Acta gastro-enterologica Belgica最新文献

Efficacy and safety of capecitabine-temozolomide (CAPTEM) regimen in patients with neuroendocrine neoplasms - experience from NETwerk, a Belgian ENETS Center of Excellence. 卡培他滨-替莫唑胺（CAPTEM）治疗神经内分泌肿瘤患者的疗效和安全性——来自比利时ENETS卓越中心NETwerk的经验

IF 1.3 4区医学

Acta gastro-enterologica Belgica Pub Date : 2025-04-01 DOI: 10.51821/88.1.13722

C Lambrechts, S Chhajlani, O Islam, L Verbruggen, C De Weerdt, L Mariën, M Simoens, M Ulenaers, D Galdermans, W Demey, I Van der Massen, W Lybaert, T Vandamme

{"title":"Efficacy and safety of capecitabine-temozolomide (CAPTEM) regimen in patients with neuroendocrine neoplasms - experience from NETwerk, a Belgian ENETS Center of Excellence.","authors":"C Lambrechts, S Chhajlani, O Islam, L Verbruggen, C De Weerdt, L Mariën, M Simoens, M Ulenaers, D Galdermans, W Demey, I Van der Massen, W Lybaert, T Vandamme","doi":"10.51821/88.1.13722","DOIUrl":"https://doi.org/10.51821/88.1.13722","url":null,"abstract":"Neuroendocrine neoplasms (NEN) are rare tumors originating from neuroendocrine cells, commonly found in the gastrointestinal tract and the pulmonary tract. Metastatic welldifferentiated neuroendocrine tumors (NET) grade 3 present unique challenges, as they are positioned between the more indolent NET grade 1-2 and the aggressive neuroendocrine carcinomas (NEC). Due to the scarcity of data regarding the optimal systemic treatment for metastatic NET grade 3 and aggressive NET grade 2 subtypes, guidelines remain inconclusive. This retrospective study analyzed data from the NETwerk database, encompassing patients treated with the capecitabinetemozolomide (CAPTEM) regimen between June 2016 and January 2024. The cohort included patients with NET grades 1-3 and NEC. The study focused on assessing the efficacy and safety of CAPTEM. In total, data from 36 patients was analyzed. The median progression-free survival (mPFS) was 13 months, and median overall survival (mOS) was 17 months. Overall response rate (ORR) was 25.8%, and the disease control rate (DCR) was 67.7%. NET grade 2 patients had the highest mPFS, while NET grade 3 exhibited the most favorable mOS. Subgroup analysis showed that panNEN had superior mPFS and mOS compared to other primary tumor sites, with significant differences in mOS based on NEN type. Safety analysis in 20 patients indicated good tolerance and safety . CAPTEM is an efficient and safe regimen for metastatic NEN, with promising outcomes in NET grade 2-3 patients. The promising findings pave the way for further exploration into various aspects of CAPTEM, to better define its position in the therapeutic landscape of NEN.","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":"88 2","pages":"119-127"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recommendations for the diagnosis and management of patients with chronic idiopathic diarrhea: Belgian multidisciplinary expert discussion based on a modified Delphi method. 慢性特发性腹泻患者的诊断和管理建议：比利时多学科专家讨论基于改进的德尔菲法。

IF 1.3 4区医学

Acta gastro-enterologica Belgica Pub Date : 2025-04-01 DOI: 10.51821/88.1.13772

T Vanuytsel, J Arts, V Casneuf, F de Clerck, D De Looze, H Deschepper, K Geboes, M Hiele, T Holvoet, H Louis, S Kindt, P Latour, F Mokaddem, S Nullens, H Piessevaux, M Surmont, J Tack, R Bisschops

{"title":"Recommendations for the diagnosis and management of patients with chronic idiopathic diarrhea: Belgian multidisciplinary expert discussion based on a modified Delphi method.","authors":"T Vanuytsel, J Arts, V Casneuf, F de Clerck, D De Looze, H Deschepper, K Geboes, M Hiele, T Holvoet, H Louis, S Kindt, P Latour, F Mokaddem, S Nullens, H Piessevaux, M Surmont, J Tack, R Bisschops","doi":"10.51821/88.1.13772","DOIUrl":"https://doi.org/10.51821/88.1.13772","url":null,"abstract":"Background: Chronic diarrhea is one of the more common reasons for referral to a gastro-enterologist. Chronic diarrhea can have a broad range of causes, making it a disease entity with a very extensive differential diagnosis. In a proportion of patients, however, a cause for the chronic diarrhea cannot be found and these patients are said to have chronic idiopathic diarrhea (CID).Methods: A Delphi model was used to establish a diagnostic strategy for patients presenting with chronic diarrhea that maximizes the chance for a positive diagnosis while minimizing the number and invasiveness of the investigations. In addition, the participating experts sought consensus on the different treatment options that can be used in these patients.Results: While a general consensus was reached on the required diagnostic tests for CID, marked differences were observed on the treatment preferences and strategies for these patients among the different experts. The main reason for this is the lack of solid scientific evidence with the different treatment options in this setting (i.e., most data have been generated in patients with IBS-D).Conclusion: the Delphi-like process that was used for this initiative proved to be a useful vehicle to fuel discussions on the management of CID among experts with different backgrounds and to sketch the current clinical practice.","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":"88 2","pages":"179-194"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Esophageal Lichen Planus: a Narrative Review of the Literature. 食管扁平苔藓：文献综述。

IF 1.3 4区医学

Acta gastro-enterologica Belgica Pub Date : 2025-04-01 DOI: 10.51821/88.1.13966

A Oosterbosch, P De Haes, G De Hertogh, J Tack, T Vanuytsel

{"title":"Esophageal Lichen Planus: a Narrative Review of the Literature.","authors":"A Oosterbosch, P De Haes, G De Hertogh, J Tack, T Vanuytsel","doi":"10.51821/88.1.13966","DOIUrl":"10.51821/88.1.13966","url":null,"abstract":"Background: Lichen planus is a mucocutaneous chronic inflammatory disorder that can also affect the esophagus in a minority of patients. Esophageal lichen planus (ELP) is likely an underdiagnosed and underreported disease entity, although it can lead to significant morbidity with esophageal stenosis or malignant transformation.Methods: A non-systematic search of Pubmed was performed using search terms 'esophageal lichen planus' and variants thereof combined with terms related to prevalence, diagnosis, and management.Results: The cutaneous and oral forms of lichen planus are relatively common, but certain mucosal forms such as genital lichen planus are rare and esophageal planus (also a mucosal form) is very rare. ELP occurs predominantly in middle-aged women. Current guidelines regarding lichen planus do not mention a screening strategy for ELP. Diagnosis of ELP is based on endoscopic and histopathological criteria. The foremost complication of ELP is formation of esophageal strictures. Malignant transformation of ELP to squamous cell carcinoma, although rare, has also been reported. We summarize the current evidence regarding optimal management of ELP.Conclusion: Even if esophageal lichen planus is a rare cause of esophageal strictures, it is important to raise awareness of this condition among gastroenterologists and endoscopists. The cornerstone of ELP treatment is an anti-inflammatory agent in conjunction with endoscopic dilatation of strictures. Further research is needed to devise an evidence-based treatment algorithm that describes the optimal anti-inflammatory drug in different stages/severities of ELP.","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":"88 2","pages":"129-140"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gliptin induced acute pancreatitis: a literature review. 格列汀诱导急性胰腺炎的文献综述。

IF 1.3 4区医学

Acta gastro-enterologica Belgica Pub Date : 2025-04-01 DOI: 10.51821/88.1.13722

G Jaya Pragadeesh, Sheik Asik Abu Sali, S Rajesh Kumar, Dhanashri Babu, D Dheepthi

引用次数: 0

Essential reading from the editorial board. 编辑委员会的重要读物。

IF 1.3 4区医学

Acta gastro-enterologica Belgica Pub Date : 2025-04-01 DOI: 10.51821/88.1.14571

H De Schepper, A Marot

引用次数: 0

Successful Endoscopic Management of Gastric Volvulus: A Case Report Highlighting Effective Treatment Strategies. 胃镜下成功治疗胃扭转：一个强调有效治疗策略的病例报告。

IF 1.3 4区医学

Acta gastro-enterologica Belgica Pub Date : 2025-04-01 DOI: 10.51821/88.1.13090

T Halbart, C Maris, S Laurent, T-H Trieu, J-B Zeevaert, E Wain

引用次数: 0

Venous malformations as a rare cause of lower gastrointestinal bleeding in a young patient with Blue Rubber Bleb Nevus Syndrome. 静脉畸形作为一个罕见的原因下消化道出血的年轻患者蓝橡胶水泡痣综合征。

IF 1.3 4区医学

Acta gastro-enterologica Belgica Pub Date : 2025-04-01 DOI: 10.51821/88.1.13772

A Mahajan, M Verma

引用次数: 0

Acute hepatitis E-related Guillain-Barré syndrome. 急性戊型肝炎相关格林-巴利综合征。

IF 1.3 4区医学

Acta gastro-enterologica Belgica Pub Date : 2025-04-01 DOI: 10.51821/88.1.13825

D Naudts, B Van Overberghe, F De Maeyer, M Peeters, T Vanwolleghem

引用次数: 0

A case report on use of TIPS for ectopic variceal bleeding. TIPS治疗异位静脉曲张出血1例报告。

IF 1.3 4区医学

Acta gastro-enterologica Belgica Pub Date : 2025-04-01 DOI: 10.51821/88.1.13326

E Brusselle, J Van Ongeval, W Pauwels, A Geerts

引用次数: 0

Assessment of Esophageal Emptying in Patients with Dysphagia: Differences Between High-Resolution Impedance Manometry and Timed Barium Esophagram. 吞咽困难患者食管排空的评估：高分辨率阻抗测压法与定时食管钡餐造影的差异。

IF 1.3 4区医学

Acta gastro-enterologica Belgica Pub Date : 2025-04-01 DOI: 10.51821/88.1.13772

D L Cohen, J Ghantus, R Tome, B Hijazi, F Abu Baker, H Shirin, D Carter, F Shibli, T Khoury, A Mari

{"title":"Assessment of Esophageal Emptying in Patients with Dysphagia: Differences Between High-Resolution Impedance Manometry and Timed Barium Esophagram.","authors":"D L Cohen, J Ghantus, R Tome, B Hijazi, F Abu Baker, H Shirin, D Carter, F Shibli, T Khoury, A Mari","doi":"10.51821/88.1.13772","DOIUrl":"10.51821/88.1.13772","url":null,"abstract":"Background/aims: Assessment of esophageal emptying is important in the evaluation of patients with dysphagia. As several modalities can evaluate this, we aimed to compare two tests frequently used for assessing esophageal emptying-highresolution impedance manometry (HRiM) and timed barium esophagram (TBE).Methods: A retrospective study compared the results of HRiM and TBE in patients with dysphagia between 2018 and 2022. Abnormal esophageal clearance was defined as ≥30% swallows with incomplete bolus clearance on HRiM and as residual barium ≥2 cm at 5 minutes on TBE.Results: 77 patients were included in the study (mean age 51.6; 69% female). The most common HRiM diagnoses were normal motility (37.7%), ineffective esophageal motility (28.6%), and achalasia (19.5%). Effective esophageal clearance was noted on HRiM in only 44 subjects (57.1%), while it was seen on TBE in 57 subjects (74.0%)(P=0.027). There was agreement between the studies in 58 subjects (75.3%). Agreement was significantly affected by the HRiM diagnosis with the highest rate (86.7%) among achalasia patients (P=0.032). The only other factor correlated to agreement between the studies was a lack of alcohol use (P=0.048).Conclusions: According to the parameters used in this study, TBE is more likely to reveal esophageal emptying than HRiM in patients with dysphagia. While there is fair agreement between the results of the two studies, results are especially concordant in achalasia patients suggesting that either study may be useful in evaluating esophageal emptying in that population.","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":"88 2","pages":"89-95"},"PeriodicalIF":1.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0