Genome instability & disease最新文献_第6页

BRCA1: a key player at multiple stages of homologous recombination in DNA double-strand break repair BRCA1:在DNA双链断裂修复中同源重组的多个阶段起关键作用

Genome instability & disease Pub Date : 2021-06-01 DOI: 10.1007/s42764-021-00042-1

Yidan Liu, Lin-Yu Lu

引用次数: 0

Human papillomavirus-mediated carcinogenesis and tumor progression 人乳头瘤病毒介导的癌变和肿瘤进展

Genome instability & disease Pub Date : 2021-04-01 DOI: 10.1007/s42764-021-00038-x

Fadi Abboodi, Nella C. Delva, Jennifer Emmel, Ariana N. Renrick, P. Buckhaults, Carolyn E. Banister, K. Creek, L. Pirisi

引用次数: 0

Nuclear envelope integrity, DNA replication, damage repair and genome stability 核膜完整性，DNA复制，损伤修复和基因组稳定性

Genome instability & disease Pub Date : 2021-04-01 DOI: 10.1007/s42764-021-00039-w

Wenjun Pu, Haihui Zhang, Peiwu Qin, Lin Deng

引用次数: 1

LncRNAs as key players in the MYC pathways lncrna在MYC通路中起关键作用

Genome instability & disease Pub Date : 2021-02-01 DOI: 10.1007/s42764-021-00032-3

Taewan Kim

引用次数: 2

Locked in a vicious cycle: the connection between genomic instability and a loss of protein homeostasis 陷入恶性循环:基因组不稳定与蛋白质体内平衡丧失之间的联系

Genome instability & disease Pub Date : 2021-02-01 DOI: 10.1007/s42764-020-00027-6

Wouter Huiting, Steven Bergink

引用次数: 8

The epigenetic DNA modification 5-carboxylcytosine promotes high levels of cyclobutane pyrimidine dimer formation upon UVB irradiation. 表观遗传 DNA 修饰 5-羧基胞嘧啶会在紫外线照射下促进环丁烷嘧啶二聚体的大量形成。

Genome instability & disease Pub Date : 2021-02-01 Epub Date: 2021-01-02 DOI: 10.1007/s42764-020-00030-x

Sang-In Kim, Gerd P Pfeifer

{"title":"The epigenetic DNA modification 5-carboxylcytosine promotes high levels of cyclobutane pyrimidine dimer formation upon UVB irradiation.","authors":"Sang-In Kim, Gerd P Pfeifer","doi":"10.1007/s42764-020-00030-x","DOIUrl":"10.1007/s42764-020-00030-x","url":null,"abstract":"In mammals, DNA methyltransferases create 5-methylcytosines (5mC) predominantly at CpG dinucleotides. 5mC oxidases convert 5mC in three consecutive oxidation steps to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and then 5-carboxylcytosine (5caC). Upon irradiation with UV light, dipyrimidines containing C, 5mC and 5hmC are known to form cyclobutane pyrimidine dimers (CPDs) as major DNA photolesions. However, the photobiology of 5fC and 5caC has remained largely unexplored. Here, we tested a series of oligonucleotides with single or multiple positions carrying cytosine (C), 5mC, 5hmC, 5fC or 5caC and irradiated them with different sources of UV irradiation. While UVC radiation produced CPDs near dipyrimidines containing all types of modified cytosine bases, UVB radiation produced by far the highest levels of CPDs near 5caC-containing sequences. Dipyrimidines one or two nucleotide positions adjacent to 5caC but not always those involving this modified base directly were the major sites for these prominent UVB photoproducts. This selectivity did not depend on whether 5caC was present on one or both DNA strands at CpG sequences. We also observed a tendency of the 5caC-containing DNA strands to undergo apparent covalent crosslinking. This reaction occurred with UVB or UVC but not with UVA irradiation. Our data show that 5-carboxylcytosine, although generally a rare base in the genome, can nonetheless make a strong contribution to sequence-specific DNA damage perhaps by acting as a DNA-intrinsic photosensitizer.","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8415257/pdf/nihms-1659482.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39389528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Structural insights into the role of DNA-PK as a master regulator in NHEJ. DNA-PK作为NHEJ的主要调节因子的结构见解。

Genome instability & disease Pub Date : 2021-01-01 DOI: 10.1007/s42764-021-00047-w

Siyu Chen, James P Lees-Miller, Yuan He, Susan P Lees-Miller

{"title":"Structural insights into the role of DNA-PK as a master regulator in NHEJ.","authors":"Siyu Chen, James P Lees-Miller, Yuan He, Susan P Lees-Miller","doi":"10.1007/s42764-021-00047-w","DOIUrl":"https://doi.org/10.1007/s42764-021-00047-w","url":null,"abstract":"DNA-dependent protein kinase catalytic subunit DNA-PKcs/PRKDC is the largest serine/threonine protein kinase of the phosphatidyl inositol 3-kinase-like protein kinase (PIKK) family and is the most highly expressed PIKK in human cells. With its DNA-binding partner Ku70/80, DNA-PKcs is required for regulated and efficient repair of ionizing radiation-induced DNA double-strand breaks via the non-homologous end joining (NHEJ) pathway. Loss of DNA-PKcs or other NHEJ factors leads to radiation sensitivity and unrepaired DNA double-strand breaks (DSBs), as well as defects in V(D)J recombination and immune defects. In this review, we highlight the contributions of the late Dr. Carl W. Anderson to the discovery and early characterization of DNA-PK. We furthermore build upon his foundational work to provide recent insights into the structure of NHEJ synaptic complexes, an evolutionarily conserved and functionally important YRPD motif, and the role of DNA-PKcs and its phosphorylation in NHEJ. The combined results identify DNA-PKcs as a master regulator that is activated by its detection of two double-strand DNA ends for a cascade of phosphorylation events that provide specificity and efficiency in assembling the synaptic complex for NHEJ.","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s42764-021-00047-w","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9587807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Repair of programmed DNA lesions in antibody class switch recombination: common and unique features. 抗体类开关重组中程序性DNA损伤的修复:共性与独特性。

Genome instability & disease Pub Date : 2021-01-01 Epub Date: 2021-03-26 DOI: 10.1007/s42764-021-00035-0

Yafang Shang, Fei-Long Meng

引用次数: 3

TIP60 recruits SUV39H1 to chromatin to maintain heterochromatin genome stability and resist hydrogen peroxide-induced cytotoxicity TIP60将SUV39H1招募到染色质上，以维持异染色质基因组的稳定性并抵抗过氧化氢诱导的细胞毒性

Genome instability & disease Pub Date : 2020-11-01 DOI: 10.1007/s42764-020-00025-8

Bo Tu, Yantao Bao, Ming Tang, Qian Zhu, Xiaopeng Lu, Hui Wang, Tianyun Hou, Ying Zhao, Ping Zhang, Wei-Guo Zhu

引用次数: 2

A new insight into base excision repair (BER) in targeted cancer therapy 肿瘤靶向治疗中碱基切除修复(BER)的新认识

Genome instability & disease Pub Date : 2020-11-01 DOI: 10.1007/s42764-020-00024-9

R. Kumar

引用次数: 1