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Genome instability & disease最新文献

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Primary microcephaly with an unstable genome 原发性小头畸形，基因组不稳定
Genome instability & disease Pub Date : 2020-09-01 DOI: 10.1007/s42764-020-00020-z
Shibin Xu, Xingxuan Wu, Bin Peng, Shenghan Cao, Xingzhi Xu
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引用次数: 5
ATM-deficient lung, prostate and pancreatic cancer cells are acutely sensitive to the combination of olaparib and the ATR inhibitor AZD6738 ATM缺陷的肺癌、前列腺癌和胰腺癌细胞对奥拉帕利和ATR抑制剂AZD6738的组合具有急性敏感性
Genome instability & disease Pub Date : 2020-07-01 DOI: 10.1007/s42764-020-00011-0
N. Jette, S. Radhamani, R. Ye, Yaping Yu, G. Arthur, S. Goutam, T. Bismar, Mehul Kumar, P. Bose, S. Yip, M. Kolinsky, S. Lees-Miller
{"title":"ATM-deficient lung, prostate and pancreatic cancer cells are acutely sensitive to the combination of olaparib and the ATR inhibitor AZD6738","authors":"N. Jette, S. Radhamani, R. Ye, Yaping Yu, G. Arthur, S. Goutam, T. Bismar, Mehul Kumar, P. Bose, S. Yip, M. Kolinsky, S. Lees-Miller","doi":"10.1007/s42764-020-00011-0","DOIUrl":"https://doi.org/10.1007/s42764-020-00011-0","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141222697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deacetylation of a deacetylase drives the DNA damage response 去乙酰化酶的去乙酰化驱动DNA损伤反应
Genome instability & disease Pub Date : 2020-07-01 DOI: 10.1007/s42764-020-00018-7
Raissa Ng, M. Huen
{"title":"Deacetylation of a deacetylase drives the DNA damage response","authors":"Raissa Ng, M. Huen","doi":"10.1007/s42764-020-00018-7","DOIUrl":"https://doi.org/10.1007/s42764-020-00018-7","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s42764-020-00018-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52770956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Autophagy and DNA damage repair 自噬和DNA损伤修复
Genome instability & disease Pub Date : 2020-07-01 DOI: 10.1007/s42764-020-00016-9
Congting Guo, Ying Zhao
{"title":"Autophagy and DNA damage repair","authors":"Congting Guo, Ying Zhao","doi":"10.1007/s42764-020-00016-9","DOIUrl":"https://doi.org/10.1007/s42764-020-00016-9","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s42764-020-00016-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52770873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Mechanisms of UV-induced mutations and skin cancer. 紫外线诱导突变与皮肤癌的机制。
Genome instability & disease Pub Date : 2020-05-01 Epub Date: 2020-03-19 DOI: 10.1007/s42764-020-00009-8
Gerd P Pfeifer
{"title":"Mechanisms of UV-induced mutations and skin cancer.","authors":"Gerd P Pfeifer","doi":"10.1007/s42764-020-00009-8","DOIUrl":"https://doi.org/10.1007/s42764-020-00009-8","url":null,"abstract":"<p><p>Ultraviolet (UV) irradiation causes various types of DNA damage, which leads to specific mutations and the emergence of skin cancer in humans, often decades after initial exposure. Different UV wavelengths cause the formation of prominent UV-induced DNA lesions. Most of these lesions are removed by the nucleotide excision repair pathway, which is defective in rare genetic skin disorders referred to as xeroderma pigmentosum. A major role in inducing sunlight-dependent skin cancer mutations is assigned to the cyclobutane pyrimidine dimers (CPDs). In this review, we discuss the mechanisms of UV damage induction, the genomic distribution of this damage, relevant DNA repair mechanisms, the proposed mechanisms of how UV-induced CPDs bring about DNA replication-dependent mutagenicity in mammalian cells, and the strong signature of UV damage and mutagenesis found in skin cancer genomes.</p>","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s42764-020-00009-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39471115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 44
Helicobacter pylori infection induced genome instability and gastric cancer 幽门螺杆菌感染诱发基因组不稳定和胃癌
Genome instability & disease Pub Date : 2020-05-01 DOI: 10.1007/s42764-020-00010-1
Xiangyu Liu, M. Irfan, Xingzhi Xu, C. Tay, B. Marshall
{"title":"Helicobacter pylori infection induced genome instability and gastric cancer","authors":"Xiangyu Liu, M. Irfan, Xingzhi Xu, C. Tay, B. Marshall","doi":"10.1007/s42764-020-00010-1","DOIUrl":"https://doi.org/10.1007/s42764-020-00010-1","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141210603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The prevention and resolution of DNA replication–transcription conflicts in eukaryotic cells 真核细胞中 DNA 复制-转录冲突的预防与解决
Genome instability & disease Pub Date : 2020-05-01 DOI: 10.1007/s42764-020-00012-z
Wei Wu, I. Hickson, Ying Liu
{"title":"The prevention and resolution of DNA replication–transcription conflicts in eukaryotic cells","authors":"Wei Wu, I. Hickson, Ying Liu","doi":"10.1007/s42764-020-00012-z","DOIUrl":"https://doi.org/10.1007/s42764-020-00012-z","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141208192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The prevention and resolution of DNA replication–transcription conflicts in eukaryotic cells 真核细胞中 DNA 复制-转录冲突的预防与解决
Genome instability & disease Pub Date : 2020-05-01 DOI: 10.1007/s42764-020-00012-z
Wei Wu, I. Hickson, Ying Liu
{"title":"The prevention and resolution of DNA replication–transcription conflicts in eukaryotic cells","authors":"Wei Wu, I. Hickson, Ying Liu","doi":"10.1007/s42764-020-00012-z","DOIUrl":"https://doi.org/10.1007/s42764-020-00012-z","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141207809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suppression of genomic instability by replicative senescence and crisis 通过复制衰老和危机抑制基因组不稳定性
Genome instability & disease Pub Date : 2020-05-01 DOI: 10.1007/s42764-020-00013-y
J. Karlseder
{"title":"Suppression of genomic instability by replicative senescence and crisis","authors":"J. Karlseder","doi":"10.1007/s42764-020-00013-y","DOIUrl":"https://doi.org/10.1007/s42764-020-00013-y","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s42764-020-00013-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52770698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Helicobacter pylori infection induced genome instability and gastric cancer 幽门螺杆菌感染诱发基因组不稳定和胃癌
Genome instability & disease Pub Date : 2020-05-01 DOI: 10.1007/s42764-020-00010-1
Xiangyu Liu, M. Irfan, Xingzhi Xu, C. Tay, B. Marshall
{"title":"Helicobacter pylori infection induced genome instability and gastric cancer","authors":"Xiangyu Liu, M. Irfan, Xingzhi Xu, C. Tay, B. Marshall","doi":"10.1007/s42764-020-00010-1","DOIUrl":"https://doi.org/10.1007/s42764-020-00010-1","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141207119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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