Frontiers in aging最新文献

{"title":"Chinese validation of \"subjective motoric cognitive risk syndrome\" screening tool in patients with coronary artery disease using Rasch analysis.","authors":"Yiyi Chai, Yanrong Gu, Xiaomin Wu, Yini Wang, Ping Lin, Qingfang Ye, Ling Li","doi":"10.3389/fragi.2025.1505847","DOIUrl":"https://doi.org/10.3389/fragi.2025.1505847","url":null,"abstract":"<p><strong>Objective: </strong>Subjective motoric cognitive risk syndrome (MCR-S) is a well-established screening tool that has been validated for objective motoric cognitive risk syndrome (MCR-O) and predicted risk of incident dementia. MCR is associated with cardiovascular factors and coronary artery disease (CAD). MCR-S is crucial for remote cognitive screening but has only been validated in community settings so far. Our study aimed to validate a Chinese version of the MCR-S in CAD patients.</p><p><strong>Method: </strong>The Chinese version of the MCR-S was obtained through a standardized forward-backward translation and cultural adaptation. 338 CAD patients were recruited. Traditional analysis based on classical test theory and Rasch analysis based on latent trait theory were performed on the MCR-S for validation. Receiver operating characteristic analysis was applied to determine the discriminative ability of MCR-S for the MCR-O in CAD patients.</p><p><strong>Results: </strong>The MCR-S met the unidimensionality, lack of local dependency or disordered thresholds, and good fit value for each item of the Rasch model, the item-person map shows that the item's estimate of capacity is appropriate. MCR-S has good content validity, criterion-related validity, and test-retest reliability. An optimal cut-score of 4.6 on the MCR-S score was determined to have good sensitivity (79.2%) and specificity (71.3%) for MCR-O in CAD patients.</p><p><strong>Conclusion: </strong>The Chinese version of MCR-S meets the requirements of the Rasch model and has good validity in CAD patients. The validated MCR-S cutoff can support long-term monitoring and early intervention for CAD patients at risk of MCR-O.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1505847"},"PeriodicalIF":3.3,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119596/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The gut microbiota and aging: interactions, implications, and interventions.","authors":"Despoina Gyriki, Christos G Nikolaidis, Eugenia Bezirtzoglou, Chrysa Voidarou, Elisavet Stavropoulou, Christina Tsigalou","doi":"10.3389/fragi.2025.1452917","DOIUrl":"https://doi.org/10.3389/fragi.2025.1452917","url":null,"abstract":"<p><p>The human microbiota, a complex ecosystem of microorganisms inhabiting various body sites, particularly the gut, plays a crucial role in maintaining health and influencing disease susceptibility. Dysbiosis, characterized by alterations in microbial composition and diversity, has been implicated in numerous diseases, including those associated with aging. This review examines the complex relationship between gut microbiota and aging, highlighting the age-associated gut microbiota alterations, the factors contributing to these changes, the links between microbiota and age-related diseases, and the potential of interventions targeting the microbiome to extend lifespan and improve health outcomes in the elderly. Further research is needed to unravel the intricate mechanisms underlying the interplay between the microbiome and aging, paving the way for innovative strategies to promote healthy aging.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1452917"},"PeriodicalIF":3.3,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12116569/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144175988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"miRNA mediated mitochondrial function and gene regulation associated with Alzheimer's disease.","authors":"Kumudu Subasinghe, Robert Barber, Nicole Phillips","doi":"10.3389/fragi.2025.1582812","DOIUrl":"10.3389/fragi.2025.1582812","url":null,"abstract":"<p><p>MicroRNAs (miRNAs) are small non-coding RNA molecules that are known to regulate gene expression in their target locations thereby contributing to epigenetic mechanisms associated with disease pathologies. Dysregulation of miRNA activity has been implicated in the pathology of Alzheimer's disease (AD), offering insights into potential biomarkers for early diagnosis and therapeutic targets. Mitochondrial dysfunction and its associated effects (such as oxidative stress) can be seen in early-onset AD. This review critically examines recent findings on mitochondrial-associated miRNAs-including miR-34a, miR-140, miR-455-3p, and miR-1273g-3p-highlighting their roles in mitochondrial bioenergetics, oxidative stress, and synaptic function. We discuss the therapeutic potential of targeting specific miRNAs to restore mitochondrial health and explore their utility as early biomarkers for AD diagnosis. A better understanding of miRNA-mediated mitochondrial regulation may open new avenues for early intervention in AD.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1582812"},"PeriodicalIF":3.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of sarcopenia and physical activity on the severity of metabolic dysfunction-associated steatotic liver disease among United States adults: NHANES 2017 - 2018.","authors":"Xiaodie Wei, Xiaohui Liu, Jinhan Zhao, Yang Zhang, Lixia Qiu, Jing Zhang","doi":"10.3389/fragi.2025.1573170","DOIUrl":"10.3389/fragi.2025.1573170","url":null,"abstract":"<p><strong>Background: </strong>Sarcopenia, physical activity (PA), and sedentary behavior are associated with metabolic dysfunction-associated steatotic liver disease (MASLD). The study aimed to evaluate the effects of sarcopenia and PA on the presence and severity of MASLD.</p><p><strong>Methods: </strong>This cross-sectional study analyzed data from the 2017-2018 National Health and Nutrition Examination Survey (NHANES). Hepatic steatosis and liver fibrosis were assessed by vibration-controlled transient elastography (VCTE). Sarcopenia was defined based on the Foundation for the National Institutes of Health criteria. PA and sedentary behavior were evaluated using the Global Physical Activity Questionnaire (GPAQ).</p><p><strong>Results: </strong>Among 1,831 participants, 664 were diagnosed with MASLD, including 482 with severe steatosis and 89 with significant fibrosis. The prevalence of sarcopenia in the MASLD and non-MASLD populations was 11.7% and 3.8%, respectively. Multivariable-adjusted models demonstrated that sarcopenia significantly increased the risk of MASLD (OR 2.45; 95% CI: 1.33-4.52), severe steatosis (OR 2.56; 95% CI: 1.40-4.66), and significant fibrosis (OR 6.10; 95% CI: 2.08-17.84). Additionally, individuals with sarcopenia and low PA had a 7.91-fold increased risk of developing significant fibrosis (OR, 7.91; 95% CI: 1.42-44.16, P = 0.022). Sarcopenia and prolonged sedentary behavior further increased the risk of MASLD (OR 3.75; 95% CI: 1.60-8.76), severe steatosis (OR 17.58; 95% CI: 1.93-159.79), and significant fibrosis (OR 4.32; 95% CI: 1.31-14.31).</p><p><strong>Conclusion: </strong>Patients with sarcopenia should increase physical activity and reduce sedentary time to decrease the risk and progression of MASLD. Increasing muscle mass and strength through resistance exercise to reduce the risk of significant fibrosis in sarcopenia patients.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1573170"},"PeriodicalIF":3.3,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144164210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Mechanistic theories of aging.","authors":"John Tower","doi":"10.3389/fragi.2025.1617783","DOIUrl":"10.3389/fragi.2025.1617783","url":null,"abstract":"","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1617783"},"PeriodicalIF":3.3,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104264/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144153025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspective on the ethics of AI at the intersection of nutrition and behaviour change.","authors":"Mariette Abrahams, Maria Raimundo","doi":"10.3389/fragi.2025.1423759","DOIUrl":"10.3389/fragi.2025.1423759","url":null,"abstract":"<p><p>Artificial intelligence (AI) has emerged as a powerful tool, that has the potential to impact society on multiple levels. Increased adoption as well as employment of AI in new product development and business processes have led to heightened interest and optimism on one hand, whilst increasing fears of potential negative societal consequences on the other. The ethics of AI has subsequently become a topical issue for academics, industry players, health practitioners and regulators, who have a goal and responsibility to protect the public and limit widening inequality. Despite the publication of numerous AI ethical frameworks, guidelines and regulations, none have specifically focused on nutrition and behaviour change. Advances in technology, including AI and machine learning, have opened up novel ways to deliver personalization to guide individuals towards healthier behaviours or to manage their conditions. This perspective synthesizes the key topics that intersect in nutrition and behaviour change where AI is leveraged to provide personalized advice. We propose a 7-pillar framework to guide the development of ethical and transparent AI solutions to build consumer and practitioner trust.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1423759"},"PeriodicalIF":3.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098540/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aging-related alternative splicing drive neoantigen emergence revealed by transcriptome analysis of 1,255 human blood samples.","authors":"Shuhan Li, Haohao Lv, Renxin Zhang, Jinjun Li, Zhiyuan Chen, Naixue Yang, Shaoxing Dai","doi":"10.3389/fragi.2025.1575862","DOIUrl":"10.3389/fragi.2025.1575862","url":null,"abstract":"<p><p>This study aimed to identify age-related genes and alternative splicing (AS) events by comprehensive transcriptome analysis of 1,255 healthy blood samples from individuals aged 8-87 years. We identified 1,029 up-regulated and 1,186 down-regulated genes in older individuals, including 17 genes overlapped with known aging-associated genes, such as TFAP2A and Klotho. Gene set enrichment analysis revealed significant alterations in immunoregulatory and metabolic pathways during aging. However, many senescence-associated secretory phenotypes (SASP) involved genes did not exhibit changes in gene expression, suggesting that AS events may reveal additional age-related mechanisms. Aging also altered 6,320 AS events in 4,566 genes, impacting immune-related protein domains. The RNA-binding protein RBMS3 emerged as a key regulator of aging-specific AS events. In addition, neoantigen prediction analyses further identified potential neoantigens generated by aging-related AS events, with the HLA-C14:02 allele presenting the most neoantigenic peptides. Notably, 60 neoantigenic peptides were confirmed using proteomic data from elderly individuals, suggesting their potential as novel targets for anti-aging immunotherapy. Our study provides new insights into the role of alternative splicing in aging, highlights promising avenues for anti-aging immunotherapy.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1575862"},"PeriodicalIF":3.3,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12098113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menopause-related changes to maxillary trabecular bone micro-architecture.","authors":"Alexandra Stein, Michael Levit, Hammaad Shah, Michael Yin, Sunil Wadhwa","doi":"10.3389/fragi.2025.1589708","DOIUrl":"10.3389/fragi.2025.1589708","url":null,"abstract":"<p><p>The number of midlife women seeking orthodontic treatment has significantly increased over the past 40 years. With this rise, orthodontists need to consider the potential impact of menopause on treatment planning. There have been no recent published studies on maxillary trabecular bone changes in humans related to menopause. This study aimed to explore the subject further. This cross-sectional cohort study was composed of qualifying participants with diagnostic maxillary CBCT images who were separated by self report into pre- (N = 21) and postmenopausal (N = 19) groups. The regions of interest were the trabecular bone of the incisive foramen and maxillary tuberosity. All scans were converted into binary images in order to draw all parametric and ratio raw data. The parameters of interest included trabecular bone volume fraction (BVF), trabecular thickness, trabecular number, and trabecular separation. In the incisive foramen subgroup, postmenopausal women showed a significant increase in trabecular separation (0.60 ± 0.25 to 0.84 ± 0.31 mm, P < 0.06). For the maxillary tuberosity subgroup, significant decreases in BV/TV (32.58 ± 15.85 to 17.63 ± 14.38 %, P <0.004), trabecular bone surface/tissue volume (2.66 ± 1.01 to 1.43 ± 1.09 %, P < 0.001) and trabecular separation (0.91 ± 0.39 to 1.58 ± 0.51 mm, P < 0.001) were observed. The findings reveal statistically significant differences in maxillary bone density at the level of the maxillary tuberosity and incisive foramen demonstrated in women who are of preversus post-menopausal status.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1589708"},"PeriodicalIF":3.3,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promising benefits of six-month <i>Phaeodactylum tricornutum</i> microalgae supplementation on cognitive function and inflammation in healthy older adults with age-associated memory impairment.","authors":"Emily Goodbody, Jonathan Maury, Andrea Doolan, Gillian DunnGalvin, Charles Kakilla, Rémi Pradelles, Timothy G Dinan","doi":"10.3389/fragi.2025.1540115","DOIUrl":"https://doi.org/10.3389/fragi.2025.1540115","url":null,"abstract":"<p><strong>Introduction: </strong>Aging is often associated with cognitive decline and memory impairment, with several factors including inflammatory cytokines and oxidative stress markers implicated in this natural process. Microalgae extracts are a natural source of many bioactive compounds that reduce inflammation and oxidative stress, and represent an innovative dietary approach to ameliorate age-related cognitive decline and memory impairment. This proof-of-concept CONSORT-compliant, double-blind, randomized controlled study was conducted to evaluate the effect of daily supplementation of microalgae extract on cognitive function, mood, stress and inflammation of healthy older adults with mild cognitive impairment over a 24-week period.</p><p><strong>Methods: </strong>Sixty-six volunteers with age-associated memory impairment (AAMI; age 55-75 years) were randomly assigned to ingest a placebo (PL, maltodextrin) or 550 mg of <i>Phaeodactylum tricornutum</i> (Pt) extract (4.4 mg of fucoxanthin, PUFAs and saturated fatty acids). Participants performed the COMPASS cognitive test battery to measure spatial, working, and episodic memory, attention, vigilance, and executive function. Sleep quality, mood, stress states and inflammation markers were also evaluated. All endpoints were collected at baseline, weeks 12 and 24.</p><p><strong>Results: </strong>There were no between-group differences for the primary outcome (Corsi Block Span Score) or other cognitive function parameters, at either 12 week or 24 weeks. However, within groups, 24 weeks of daily intake of microalgae extract derived from Phaeodactylum tricornutum attenuated age-induced readouts in Stroop task overall reaction time (p = 0.005; Cohen's d = 0.8) and Word recall delayed score (p = 0.010; Cohen's d = 0.5) as compared to baseline week 0, while no significance was reported for these readouts in the placebo group. Similar findings were reported for participants' perceived stress (p = -0.04; Cohen's d = 0.4). There was a significant decrease in blood hs-CRP from 3.9mg/L to 2.1mg/L following 24-weeks of Pt extract supplementation as compared to placebo (p = 0.002; Cohen's d = 0.8), while there was no adverse impact on safety clinical blood tests or reported side effects, with the product deemed safe and tolerable.</p><p><strong>Discussion: </strong>The findings suggest promising benefits of daily intake of microalgae extract on cognitive function and immune markers in older subjects with AAMI. Future research into the preventive role of Pt extract in age-assocaited cognitive decline is warranted.</p><p><strong>Clinical trial registration: </strong>Identifier #NCT04832412.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1540115"},"PeriodicalIF":3.3,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075122/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the exercise for enhancing postural control, gait, and muscle strength in older adults with diabetic peripheral neuropathy: a systematic review and meta-analysis.","authors":"Xiangsheng Pang, Dongmei Wang, Fei Zhang, Bin Guo, Wenming Liu","doi":"10.3389/fragi.2025.1507232","DOIUrl":"10.3389/fragi.2025.1507232","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of this study was to conduct a systematic review and meta-analysis to evaluate the effects of exercise on postural control, gait, and muscle strength in older adults with diabetic peripheral neuropathy (DPN).</p><p><strong>Research design: </strong>Systematic review and meta-analysis.</p><p><strong>Methods: </strong>An extensive literature search was performed in PubMed, EBSCO, Web of Science and Cochrane Library from database inception to 30 September 2023. The inclusion criteria were exercise intervention on postural control, gait characteristics, and muscle strength in older adults with DPN. Two reviewers independently extracted data and assessed the quality of studies by Cochrane Risk of Bias.</p><p><strong>Results: </strong>The literature search elicited a total of 523 references, 23 articles were included in this systematic review and meta-analyses. Exercise could effectively decrease the Centre of Pressure (COP) path (SMD = -0.38, 95%CI = -0.77 <math><mrow><mo>∼</mo></mrow> </math> 0.01), increase gait speed (MD = 0.08, 95%CI = 0.05 <math><mrow><mo>∼</mo></mrow> </math> 0.11), but did not change stride length (MD = 0.04, 95%CI = -0.01 <math><mrow><mo>∼</mo></mrow> </math> 0.09), and enhance muscle strength (SMD = 0.76, 95%CI = 0.19 <math><mrow><mo>∼</mo></mrow> </math> 1.33).</p><p><strong>Conclusion: </strong>Exercise improves postural control, gait speed, and muscle strength in older adults with DPN, reducing fall risk and enhancing lower limb strength, though evidence on stride length improvement is limited.</p><p><strong>Systematic review registration: </strong>identifier CRD42023436799.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1507232"},"PeriodicalIF":3.3,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12069999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}