Frontiers in aging最新文献

{"title":"Confronting polypharmacy and social isolation in elderly care: a general practitioner's perspective on holistic primary care.","authors":"Waseem Jerjes, Daniel Harding","doi":"10.3389/fragi.2024.1384835","DOIUrl":"10.3389/fragi.2024.1384835","url":null,"abstract":"","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"5 ","pages":"1384835"},"PeriodicalIF":0.0,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11176503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141332582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Stem cell exhaustion in aging.","authors":"Sarallah Rezazadeh, Georgina May Ellison-Hughes","doi":"10.3389/fragi.2024.1433702","DOIUrl":"10.3389/fragi.2024.1433702","url":null,"abstract":"","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"5 ","pages":"1433702"},"PeriodicalIF":0.0,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11177088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141332583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Naïve T-cell decline is a significant contributor to expression changes in ageing blood.","authors":"Cameron Fraser, Brady M Owen","doi":"10.3389/fragi.2024.1389789","DOIUrl":"10.3389/fragi.2024.1389789","url":null,"abstract":"<p><p>No clear consensus has emerged from the literature on the gene expression changes that occur in human whole blood with age. In this study we compared whole blood ageing genes from the published literature with data on gene specificity for leukocyte subtypes. Surprisingly we found that highly ranked ageing genes were predominantly expressed by naïve T cells, with limited expression from more common cell types. Highly ranked ageing genes were also more likely to have decreased expression with age. Taken together, it is plausible that much of the observed gene expression changes in whole blood is reflecting the decline in abundance of naïve T cells known to occur with age, rather than changes in transcription rates in common cell types. Correct attribution of the gene expression changes that occur with age is essential for understanding the underlying mechanisms.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"5 ","pages":"1389789"},"PeriodicalIF":0.0,"publicationDate":"2024-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11169655/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141319161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum: A conceptual view of cognitive intervention in older adults with and without cognitive decline-a systemic review.","authors":"Liliana Mendes, Joana Oliveira, Fernando Barbosa, Miguel Castelo-Branco","doi":"10.3389/fragi.2024.1422949","DOIUrl":"https://doi.org/10.3389/fragi.2024.1422949","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fragi.2022.844725.].</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"5 ","pages":"1422949"},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11130471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141163064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amelioration of age-related cognitive decline and anxiety in mice by <i>Centella asiatica</i> extract varies by sex, dose and mode of administration.","authors":"Nora E Gray, Wyatt Hack, Mikah S Brandes, Jonathan A Zweig, Liping Yang, Luke Marney, Jaewoo Choi, Armando Alcazar Magana, Natasha Cerruti, Janis McFerrin, Seiji Koike, Thuan Nguyen, Jacob Raber, Joseph F Quinn, Claudia S Maier, Amala Soumyanath","doi":"10.3389/fragi.2024.1357922","DOIUrl":"10.3389/fragi.2024.1357922","url":null,"abstract":"<p><p><b>Background:</b> A water extract (CAW) of the Ayurvedic plant <i>Centella asiatica</i> administered in drinking water has been shown to improve cognitive deficits in mouse models of aging and neurodegenerative diseases. Here the effects of CAW administered in drinking water or the diet on cognition, measures of anxiety and depression-like behavior in healthy aged mice are compared. <b>Methods:</b> Three- and eighteen-month-old male and female C57BL6 mice were administered rodent AIN-93M diet containing CAW (0, 0.2, 0.5 or 1% w/w) to provide 0, 200 mg/kg/d, 500 mg/kg/d or 1,000 mg/kg/d CAW for a total of 5 weeks. An additional group of eighteen-month-old mice were treated with CAW (10 mg/mL) in their drinking water CAW for a total of 5 weeks to deliver the same exposure of CAW as the highest dietary dose (1,000 mg/kg/d). CAW doses delivered were calculated based on food and water consumption measured in previous experiments. In the fourth and fifth weeks, mice underwent behavioral testing of cognition, anxiety and depression (n = 12 of each sex per treatment group in each test). <b>Results:</b> Aged mice of both sexes showed cognitive deficits relative to young mice while only female aged mice showed increased anxiety compared to the young female mice and no differences in depression were observed between the different ages. CAW (1,000 mg/kg/d) in the drinking water improved deficits in aged mice in learning, executive function and recognition memory in both sexes and attenuated the increased measures of anxiety observed in the aged female mice. However, CAW in the diet only improved executive function in aged mice at the highest dose (1,000 mg/kg/d) in both sexes and did so less robustly than when given in the water. There were no effects of CAW on depression-like behavior in aged animals regardless of whether it was administered in the diet or the water. <b>Conclusions:</b> These results suggest that CAW can ameliorate age-related changes in measures of anxiety and cognition and that the mode of administration is important for the effects of CAW on resilience to these age-related changes.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"5 ","pages":"1357922"},"PeriodicalIF":0.0,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11102990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141072461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperbaric oxygen therapy: future prospects in regenerative therapy and anti-aging.","authors":"Manoj Gupta, Jaishriram Rathored","doi":"10.3389/fragi.2024.1368982","DOIUrl":"https://doi.org/10.3389/fragi.2024.1368982","url":null,"abstract":"<p><p>Hyperbaric Oxygen Therapy (HBOT) utilizes 100% oxygen at high atmospheric pressure for clinical applications. HBOT has proven to be an effective supplementary treatment for a variety of clinical and pathological disorders. HBOT's therapeutic results are based on the physiological effects of increased tissue oxygenation, or improved oxygen bioavailability. HBOT's current indications in illnesses like as wound healing, thermal or radiation burns, and tissue necrosis point to its function in facilitating the regeneration process. Various research has revealed that HBOT plays a function in vascularization, angiogenesis, and collagen production augmentation. Individual regeneration capacity is influenced by both environmental and genetic factors. Furthermore, the regenerating ability of different types of tissues varies, and this ability declines with age. HBOT affects physiological processes at the genetic level by altering gene expression, delaying cell senescence, and assisting in telomere length enhancement. The positive results in a variety of indications, ranging from tissue regeneration to better cognitive function, indicate that it has enormous potential in regenerative and anti-aging therapy.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"5 ","pages":"1368982"},"PeriodicalIF":0.0,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11097100/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Amino acid restriction, aging, and longevity: an update.","authors":"S N Austad, J R Smith, J M Hoffman","doi":"10.3389/fragi.2024.1393216","DOIUrl":"10.3389/fragi.2024.1393216","url":null,"abstract":"<p><p>Various so-called dietary restriction paradigms have shown promise for extending health and life. All such paradigms rely on <i>ad libitum</i> (hereafter <i>ad lib</i>) feeding, something virtually never employed in animals whose long-term health we value, either as a control or, except for food restriction itself, for both control and treatment arms of the experiment. Even though the mechanism(s) remain only vaguely understood, compared to <i>ad lib</i>-fed animals a host of dietary manipulations, including calorie restriction, low protein, methionine, branched-chain amino acids, and even low isoleucine have demonstrable health benefits in laboratory species in a standard laboratory environment. The remaining challenge is to determine whether these health benefits remain in more realistic environments and how they interact with other health enhancing treatments such as exercise or emerging geroprotective drugs. Here we review the current state of the field of amino acid restriction on longevity of animal models and evaluate its translational potential.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"5 ","pages":"1393216"},"PeriodicalIF":3.3,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11096585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140960287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep status of older adults with sleep apnoea syndrome may vary by body mass index.","authors":"Yuji Tanaka, Naana Baba-Mori, Takaaki Yonaga, Kazuki Mochizuki, Satoshi Igarashi, Takashi Ando, Takashi Kohda, Yasumi Ito, Kenzo Soejima, Daiju Sakurai","doi":"10.3389/fragi.2024.1331448","DOIUrl":"10.3389/fragi.2024.1331448","url":null,"abstract":"<p><p>Obesity and ageing are the most important risk factors for sleep apnoea syndrome (SAS); however, the role of body mass index (BMI) on sleep status in healthy older adults is unclear. To explore sleep parameters according to BMI among active older adults, we cross-sectionally examined the relationship between sleep-related parameters and BMI in 32 Japanese adults aged from 83 to 95 years without long-term care who were unaware of having SAS. Correlation and linear regression analyses were performed. Moderate or severe SAS prevalence was high in both those with low (68.8%) and high (68.8%) BMI. A higher increase in apnoea-hypopnoea index (AHI) was negatively correlated with sleep depth in the high-BMI group. In the low-BMI group, the number of awakenings and age were positively correlated with AHI. Older adults may have SAS regardless of their BMI, and the sleep status of patients with SAS may vary by BMI.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"5 ","pages":"1331448"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11094249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140946522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Task-specific resistance training adaptations in older adults: comparing traditional and functional exercise interventions.","authors":"Jason I Pagan, Bethany A Bradshaw, Brisilda Bejte, Jordan N Hart, Vanjeliz Perez, Kevan S Knowles, Jonathan P Beausejour, Marc Luzadder, Reed Menger, Carlos Osorio, Kylie K Harmon, William J Hanney, Abigail T Wilson, Jeffrey R Stout, Matt S Stock","doi":"10.3389/fragi.2024.1335534","DOIUrl":"10.3389/fragi.2024.1335534","url":null,"abstract":"<p><p>Muscle strength declines ∼3% per year after the age of 70. Resistance training guidelines for older adults are often based on free-weight and machine exercises, which may be inaccessible and lack carryover to activities of daily living. We tested the hypothesis that resistance training adaptations in older adults are task-specific. Thirty adults (8 males, 22 females; mean age = 71 years) were randomly assigned to participate in 6 weeks of supervised, high-intensity resistance training (twice per week) utilizing free-weight and machine exercises (traditional) <i>versus</i> functional activities that were overloaded with a weighted vest (functional). Participants were thoroughly familiarized with the exercises and testing prior to beginning the study. Major outcome measures included assessments of functional performance, five-repetition maximum strength, isometric knee extensor force, and quadriceps muscle size. Physical activity and nutrition were monitored. The study results demonstrate that the magnitude of improvement within a given outcome was largely dependent on group assignment, with greater improvements in gait speed and the timed-up-and-go in the functional group, but 2-3× greater five repetition maximum strength improvements for the trap bar deadlift, leg press, and leg extension following traditional resistance training. Both groups showed improvements in isometric knee extensor force and muscle size, suggesting that some aspects of the observed adaptations were generic, rather than specific. Overall, these novel findings suggest that, among older adults, 1) resistance training adaptations exhibit a high degree of task specificity and 2) significant improvements in functional outcomes can be achieved with the use of a weighted vest.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"5 ","pages":"1335534"},"PeriodicalIF":0.0,"publicationDate":"2024-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11091347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140923579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mother's Curse effects on lifespan and aging.","authors":"Suzanne Edmands","doi":"10.3389/fragi.2024.1361396","DOIUrl":"10.3389/fragi.2024.1361396","url":null,"abstract":"<p><p>The Mother's Curse hypothesis posits that mothers curse their sons with harmful mitochondria, because maternal mitochondrial inheritance makes selection blind to mitochondrial mutations that harm only males. As a result, mitochondrial function may be evolutionarily optimized for females. This is an attractive explanation for ubiquitous sex differences in lifespan and aging, given the prevalence of maternal mitochondrial inheritance and the established relationship between mitochondria and aging. This review outlines patterns expected under the hypothesis, and traits most likely to be affected, chiefly those that are sexually dimorphic and energy intensive. A survey of the literature shows that evidence for Mother's Curse is limited to a few taxonomic groups, with the strongest support coming from experimental crosses in <i>Drosophila</i>. Much of the evidence comes from studies of fertility, which is expected to be particularly vulnerable to male-harming mitochondrial mutations, but studies of lifespan and aging also show evidence of Mother's Curse effects. Despite some very compelling studies supporting the hypothesis, the evidence is quite patchy overall, with contradictory results even found for the same traits in the same taxa. Reasons for this scarcity of evidence are discussed, including nuclear compensation, factors opposing male-specific mutation load, effects of interspecific hybridization, context dependency and demographic effects. Mother's Curse effects may indeed contribute to sex differences, but the complexity of other contributing factors make Mother's Curse a poor general predictor of sex-specific lifespan and aging.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"5 ","pages":"1361396"},"PeriodicalIF":3.3,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10957651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140208309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}