Acta gastro-enterologica Belgica最新文献_第10页

An unusual case of acute cholestatic hepatitis: visceral leishmaniasis with secondary haemophagocytic lymphohistiocytosis. 急性胆汁淤积性肝炎罕见病例：内脏利什曼病伴继发性噬血细胞淋巴组织细胞增多症。

IF 1.3 4区医学

Acta gastro-enterologica Belgica Pub Date : 2025-01-01 DOI: 10.51821/88.1.13361

N Gestels, E Bottieau, A De Vooght, S van Ierssel, S Libbrecht, A Driessen, S Francque, T Vanwolleghem, W J Kwanten

引用次数: 0

Selective internal radiation therapy for neuroendocrine liver metastases: efficacy, safety and prognostic factors. A retrospective single institution study. 选择性内放疗治疗神经内分泌性肝转移：疗效、安全性及预后因素。回顾性单机构研究。

IF 1.3 4区医学

Acta gastro-enterologica Belgica Pub Date : 2025-01-01 DOI: 10.51821/88.1.13706

D Briol, A Ceratti, R Lhommel, L Annet, C Dragean, E Danse, P Trefois, M Van Den Eynde, A De Cuyper, P Goffette, I Borbath

{"title":"Selective internal radiation therapy for neuroendocrine liver metastases: efficacy, safety and prognostic factors. A retrospective single institution study.","authors":"D Briol, A Ceratti, R Lhommel, L Annet, C Dragean, E Danse, P Trefois, M Van Den Eynde, A De Cuyper, P Goffette, I Borbath","doi":"10.51821/88.1.13706","DOIUrl":"10.51821/88.1.13706","url":null,"abstract":"Background and study aims: Selective internal radiation therapy (SIRT) has shown good results in unresectable liver metastases from neuroendocrine neoplasms (NELM) with a high disease control rate (DCR) reported. The aims of the study is to assess retrospectively the efficacy and safety of 10y of SIRT for NELM.Patients and methods: Primary endpoint was objective response rate (ORR) and DCR by RECIST 1.1 at 2, 4 and 12 months (m). Secondary endpoints were overall survival (OS), liver progressionfree survival (liver-PFS), clinical response (NEN-related symptoms improvement) and safety.Results: 50 consecutive patients with NELM who got SIRT from 2011 to 2021 in one center. The two major NEN primary sites were pancreas (46%) and small intestine (36%). Histological NEN grades were 10%, 46% and 44% for grades 1, 2 and 3 respectively. ORR and DCR were 16% and 80% at 2m, 22% and 92% at 4m and 32% and 82% at 12m. Survival rates at 1 and 2 y were 76% and 72% respectively. Prognostic factors for OS and liver-PFS were NEN histological grade (3 vs 1+2) (hazard ratio (HR) for OS: 4.33 [1.8-10.6], for liver-PFS: 3.91 [1.3-11.4]), and early (2m) DCR (HR for OS: 0.14 [0.1-0.4], for liver-PFS: 0.016 [0.003-0.08]). Clinical response occurred in 7 of the 10 symptomatic patients. One patient died from radioembolization-induced liver disease.Conclusion: SIRT showed efficacy in NELM pts, with a high DCR and an good safety profile. G1-2 grade and early DCR were associated with a better OS and liver-PFS.","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":"88 1","pages":"3-11"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Switching intravenous to subcutaneous infliximab was safe and successful during 1-year follow up in Ulcerative Colitis and Crohn patients - a Belgian single center experience. 在溃疡性结肠炎和克罗恩患者的1年随访中，将静脉注射改为皮下注射英夫利昔单抗是安全且成功的-比利时单中心经验。

IF 1.3 4区医学

Acta gastro-enterologica Belgica Pub Date : 2025-01-01 DOI: 10.51821/88.1.13222

L Cornelis, E De Jonckere, J Bossuyt, H Vanpoucke, L Desomer, D De Wulf, F Baert

{"title":"Switching intravenous to subcutaneous infliximab was safe and successful during 1-year follow up in Ulcerative Colitis and Crohn patients - a Belgian single center experience.","authors":"L Cornelis, E De Jonckere, J Bossuyt, H Vanpoucke, L Desomer, D De Wulf, F Baert","doi":"10.51821/88.1.13222","DOIUrl":"10.51821/88.1.13222","url":null,"abstract":"Background: Subcutaneous (SC) infliximab CT-P13 (IFX) has recently been registered for the treatment of moderate-to-severe inflammatory bowel disease (IBD). The SC route is an attractive option for patients. However, many open questions remain on how to safely switch patients from maintenance IV to SC administration.Objective: to assess switching from IV to SC IFX therapy in IBD patients through clinical and biochemical evaluation.Methods: Patients in durable remission on eight-weekly (or six-weekly) IV infliximab and therapeutic IFX trough levels were switched to SC therapy every two weeks. All patients were monitored prospectively every 3 months with patient reported outcomes (PRO), labs including IFX concentrations and faecal calprotectin every 6 months for minimum one-year follow up.Results: 55 patients (21 UC, 34 CD) agreed to switch to SC therapy. The median follow up in CD patients was 15.5 months, respectively 20 months in UC patients. All patients remained in deep remission according to PRO2, CRP and calprotectin. IFX serum concentrations more than tripled 3 months after the switch (18.31 ± 10.53 μg/mL vs. 4.82 ± 3.06 μg/mL at the start) and remained stable during further follow up. Local pain and injection site reactions both transient were reported in 47% and 42% patients respectively but disappeared in > 50% when injecting in the abdomen or when changing pen to syringe.Conclusion: Switching UC and Crohn patients in clinical remission and adequate trough levels from maintenance IV tot SC infliximab therapy was successful for at least one year. A proportion of patients experienced pain and or injection site reactions.","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":"88 1","pages":"18-22"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Essential reading from the editorial board. 编辑委员会的重要读物。

IF 1.3 4区医学

Acta gastro-enterologica Belgica Pub Date : 2025-01-01 DOI: 10.51821/88.1.14

C Reenaers

引用次数: 0

Unexplained portal hypertension and confusion in an elderly patient: a late presentation of congenital hepatic fibrosis. 老年患者不明原因的门静脉高压症和精神错乱：先天性肝纤维化的晚期表现。

IF 1.3 4区医学

Acta gastro-enterologica Belgica Pub Date : 2025-01-01 DOI: 10.51821/88.1.13474

B Rombouts, E Van der Wijst, P Schoeters, A Driessen, T Steinhauser, T Vanwolleghem, W Kwanten, J Derdeyn, L Vonghia, S Francque

引用次数: 0

An unusual hidden secret of a Meckel's diverticulum: a rare case of small bowel adenocarcinoma. 梅克尔憩室不寻常的隐藏秘密：一例罕见的小肠腺癌。

IF 1.3 4区医学

Acta gastro-enterologica Belgica Pub Date : 2025-01-01 DOI: 10.51821/88.1.13489

T Hendrickx, F Van Herpe, A D'Hoore, R C Dresen, J Sabino

引用次数: 0

Knee extension strength in patients with liver cirrhosis and the impact of interventions: systematic review and meta-analysis. 肝硬化患者的膝关节伸展强度和干预措施的影响：系统回顾和荟萃分析。

IF 1.3 4区医学

Acta gastro-enterologica Belgica Pub Date : 2025-01-01 DOI: 10.51821/88.1.13033

A Couret, F Rannou, B Pereira, M Duclos, S Mazeaud, J A King, A Abergel, G Ennequin

{"title":"Knee extension strength in patients with liver cirrhosis and the impact of interventions: systematic review and meta-analysis.","authors":"A Couret, F Rannou, B Pereira, M Duclos, S Mazeaud, J A King, A Abergel, G Ennequin","doi":"10.51821/88.1.13033","DOIUrl":"10.51821/88.1.13033","url":null,"abstract":"Background: Sarcopenia is common in patients with cirrhosis and lower limb muscle strength could represent a factor of morbidity. A systematic review with meta-analysis on knee extension muscle strength in patients with cirrhosis was performed.Methods: Literature was reviewed in electronic databases from inception until March 2023. Two independent researchers applied the inclusion criteria to assess the eligibility of articles. Of the 28 retrieved articles; 21 of them met the eligibility requirements.Results: Muscle strength was impaired in patients with cirrhosis versus age-matched control (standardized mean difference, SMD: 3.48, 95% CI 2.35-4.61, I² = 96.5%, p<0.001) and was negatively influenced by increasing disease severity, with Child-Pugh A and B superior to C (SMD: 2.62, 95% CI 0.54-4.71, p<0.014; SMD 0.71, 95% CI 0.29-1.13, p<0.001, respectively). Exercise training tended to increase (SMD: 1.21, 95% CI 0.16-2.59, p=0.085), while liver transplantation decreased knee extension strength (SMD: -0.45, 95% CI -0.88 -0.01, p=0.045).Conclusion: The negative impact of liver cirrhosis on knee extension strength is worsened by the severity of the disease. Transplantation leads to impaired knee extension strength. Conversely, exercise training tends to be beneficial, making rehabilitation pre and post-transplantation an attractive strategy to prevent muscle mass and strength loss.","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":"88 1","pages":"43-60"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoscopic retrograde cholangiopancreatography in patients with different types of total and partial gastrectomy. 内镜逆行胰胆管造影在不同类型胃全、部分切除术患者中的应用。

IF 1.3 4区医学

Acta gastro-enterologica Belgica Pub Date : 2025-01-01 DOI: 10.51821/88.1.13779

F Fortunati, L Monino, P Deprez, H Piessevaux, T Moreels

{"title":"Endoscopic retrograde cholangiopancreatography in patients with different types of total and partial gastrectomy.","authors":"F Fortunati, L Monino, P Deprez, H Piessevaux, T Moreels","doi":"10.51821/88.1.13779","DOIUrl":"10.51821/88.1.13779","url":null,"abstract":"Background and study aims: Endoscopic retrograde cholangiopancreatography (ERCP) in surgically altered anatomy patients is challenging. We analyzed ERCP procedures after gastric surgery with maintained Vater's papilla: total/partial gastrectomy Roux-en-Y, Billroth II gastrectomy, sleeve gastrectomy and gastrojejunostomy.Methods: Monocentric retrospective analysis of prospective ERCP cohort in surgically altered gastric anatomy (SAGA) patients with maintained Vater's papilla between 2006 and 2024.Results: 186 ERCP procedures in 110 patients with SAGA proportions: 37% total gastrectomy Roux-en-Y, 32% Billroth II partial gastrectomy, 15% partial gastrectomy Roux-en-Y, 11% gastrojejunostomy, 4% sleeve gastrectomy and 1% less common reconstructions. ERCP indications were mainly biliary (87%). Total technical success was 82% with lower technical success in Roux-en-Y gastric surgery (73%) vs gastric surgery without Rouxen- Y (92%). 13 adverse events (GRADE II - IV) were encountered (7%) with 1 mortality due to perprocedural cardiac arrest. Sleeve gastrectomy allowed the use of conventional duodenoscopes with 100% technical success. In Billroth II patients both duodenoscopes, gastroscopes and colonoscopes as well as balloon-assisted enteroscopes were used with high technical success (94-100%), as well as in gastrojejunostomy patients (57-100%). For Roux-en-Y reconstructions, only single-balloon enteroscopes were used with acceptable success (75% in partial and 74% in total gastrectomy Roux-en-Y).Conclusions: ERCP in SAGA patients is challenging requiring different types of endoscopes, especially after Roux-en-Y total or partial gastrectomy with lower technical success as compared tods Billroth II gastrectomy, sleeve gastrectomy and gastrojejunostomy. Adverse event rates are comparable to ERCP procedures in patients with normal anatomy.","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":"88 1","pages":"23-30"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medical malpractice litigations against gastroenterologists in Belgium. 针对比利时胃肠病学家的医疗事故诉讼。

IF 1.3 4区医学

Acta gastro-enterologica Belgica Pub Date : 2025-01-01 DOI: 10.51821/88.1.14028

N Meyten, T G Moreels

{"title":"Medical malpractice litigations against gastroenterologists in Belgium.","authors":"N Meyten, T G Moreels","doi":"10.51821/88.1.14028","DOIUrl":"10.51821/88.1.14028","url":null,"abstract":"Introduction: Medical malpractice litigations represent a reality for clinical physicians. However, no data are available about the impact on gastroenterologists in Belgium.Aim: We estimated the number of malpractice litigations against gastroenterologists in Belgium based on the annual reports of the Fund for Medical Accidents (FMA), residing under the Belgian national social security service (RIZIV-INAMI).Methods: FMA annual reports are available online in the public domain from 2012 onwards. We reviewed all available annual reports, focussing on results within the fields of Gastroenterology and Cardiology.Results: From 2010 to 2023 a total of 6884 applications for malpractice litigations were filed resulting in a final decision for 3185 care providers between 2014 and 2023. In this 10 years period claims were filed against 92 gastroenterologists, placing them in the top 10 of care providers at risk for malpractice litigations in Belgium. There are currently 777 practicing gastroenterologists in Belgium, indicating that over 10 years time the cumulative risk of malpractice litigation through the FMA alone is as high as 12%. The subject of the claims is not mentioned in the FMA reports, and therefore remains unknown. Compared to Cardiology, another interventional speciality within the field of Internal Medicine, gastroenterologists are more prone to malpractice litigations. Only 73 (6%; p<0.001 Chi-square) on a total of 1237 practicing cardiologists faced malpractice litigations through the FMA.Conclusion: Based on the FMA annual reports, Belgian gastroenterologists are considerably at risk of malpractice litigations reaching 12% over a 10 years time period, as compared to only 6% cumulative risk of practicing cardiologists. Endoscopy-related complications are supposedly the most common reason of malpractice litigation and Belgian gastroenterologists should be aware of this risk.","PeriodicalId":7322,"journal":{"name":"Acta gastro-enterologica Belgica","volume":"88 1","pages":"38-42"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143439699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pancreatic cystic lymphangioma in an adult: a rare clinical entity. 成人胰腺囊性淋巴管瘤：罕见的临床病例。

IF 1.3 4区医学

Acta gastro-enterologica Belgica Pub Date : 2025-01-01 DOI: 10.51821/88.1.13325

M Staessens

引用次数: 0