Frontiers in aging最新文献

{"title":"Association of systemic immune-inflammatory index with all-cause and cancer mortality in Americans aged 60 years and older.","authors":"Wangfeng Lu, Yuliang Gong, Lei Liu, Yonghong Zhang, Xiaojian Tian, Huanxian Liu","doi":"10.3389/fragi.2025.1502746","DOIUrl":"10.3389/fragi.2025.1502746","url":null,"abstract":"<p><strong>Background: </strong>This research delved into the association between the systemic immune-inflammatory index (SII) and both all-cause and cancer-specific mortality among individuals aged 60 years and above in the United States during the period from 1999 to 2018, with follow-up extending until 31 December 2019. The data utilized was sourced from 4295 population-based participants in the National Health and Nutrition Examination Survey (NHANES).</p><p><strong>Methods: </strong>To analyze the relationship between SII and mortality, the study employed Cox proportional-risk models, restricted cubic spline curves, survival curves, and subgroup analyses.</p><p><strong>Results: </strong>The average age of the participants was 70.7 (±7.6) years, the median follow-up duration was 131.7 (±59.8) months, and the all-cause mortality rate stood at 50.5%. Findings from the Cox regression model indicated that, after adjusting for covariates, SII was significantly and linearly related to all-cause mortality (hazard ratio HR = 1.31, 95% confidence interval CI = 1.15-1.48). Moreover, the relationship between SII and cancer mortality exhibited a U-shaped pattern. Results from the survival curves suggested that a higher SII was associated with an augmented risk of both all-cause mortality and cancer mortality.</p><p><strong>Conclusion: </strong>There is a significant association between higher SII levels and increased risk of all-cause and cancer-specific mortality in the US population aged 60 years and older.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1502746"},"PeriodicalIF":3.3,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11931307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiplexing and massive parallel sequencing of targeted DNA methylation to predict chronological age.","authors":"Bowen Zhu, Dean Li, Guojing Han, Xue Yao, Hongqin Gu, Tao Liu, Linghua Liu, Jie Dai, Isabella Zhaotong Liu, Yanlin Liang, Jian Zheng, Zheming Sun, He Lin, Nan Liu, Haidong Yu, Meifang Shi, Gaofang Shen, Zhaohui Hu, Lefeng Qu","doi":"10.3389/fragi.2025.1467639","DOIUrl":"https://doi.org/10.3389/fragi.2025.1467639","url":null,"abstract":"<p><p>Estimation of chronological age is particularly informative in forensic contexts. Assessment of DNA methylation status allows for the prediction of age, though the accuracy may vary across models. In this study, we started with a carefully designed discovery cohort with more elderly subjects than other age categories, to diminish the effect of epigenetic drifting. We applied multiplexing and massive parallel sequencing of targeted DNA methylation, which let us to construct a model comprising 25 CpG sites with substantially improved accuracy (MAE = 2.279, R = 0.920). This model is further validated by an independent cohort (MAE = 2.204, 82.7% success (±5 years)). Remarkably, in a multi-center test using trace blood samples from forensic caseworks, the correct predictions (±5 years) are 91.7%. The nature of our analytical pipeline can easily be scaled up with low cost. Taken together, we propose a new age-prediction model featuring accuracy, sensitivity, high-throughput, and low cost. This model can be readily applied in both classic and newly emergent forensic contexts that require age estimation.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1467639"},"PeriodicalIF":3.3,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11906720/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of characteristics of bimanual coordinated movements in older adults with frailty, pre-frailty, and robust health.","authors":"Shoya Fujikawa, Shin Murata, Akio Goda, Shun Sawai, Ryosuke Yamamoto, Yusuke Shizuka, Takayuki Maru, Kotaro Nakagawa, Hideki Nakano","doi":"10.3389/fragi.2025.1519129","DOIUrl":"10.3389/fragi.2025.1519129","url":null,"abstract":"<p><strong>Introduction: </strong>Despite the growing concern regarding a potential increase in the number of older adults with frailty owing to an aging global population, the characteristics of bimanual coordination in such older adults remain unclear. This study aimed to compare bimanual coordinated movements among community-dwelling older adults with frailty, pre-frailty, and robust health and identify the specific characteristics of these movements in older adults with frailty.</p><p><strong>Methods: </strong>Participants were categorized into frail, pre-frail, and robust groups based on Kihon Checklist scores. They performed bimanual coordination tasks in-phase (tapping the thumb and index finger together as fast as possible) and anti-phase (alternating the movement between the left and right fingers), and the task parameters were compared among the groups.</p><p><strong>Results: </strong>The total travel distance during the anti-phase task in the frail group was significantly shorter than that in the robust group. However, all three groups showed lower finger dexterity during the anti-phase task than in the in-phase task and the left hand than in the right hand.</p><p><strong>Conclusion: </strong>Older adults with frailty exhibit less movement during bimanual coordination tasks than robust older adults, suggesting that such tasks may be useful tools for assessing frailty.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1519129"},"PeriodicalIF":3.3,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143626954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Demographic, health, and behaviors profile of Saudi Arabia's aging population 2022-2023.","authors":"Nasser F Bindhim, Mohammed Senitan, Madhawi N Almutairi, Leen S Alhadlaq, Sundus A Alnajem, Maryam Ali Alfaifi, Nora A Althumiri","doi":"10.3389/fragi.2025.1491146","DOIUrl":"10.3389/fragi.2025.1491146","url":null,"abstract":"<p><strong>Background: </strong>The population aged 60 years and older in Saudi Arabia is rapidly increasing, leading to concerns regarding their health, socioeconomic status, and lifestyle behaviors. Aging is associated with a higher risk of chronic diseases, multimorbidity, and mental health issues, which can significantly affect the quality of life. However, national data on older people in Saudi Arabia remain limited.</p><p><strong>Aim: </strong>This study aims to profile older people in Saudi Arabia during the years 2022-2023, focusing on their demographic characteristics, socioeconomic status, health conditions, and lifestyle behaviors.</p><p><strong>Methods: </strong>Data were drawn from the Sharik Health Indicators Surveillance System (SHISS) 2022-2023, a nationwide cross-sectional survey conducted through phone interviews. The final analysis included 2,702 participants aged 60 years and older. Descriptive statistics were employed to summarize demographic, health, and behavioral data.</p><p><strong>Results: </strong>The study revealed that over half (52%) of the participants had two or more chronic conditions, with hypertension, hypercholesterolemia, and type 2 diabetes being the most common. Mental health assessments indicated that 17.7% of older people were at risk of depression, and another 17.7% were at risk of anxiety. Additionally, the study found low adherence to healthy behaviors, with only 11.1% meeting the recommended fruit and vegetable intake and 20.1% engaging in sufficient physical activity. Furthermore, 67% of older people were classified as overweight or obese.</p><p><strong>Conclusion: </strong>Older people in Saudi Arabia face significant health challenges, including high rates of multimorbidity, mental health risks, and poor lifestyle behaviors. These findings highlight the urgent need for targeted health interventions and educational programs tailored to older people, aiming to improve their quality of life and contribute to the national goals outlined in Saudi Arabia's Vision 2030.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1491146"},"PeriodicalIF":3.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143617881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Klotho protects INS-1 pancreatic β-cells from senescence and enhances mitochondrial function.","authors":"Zhihong Wang, Yunzhi Ni, Yan-Ru Lou, Gerald J Prud'homme, Qinghua Wang","doi":"10.3389/fragi.2025.1512322","DOIUrl":"10.3389/fragi.2025.1512322","url":null,"abstract":"<p><p>Aging is an important contributing factor for β-cell failure which could lead to the development of type 2 diabetes (T2D). Aging β-cell exhibits signs of senescence and develops senescence-associated secretory phenotype (SASP), causing the senescence and dysfunction of neighboring cells through paracrine action. <i>Klotho</i> is recognized as an anti-aging gene, and the corresponding protein is α-Klotho (KL). KL exerts potent anti-aging effects on multiple cell types, but its role in β-cell aging remains unclear. Here we showed that pancreatic INS-1 cell (a rat insulinoma cell line commonly used to study pancreatic β-cell function) developed the typical hallmarks of senescent cells when treated with doxorubicin <i>in vitro</i>, and this was accompanied by downregulation of endogenous KL expression. Supplementation with exogenous KL protein protected pancreatic INS-1 cell against senescence, as indicated by downregulation of senescent markers and SA-β-gal staining. Notably, these effects were associated with improved mitochondrial ATP production and mitochondrial dynamic balance, as well as reduced ROS production. Our study further revealed that INS-1 cell treated with doxorubicin exhibited a reduced insulin secretion response to glucose stimulation, while supplementation with KL could reverse this effect. Our results indicate the important role of KL in regulating β-cell senescence and provide new mechanistic insights into its role in β-cell aging.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1512322"},"PeriodicalIF":3.3,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age- and sex-related development of osteosarcopenia in the aging <i>Octodon degus</i> rodent model.","authors":"Pablo Gallo-Soljancic, Maria Egle De Stefano, Ana-María Lucas-Ochoa, Consuelo Sánchez-Rodrigo, Lorena Cuemca-Bermejo, Ana-María González-Cuello, Emiliano Fernández-Villalba, María-Trinidad Herrero","doi":"10.3389/fragi.2025.1486670","DOIUrl":"10.3389/fragi.2025.1486670","url":null,"abstract":"<p><p>The increase in life expectancy in recent years has resulted in a higher incidence of age-related diseases. Among these, osteoporosis and sarcopenia, collectively known as osteosarcopenia, have the most significant impact on the quality of life, general health and frailty in the elderly. As for other age-related diseases, pre-clinical studies on these conditions are primarily limited by the availability of experimental model systems. The <i>Octodon degus</i> (<i>O. degus</i>) is a long-lived diurnal rodent identified as a potential tool in ageing research. However, age-related osteosarcopenia changes have not yet been explored. In this study, male and female <i>O. degus</i> from juvenile to senile ages were used (6 months-7 years old). Changes in the volume of several forelimbs and hindlimbs muscles, e.g., biceps femoris, triceps brachii, femur, and humerus, were evaluated using computed tomography. Aged animals showed a significant decrease in muscle volume in both hindlimbs and forelimbs, along with a significant reduction in cortical bone volume. With ageing, sex differences were also observed, with female <i>O. degus</i> showing greater cortical bone volume in both hind and forelimbs, and greater muscle mass in the sole hindlimbs, compared to male. These findings enhance the characterization of <i>O. degus</i> as a model to study age-related pathologies, also considering sex differences, and lay down solid foundations for future studies that can address in more detail the molecular mechanisms underlying the initiation and progression of osteosarcopenia.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1486670"},"PeriodicalIF":3.3,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11865034/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143525292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between albumin-corrected anion gap and lumbar spine bone mineral density: a cross-sectional study.","authors":"Aiguo Liu, Ting Ying, Shuang Deng, Chenxu Wang, Ziwen Zhao, Sitong Zhang, Han Xiao, Chengqing Yi, Dejian Li","doi":"10.3389/fragi.2025.1511294","DOIUrl":"10.3389/fragi.2025.1511294","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to investigate the relationship between albumin-corrected anion gap (ACAG) and lumbar spine bone mineral density (BMD) in a diverse population, assessing how variations in ACAG levels correlate with changes in lumbar spine BMD and the potential implications for osteoporosis risk.</p><p><strong>Methods: </strong>A cross-sectional analysis was conducted involving 3,057 participants (1,555 males and 1,502 females). Participants were stratified into quartiles based on baseline ACAG levels. Demographic and clinical characteristics were analyzed, including age, sex, education level, body mass index (BMI), and prevalence of diabetes and hypertension. The association between ACAG and lumbar spine BMD was evaluated using multiple regression models, and a generalized additive model was employed to identify potential nonlinear relationships.</p><p><strong>Results: </strong>The analysis revealed a significant negative correlation between ACAG and lumbar spine BMD (<i>P</i> < 0.001). For each 1-unit increase in ACAG, BMD decreased with β coefficients of -0.004 to -0.005 across various models. Quartile analysis indicated that participants in the highest ACAG quartile (≥19.55) experienced the most substantial reductions in BMD (β coefficients ranging from -0.034 to -0.036, <i>P</i> < 0.001). Furthermore, a U-shaped relationship was identified, with a turning point at an ACAG value of 22.15, indicating that lower ACAG levels were associated with decreased BMD, while higher levels showed a positive effect. Subgroup analyses by sex demonstrated consistent findings, with significant associations in both males and females.</p><p><strong>Conclusion: </strong>The findings underscore a significant association between elevated ACAG levels and reduced lumbar spine BMD, suggesting that ACAG may serve as a valuable biomarker for assessing osteoporosis risk. The identified nonlinear relationship further emphasizes the complexity of metabolic influences on bone health. These results warrant further investigation into the mechanisms underlying ACAG's impact on bone density and its potential role in osteoporosis prevention strategies.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1511294"},"PeriodicalIF":3.3,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143506492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of group music sessions on cognitive and psychological functions in healthy older adults.","authors":"Takamitsu Shinada, Michio Takahashi, Akari Uno, Keishi Soga, Yasuyuki Taki","doi":"10.3389/fragi.2025.1513359","DOIUrl":"10.3389/fragi.2025.1513359","url":null,"abstract":"<p><strong>Introduction: </strong>With the rapid aging of the population worldwide and the prevalence of dementia and mental health problems among older adults, it is important to extend healthy life expectancy by maintaining brain and mental health. Playing musical instruments, which requires the integration of auditory, visual, and somatosensory functions, is considered an effective way to prevent the development of dementia. However, the effectiveness of group (band) music sessions in healthy older adults has not been investigated. Our purpose, therefore, was to investigate the effects of group music sessions on cognitive and psychological functions among healthy older adults.</p><p><strong>Methods: </strong>In this open-label randomized controlled trial, participants aged 65-74, who had no musical experience, were randomly assigned to either the intervention or control group. The intervention group received in weekly 90-minute sessions with the instrument for 16 weeks. The control group received no intervention.</p><p><strong>Results: </strong>The results showed that the Mini-Mental State Examination (MMSE) total score and the Wechsler Memory Scale Logical Memory Ⅱ (WMS-LM Ⅱ) score improved significantly, and the Vigor-Activity subscale score of the Profile of Mood States 2nd Edition (POMS 2) tended to improve.</p><p><strong>Discussion: </strong>These findings indicated that group music sessions have a potentially beneficial effect for maintaining and improving cognitive and psychological functions in healthy older adults.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1513359"},"PeriodicalIF":3.3,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Pathogen-induced immunosenescence: where do vaccines stand?","authors":"Mehrnoosh Doroudchi, Hamed Fouladseresht","doi":"10.3389/fragi.2025.1560009","DOIUrl":"10.3389/fragi.2025.1560009","url":null,"abstract":"","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1560009"},"PeriodicalIF":3.3,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11839823/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating shared risk variants and genetic etiology between Alzheimer's disease and three stress-related psychiatric disorders: a large-scale genome-wide cross-trait analysis.","authors":"Weijia Dang, Tianqi Hao, Ning Li, Hualin Zhang, Ziqi Li, Hongmei Yu, Yalu Wen, Deqiang Zheng, Long Liu","doi":"10.3389/fragi.2025.1488528","DOIUrl":"10.3389/fragi.2025.1488528","url":null,"abstract":"<p><strong>Introduction: </strong>Observational studies have reported that patients with Alzheimer's disease (AD) have a greater burden of comorbidities typically associated with stress-related psychiatric disorders. However, the contribution of hereditary factors to this comorbidity remains unclear. We evaluated phenotypic associations using observational data from the UK Biobank.</p><p><strong>Method: </strong>Our study focused on investigating the shared risk variants and genetic etiology underlying AD and three stress-related psychiatric disorders: post-traumatic stress disorder, anxiety disorder, and major depressive disorder. By leveraging summary statistics from genome-wide association studies, we investigated global genetic correlations using linkage disequilibrium score regression, genetic covariance analysis, and high-definition likelihood. Genome-wide cross-trait analysis with association analysis based on subsets and cross-phenotype association were performed to discover genome-wide significant risk variants shared between AD and the three stress-related psychiatric disorders.</p><p><strong>Results: </strong>A significant positive genetic correlation was observed between AD and major depressive disorder using linkage disequilibrium score regression (rg = 0.231; <i>P</i> = 0.018), genetic covariance analysis (rg = 0.138; <i>P</i> < 0.001), and high-definition likelihood (rg = 0.188; <i>P</i> < 0.001). Association analysis based on subsets and cross-phenotype association revealed thirteen risk variants in six genes shared between AD and post-traumatic stress disorder; seven risk variants in four genes shared between AD and anxiety disorder; and 23 risk variants in four genes shared between AD and major depressive disorder. Functional annotation and gene-set enrichment analysis indicated that 12 genes for comorbidity shared between patients with AD and all three stress-related psychiatric disorders were enriched in the spleen, pancreas, and whole blood.</p><p><strong>Conclusion: </strong>These results advance our knowledge of the shared genetic origins of comorbidities and pave the way for advancements in the diagnosis, management, and prevention of stress-related AD.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1488528"},"PeriodicalIF":3.3,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11837265/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143461065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}