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Genome instability & disease最新文献

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Repair of programmed DNA lesions in antibody class switch recombination: common and unique features. 抗体类开关重组中程序性DNA损伤的修复:共性与独特性。
Genome instability & disease Pub Date : 2021-01-01 Epub Date: 2021-03-26 DOI: 10.1007/s42764-021-00035-0
Yafang Shang, Fei-Long Meng
{"title":"Repair of programmed DNA lesions in antibody class switch recombination: common and unique features.","authors":"Yafang Shang,&nbsp;Fei-Long Meng","doi":"10.1007/s42764-021-00035-0","DOIUrl":"https://doi.org/10.1007/s42764-021-00035-0","url":null,"abstract":"<p><p>The adaptive immune system can diversify the antigen receptors to eliminate various pathogens through programmed DNA lesions at antigen receptor genes. In immune diversification, general DNA repair machineries are applied to transform the programmed DNA lesions into gene mutation or recombination events with common and unique features. Here we focus on antibody class switch recombination (CSR), and review the initiation of base damages, the conversion of damaged base to DNA double-strand break, and the ligation of broken ends. With an emphasis on the unique features in CSR, we discuss recent advances in the understanding of DNA repair/replication coordination, and ERCC6L2-mediated deletional recombination. We further elaborate the application of CSR in end-joining, resection and translesion synthesis assays. In the time of the COVID-19 pandemic, we hope it help to understand the generation of therapeutic antibodies.</p>","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":"2 2","pages":"115-125"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s42764-021-00035-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25561505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
TIP60 recruits SUV39H1 to chromatin to maintain heterochromatin genome stability and resist hydrogen peroxide-induced cytotoxicity TIP60将SUV39H1招募到染色质上，以维持异染色质基因组的稳定性并抵抗过氧化氢诱导的细胞毒性
Genome instability & disease Pub Date : 2020-11-01 DOI: 10.1007/s42764-020-00025-8
Bo Tu, Yantao Bao, Ming Tang, Qian Zhu, Xiaopeng Lu, Hui Wang, Tianyun Hou, Ying Zhao, Ping Zhang, Wei-Guo Zhu
{"title":"TIP60 recruits SUV39H1 to chromatin to maintain heterochromatin genome stability and resist hydrogen peroxide-induced cytotoxicity","authors":"Bo Tu, Yantao Bao, Ming Tang, Qian Zhu, Xiaopeng Lu, Hui Wang, Tianyun Hou, Ying Zhao, Ping Zhang, Wei-Guo Zhu","doi":"10.1007/s42764-020-00025-8","DOIUrl":"https://doi.org/10.1007/s42764-020-00025-8","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":"1 1","pages":"339-355"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s42764-020-00025-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52771548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A new insight into base excision repair (BER) in targeted cancer therapy 肿瘤靶向治疗中碱基切除修复(BER)的新认识
Genome instability & disease Pub Date : 2020-11-01 DOI: 10.1007/s42764-020-00024-9
R. Kumar
{"title":"A new insight into base excision repair (BER) in targeted cancer therapy","authors":"R. Kumar","doi":"10.1007/s42764-020-00024-9","DOIUrl":"https://doi.org/10.1007/s42764-020-00024-9","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":"1 1","pages":"310-317"},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s42764-020-00024-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52771298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Primary microcephaly with an unstable genome 原发性小头畸形，基因组不稳定
Genome instability & disease Pub Date : 2020-09-01 DOI: 10.1007/s42764-020-00020-z
Shibin Xu, Xingxuan Wu, Bin Peng, Shenghan Cao, Xingzhi Xu
{"title":"Primary microcephaly with an unstable genome","authors":"Shibin Xu, Xingxuan Wu, Bin Peng, Shenghan Cao, Xingzhi Xu","doi":"10.1007/s42764-020-00020-z","DOIUrl":"https://doi.org/10.1007/s42764-020-00020-z","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":"1 1","pages":"235-264"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s42764-020-00020-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52771146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
ATM-deficient lung, prostate and pancreatic cancer cells are acutely sensitive to the combination of olaparib and the ATR inhibitor AZD6738 ATM缺陷的肺癌、前列腺癌和胰腺癌细胞对奥拉帕利和ATR抑制剂AZD6738的组合具有急性敏感性
Genome instability & disease Pub Date : 2020-07-01 DOI: 10.1007/s42764-020-00011-0
N. Jette, S. Radhamani, R. Ye, Yaping Yu, G. Arthur, S. Goutam, T. Bismar, Mehul Kumar, P. Bose, S. Yip, M. Kolinsky, S. Lees-Miller
{"title":"ATM-deficient lung, prostate and pancreatic cancer cells are acutely sensitive to the combination of olaparib and the ATR inhibitor AZD6738","authors":"N. Jette, S. Radhamani, R. Ye, Yaping Yu, G. Arthur, S. Goutam, T. Bismar, Mehul Kumar, P. Bose, S. Yip, M. Kolinsky, S. Lees-Miller","doi":"10.1007/s42764-020-00011-0","DOIUrl":"https://doi.org/10.1007/s42764-020-00011-0","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":" 1","pages":"197-205"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141222697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deacetylation of a deacetylase drives the DNA damage response 去乙酰化酶的去乙酰化驱动DNA损伤反应
Genome instability & disease Pub Date : 2020-07-01 DOI: 10.1007/s42764-020-00018-7
Raissa Ng, M. Huen
{"title":"Deacetylation of a deacetylase drives the DNA damage response","authors":"Raissa Ng, M. Huen","doi":"10.1007/s42764-020-00018-7","DOIUrl":"https://doi.org/10.1007/s42764-020-00018-7","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":"1 1","pages":"151-154"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s42764-020-00018-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52770956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Autophagy and DNA damage repair 自噬和DNA损伤修复
Genome instability & disease Pub Date : 2020-07-01 DOI: 10.1007/s42764-020-00016-9
Congting Guo, Ying Zhao
{"title":"Autophagy and DNA damage repair","authors":"Congting Guo, Ying Zhao","doi":"10.1007/s42764-020-00016-9","DOIUrl":"https://doi.org/10.1007/s42764-020-00016-9","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":"1 1","pages":"172-183"},"PeriodicalIF":0.0,"publicationDate":"2020-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s42764-020-00016-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52770873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Mechanisms of UV-induced mutations and skin cancer. 紫外线诱导突变与皮肤癌的机制。
Genome instability & disease Pub Date : 2020-05-01 Epub Date: 2020-03-19 DOI: 10.1007/s42764-020-00009-8
Gerd P Pfeifer
{"title":"Mechanisms of UV-induced mutations and skin cancer.","authors":"Gerd P Pfeifer","doi":"10.1007/s42764-020-00009-8","DOIUrl":"https://doi.org/10.1007/s42764-020-00009-8","url":null,"abstract":"<p><p>Ultraviolet (UV) irradiation causes various types of DNA damage, which leads to specific mutations and the emergence of skin cancer in humans, often decades after initial exposure. Different UV wavelengths cause the formation of prominent UV-induced DNA lesions. Most of these lesions are removed by the nucleotide excision repair pathway, which is defective in rare genetic skin disorders referred to as xeroderma pigmentosum. A major role in inducing sunlight-dependent skin cancer mutations is assigned to the cyclobutane pyrimidine dimers (CPDs). In this review, we discuss the mechanisms of UV damage induction, the genomic distribution of this damage, relevant DNA repair mechanisms, the proposed mechanisms of how UV-induced CPDs bring about DNA replication-dependent mutagenicity in mammalian cells, and the strong signature of UV damage and mutagenesis found in skin cancer genomes.</p>","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":"1 3","pages":"99-113"},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s42764-020-00009-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39471115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 44
Helicobacter pylori infection induced genome instability and gastric cancer 幽门螺杆菌感染诱发基因组不稳定和胃癌
Genome instability & disease Pub Date : 2020-05-01 DOI: 10.1007/s42764-020-00010-1
Xiangyu Liu, M. Irfan, Xingzhi Xu, C. Tay, B. Marshall
{"title":"Helicobacter pylori infection induced genome instability and gastric cancer","authors":"Xiangyu Liu, M. Irfan, Xingzhi Xu, C. Tay, B. Marshall","doi":"10.1007/s42764-020-00010-1","DOIUrl":"https://doi.org/10.1007/s42764-020-00010-1","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":"81 16","pages":"129-142"},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141210603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The prevention and resolution of DNA replication–transcription conflicts in eukaryotic cells 真核细胞中 DNA 复制-转录冲突的预防与解决
Genome instability & disease Pub Date : 2020-05-01 DOI: 10.1007/s42764-020-00012-z
Wei Wu, I. Hickson, Ying Liu
{"title":"The prevention and resolution of DNA replication–transcription conflicts in eukaryotic cells","authors":"Wei Wu, I. Hickson, Ying Liu","doi":"10.1007/s42764-020-00012-z","DOIUrl":"https://doi.org/10.1007/s42764-020-00012-z","url":null,"abstract":"","PeriodicalId":73144,"journal":{"name":"Genome instability & disease","volume":"46 9","pages":"114-128"},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141208192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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