Frontiers in aging最新文献

{"title":"Normative values to assess functional fitness in older adults in a region of Chile.","authors":"Marco Cossio-Bolaños, Rubén Vidal-Espinoza, Luis F Castelli Correia de Campos, Jose Sulla-Torres, Camilo Urra-Albornoz, Fernando Alvear-Vasquez, Jose Fuentes-Lopez, Marcella Silva Ramos de Lazari, Rossana Gomez-Campos","doi":"10.3389/fragi.2025.1554783","DOIUrl":"https://doi.org/10.3389/fragi.2025.1554783","url":null,"abstract":"<p><strong>Introduction: </strong>Aging is a global phenomenon that has generated great concerns and challenges in terms of public health and medical care, associated with a lower quality of life. The objective to study was to compare the functional fitness of older adults in a region of Chile with other countries, and to propose normative values according to age range and sex.</p><p><strong>Methods: </strong>A descriptive cross-sectional study was carried out in older adults of the central-south region of Chile. The sample selection was non-probabilistic. A total of 787 older adults (180 males and 607 females) with an age range of 60-85 years were investigated. The sample represents a group of physically active older adults. Weight and height were assessed. Body mass index (BMI) was calculated. The four physical tests evaluated were: 30-s push-up (reps), 30-s standing chair (rep), 8-ft up-and-go (sec), 2-min step test (rep) and 6-min walk (m). Percentiles were calculated for p10, p25, p50, p75 and p90), through the LMS method (L: Lambda; skewness), M: Mu; median and S: Sigma; coefficient of variation).</p><p><strong>Results: </strong>Discrepancies in BMI were observed between countries (in males from ∼4.3 to 7.0 kg/m2 and in females from ∼6.7-7.5 kg/m2). In the 30-s push-up test) there were variations from ∼3 to six repetitions in both sexes. In the 8-ft up-and-go test, discrepancies ranged from ∼1.1 to 4.4 s. In the aerobic 2-min step test, discrepancies ranged in both sexes from ∼21 to 41 repetitions. In the 6-min walk test, the variations between studies ranged from ∼150 to 245 m in both sexes. In the 30-s standing chair test, performance in both sexes was relatively homogeneous, varying from ∼1 to 2 repetitions. Percentiles by age range and sex were developed for BMI and the five functional fitness tests.</p><p><strong>Conclusion: </strong>This study demonstrated that there were discrepancies in BMI and functional fitness performance of older adults between countries in various geographic regions of the world. In addition, the proposed percentiles are an important tool to track individual changes and can be used to evaluate and plan intervention programs in older adults in Chile.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1554783"},"PeriodicalIF":3.3,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of an intergenerational Kindermusik class on stress and affect in older adults with dementia and their caregivers: a pilot study using ecological momentary assessment.","authors":"Amber Thro, Phyllis Babcock, T Lee Covington, Kelly Green, Carol Penney, Jason Fanning, Christina E Hugenschmidt","doi":"10.3389/fragi.2025.1448293","DOIUrl":"https://doi.org/10.3389/fragi.2025.1448293","url":null,"abstract":"<p><strong>Introduction: </strong>The objectives of this pilot study were to determine the feasibility of collecting ecological momentary assessments from caregivers of older adult persons with dementia as they attended a weekly, intergenerational Kindermusik class, and to examine relationships between Kindermusik participation and momentary stress and affect for the caregiver and person with dementia.</p><p><strong>Methods: </strong>Over a 12-week period, 14 persons with dementia attended a weekly intergenerational Kindermusik class. Caregivers completed up to six daily ecological momentary assessments on affective valence and stress for themselves and the person with dementia during Weeks 1 and 12. Salivary cortisol data were collected from the persons with dementia during Weeks 1 and 12.</p><p><strong>Results: </strong>Overall, ecological momentary assessment response rates were low (37.7% completion). Caregiver ecological momentary assessment ratings of their personal stress and affect were significantly and positively associated with their perceptions of affect and stress in the person with dementia. The caregiver's affective state tended to improve on days when the person with dementia attended Kindermusik, especially when they perceived the person with dementia as having more positive affect.</p><p><strong>Discussion: </strong>Additional research is required to determine how to best support survey completion while minimizing caregiver burden, and to investigate the impact of more frequent involvement in an intergenerational music and movement program.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1448293"},"PeriodicalIF":3.3,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12209361/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of burden and needs of family caregivers for the elderly, a scoping review.","authors":"Elodie Le Toullec, Anne Le Gagne, Emilie Leblong, Alain Somat, Patrice Piette","doi":"10.3389/fragi.2025.1578911","DOIUrl":"10.3389/fragi.2025.1578911","url":null,"abstract":"<p><strong>Background: </strong>Family caregivers play a central role in supporting older adults. Their role is complex and challenging. Their assessment is essential for planning support systems. This review aims to catalog the different scales, identify the spectrum of dimensions they cover, and evaluate their psychometric quality, with the aim of reflecting on potential clinical recommendations.</p><p><strong>Method: </strong>A systematic review of MEDLINE, PsycINFO, google scholar and CINAHL databases identified tools for measuring family caregiver engagement. Two reviewers selected relevant studies using predefined criteria. Keywords included \"family caregivers,\" \"engagement,\" \"measurement,\" and \"psychometrics.\" Extracted data was analyzed for reliability, validity, and other psychometric properties.</p><p><strong>Results: </strong>We identified 140 articles, 38 of which were analyzed, utilizing 29 different scales to assess caregiver support across various dimensions such as burden, stress, or needs. Clinimetric assessment using an abbreviated COSMIN checklist revealed significant variability in the reliability and validity of these scales, with only 2 meeting clinical research standards. Notable deficiencies were found in internal consistency, reproducibility, and construct validity. None of the scales cover the entire range of complex dimensions associated with family caregivers.</p><p><strong>Conclusion: </strong>The study underscores the need for improved measurement tools tailored to the complexities of caregiver engagement. Future work should focus on developing more refined scales that better capture the diverse needs of family caregivers to enhance support.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1578911"},"PeriodicalIF":3.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12202512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulatory titin and miR-451a are possible sarcopenia biomarkers in elderly people.","authors":"Roberta Mancuso, Lorenzo Agostino Citterio, Simone Agostini, Rossella Miglioli, Riccardo Nuzzi, Laura Antolini, Fabio Trecate, Mario Clerici","doi":"10.3389/fragi.2025.1587438","DOIUrl":"10.3389/fragi.2025.1587438","url":null,"abstract":"<p><strong>Introduction: </strong>Sarcopenia is a clinical syndrome characterized by decline of muscle mass, strength or physical performance that occur with advancing age. Diagnosis is currently based on assessment of muscle mass and performance. New biomarkers are needed in clinical practice for diagnosis, monitoring and treatment of sarcopenia. The measurement in urine of titin (TTN), a muscular protein essential for structure and function of sarcomere, has been recently suggested as useful biomarker for the diagnosis of sarcopenia. The titin N-terminal fragment (N-TTN), produced by proteolysis during muscle damage, is released in the bloodstream and is secreted in the urine, and it was suggested as indicator of muscle injury. The primary aim of our study is to evaluate the potential of serum TTN and N-TTN expression as biomarker of sarcopenia, an aspect that has not been the subject of much research so far. Additionally, the secondary aim is to explore possible relationship between the serum expression of titin and miR-451a, its possible miRNA regulator.</p><p><strong>Methods: </strong>We verified serum TTN, N-TTN and miR-451a concentration in a cohort of 70 sarcopenic patients who were undergoing rehabilitation; results were compared to those obtained in 90 age- and sex-matched healthy controls (HC).</p><p><strong>Results: </strong>Results showed that TTN and N-terminal TTN (N-TTN) (p < 0.0005 for both) and miR-451a (p < 0.0001) were significantly upregulated in serum of patients compared to HC. Rehabilitation significantly reduced TTN and N-TTN expression (p < 0.05 for all), while induced a significant increase in miR-451a expression (p = 0.008); ROC analysis showed that the change of miR-451a may be a predictive biomarker for rehabilitation outcome (p = 0.0198).</p><p><strong>Discussion: </strong>This study suggests the involvement of TTN, N-TTN and miR-451a in sarcopenia; moreover, the monitoring of miR-451a concentration may be useful proxy to measure the effectiveness of rehabilitation intervention.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1587438"},"PeriodicalIF":3.3,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12198232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telomere length and COVID-19 disease severity: insights from hospitalized patients.","authors":"Stijn Vos, Dries S Martens, Elien De Waele, Geert Dewyspelaere, Geert Mistiaen, Pieter Goeminne, Tim S Nawrot","doi":"10.3389/fragi.2025.1577788","DOIUrl":"10.3389/fragi.2025.1577788","url":null,"abstract":"<p><strong>Introduction: </strong>Telomere length is associated with various disease and immune function and may therefore impact COVID-19 disease severity. We studied the associations between telomere length as a geroprotective susceptibility marker and clinical outcomes in hospitalized COVID-19 patients.</p><p><strong>Methods: </strong>283 hospitalised COVID-19 patients (before vaccination, recruited between May 2020 and March 2021) were recruited for this cross-sectional study. Blood telomere length was determined by qPCR. The association between blood telomere length and clinical outcomes was examined using logistic regression, while adjusting for various covariates and confounders including demographic factors, comorbidity, body-mass index and blood cell counts. The primary clinical outcomes assessed were duration of stay, risk of ICU admission, and risk of requiring ventilation support.</p><p><strong>Results: </strong>Independent of sex and chronological age, an interquartile-range (IQR) increase in blood telomere length was associated with more favourable clinical outcomes in hospitalised COVID-19 patients: specifically, the odds ratio for ICU admission was 0.55 (95%CI: 0.32-0.88). Moreover, the odds ratio for the risk of ventilation was 0.52 (95%CI: 0.31-0.84). Finally, ordinal logistic regression revealed a lower odds for being in a higher quantile of hospital duration (OR: 0.79, 95%CI: 0.58-1.06).</p><p><strong>Discussion: </strong>To conclude, we found that in hospitalised COVID-19 patients, longer telomeres was associated with lower diseases severity in hospitalised COVID-19 patients, that could not be explained by shifts in blood cell counts. Therefore supporting the geroprotective or immunoprotective effects associated with longer telomeres conferring lower susceptibility to severe COVID-19 outcomes.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1577788"},"PeriodicalIF":3.3,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12185540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, attitude, and practice of osteoporosis prevention in elder patients following lumbar fusion surgery: a cross-sectional study.","authors":"Shaoying Sheng, Manman Wang, Chengfei Yu, Qing Li, Zhan Wang, Yaojing Ma","doi":"10.3389/fragi.2025.1543839","DOIUrl":"10.3389/fragi.2025.1543839","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the knowledge, attitudes, and practices (KAP) regarding osteoporosis prevention among older adult patients following lumbar fusion surgery and identify associated factors.</p><p><strong>Patients and methods: </strong>A cross-sectional study was conducted with participants aged ≥50 years. Data on demographic characteristics, KAP related to osteoporosis prevention, and lifestyle behaviors were collected using structured questionnaires. Chi-square tests were performed to explore associations between demographic variables and knowledge levels.</p><p><strong>Results: </strong>A total of 217 participants were included in the study. Participants demonstrated varying levels of knowledge, with 28.6% scoring high on the OPAAT. Female gender, higher educational attainment, urban residence, and diabetes were significantly associated with higher knowledge levels. Positive lifestyle practices, such as calcium and vitamin D supplementation, were observed in 64.5% and 41.0% of participants, respectively, while regular outdoor exercise and dairy product consumption were less common.</p><p><strong>Conclusion: </strong>The findings highlight gaps in osteoporosis prevention KAP among older adult patients following lumbar fusion surgery. Tailored educational programs and interventions are necessary to enhance awareness and promote healthier behaviors.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1543839"},"PeriodicalIF":3.3,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12185519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EI24 binds to IGF1R, enhancing glucose homeostasis and fostering healthy aging in male mice.","authors":"You-Min Kim, Seung Eon Lee, Yaechan Song, Tae Wook Nam, Jaehoon Lee, Je Kyung Seong, Wan Namkung, Han-Woong Lee","doi":"10.3389/fragi.2025.1564730","DOIUrl":"10.3389/fragi.2025.1564730","url":null,"abstract":"<p><strong>Introduction: </strong>The etoposide-induced 2.4 kb transcript (EI24) plays a crucial role in autophagy, facilitating the clearance of damaged proteins and organelles to maintain cellular homeostasis. While autophagy is widely recognized for its beneficial effects on healthy aging, the effects of EI24 overexpression remain unclear.</p><p><strong>Methods: </strong>We analyzed the interaction of EI24 with the insulin-like growth factor 1 receptor (IGF1R), a key molecule associated with aging. <i>Ei24</i> transgenic (TG) mice were generated to assess the effects of Ei24 overexpression on aging, glucose homeostasis, and resistance to streptozotocin (STZ)-induced diabetes.</p><p><strong>Results: </strong>EI24 was found to bind to IGF1R, specifically engaging with its transmembrane (TM) domain near the cytoplasmic membrane, and suppress its phosphorylation. Male <i>Ei24</i> TG mice exhibited signs of healthier aging, with reduced aging markers in the kidney, liver, and pancreas. Moreover, Ei24 overexpression enhanced glucose uptake, likely due to increased Glut4 expression in muscle tissue. <i>Ei24</i> TG mice also demonstrated resistance to high-dose STZ-induced diabetes.</p><p><strong>Conclusion: </strong>These findings suggest that Ei24 overexpression contributes to improved glucose regulation and healthier aging across multiple organs. By interacting with IGF1R, EI24 may provide a novel mechanism for promoting metabolic and age-related health.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1564730"},"PeriodicalIF":3.3,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12185461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The curvilinear associations between Life's Crucial 9 and frailty: cross-sectional study of NHANES 2003 - 2023.","authors":"Bo Wang, Chunqi Jiang, Ning Wang, Yinuo Qu, Jun Wang, Guang Zhao, Xin Zhang","doi":"10.3389/fragi.2025.1528338","DOIUrl":"10.3389/fragi.2025.1528338","url":null,"abstract":"<p><strong>Background: </strong>Frailty not only affects disease survival rates but also the quality of life. The Life's Crucial 9 (LC9) is a recently proposed cardiovascular health risk score that incorporates mental health along with Life's Essential 8 (LE8). The association between LC9 and frailty has not yet been reported. This study aims to explore the link between LC9 scores and levels of frailty.</p><p><strong>Methods: </strong>We used a weighted multiple logistic regression model to evaluate the relationship between Life's Essential 8 (LE8) and LC9 with frailty, and conducted trend tests to assess the stability of this association. Additionally, we employed smooth curve fitting to explore the potential curvilinear relationship between LE8 and LC9 with frailty. To identify inflection points, we applied recursive partitioning algorithms in conjunction with a two-stage linear regression model. Stratified analyses were performed to examine heterogeneity within various populations.</p><p><strong>Results: </strong>Our study included a total of 28,557 participants. In the regression model that accounted for all covariates, the odds ratios (ORs) for the association of LE8 and LC9 scores with frailty were 0.95 (95% CI: 0.94, 0.95) and 0.93 (95% CI: 0.93, 0.93), respectively, indicating a significantly stronger negative correlation with LC9 scores. Sensitivity analysis confirmed the robustness of this relationship. Smooth curve fitting revealed a nonlinear correlation between LE8 and LC9 scores and the degree of frailty. Further analysis using a two-piecewise linear regression model identified inflection points at 53.12 for LE8 and 68.89 for LC9. Below these thresholds, both LE8 and LC9 demonstrated a significant negative association with frailty. However, above these points, the strength of the negative correlation was somewhat reduced but remained statistically significant. In stratified analyses, both LE8 and LC9 exhibited significant negative associations with frailty, with LC9 showing a more pronounced relationship. Significant interaction effect was detected within the education level groups.</p><p><strong>Conclusion: </strong>We found a curvilinear relationship between LE8, LC9 and frailty, and the relationship between LC9 and frailty was more significant. This implies that LC9 can facilitate the early and precise identification of individuals at high risk of frailty, thereby providing a foundation for the development of targeted intervention strategies.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1528338"},"PeriodicalIF":3.3,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12179158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144478094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Membrane transporter progressive ankylosis protein homologue (<i>ANKH</i>/<i>Ank</i>) partially mediates senescence-derived extracellular citrate and is regulated by DNA damage, inflammation, and ageing.","authors":"Emma Naomi James, Muy-Teck Teh, Yufeng Li, Christine Wagner-Bock, Zahra Falah Al-Khateeb, Lee Peng Karen-Ng, Terry Roberts, Linnea Synchyshyn, Amy Lewis, Ana O'Loghlen, Andrew Silver, Adina Teodora Michael-Titus, Mark Bennett, Jacob Guy Bundy, Maria Elzbieta Mycielska, Eric Kenneth Parkinson","doi":"10.3389/fragi.2025.1583288","DOIUrl":"10.3389/fragi.2025.1583288","url":null,"abstract":"<p><strong>Introduction: </strong>A considerable body of recent evidence supports citrate transport as a major regulator of organismal lifespan and healthspan. Citrate accumulates outside senescent cells <i>in vitro</i> and <i>in vivo</i>. However, the detailed mechanism of senescent cell extracellular citrate (EC) accumulation is not clear.</p><p><strong>Methods: </strong>EC following various drug and cytokine treatments was measured in human fibroblast and keratinocyte conditioned medium by gas chromatography/mass spectroscopy and liquid chromatography/mass spectroscopy. Membrane transporters in similar human fibroblasts cultures were measured by western blotting and more extensively by reverse transcription and quantitative polymerase chain reaction (qPCR) in human fibroblasts, keratinocytes, myoblasts, adipocytes and astrocytes. Mouse tissues were tested for senescence markers and by qPCR, immunofluorescence and immunoFISH telomere associated foci (TAF) staining. Cytokine levels in conditioned medium were measured by the enzyme-linked immunosorbent assay and in mouse brain tissue and plasma samples using the V-PLEX proinflammatory panel 1 mouse kit.</p><p><strong>Results and discussion: </strong>We show here that EC is partially mediated by a newly described plasma membrane citrate transporter <i>ANKH/SLC62A1</i> (progressive human ankylosis -<i>ANKH</i>) in senescent fibroblasts. Analogous to interleukin 6 (IL-6), EC and/or <i>ANKH</i> are regulated by telomere dysfunction, the p38 mitogen-activated kinase axis, transforming growth factor beta and p53, but in contrast not by steroids, sodium butyrate, or Ataxia Telangiectasia Mutated (ATM). ANKH was upregulated in other senescent cell types relevant to ageing but not keratinocytes. In contrast, EC and <i>ANKH</i> were inhibited by interleukin 1α (IL-1α) in dividing and senescent fibroblasts, accompanied by an increase in IL-6 secretion. Loss- and gain of function mutations of <i>ANKH/Ank</i> are associated with disease and interestingly, <i>Ank</i> is also downregulated in both aged mouse liver and brain tissues in parallel with increased senescence markers and several cytokines, suggesting that inflammatory cytokines could inhibit EC production <i>in vivo</i>. These data identify <i>ANKH/Ank</i> as a novel regulator of senescence-derived EC in both humans and mice.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1583288"},"PeriodicalIF":3.3,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12174118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Right hemisphere engagement in language abilities in older adults: indication of compensation rather than decline.","authors":"Daniel Solomons, Maria Rodriguez-Fernandez, Francisco Mery-Muñoz, Leonardo Arraño-Carrasco, David Toloza-Ramirez, Francisco Sahli-Costabal, Carolina Mendez-Orellana","doi":"10.3389/fragi.2025.1458692","DOIUrl":"10.3389/fragi.2025.1458692","url":null,"abstract":"<p><strong>Introduction: </strong>Structural brain changes during aging have been used as specific markers to distinguish normal aging from dementia. Changes in specific cognitive abilities such as episodic memory, processing speed, and executive functions, are observed in healthy aging. Limited evidence reports changes in linguistic functions alongside structural and functional brain changes. This study investigates correlations between language performance, gray matter volume (GMV), and neural activity in language regions, adjusted for demographic factors, in healthy older adults.</p><p><strong>Methods: </strong>Twenty-seven right-handed participants aged 60-87 were evaluated for overall linguistic performance using the Spanish version of ScreeLing (SCL) test and phonemic fluency and semantic verbal fluency tasks (PF and SF). Participants also underwent an MRI session during which they performed a functional MRI language task. T1-weighted MRI scans were used to measure GMV in specific language-related regions and assess language lateralization. Correlational analyses were conducted between language scores, GMV, years of education, age, sex, and fMRI lateralization.</p><p><strong>Results: </strong>In the right hemisphere (RH), significant positive correlations were found between SCL scores and GMV in the orbital inferior frontal gyrus (r = 0.5402; p = 0.0044) and the superior temporal gyrus (r = 0.516; p = 0.007). Furthermore, SCL and Phonemic fluency positively correlated with years of education, indicating that higher education enhances speech performance. No significant correlations were found in the left hemisphere (LH). Age, sex, and fMRI lateralization did not significantly correlate with specific linguistic scores.</p><p><strong>Discussion: </strong>These results challenge the current view of the role of the right hemisphere in language performance as increased GMV in specific right hemisphere language regions is associated with better language performance, highlighting the role of the right hemisphere in supporting language skills during healthy aging.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1458692"},"PeriodicalIF":3.3,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12171297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}