment options for HCC remain limited with portal hypertension (PH), thus statins could represent an inexpensive alternative, increasing survival of patients with HCC and PH. These drugs cannot be considered standard of care without a cardiac-metabolic indication to prescription in this patient group, although the potential beneficial effect should be indication for prompt use whenever considered appropriate. Our aim is to review the effects of statins on PH and on HCC, both in the pre-clinical and clinical setting in literature, discussing safety issues and limitations to the current body of evidence.</p>","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":"87 3","pages":"395-402"},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Signet ring cells in the gastrointestinal tract: not always what it seems. 胃肠道中的盾形环细胞：并非总是表里如一。
IF 1.3 4区 医学
Acta gastro-enterologica Belgica Pub Date : 2024-07-01 DOI: 10.51821/87.3.12986
M Vanhooren, A Billiet, T Hendrickx, J Vancanneyt, R Bisschop, F Van Here, H Topal, G De Hertogh, X Sagaert, J Dekervel, G Rasschaert
{"title":"Signet ring cells in the gastrointestinal tract: not always what it seems.","authors":"M Vanhooren, A Billiet, T Hendrickx, J Vancanneyt, R Bisschop, F Van Here, H Topal, G De Hertogh, X Sagaert, J Dekervel, G Rasschaert","doi":"10.51821/87.3.12986","DOIUrl":"10.51821/87.3.12986","url":null,"abstract":"<p><p>We describe two cases of pseudo-signet ring cells in gastric biopsies of otherwise asymptomatic adult patients. One male patient was diagnosed during follow-up of a previous intestinal type gastric adenocarcinoma and underwent surgery before recognition of this non-malignant entity. He suffered from a secondary anastomotic stenosis requiring dilatation. A second male patient was spared from surgery thanks to timely recognition by the pathologist and is still declared cancer-free until today. This extremely rare nonmalignant mimicker of cancerous signet ring cells, as seen in diffuse type gastric cancer can potentially mislead the clinician. The absence of any endoscopic abnormality should prompt a revision by an experienced pathologist, digestive oncologist and surgeon to avoid unnecessary interventions and morbidity.</p>","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":"87 3","pages":"418-420"},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Isolated intestinal manifestation of an invasive varicella zoster virus reactivation in an immunocompromised patient: a case report. 一名免疫力低下患者的侵袭性水痘带状疱疹病毒再激活的孤立肠道表现：病例报告。
IF 1.3 4区 医学
Acta gastro-enterologica Belgica Pub Date : 2024-07-01 DOI: 10.51821/87.3.11221
M Maly, G Coppens
{"title":"Isolated intestinal manifestation of an invasive varicella zoster virus reactivation in an immunocompromised patient: a case report.","authors":"M Maly, G Coppens","doi":"10.51821/87.3.11221","DOIUrl":"https://doi.org/10.51821/87.3.11221","url":null,"abstract":"<p><p>Invasive varicella zoster infection is a rare but severe infectious disease, potentially affecting almost every organ system and presenting with a variety of symptoms. It is usually seen in immunocompromised patients, but also occurs in immunocompetent patients. Isolated intestinal manifestations without skin lesions are even more scarce. We present a case of a 78-year old immunocompromised man with an isolated intestinal Varicella Zoster reactivation. If not early diagnosed and treated, an invasive infection can lead to life-threatening complications. Therefore, awareness in both immunocompromised as immunocompetent patients is very important in the daily clinical practice.</p>","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":"87 3","pages":"421-423"},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Need to treat? 需要治疗吗？
IF 1.3 4区 医学
Acta gastro-enterologica Belgica Pub Date : 2024-07-01 DOI: 10.51821/87.3.12234
L Lanneer, J Flamaing, P Roelandt
{"title":"Need to treat?","authors":"L Lanneer, J Flamaing, P Roelandt","doi":"10.51821/87.3.12234","DOIUrl":"https://doi.org/10.51821/87.3.12234","url":null,"abstract":"","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":"87 3","pages":"435"},"PeriodicalIF":1.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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