Helicobacter pylori prevalence and antibiotic resistance in patients undergoing bariatric surgery in Luxembourg: Impact and implications.

IF 1.2 4区医学 Q4 GASTROENTEROLOGY & HEPATOLOGY

Acta gastro-enterologica Belgica Pub Date : 2026-04-01 DOI:10.51821/89.2.15228

J Collot, S Sofos, P Feiereisen, P Deprez, R Garcés-Durán, C Tsobo Blistain, J Santiago Azagra, M Goergen, G Berchem, M Felten

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引用次数: 0

Abstract

Background: Helicobacter pylori (H. pylori) infection is a global health concern and may be relevant in candidates for bariatric surgery, yet data on prevalence and antimicrobial resistance in Luxembourg are limited.

Materials and methods: We conducted a retrospective, single-center cohort study including 1,110 patients with obesity evaluated for bariatric surgery at the Centre Hospitalier de Luxembourg between 2010 and 2020. H. pylori status was determined on gastric biopsy and antimicrobial resistance by susceptibility testing. Collected variables included demographics, BMI, eradication outcomes, and postoperative results (BMI loss and complications). A comparative group of 125 patients without obesity with biopsy-proven H. pylori infection was included for descriptive comparison.

Results: H. pylori prevalence among bariatric candidates was 29.3%. Among infected patients, 23.3% had strains resistant to at least one antibiotic, and first-line eradication was successful in 86.3%. Infection prevalence differed by nationality, being higher among Portuguese nationals than Luxembourgish patients or those from neighboring countries and was slightly higher in women than in men. Postoperatively, mean BMI reduction was 13.7 kg/m² after sleeve gastrectomy and 14.9 kg/m² after bypass surgery. H. pylori status was not associated with weight-loss outcomes or postoperative complications after adjustment.

Conclusion: Approximately one-third of bariatric surgery candidates in Luxembourg have H. pylori infection, with notable antibiotic resistance and variation by nationality and sex. After eradication and adjustment for confounders, H. pylori status was not linked to postoperative weight loss or complication rates.

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幽门螺杆菌患病率和抗生素耐药性在卢森堡接受减肥手术的患者：影响和意义。

背景：幽门螺杆菌（H. pylori）感染是一个全球性的健康问题，可能与减肥手术的候选者有关，但卢森堡的患病率和抗菌素耐药性数据有限。材料和方法：我们进行了一项回顾性、单中心队列研究，纳入了2010年至2020年在卢森堡医院中心接受减肥手术评估的1110例肥胖患者。胃活检及药敏试验检测幽门螺杆菌状态。收集的变量包括人口统计学、BMI、根除结果和术后结果（BMI下降和并发症）。对照组为125例无肥胖但活检证实幽门螺杆菌感染的患者，进行描述性比较。结果：幽门螺杆菌在肥胖候选人中的患病率为29.3%。在感染患者中，23.3%的患者至少有一种抗生素耐药，86.3%的患者一线根除成功。感染流行率因国籍而异，葡萄牙国民高于卢森堡患者或来自邻国的患者，女性略高于男性。术后，套筒胃切除术后BMI平均下降13.7 kg/m²，旁路手术后BMI平均下降14.9 kg/m²。调整后的幽门螺杆菌状态与减肥结果或术后并发症无关。结论：卢森堡约三分之一的减肥手术患者有幽门螺杆菌感染，且抗生素耐药性明显，且因国籍和性别而异。根除和调整混杂因素后，幽门螺杆菌状态与术后体重减轻或并发症发生率无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta gastro-enterologica Belgica Medicine-Gastroenterology

CiteScore

2.30

自引率

20.00%

发文量

期刊介绍： The Journal Acta Gastro-Enterologica Belgica principally publishes peer-reviewed original manuscripts, reviews, letters to editors, book reviews and guidelines in the field of clinical Gastroenterology and Hepatology, including digestive oncology, digestive pathology, as well as nutrition. Pure animal or in vitro work will not be considered for publication in the Journal. Translational research papers (including sections of animal or in vitro work) are considered by the Journal if they have a clear relationship to or relevance for clinical hepato-gastroenterology (screening, disease mechanisms and/or new therapies). Case reports and clinical images will be accepted if they represent an important contribution to the description, the pathogenesis or the treatment of a specific gastroenterology or liver problem. The language of the Journal is English. Papers from any country will be considered for publication. Manuscripts submitted to the Journal should not have been published previously (in English or any other language), nor should they be under consideration for publication elsewhere. Unsolicited papers are peer-reviewed before it is decided whether they should be accepted, rejected, or returned for revision. Manuscripts that do not meet the presentation criteria (as indicated below) will be returned to the authors. Papers that go too far beyond the scope of the journal will be also returned to the authors by the editorial board generally within 2 weeks. The Journal reserves the right to edit the language of papers accepted for publication for clarity and correctness, and to make formal changes to ensure compliance with AGEB’s style. Authors have the opportunity to review such changes in the proofs.