Advances in Clinical and Experimental Medicine最新文献

{"title":"Electromyographic activity of the orbicularis oris muscle in children with and without lip competence: A cross-sectional study.","authors":"Liliana Szyszka-Sommerfeld, Monika E Machoy, Jacek Świtała, Magdalena Sycińska-Dziarnowska, Krzysztof Woźniak, Gianrico Spagnuolo, Luigi Esposito, Carlo Rengo","doi":"10.17219/acem/208381","DOIUrl":"https://doi.org/10.17219/acem/208381","url":null,"abstract":"<p><strong>Background: </strong>The \"equilibrium theory\" posits that the tongue and perioral muscles, including the orbicularis oris (OO) muscle, function synergistically to maintain balanced tooth positioning. Surface electromyography (sEMG) is a valuable, nonivasive method for assessing muscle activity. However, previous electromyographic (EMG) studies comparing lip muscle activity in children with and without lip competence (LC) have yielded inconsistent results. Therefore, further research is needed to clarify OO muscle activity patterns in this population.</p><p><strong>Objectives: </strong>The aim of the study was to evaluate the EMG activity of the superior (SOO) and inferior orbicularis oris (IOO) muscles in children with and without LC.</p><p><strong>Material and methods: </strong>The sample comprised 30 children with lip incompetence (LI) (mean age 9.46 ± 1.76 years) and 30 children with LC (mean age 8.85 ± 1.52 years). Electromyographic recordings of the SOO and IOO muscles were obtained using a DAB Bluetooth Instrument (Zebris Medical GmbH, Isny im Allgäu, Germany) at clinical rest, during saliva swallowing, lip protrusion (\"kissing\" position), lip compression, and while articulating the syllables /pa/, /ba/, and /ma/. Statistical analyses were performed using Stata v. 11.0 (StataCorp, College Station, USA). The level of significance was set at p < 0.05.</p><p><strong>Results: </strong>Electromyographic activity of the SOO and IOO muscles during saliva swallowing (p < 0.001, adjusted p (padj) = 0.002) and lip compression (p = 0.001, padj = 0.013 for SOO; p < 0.001, padj = 0.005 for IOO) was significantly greater in children with LI compared to those with LC. Similar EMG activity at rest and during speech production was observed in children with and without LC.</p><p><strong>Conclusions: </strong>Children with LI demonstrate increased SOO and IOO muscle activity during saliva swallowing and lip compression, suggesting greater muscular effort is required to achieve lip seal. This increased activity may disturb the muscular force balance essential for proper maxillofacial growth and could contribute to the development of malocclusion.</p>","PeriodicalId":7306,"journal":{"name":"Advances in Clinical and Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147687340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A new peer reviewer? Comparing AI with human performance in randomized controlled trial risk-of-bias assessment.","authors":"Jonathan Lettner, Marko Ostojic, Aleksandra Królikowska, Mahmut Enes Kayaalp, Nikolai Ramadanov, Robert Prill","doi":"10.17219/acem/216070","DOIUrl":"10.17219/acem/216070","url":null,"abstract":"<p><strong>Background: </strong>Risk-of-bias (RoB) assessment is essential for evidence synthesis but remains time-consuming and inherently subjective. Artificial intelligence (AI) may improve the efficiency of systematic reviews; however, its reliability in reproducing expert RoB judgements remains uncertain.</p><p><strong>Objectives: </strong>To compare the performance of AI models and human raters in RoB assessment of randomized controlled trials (RCTs) using the revised JBI critical appraisal tool.</p><p><strong>Material and methods: </strong>Thirteen RCTs published between 2023 and 2025 in orthopedic journals were independently assessed by 2 human raters (an expert (R1) and a novice (R2)) and 2 AI models (ChatGPT-4.0 (CGPT) and DeepSeek-R1 (DS)) using the 13-domain JBI checklist. Deep-reasoning functionalities (e.g., chain-of-thought prompting) were applied. Inter-rater agreement, deviations from the expert assessment (reference standard), and binary disagreements (e.g., Yes vs No) were analyzed to evaluate consistency.</p><p><strong>Results: </strong>The AI models demonstrated high inter-model agreement (91%), exceeding human-AI agreement (CGPT vs R1: 64%; DS vs R1: 68%). However, both AI systems showed substantial divergence from expert judgements in interpretive domains, including allocation concealment (Q2), blinding (Q7), and overall trial design (Q13), with deviation rates ranging from 30% to 38.5%. Binary decision reversals were more frequent in AI assessments (CGPT: 8.9%; DS: 7.7%) than in the human comparison (R2 vs R1: 2.4%). Human raters showed stronger agreement in contextual interpretation (R1-R2: 89.3%), whereas AI models performed better in rule-based domains (Q8/Q9: 100% agreement).</p><p><strong>Conclusions: </strong>AI can reliably support the automation of objective components of RoB assessment but remains limited in handling interpretive, context-dependent judgements. A hybrid approach combining AI-assisted pre-screening with expert evaluation may enhance the scalability of systematic reviews without compromising methodological rigor.</p>","PeriodicalId":7306,"journal":{"name":"Advances in Clinical and Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147637498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of EBV infection with increased cancer aggressiveness in prostate cancer patients: A systematic review and meta-analysis.","authors":"Syed Hani Abidi, Olaoluwa Tolulope Fabiyi, Zhannur Omarova, Alisalman Sheikh, Khalid Ahmed, Ram Bajpai","doi":"10.17219/acem/218967","DOIUrl":"https://doi.org/10.17219/acem/218967","url":null,"abstract":"<p><strong>Background: </strong>Several studies have reported the presence of Epstein-Barr virus (EBV) in prostate carcinoma tissues and have investigated how EBV might contribute to prostate cancer (PCa) development. To the best of our knowledge, no comprehensive systematic review and meta-analysis have been performed to: 1) estimate the pooled prevalence of EBV in PCa, particularly in samples with high and low Gleason scores; and 2) examine the association between EBV and PCa aggressiveness, measured using high-grade and/or Gleason scores.</p><p><strong>Objectives: </strong>This study aimed to achieve 2 primary objectives: 1) to estimate the pooled prevalence of EBV in PCa; and 2) to determine the association between EBV infection and cancer aggressiveness, specifically in relation to moderate-to-high Gleason scores (7 and above).</p><p><strong>Material and methods: </strong>PubMed, Embase, and Google Scholar were systematically searched for relevant observational studies on EBV and PCa from database inception through December 31, 2024. The quality of the studies was assessed using the JBI criteria based on study design. A meta-analysis was conducted using 9 and 4 studies, respectively, to estimate the pooled EBV prevalence and the association between EBV infection and Gleason scores, along with 95% confidence and prediction intervals.</p><p><strong>Results: </strong>A total of 9 studies were included in the analysis. The pooled EBV prevalence among 927 PCa samples was estimated at 33% (95% confidence interval (95% CI): 16-52%; I2 = 94.17%), while EBV prevalence in PCa samples with moderate-to-high (≥7) and low (6) Gleason scores was 59% (95% CI: 21-92%; I2 = 90.86%) and 34% (95% CI: 15-56%; I2 = 0.00%), respectively. Similarly, EBV presence in PCa samples was associated with increased odds of moderate-to-high Gleason scores (odds ratio (OR) = 2.38, 95% CI: 1.82-3.13, I2 = 0.00%, p = 0.002).</p><p><strong>Conclusion: </strong>This study highlights EBV as a possible risk factor for aggressive prostate cancer (PCa). Additional research is necessary to explore how EBV proteins contribute to PCa development.</p>","PeriodicalId":7306,"journal":{"name":"Advances in Clinical and Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147637524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arthroscopic vs open surgery for shoulder dislocation and instability: A network meta-analysis of treatment outcomes.","authors":"Chenghong Wen, Qiang Hua, Wenduo Qian, Jide Su, Mingming Lei","doi":"10.17219/acem/208614","DOIUrl":"https://doi.org/10.17219/acem/208614","url":null,"abstract":"<p><strong>Background: </strong>No comprehensive comparative research has been conducted to evaluate open Bankart (OB), arthroscopic Bankart (AB), open Latarjet (OL), and arthroscopic Latarjet (AL) simultaneously across all relevant clinical outcomes and parameters.</p><p><strong>Objectives: </strong>To compare the efficacy of OB, AB, OL, and AL procedures in the treatment of shoulder dislocation.</p><p><strong>Material and methods: </strong>The databases PubMed, Embase, the Cochrane Library, and Web of Science were utilized for the literature search. The study evaluated recurrent instability, re-dislocation, apprehension, functional outcomes, and postoperative pain. The results were visually represented through network diagrams, forest plots, league tables, and rank probability plots to provide a comprehensive understanding of each outcome.</p><p><strong>Results: </strong>Overall, 37 studies were included in the analysis. Individuals who underwent OL experienced a notably reduced risk of recurrent instability compared with those who underwent AB (random-effects model pooled relative risk (RR) = 0.34, 95% credible interval (95% CrI): 0.24-0.48) and OB (random-effects model pooled RR = 0.51, 95% CrI: 0.31-0.85). The risk of re-dislocation was also significantly lower for patients treated with OL compared with AB (pooled RR = 0.15, 95% CrI: 0.04-0.45). While not statistically significant, the OL procedure tended to have the lowest risk of apprehension and the highest Subjective Shoulder Value (SSV) score. Regarding postoperative pain, patients who underwent OB had the highest likelihood of attaining the lowest scores on the visual analogue scale (VAS). In addition, OL was associated with the highest probability of complications.</p><p><strong>Conclusion: </strong>The open Latarjet procedure appears to offer superior shoulder stability; however, while functional outcomes for patients undergoing OL are likely to be non-inferior, the procedure is not significantly associated with reduced postoperative pain as measured with the VAS score. Additionally, the OL procedure is associated with an increased likelihood of complications. Consequently, it is essential to implement preventive measures to manage postoperative pain and address potential complications following OL procedure.</p>","PeriodicalId":7306,"journal":{"name":"Advances in Clinical and Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147626442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating medication adherence in chronic diseases.","authors":"Izabella Uchmanowicz, Maria Jędrzejczyk, Grzegorz K Jakubiak, Agnieszka Chłopaś-Konowałek, Paolo Iovino, Heba Mohammed Aldossary, Agnieszka Piwowar, Bartosz Uchmanowicz, Katarzyna Lomper, Jacek Gonos, Rafał Jaros, Filip Sawczak, Miłosz Jaguszewski, Aleksandra Kołtuniuk","doi":"10.17219/acem/219664","DOIUrl":"https://doi.org/10.17219/acem/219664","url":null,"abstract":"<p><p>Adherence is defined as taking medications as prescribed to achieve a therapeutic outcome. It consists of 3 main components: initiation, implementation, and discontinuation. Methods of assessing adherence can be broadly classified as direct or indirect. Factors influencing adherence include patient-related, therapy-related, and healthcare system-related variables. Poor adherence in chronic disease management leads to a cascade of negative clinical, economic, and psychosocial outcomes. Evidence consistently demonstrates that non-adherence is not merely a patient-level issue but a systemic healthcare challenge. Effective strategies to improve adherence must therefore be comprehensive, targeting barriers at multiple levels to achieve meaningful improvements in patient outcomes and quality of life. These strategies include supporting the initiation phase, improving implementation, and addressing challenges related to treatment discontinuation. This paper presents key findings from a literature review on adherence and its importance in clinical practice, as well as current and emerging strategies to enhance medication adherence among patients with chronic diseases.</p>","PeriodicalId":7306,"journal":{"name":"Advances in Clinical and Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147626560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GPR149 (G protein-coupled receptor 149): Structure, signaling, and emerging roles in reproduction, metabolism, and neural function.","authors":"Mahdi Esmaeilzadeh, Adeel Ahmed, Carlos Vasconcelos, Ali Fereidouni, Nasrollah Moradikor","doi":"10.17219/acem/218248","DOIUrl":"https://doi.org/10.17219/acem/218248","url":null,"abstract":"<p><p>G protein-coupled receptors (GPCRs) constitute one of the largest and most versatile families of membrane proteins, mediating a wide range of physiological functions through intracellular signaling pathways. Among them, G protein-coupled receptor 149 (GPR149) is an orphan receptor that has recently attracted increasing attention due to its distinctive structure and emerging biological roles. Although initially identified as an \"antifertility\" gene with high ovarian expression, accumulating evidence suggests a broader physiological relevance, including roles in metabolic and neurological regulation. This narrative review summarizes and integrates current evidence on the structure, expression patterns, and functional roles of GPR149 across multiple biological systems, including reproduction, metabolism, and the central nervous system (CNS), while highlighting existing knowledge gaps and future research directions. GPR149 appears to act as a negative regulator of fertility and ovulation, influencing oocyte maturation and granulosa cell signaling. In metabolic regulation, GPR149 deficiency is associated with resistance to diet-induced obesity and improved insulin sensitivity. In the nervous system, GPR149 expression in glial and neuronal populations has been linked to myelination and neuroendocrine signaling, primarily through modulation of the MAPK/ERK pathway. Altered expression of GPR149 under diabetic and neurological conditions further supports its multifunctional role. Collectively, current evidence positions GPR149 as a multifunctional orphan GPCR involved in the regulation of reproductive, metabolic, and neural processes. Elucidating its ligand interactions and signaling mechanisms may open new therapeutic avenues for reproductive disorders, metabolic syndromes, and neurodegenerative diseases.</p>","PeriodicalId":7306,"journal":{"name":"Advances in Clinical and Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147626543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular effects of electronic cigarettes and heated tobacco products: Clinical evidence from a narrative review.","authors":"Silvio Festinese, Dimitris Richter","doi":"10.17219/acem/217292","DOIUrl":"https://doi.org/10.17219/acem/217292","url":null,"abstract":"<p><p>This review critically examines the cardiovascular (CV) implications of switching from combustible cigarettes (CCs) to combustion-free nicotine products, namely heated tobacco products (HTPs) and electronic cigarettes (e-cigarettes). Noncommunicable diseases, particularly cardiovascular disease (CVD), remain the leading global cause of mortality, with smoking as a major modifiable risk factor. While complete smoking cessation provides the greatest health benefit, many smokers transition to alternative nicotine delivery systems. Evidence from randomized trials, observational studies, and cohort analyses indicates that switching to HTPs or e-cigarettes significantly reduces exposure to harmful and potentially harmful constituents (HPHCs), including carbon monoxide (CO) and carcinogens, with biomarker improvements comparable to those observed after smoking cessation. Short-term studies suggest favorable changes in endothelial function, arterial stiffness, and oxidative stress, although nicotine-containing products may still exert acute CV effects. Long-term data, although limited, indicate a reduced incidence of major adverse cardiovascular events (MACEs) among exclusive users compared with continued smokers. However, heterogeneity in product design, usage patterns, and study methodologies limits the ability to draw definitive conclusions. Overall, current evidence suggests that non-combustible nicotine products may represent a harm reduction strategy for smokers who are unable or unwilling to quit, although they are not risk-free. Further large-scale, long-term studies with clinically relevant endpoints are required to clarify their CV safety profile and to inform evidence-based public health policies.</p>","PeriodicalId":7306,"journal":{"name":"Advances in Clinical and Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147607584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxaliplatin-induced peripheral neuropathy in cancer treatment: Mechanisms, risk factors, and management strategies.","authors":"Justyna A Pigońska, Marta Banach, Paweł S Walkowiak, Aneta Zygulska","doi":"10.17219/acem/213218","DOIUrl":"https://doi.org/10.17219/acem/213218","url":null,"abstract":"<p><p>Oxaliplatin (OXI) is a platinum-based chemotherapeutic agent commonly used in the systemic treatment of colorectal, gastric, pancreatic, and esophageal cancers. Like other cytotoxic agents, OXI is associated with various adverse effects; however, OXI-induced peripheral neuropathy (OIPN) represents a particularly challenging clinical problem for both oncologic patients and their clinicians. The severity of neuropathic symptoms may necessitate dose reduction or premature discontinuation of therapy, which can ultimately shorten recurrence-free survival. This paper discusses the symptoms, mechanisms of onset, risk factors, preventive strategies, treatment options, and grading scales associated with OIPN. Both the prevention and treatment of OIPN require further innovative and effective research. It is hoped that the outcomes of ongoing trials will address both chronic and acute OIPN in the near future, as this condition remains a persistent clinical concern for patients with gastrointestinal cancers.</p>","PeriodicalId":7306,"journal":{"name":"Advances in Clinical and Experimental Medicine","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147607576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement of platelet reactivity in thrombocytopenic patients on dual antiplatelet therapy after percutaneous coronary intervention.","authors":"Daiwa Wilczewska, Mikołaj Błaziak, Kornelia Gajek, Bożena Karolko, Magdalena Cielecka, Kamila Florek, Weronika Wietrzyk, Wojciech Stefaniak, Jakub Sokołowski, Urszula Woźniak, Dominik Mendyka, Andrzej Mysiak, Wiktor Kuliczkowski","doi":"10.17219/acem/207803","DOIUrl":"https://doi.org/10.17219/acem/207803","url":null,"abstract":"<p><strong>Background: </strong>Thrombocytopenia remains a significant problem in patients with cardiovascular disease (CVD) due to the indispensable use of antiplatelet therapy.</p><p><strong>Objectives: </strong>The aim of this study was to establish a novel flow cytometry (FC)-based method for measuring platelet reactivity during dual antiplatelet therapy (DAPT) and to compare it with impedance aggregometry (IA) in thrombocytopenic patients undergoing percutaneous coronary intervention (PCI).</p><p><strong>Material and methods: </strong>This prospective cross-sectional study included 30 patients with thrombocytopenia. Platelet aggregation was assessed using IA and FC.</p><p><strong>Results: </strong>A similar response to arachidonic acid (AA), reflecting the effect of acetylsalicylic acid (ASA), was observed in both groups. Responses to thrombin receptor agonist peptide (TRAP) and adenosine diphosphate (ADP), measured with aggregometry, were significantly higher in thrombocytopenic patients than in patients with normal platelet counts. When the FC method was used, the response to AA was significantly higher in thrombocytopenic patients. The optimal cut-off value for the FC method to define adequate platelet reactivity inhibition with clopidogrel in thrombocytopenic patients was <25.7%.</p><p><strong>Conclusions: </strong>In patients with thrombocytopenia, IA is useful for assessing ASA response, whereas the presented FC method may be more accurate for evaluating response to clopidogrel.</p>","PeriodicalId":7306,"journal":{"name":"Advances in Clinical and Experimental Medicine","volume":"35 4","pages":"591-597"},"PeriodicalIF":1.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of peribulbar block and incisionless sub-Tenon's block on sleep quality after cataract surgery.","authors":"Yeliz Kılıç, Haluk Hüseyin Gürsoy, Mustafa Değer Bilgeç, Ali Rıza Ata, Mehmet Sacit Güleç","doi":"10.17219/acem/207603","DOIUrl":"10.17219/acem/207603","url":null,"abstract":"<p><strong>Background: </strong>Sleep quality often decreases in patients after surgery and may affect postoperative outcomes.</p><p><strong>Objectives: </strong>The aim of this study was to compare the effects of peribulbar block and incisionless sub-Tenon's block on postoperative sleep quality.</p><p><strong>Material and methods: </strong>Patients who underwent cataract surgery under peribulbar block (n = 36) or incisionless sub-Tenon's block (n = 31) were included in the study. The 2 blocks were compared with each other in terms of eyelid and globe movements, corneal sensation, complications, pain, and postoperative sleep quality (evaluated using the Richard-Campbell Sleep Questionnaire (RCSQ) score).</p><p><strong>Results: </strong>Sixty-seven patients with a mean age of 67 years were included in the study. At the 15th minute after the block (p = 0.066) and at the end of surgery (p = 0.098), akinesia was better in the incisionless sub-Tenon's group, with p-values close to the level of statistical significance. Chemosis was found to be significantly lower in the peribulbar block group than in the incisionless sub-Tenon's block group (p = 0.033) 3 h after surgery. All minor complications, including chemosis, subconjunctival petechiae, and subconjunctival hemorrhage, were observed less frequently in the peribulbar block group, although the differences were not statistically significant (p > 0.05). Pain scores were comparable between the groups (p > 0.05). The total RCSQ score (p = 0.396) and overall sleep perception (p = 0.355) were also comparable between the groups.</p><p><strong>Conclusions: </strong>The incisionless sub-Tenon's block was superior to the peribulbar block in terms of providing akinesia and reducing the need for maintenance anesthetic medications such as sedatives or analgesics. Although chemosis and subconjunctival hemorrhage occurred more frequently in the incisionless sub-Tenon's group, all events were transient and had no serious clinical significance. The 2 regional techniques were similar in terms of postoperative sleep quality and patient satisfaction.</p>","PeriodicalId":7306,"journal":{"name":"Advances in Clinical and Experimental Medicine","volume":" ","pages":"673-681"},"PeriodicalIF":1.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147466680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}