N. Jette, S. Radhamani, R. Ye, Yaping Yu, G. Arthur, S. Goutam, T. Bismar, Mehul Kumar, P. Bose, S. Yip, M. Kolinsky, S. Lees-Miller
{"title":"ATM-deficient lung, prostate and pancreatic cancer cells are acutely sensitive to the combination of olaparib and the ATR inhibitor AZD6738","authors":"N. Jette, S. Radhamani, R. Ye, Yaping Yu, G. Arthur, S. Goutam, T. Bismar, Mehul Kumar, P. Bose, S. Yip, M. Kolinsky, S. Lees-Miller","doi":"10.1007/s42764-020-00011-0","DOIUrl":"https://doi.org/10.1007/s42764-020-00011-0","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":" 1","pages":"197-205"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141222697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Deacetylation of a deacetylase drives the DNA damage response","authors":"Raissa Ng, M. Huen","doi":"10.1007/s42764-020-00018-7","DOIUrl":"https://doi.org/10.1007/s42764-020-00018-7","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":"1 1","pages":"151-154"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s42764-020-00018-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52770956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mechanisms of UV-induced mutations and skin cancer.","authors":"Gerd P Pfeifer","doi":"10.1007/s42764-020-00009-8","DOIUrl":"https://doi.org/10.1007/s42764-020-00009-8","url":null,"abstract":"<p><p>Ultraviolet (UV) irradiation causes various types of DNA damage, which leads to specific mutations and the emergence of skin cancer in humans, often decades after initial exposure. Different UV wavelengths cause the formation of prominent UV-induced DNA lesions. Most of these lesions are removed by the nucleotide excision repair pathway, which is defective in rare genetic skin disorders referred to as xeroderma pigmentosum. A major role in inducing sunlight-dependent skin cancer mutations is assigned to the cyclobutane pyrimidine dimers (CPDs). In this review, we discuss the mechanisms of UV damage induction, the genomic distribution of this damage, relevant DNA repair mechanisms, the proposed mechanisms of how UV-induced CPDs bring about DNA replication-dependent mutagenicity in mammalian cells, and the strong signature of UV damage and mutagenesis found in skin cancer genomes.</p>","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":"1 3","pages":"99-113"},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s42764-020-00009-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39471115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The prevention and resolution of DNA replication–transcription conflicts in eukaryotic cells","authors":"Wei Wu, I. Hickson, Ying Liu","doi":"10.1007/s42764-020-00012-z","DOIUrl":"https://doi.org/10.1007/s42764-020-00012-z","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":"46 9","pages":"114-128"},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141208192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The prevention and resolution of DNA replication–transcription conflicts in eukaryotic cells","authors":"Wei Wu, I. Hickson, Ying Liu","doi":"10.1007/s42764-020-00012-z","DOIUrl":"https://doi.org/10.1007/s42764-020-00012-z","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":"5 2","pages":"114-128"},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141207809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Suppression of genomic instability by replicative senescence and crisis","authors":"J. Karlseder","doi":"10.1007/s42764-020-00013-y","DOIUrl":"https://doi.org/10.1007/s42764-020-00013-y","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":"57 1","pages":"143-150"},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s42764-020-00013-y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52770698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}