Frontiers in aging最新文献

{"title":"A new blue zone? exceptional late-life survival in Bolotana, Sardinia.","authors":"Giovanni Mario Pes, Steven N Austad, Dan Buettner, Salvatore Pedde, Vittorio Romerio, Hiram Beltrán-Sánchez, S Jay Olshansky","doi":"10.3389/fragi.2026.1951042","DOIUrl":"https://doi.org/10.3389/fragi.2026.1951042","url":null,"abstract":"<p><strong>Background: </strong>Exceptional longevity in Sardinia has historically been associated with the original Sardinian Blue Zone. We investigated whether Bolotana, a small mountain municipality outside that area, exhibits a distinct late-life survival profile.</p><p><strong>Methods: </strong>Using validated civil and parish records, we constructed sex-specific partial period life tables for 2021-2025. Late-life survival was defined as survival from age 70 onward and assessed through remaining life expectancy at age 70 (e₇₀) and conditional survival from age 70 to 100 [S_(70→100)]. Estimates were compared descriptively with Nuoro Province, Sardinia, and Italy, the original Sardinian Blue Zone, and published international benchmark. Statistical uncertainty was evaluated using parametric Poisson bootstrap. Sensitivity analyses included 2020-2025 and a period-matched 2015-2019 analysis.</p><p><strong>Results: </strong>In 2021-2025, e₇₀ was 16.02 years in men (95% CI, 14.55-17.79) and 20.85 years in women (19.42-22.43); S_(70-100) was 4.92% (1.58-12.76) and 13.83% (7.33-23.75), respectively. Female estimates _(70-100) exceeded contemporary values for Nuoro Province, Sardinia, and Italy. Among international benchmarks, Bolotana women ranked second only to Hong Kong for both indicators, and S_(70→100) was more than three times that of U.S. women. Inclusion of 2020 to address the potential effects of COVID-19 produced modest reductions, whereas the period-matched 2015-2019 analysis yielded a less pronounced late-life survival profile, particularly for survival to age 100.</p><p><strong>Conclusion: </strong>Bolotana exhibited a distinctive, predominantly female pattern of exceptional late-life survival and may be considered a candidate longevity blue zone. However, the magnitude of this advantage varied by calendar period. Longer observation and continued demographic validation, are required before Bolotana can be considered an established longevity blue zone.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"7 ","pages":"1951042"},"PeriodicalIF":4.9,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13679626/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149229546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opportunities to enhance assisted living facility care quality through interprofessional collaborative practice.","authors":"David Hage, Rekha Pudur, Jan Golembiski","doi":"10.3389/fragi.2026.1870661","DOIUrl":"10.3389/fragi.2026.1870661","url":null,"abstract":"<p><p>Interprofessional Education (IPE) is increasingly recognized as a vital strategy for enhancing the quality of care in assisted living facility (ALF) settings. By fostering collaboration among healthcare professionals such as nurses, nurses' aides, social workers, physicians, and administrators, IPE promotes a shared and more robust understanding of resident needs and care goals. This opinion article argues that greater integration of IPE and interprofessional collaborative practice (IPCP) into long-term care training programs can significantly improve communication, reduce errors, and enhance person-centered care. Assisted living communities face complex challenges, including managing chronic conditions, supporting cognitive issues, changes in resident acuity, and addressing psychosocial needs. IPCP equips staff with the skills to navigate these challenges collectively, leading to more coordinated and effective care. While barriers such as scheduling challenges and institutional silos frequently persist, the potential benefits of IPCP include broader integration of IPCP towards improved resident outcomes, resident and staff satisfaction, and operational efficiencies that warrant its broader adoption. This article calls for greater prioritization of IPCP in assisted living facility settings to enhance resident outcomes and staff collaboration.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"7 ","pages":"1870661"},"PeriodicalIF":4.9,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149217416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between tooth retention and lower inflammatory dietary pattern in older adults.","authors":"Lyzbeth B Ortiz-Barrios, Paola Garcia-delaTorre, Berenice Rivera-Paredez, Sergio Sánchez-García, Berenice Palacios-González","doi":"10.3389/fragi.2026.1945744","DOIUrl":"10.3389/fragi.2026.1945744","url":null,"abstract":"<p><strong>Introduction: </strong>Tooth loss is highly prevalent among older adults and may compromise food selection, diet quality, and adherence to proinflammatory dietary patterns, thereby contributing to chronic inflammation and adverse health outcomes. This study investigated the association between tooth retention and the inflammatory potential of the diet among older adults.</p><p><strong>Methods: </strong>A cross-sectional analysis was conducted among 1,075 adults aged 60 years or older. According to the oral examination, participants were categorized as having ≥21, 11-20, 1-10, or no natural teeth, and as edentulous. The Dietary Inflammatory Index was constructed using a food-frequency questionnaire.</p><p><strong>Results: </strong>Individuals with more teeth were younger, possessed higher educational attainment, were less likely to smoke, and exhibited elevated Mini-Mental State Examination scores. After adjustment for potential confounders, older adults with 1-10 natural teeth had significantly higher odds of belonging to a more pro-inflammatory dietary category than those with 21-28 teeth (OR = 2.19; 95% CI: 1.44-3.33; p-value <0.001).</p><p><strong>Conclusion: </strong>Our findings suggest that tooth retention is closely associated with the inflammatory potential of the diet in older adults and supports the integration of oral health into nutritional assessment and healthy aging strategies.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"7 ","pages":"1945744"},"PeriodicalIF":4.9,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13672328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149217400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synovial fluid-derived extracellular vesicles modulate joint cell function in osteoarthritis.","authors":"Alvaro Compañ, Vittoria Carrabs, María Luisa Ferrándiz, Antonio Silvestre, Ignacio Muñoz, María Carmen Carceller, María Isabel Guillén","doi":"10.3389/fragi.2026.1894052","DOIUrl":"10.3389/fragi.2026.1894052","url":null,"abstract":"<p><strong>Introduction: </strong>Osteoarthritis (OA) is an age-related joint disease characterized by chronic inflammation and extracellular matrix degradation. Extracellular vesicles (EVs) in synovial fluid (SF) may modulate intercellular communication and influence disease progression.</p><p><strong>Material and methods: </strong>SF, cartilage, and synovial tissue were collected from knee OA patients (n = 68). SF-derived EVs (SF-EVs) were isolated by size exclusion chromatography and characterized by transmission electron microscopy (TEM), tunable resistive pulse sensing (qNano), and ELISA analysis of EV-associated markers (CD9, CD81, TSG101, and PDCD6IP) and the negative marker calnexin. <i>In vitro</i> experiments were performed using primary synoviocytes and chondrocytes stimulated with interleukin (IL)-1β in the presence or absence of SF-EVs. Inflammatory and catabolic markers were measured.</p><p><strong>Results: </strong>SF-EVs (∼261 nm; ∼7 × 10⁸ particles/mL) expressed canonical EV markers. In synoviocytes, SF-EVs reduced IL-1β-induced proliferation and decreased IL-6 and MMP-3 while increasing hyaluronic acid (HA). In chondrocytes, SF-EVs reduced IL-6 and MMP-13 and enhanced HA and IL-1Ra production, with sustained effects over time.</p><p><strong>Conclusion: </strong>These findings suggest that SF-EVs can modulate inflammatory and matrix-related responses in joint-resident cells under IL-1β-induced inflammatory conditions. Their distinct effects on synoviocytes and chondrocytes highlight the potential role of SF-EVs in regulating cell-specific responses within the osteoarthritic joint and warrant further investigation into their contribution to OA pathophysiology.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"7 ","pages":"1894052"},"PeriodicalIF":4.9,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13661546/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Promoting healthy aging in a digital world: leveraging technology for enhanced elderly care and wellbeing.","authors":"Patrizio Armeni, Irem Polat, Leonardo Maria De Rossi, Lorenzo Diaferia, Sara De Padova, Athena Gatti, Severino Meregalli","doi":"10.3389/fragi.2026.1988532","DOIUrl":"https://doi.org/10.3389/fragi.2026.1988532","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fragi.2026.1687784.].</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"7 ","pages":"1988532"},"PeriodicalIF":4.9,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149198198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comprehensive profiling of phenotypic features of memory T- and B-cells from birth to the onset of old age.","authors":"Joaquim Pedro Brito-de-Sousa, Laise Rodrigues Reis, Ismael Artur da Costa-Rocha, Vanessa Peruhype-Magalhães, Christiane Costa-Pereira, Julia Pereira Martins, Lis Ribeiro do Valle Antonelli, Cristiana Couto Garcia, Angelica Oliveira Gomes, Jordana Grazziela Alves Coelho-Dos-Reis, Ana Maria de Caetano Faria, Andréa Teixeira-Carvalho, Ana Carolina Campi-Azevedo, Karen Cecília de Lima Torres, Olindo Assis Martins-Filho","doi":"10.3389/fragi.2026.1890974","DOIUrl":"https://doi.org/10.3389/fragi.2026.1890974","url":null,"abstract":"<p><strong>Introduction: </strong>Human aging is accompanied by profound and continuous remodeling of the immune system, characterized by rhythmic, stage-specific patterns. These features are characterized by waves of cellular differentiation, network reorganization, and functional recalibration, a phenomenon encompassed by the concept of immunobiography.</p><p><strong>Methods: </strong>This study focuses on T- and B-cell memory immunophenotypes that shape adaptive immunity, including interferon-activated cells from healthy volunteers of both sexes, aged 9 months to 65 years, stratified into 12 consecutive age subgroups. Significant shifts were concentrated in intermediate age subgroups, particularly at 5-6 years, 10-19 years (the most pronounced), and 20-29 years.</p><p><strong>Results: </strong>Although women exhibited an earlier onset of changes, men demonstrated greater lifelong variability in differentiated subsets, especially for early effector CD4⁺ cells. Additionally, other cell subsets showed variability, especially in men, including early effector CD4⁺ and CD8⁺, interferon- mediated CD4⁺ and CD8⁺, central and effector memory CD4⁺, non-interferon-mediated CD4⁺, and naïve CD19⁺ B-cells, predominantly between 10 and 39 years. Signature analyses confirmed sex-specific peaks occurring at distinct ages. Naïve cells displayed the highest overall connectivity, whereas B-cell network connectivity increased with age in women but decreased sharply in men after 20 years. Notably, the upregulation of immune memory cell subsets was accompanied by an increase in global connectivity.</p><p><strong>Discussion: </strong>Our findings indicate that immune memory remodeling across the human lifespan occurs in discrete, sex-dependent waves, probably shaped by cumulative antigen exposure and endocrine transitions. These trajectories may differentially balance adaptive immunity and inflammatory differentiation, potentially influencing long-term immune resilience and susceptibility to chronic inflammatory conditions.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"7 ","pages":"1890974"},"PeriodicalIF":4.9,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13662096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149198254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune system ontogeny-a subtle evolution to perfection.","authors":"Adriana Narcisa Munteanu, Mihaela Surcel, Elena Georgiana Dobre, Carolina Constantin, Monica Neagu","doi":"10.3389/fragi.2026.1872955","DOIUrl":"https://doi.org/10.3389/fragi.2026.1872955","url":null,"abstract":"<p><p>It is well known that both innate and adaptive immune systems in newborns are immature, making them highly susceptible to infection. Additionally, pre-term newborns with hindered immune systems are more prone to increased mortality and morbidity. Newborns are capable of mounting adaptive immune responses, but their capability to develop long-lasting immunity is limited. Thus, the fetus and newborn's immune system is considered \"immature\" due to functional disorders in immune response or suppression by regulatory cells. Aging is another factor that leads to impaired immune responses due to a state of chronic low-grade inflammation (inflammaging), which compromises defense against pathogens and malignancies and favors the onset of age-related disorders. However, in this complicated scenario, centenarians emerged as a paradigm shift due to their particular immune system that prevents inflammaging and enables them to achieve longevity. Therefore, the present review aims to provide an updated overview of immune response development through neonatal, infant, and adult life in order to highlight stage-specific mechanisms and uniquely regulated immune responses. Taken together, this information provides mechanistic insights that can be harnessed to develop age-adapted interventional strategies and prevent the onset of age-associated disorders in older adults.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"7 ","pages":"1872955"},"PeriodicalIF":4.9,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13658606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New insight into Alzheimer's disease: small molecule-Aβ in the brain transport and peripheral organ clearance.","authors":"Tianci Ma, Yongyi Li, Yuting Ding, Shijie Liu, Chuanhao Gao, Xiang Li, Zhiqian Tong, Yan Lv","doi":"10.3389/fragi.2026.1921485","DOIUrl":"https://doi.org/10.3389/fragi.2026.1921485","url":null,"abstract":"<p><p>Alzheimer's disease (AD) represents one of the most prevalent neurodegenerative disorders without approved disease-modifying therapies. A major contributing factor is that, for decades, drug development has focused almost exclusively on repairing or removing lesions within the brain itself. Yet a growing body of work now points to AD as a systemic disorder, rooted in a breakdown of whole-body Aβ homeostasis. Nevertheless cerebral Aβ transport and peripheral Aβ clearance are commonly investigated as independent processes, and the coordinated interplay… remains insufficiently characterized. This review bridges the current research gap by systematically elaborating the full trafficking cascade of brain-derived Aβ from intracerebral drainage to peripheral elimination. Four major intracranial clearance pathways are comprehensively summarized, including the blood-brain barrier, blood-cerebrospinal fluid barrier, arachnoid granulation venous outflow, and meningeal lymphatic/glymphatic system. The peripheral clearance processes of circulating Aβ in the blood, liver, kidney, and gastrointestinal tract are further illustrated. A broad spectrum of emerging therapeutic strategies targeting Aβ transport and clearance is also reviewed, including specific pathway modulators, microglia regulators, Aβ aggregation inhibitors, natural multi-target compounds, ultrasound-mediated blood-brain barrier opening, and exosome-based intervention approaches. When we compare the relative contributions of central versus peripheral clearance, Comparative analysis of central and peripheral Aβ clearance indicates that the liver appears to dominate the peripheral elimination of Aβ, yet the real driver of cerebral Aβ deposition is not the failure of any single route, but rather the loss of synergy among multiple pathways. This mechanistic framework explains why purely brain-centric therapeutics are unlikely to correct a systemic Aβ imbalance. Instead, future translational efforts should give higher priority to combination regimens that simultaneously facilitate intracerebral drainage and bolster peripheral organ clearance. This review further discusses current hurdles and emerging opportunities in systemic AD drug discovery, with the aim of offering a unified conceptual framework-one that providing a unified conceptual framework for understanding AD pathogenesis and facilitating the exploration of novel therapeutic paradigms.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"7 ","pages":"1921485"},"PeriodicalIF":4.9,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13658164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149186564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonographic evaluation of quadriceps femoris muscle mass in critically ill patients aged 60 years and older: a prospective observational study.","authors":"Nestor-Julian Zarate-Herran, Johan-Sebastián Villada-Gómez, Nestor-David Caicedo, Diana-María Trejos-Gallego, Fernando Gomez","doi":"10.3389/fragi.2026.1792585","DOIUrl":"10.3389/fragi.2026.1792585","url":null,"abstract":"<p><strong>Background and aims: </strong>Muscle wasting is a common complication in critically ill older adults admitted to intensive care units (ICU), with significant implications for morbidity and mortality. Ultrasound represents a promising bedside tool for assessing muscle mass changes. This study aimed to evaluate changes in quadriceps femoris muscle mass using ultrasonography at ICU admission and after 7 days of stay in patients aged 60 years and older.</p><p><strong>Methods: </strong>A prospective cohort study with repeated measurements was conducted between December 2024 and May 2025. Patients aged ≥60 years admitted to the ICU were included. Ultrasonographic measurements included rectus femoris cross-sectional area (RFCSA), bilateral quadriceps muscle thickness, and rectus femoris pennation angle at admission and day 7. Clinical characteristics, severity scores (APACHE II, SOFA), and functional status (Barthel index) were recorded. Statistical analysis included Wilcoxon signed-rank test and robust statistics.</p><p><strong>Results: </strong>Fifty patients were analyzed (60% male, median age 72.5 years). <i>Significant</i> muscle mass reductions were observed: RFCSA decreased by 16.2% (2.525-2.115 cm², p < 0.001), right quadriceps thickness by 14.6% (2.012-1.719 cm, p < 0.001), left quadriceps thickness by 20.2% (2.049-1.635 cm, p < 0.001), and pennation angle by 18.2% (7.664°-6.270°, p < 0.001). ICU mortality was 30%. Multivariate analysis identified advanced age, female sex, hypoglycemic agent use, higher SOFA scores, and lower premorbid Barthel index as factors associated with greater muscle loss.</p><p><strong>Conclusion: </strong>Critically ill older adults experience significant quadriceps muscle mass loss within the first week of ICU stay, as measured by bedside ultrasonography. These findings support the implementation of early muscle assessment and targeted interventions in this vulnerable population.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"7 ","pages":"1792585"},"PeriodicalIF":4.9,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13646096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149139536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Cognitive and behavioral benefits of newspaper reading in community-dwelling older adults: a feasibility randomized controlled trial.","authors":"Mamoru Sato, Sawako Negoto, Shinya Nakano, Chihoko Urata, Tetsuya Ioji, Hideya Kodama, Emi Yoshimura, Yukinori Tasaki, Shinichiro Goroku, Kiichiro Morita, Yoshihisa Shoji","doi":"10.3389/fragi.2026.1992402","DOIUrl":"https://doi.org/10.3389/fragi.2026.1992402","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fragi.2026.1929793.].</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"7 ","pages":"1992402"},"PeriodicalIF":4.9,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13635729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149119348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}