Frontiers in aging最新文献

{"title":"Association between oxidative balance score and gallstone in US adults: a cross-sectional study.","authors":"Xiaoya Chen, Xiongwei Huo, Changchun Ye, Zhengshui Xu, Zilu Chen, Shiyuan Liu","doi":"10.3389/fragi.2025.1621107","DOIUrl":"10.3389/fragi.2025.1621107","url":null,"abstract":"<p><strong>Introduction: </strong>The Oxidative Balance Score (OBS) serves as a means to evaluate the systemic oxidative stress status, where the higher OBS score indicates a greater exposure to antioxidants. Few studies have delved into the connection between the systemic oxidative stress status and gallstone.</p><p><strong>Methods: </strong>A total of 4,376 from the NHANES participants were included in this cross-sectional analysis using 2017-2020 survey cycles. Gallstone was diagnosed by the Patient Health Questionnaire. OBS was scored by 16 dietary factors and 4 lifestyle factors. Logistic regression, subgroup analysis and restricted cubic splines (RCS) were used to assess the association between OBS and gallstone.</p><p><strong>Results: </strong>In a sample comprising 4,376 individuals, logistic regression illuminated a negative association between OBS and gallstone [OR = 0.96 (0.94, 0.98), p < 0.001]. Compared to the lowest quartile of OBS, the fully adjusted ORs for the highest quartile of total OBS and gallstone were 0.65 (0.45, 0.95), p=0.025. Robust associations were also discerned between gallstone and both dietary and lifestyle OBS. The results of the subgroup analysis showed significant differences in the association between lifestyle OBS and gallstone with respect to age and marital status. RCS analysis indicated a significant linear relationship between OBS and gallstone.</p><p><strong>Discussion: </strong>Our study exhibited a reverse relationship between OBS and the prevalence of gallstone among American adults, which provided a theoretical foundation for designing personalized dietary regimens and lifestyle modifications to mitigate gallstone formation.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1621107"},"PeriodicalIF":4.3,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elderly stroke burden: a comprehensive global study over three decades.","authors":"Ruoyu Gou, Changjun Luo, Xudong Liang, Shuitao Qin, Hao Wu, Bing Li, Fengqi Pan, Jinwei Li, Jun-An Chen","doi":"10.3389/fragi.2025.1489914","DOIUrl":"10.3389/fragi.2025.1489914","url":null,"abstract":"<p><strong>Background: </strong>Stroke is a serious disease that negatively affects the quality of life of patients and has become a global public health problem. This study used data from the 2021 Global Burden of Disease (GBD) study to assess the burden of stroke in the elderly population between 1990 and 2021.</p><p><strong>Methods: </strong>This cross-sectional study utilised data from the Global Burden of Disease (GBD) 2021, encompassing 204 countries and territories. The analysis included data from older patients who had experienced a stroke. The analysis includes morbidity, all-cause and cause-specific mortality, disability-adjusted life years, and corresponding estimated annual percentage changes (APCs).</p><p><strong>Results: </strong>From 1990 to 2021, the total number of stroke cases among the global elderly population rose from approximately 4.39 million to 8.19 million, with the age-standardized incidence (ASIR) decreasing from 996.06 cases per 100,000 people to 775.68 cases per 100,000 people (EAPC-0.784). The number of deaths increased from 4.08 million to 6.19 million, and the age-standardized mortality rate (ASMR) decreased from 981.87 to 600.08 deaths per 100,000 people (EAPC-1.446). The number of disability-adjusted life years (DALYs) increased from 75.96 million to approximately 111.14 million, with the age-standardized DALYs rate (ASDR) declining (EAPC-1.596). In five Socio-Demographic Index (SDI) regions, the disease burden was higher in men than in women.</p><p><strong>Conclusion: </strong>The number of stroke cases, deaths and DALYs increased in the elderly, while the global incidence, mortality and mortality rates of stroke decreased, with a higher burden on older men than women.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1489914"},"PeriodicalIF":4.3,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12303880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depressed mood affects the process of biological aging, analyses from the NHANES dataset.","authors":"Yuan Tian, Qiao Lu, Jing Li, Xiaobo Zhou, Luyao Wang, Xuemei Zhong, Yiping Luo","doi":"10.3389/fragi.2025.1516664","DOIUrl":"10.3389/fragi.2025.1516664","url":null,"abstract":"<p><strong>Background: </strong>Depressive mood may influence biological aging and the difference (δ-age) between biological age (BA) and chronological age (CA). This study explores the relationship between depressive mood and whole-body delta age (δ-age).</p><p><strong>Methods: </strong>A total of 7,383 U.S. adults were selected from the National Health and Nutrition Examination Survey (NHANES) conducted between 2007 and 2018. Depressed mood was evaluated using PHQ-9 scores. Biological age (BA) was estimated based on circulating biomarkers, and the calculated delta age (δ-age) was validated through a generalized linear regression analysis.</p><p><strong>Results: </strong>After adjusting for confounding variables, logistic regression analysis demonstrated a significant association between elevated depressive symptoms and accelerated biological aging. The restricted cubic splines (RCS) results further indicated a positive dose-response relationship between depression scale scores and the risk of biological aging. Additionally, the weighted quantile sum regression (WQS) findings revealed a positive, though non-significant, trend linking depressive mood to the risk of biological aging. Notably, overeating and low self-perception emerged as the most significant contributors to the scores on the Patient Health Questionnaire-9 (PHQ-9) scale.</p><p><strong>Conclusion: </strong>Depressive symptoms are linked to accelerated biological aging. Thus, interventions aimed at improving mood may help slow biological aging and contribute to delaying the aging process.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1516664"},"PeriodicalIF":3.3,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279787/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatial navigation skills in older adults with and without cognitive impairment.","authors":"Dorota Kossowska-Kuhn, Michael J Prevratil, Neil Charness, Walter R Boot, Sara J Czaja, Wendy A Rogers","doi":"10.3389/fragi.2025.1587003","DOIUrl":"10.3389/fragi.2025.1587003","url":null,"abstract":"<p><strong>Introduction: </strong>Navigation is a fundamental cognitive ability essential for daily functioning. However, navigation skills decline with age and are further impaired in individuals with cognitive impairment (CI). Understanding these deficits is critical for developing interventions to support affected populations.</p><p><strong>Methods: </strong>This study compared navigation abilities in older adults with CI (n = 20) to a previously collected community-dwelling sample of older adults (n = 380) using a consistent protocol. Both groups completed objective navigation tasks, subjective navigation assessments, and subjective memory evaluations.</p><p><strong>Results: </strong>Older adults with CI exhibited significantly lower performance on objective navigation tasks and subjective memory assessments compared to the community sample. Among the three subjective navigation measures, only one demonstrated a significant difference between the groups. Additionally, subjective navigation measures were not reliably predicted by subjective memory or objective navigation performance.</p><p><strong>Discussion: </strong>These findings highlight a unique and complex relationship between navigation, aging, and cognitive impairment. The results underscore the need for further research to explore the effects of different types of CI on navigation and identify strategies to mitigate these deficits.</p><p><strong>Conclusion: </strong>This study provides valuable insights into navigation impairments associated with cognitive decline in aging populations, paving the way for targeted interventions to preserve navigation skills in affected individuals.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1587003"},"PeriodicalIF":3.3,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12279796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144692637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the influence of mineral content changes on mechanical properties through ligament insertion.","authors":"Afif Gouissem, Fadi Alkhatib, Malek Adouni","doi":"10.3389/fragi.2025.1556577","DOIUrl":"10.3389/fragi.2025.1556577","url":null,"abstract":"<p><strong>Introduction: </strong>This study investigates the relationship between mineral content and mechanical properties in collagenous tissues using a mesoscopic model. Unlike previous studies that assumed uniform mineral distributions, our model mimics the impact of combined intrafibrillar and extrafibrillar progressive mineralization on the ligament insertion using a realistic mineral gradient. To our knowledge, this is the first study on a minerally graded region that combines both mineral phases within a mesoscopic Molecular Dynamics framework.</p><p><strong>Methods: </strong>A collagen fibril model is constructed, and Molecular Dynamics (MD) simulations are performed at five equidistant locations along the insertion to analyze the influence of mineralization on collagen fibrils. The model captures the real randomness in mineral cluster size and distribution, improving its accuracy.</p><p><strong>Results: </strong>Results show that while Young's modulus and ultimate tensile strain remain relatively unchanged, ultimate tensile strength, yield strain, and yield strength are significantly affected by the presence of the mineral content. These changes are mainly caused by the interatomic bonds that restrain the collagen molecular sliding within the fibril.</p><p><strong>Discussion: </strong>Clinically, this research sheds light on the mechanical role that the progressive mineral gradient plays in load transfer and stress distribution. It also lays the ground for exploring the effects of aging and other pathological conditions such as ectopic mineralization or calcific tendinopathy, which alter the natural mineral gradient and increase the risk of tissue failure.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1556577"},"PeriodicalIF":3.3,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12277273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144683727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular constraints of sarcopenia in the ageing muscle.","authors":"S Damanti, E Senini, R De Lorenzo, A Merolla, S Santoro, C Festorazzi, M Messina, G Vitali, C Sciorati, A A Manfredi, P Rovere-Querini","doi":"10.3389/fragi.2025.1588014","DOIUrl":"10.3389/fragi.2025.1588014","url":null,"abstract":"<p><p>Sarcopenia, the age-related loss of skeletal muscle mass, strength, and function, is driven by a convergence of molecular, cellular, hormonal, nutritional, and neurological alterations. Skeletal muscle comprises multinucleated fibers supported by satellite cells-muscle stem cells essential for repair and regeneration. With age, both the structure and function of these components deteriorate: myonuclei become disorganized, gene expression skews toward catabolic, inflammatory, and fibrotic pathways, and satellite cell numbers and activity decline. Concurrently, mitochondrial dysfunction, impaired proteostasis, and vascular rarefaction limit energy availability and regenerative capacity. Neurodegeneration and age-related muscle fibers denervation further exacerbate muscle loss, particularly affecting fast-twitch fibers, and reduce motor unit integrity. These neural deficits, alongside changes at the neuromuscular junction, contribute to functional decline and diminished contractility. Hormonal changes-including reduced levels of growth hormone, testosterone, and IGF-1-undermine anabolic signaling and promote muscle atrophy. Nutritional factors are also pivotal: anorexia of aging and reduced dietary protein intake lead to suboptimal nutrient availability. Compounding this is anabolic resistance, a hallmark of aging muscle, in which higher levels of dietary protein and amino acids are required to stimulate muscle protein synthesis effectively. Physical inactivity and immobility, often secondary to chronic illness or frailty, further accelerate sarcopenia by promoting disuse atrophy. The molecular constraints of sarcopenia are deeply intertwined with non-molecular mechanisms-such as neuromuscular degeneration, hormonal shifts, inadequate nutrition, and reduced physical activity-creating a complex and self-reinforcing cycle that impairs muscle maintenance and regeneration in the elderly. This review synthesizes current evidence on these interconnected factors, highlighting opportunities for targeted interventions to preserve muscle health across the lifespan.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1588014"},"PeriodicalIF":3.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12267276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping the global research landscape and trends of older people living alone: a bibliometric analysis.","authors":"Yu-Dan Wu, Jia-Xin Dong, Fu-Min Yu, Zhe-Hao Dong, Wei Ma, Yue Cai, Yu-Qing Cai, Yang Mu, Xiang Cui, Yi-Ran Wang, Hui-Jun Li, Xiao-Tao Yang, Duo-Ning Yuan, Shuang Wang, Nuo Cheng, Guang-Wei Zhang","doi":"10.3389/fragi.2025.1524673","DOIUrl":"10.3389/fragi.2025.1524673","url":null,"abstract":"<p><strong>Background: </strong>The global aging trend is becoming increasingly severe, leading to a rise in the number of older adults living alone. As research on this population grows, a comprehensive analysis is essential.</p><p><strong>Objective: </strong>This study examines the current state of research on older adults living alone, identifies key trends and emerging topics, and provides a foundation for future investigations.</p><p><strong>Methodology: </strong>We conducted a subject search in the Web of Science (WOS) Core Collection database, retrieving articles related to older adults living alone based on titles, abstracts, and keywords from 1965 to 2024. Using CiteSpace (version 6.4.R1 Advanced), we generated collaborative networks among countries and authors, revealing research hotspots and frontiers in this field.</p><p><strong>Results: </strong>The study identified 740 relevant articles, showing an overall upward trend in publications. South Korea and China emerged as major contributors, though research remains decentralized. A total of 1,136 cited authors contributed to this field. Recent advances include the application of spatial recognition technology and artificial intelligence to prevent hazardous events among older adults living alone, highlighting a shift toward personalized and intelligent care solutions.</p><p><strong>Conclusion: </strong>This study demonstrates that older adults living alone represent an emerging focus in nursing research, yet international collaboration remains limited. The integration of intelligent devices and technologies to address caregiving challenges has become a prominent research hotspot in recent years.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1524673"},"PeriodicalIF":3.3,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12268210/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selenium intake is associated with gait speed in very old adults.","authors":"Camila Dias Nascimento Rocha, Gilberto Simeone Henriques, Karine Aglio Vasconcelos, Lucca Ferreira Machado, Maria Aparecida Camargos Bicalho, Rodrigo Ribeiro Dos Santos, Ann Kristine Jansen","doi":"10.3389/fragi.2025.1473371","DOIUrl":"10.3389/fragi.2025.1473371","url":null,"abstract":"<p><strong>Introduction: </strong>Selenium seems to have protective effect on muscle function, contribute to healthy aging and longevity, however, in older adults this relationship has not been well studied. Objective: To evaluate the nutritional status of selenium in very old adults and its relationship with muscle strength, muscle mass and physical performance.</p><p><strong>Methods: </strong>A cross-sectional observational study investigating functionally independent individuals aged ≥80 years was conducted. Appendicular skeletal mass was determined by electrical bioimpedance, and physical performance and hand-grip strength were evaluated. Selenium intake and status in plasma and erythrocytes were evaluated. For statistical analysis. Poisson multivariate analysis was performed, and prevalence ratio used as a measure of effect.</p><p><strong>Results: </strong>A total of 72 older adults with a median age of 84 years were evaluated. Median Selenium intake was 71.58 mcg, and adequacy 73.5% overall, with a higher rate among men. In the total sample, 87.5% had optimal selenium plasma concentrations and no participants were deficient. All participants had adequate erythrocyte selenium levels. Gait speed was associated and correlated with selenium intake, even in the adjusted model The prevalence of low adequacy on the gait test was reduced by 3%-5% for every 1 mg increase in selenium consumption (PR 0.95; 95% CI: 0.93, 0.98).</p><p><strong>Conclusion: </strong>The gait speed results reinforce the hypothesis of an antioxidant role of selenium in muscle function. The very old adults studied demonstrated that homeostatic mechanisms control circulating selenium levels, highlighting the need for a specific reference value for the oldest-old population, besides the importance of analyzing blood markers associated with food intake and dietary patterns, since supplementation may prove iatrogenic.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1473371"},"PeriodicalIF":3.3,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144651400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a clinical prediction model for osteoporosis diagnosis by lumbosacral X-ray and radiomics.","authors":"Xiaofeng Chen, Dongling Cai, Hao Li, Weijun Guo, Qian Li, Jinjun Liang, Junxian Xie, Jincheng Liu, Zhen Xiang, Wenxuan Dong, Sihong OuYang, Zhuozheng Deng, Qipeng Wei","doi":"10.3389/fragi.2025.1476902","DOIUrl":"10.3389/fragi.2025.1476902","url":null,"abstract":"<p><strong>Purpose: </strong>To develop a clinical prediction model for the diagnosis of osteoporosis using lumbosacral X-ray images through radiomics analysis.</p><p><strong>Methods: </strong>A total of 272 patients who underwent dual-energy X-ray absorptiometry (DXA) and lumbosacral X-ray examinations were categorized into two groups: (1) the training set (n = 191) and (2) the validation set (n = 81). Radiomic features were extracted using 3D Slicer software, and radiomic scores were calculated using the least absolute contraction and selection operator logistic regression, facilitating the generation of radiomic features. Subsequently, a clinical model, in conjunction with the radiomic features, was employed to develop a column-line diagram for the clinical and imaging feature prediction model. Performance evaluations for various models were conducted, encompassing recognition ability, accuracy, and clinical value, with the aim of identifying and optimizing prediction models.</p><p><strong>Results: </strong>The 12 most optimal imaging features were identified. Upon comprehensive performance analysis across different models, the clinical and radiomics model emerged as the most effective. The training set and test set area under the curves (AUCs) were 0.818 and 0.740, respectively. Additionally, the model exhibited a sensitivity and specificity of 81.6%, 80.6% and 77.5%, 73.2%, respectively.</p><p><strong>Conclusion: </strong>In this study, we developed a column-line diagram that integrates clinical and radiomics feature, presenting a novel screening tool for osteoporosis in primary hospitals. This tool aims to enhance the efficiency of osteoporosis diagnosis in primary hospitals.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1476902"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12259612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From frailty to resilience: exploring adaptive capacity and reserve in older adults-a narrative review.","authors":"Caglar Cosarderelioglu, Jeremy D Walston, Peter M Abadir","doi":"10.3389/fragi.2025.1520842","DOIUrl":"10.3389/fragi.2025.1520842","url":null,"abstract":"<p><p>Resilience, the capacity to adapt and recover from adversity, plays a critical role in the health and wellbeing of older adults. In geriatric populations, resilience encompasses physical, cognitive, and psychosocial domains and is essential for maintaining functional independence and quality of life amidst the challenges of aging. This review explores the concept of resilience within geriatric medicine across physical, cognitive, and psychosocial domains, highlights the differences from frailty and reserve, underscores importance of stressors, summarizes key biomarkers that predict resilience, and evaluates interventions designed to enhance resilience in older adults.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1520842"},"PeriodicalIF":3.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12259552/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144644286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}