Frontiers in aging最新文献

{"title":"The truncated isoform of the receptor for hyaluronan-mediated motility (RHAMM^Δ163) modulates shelterin and telomerase reverse transcriptase transcription affecting telomerase activity.","authors":"Kaustuv Basu","doi":"10.3389/fragi.2025.1604051","DOIUrl":"10.3389/fragi.2025.1604051","url":null,"abstract":"<p><strong>Introduction: </strong>The receptor for hyaluronan-mediated motility (RHAMM), a centrosomal protein expressing in multiple isoforms, is implicated in telomerase-independent aging. However, its involvement in telomerase regulation is unproven. This study aims to investigate whether RHAMM correlates with telomerase activity in mammalian cells.</p><p><strong>Methods: </strong>Mouse embryonic fibroblasts expressing or lacking full-length RHAMM (RHAMM^FL, amino acids 1-794) and the shorter isoform RHAMM^Δ163 (amino acids 164-794), were explored to examine the effect of RHAMM isoforms on mRNA expression of telomerase reverse transcriptase (TERT) and selective shelterin proteins regulating telomere maintenance.</p><p><strong>Results: </strong>The preliminary findings revealed that RHAMM regulated <i>Tert</i> expression based on its isoforms. RHAMM^Δ163 enhanced <i>Tert</i> mRNA expression and promoted telomerase activity by stimulating sirtuin 1 (<i>Sirt1</i>), shelterin proteins <i>Tpp1</i>, and <i>Pot1a</i> and repressing the telomerase inhibitor <i>Pinx1</i> levels. In contrast, RHAMM^FL did not have significant effect on TERT expression and telomerase activity. Increasing <i>Tert</i> mRNA expression by blocking leucine zipper sequence with function-blocking RHAMM peptide NP-110 in a TERT-deficient mouse model of idiopathic pulmonary fibrosis, alongside suppressing <i>Tpp1</i> and <i>Pot1a</i> expression in mouse embryonic fibroblasts using ERK1 inhibitor PD98059, highlights the importance of the HATABD domain (amino acids 718-751), which includes leucine zipper and ERK-binding sequences at the C-terminus of mouse RHAMM in regulating telomerase function. Increased telomerase activity raised <i>Hmmr</i> expression, suggesting a potential feedback loop between RHAMM and TERT expression.</p><p><strong>Discussion: </strong>Taken together, this report provides the first evidence that RHAMM^Δ163 regulates TERT and shelterin expression and telomerase activity in mammalian cells.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1604051"},"PeriodicalIF":3.3,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12256479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiomics based on lumbar CT to identify high-risk patients for OVCF in postmenopausal women.","authors":"Qingsong Yu, Huangda An, Jiabao Chen, Aoran Ding, Zhe Lu, Haidong Wang, Lei Ma","doi":"10.3389/fragi.2025.1472060","DOIUrl":"10.3389/fragi.2025.1472060","url":null,"abstract":"<p><strong>Objective: </strong>Osteoporosis vertebral compressive fracture (OVCF) is a severe complication in patients with osteoporosis. There were limitations in finding the risk factor of OVCF in previous evaluation techniques. In this study, we developed a radiomics model (R-model) based on a lumbar CT scan to identify vertebrae at high risk of OVCF in postmenopausal women.</p><p><strong>Method: </strong>Radiographic data of postmenopausal patients in our hospital from January 2021 to August 2022 were collected. All the patients received both dual-energy X-ray absorptiometry (DEXA) and lumbar CT scan. Images in a dataset of 329 vertebral bodies without compressive fracture in lumbar 1 to 4 were extracted by a 3D slicer and randomly divided into a training group (n = 230) and a test group (n = 99). A number of radiomics features (129) were automatically calculated by the pyradiomics module, and minimum-redundancy maximum-relevancy (mRMR), least absolute shrinkage, and selection operator (LASSO) were used to shrink features for R-model construction. The sensitivity, specificity, accuracy, and area under the receiver operating characteristic curve (AUC) of the T-scores and R-scores were calculated. The AUCs of the two models were compared using the DeLong test. Decision curve analysis (DCA) shows the clinical usefulness of the R-model.</p><p><strong>Results: </strong>Eight features were chosen to construct the R-model. The AUCs of the T-score and R-score in the training group were 0.845 and 0.945, respectively, and 0.818 and 0.914, respectively, in the test group. There was a significant difference (p < 0.001) between the AUCs of the two models, and the decision curve analysis (DCA) shows the R-model has a better overall net benefit than the T-score model.</p><p><strong>Conclusion: </strong>The radiomics model based on lumbar CT scans in postmenopausal women can identify and predict patients at high risk of OVCF with better sensitivity and accuracy than DEXA, even in patients with the same T-scores.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1472060"},"PeriodicalIF":3.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12246753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possibility of screening for mild cognitive impairment via an eye tracking-based cognitive scale.","authors":"Naoki Kodama, Sou Takahashi, Masazumi Tsuji, Yuji Kawase, Satoshi Naruse, Katsuya Urakami","doi":"10.3389/fragi.2025.1532550","DOIUrl":"10.3389/fragi.2025.1532550","url":null,"abstract":"<p><strong>Introduction: </strong>The Montreal Cognitive Assessment (MoCA) is widely used as a screening test for mild cognitive impairment (MCI). However, the MoCA takes approximately 15 min to administer and evaluate by skilled examiners, such as medical professionals. This study assessed whether an eye tracking-based cognitive scale using virtual reality (VR) was accurate and efficient to screen for MCI.</p><p><strong>Methods: </strong>This study included 143 patients. The Virtual Reality-Based Cognitive Function Examination (VR-E) was used with all participants to evaluate their memory, judgment, spatial cognition, calculation, and language function.</p><p><strong>Results: </strong>Significant differences were observed in all cognitive domains of memory, judgment, spatial cognition, calculation, and language function between the Alzheimer's disease (AD), MCI, and older healthy control (HC) groups. The area under the curve value of the VR-E score for the HC and MCI groups was 0.857, and that for the AD and MCI groups was 0.870. The correlation coefficient between the MMSE and VR-E scores was 0.566 (p < 0.001), and that between the Japanese version of the MoCA (MoCA-J) and VR-E scores was 0.648 (p < 0.001), which indicated a moderate correlation in both comparisons.</p><p><strong>Conclusion: </strong>The VR-E had the same diagnostic performance results as the MoCA-J, thus the VR-E has potential for use in screening patients for MCI.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1532550"},"PeriodicalIF":3.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12246754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic characterization of oropharyngeal dysphagia in patients with dementia.","authors":"Sara Peranovic, Maryam Pourhassan, Bendix Labeit, Paul Muhle, Sonja Suntrup-Krueger, Tobias Warnecke, Rainer Dziewas, Ulrike Trampisch, Rainer Wirth, Gero Lueg","doi":"10.3389/fragi.2025.1535137","DOIUrl":"10.3389/fragi.2025.1535137","url":null,"abstract":"<p><strong>Objective: </strong>Diagnosing and treating dysphagia in patients with dementia is challenging and few studies have been performed to characterize dysphagia based on Flexible Endoscopic Evaluation of Swallowing (FEES). Therefore, we aimed to characterize and compare the dysphagia pathologies in various stages and types of dementia.</p><p><strong>Methods: </strong>This is a retrospective study of 107 hospitalized geriatric patients with dysphagia and Alzheimer's dementia, Alzheimer's dementia with moderate to severe cerebral vasculopathy (mixed dementia), and patients with dementia associated with Parkinson's syndrome who underwent FEES. A standardized FEES protocol was used to characterize the dysphagia pathologies, including premature bolus spillage, delayed swallowing reflex and bolus residue as well as penetration and aspiration and the white-out intensity. The distribution of different dysphagia pathologies was cross-tabulated with χ2 statistics across different types of dementia.</p><p><strong>Results: </strong>A comparative analysis of dysphagia pathologies across the three dementia types revealed a relatively mixed picture of various dysphagia findings in all dementia types. However, a significantly higher prevalence of bolus penetration and complex dysphagia, which was defined as presence of at least two major findings simultaneously within a patient, was seen in patients with Parkinson's-related dementia compared to other forms of dementia. In general, residue was the most frequent finding in all types of dementia (78%-100%). In contrast, aspiration was the least prevalent finding with no significant variation between dementia types.</p><p><strong>Conclusion: </strong>Although participants with Parkinson's-related dementia exhibited minor specific findings, our study revealed no distinct endoscopic dysphagia pathologies across various types of dementia.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1535137"},"PeriodicalIF":3.3,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12241064/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144610384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The lifespan-extending MEK1 inhibitor trametinib promotes regulation of de novo lipogenesis enzymes by chaperone-mediated autophagy.","authors":"Jiexian Chen, Joshua Berg, Calvin M Burns, Hanyi Jia, Xinna Li, Richard A Miller, S Joseph Endicott, Gonzalo Garcia","doi":"10.3389/fragi.2025.1621808","DOIUrl":"10.3389/fragi.2025.1621808","url":null,"abstract":"<p><p>The availability of multiple slow-aging mice allows a search for possible shared mechanisms that affect the rate of aging. Previous work has shown downregulation of the MEK1-ERK-MNK kinase cascade, which regulates protein translation through eIF4E, in response to four anti-aging drugs. Here we show that decreased protein abundance of enzymes involved in hepatic <i>de novo</i> lipogenesis (DNL) is characteristic of mice exposed to two anti-aging drugs that modulate glucose homeostasis (acarbose and canagliflozin), as well as in calorically restricted mice and in two long-lived mutant models. The same pattern of changes in the <i>de novo</i> lipogenesis enzymes can be produced, in cultured cells or in intact mice, by trametinib, a drug that inhibits the MEK-ERK kinase cascade, and which has been shown to extend mouse lifespan. The trametinib effect on DNL enzymes is, unexpectedly, not related to transcriptional changes, but depends on selective protein degradation through chaperone-mediated autophagy. Our data support models in which chaperone-mediated proteomic alterations, triggered through the MEK1-ERK-MNK kinase pathway, may collaborate with mTORC1 changes to slow aging and extend mouse lifespan.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1621808"},"PeriodicalIF":3.3,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237883/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age and sex-specific changes in mitochondrial quality control in skeletal and cardiac muscle.","authors":"Catherine B Springer-Sapp, Olayinka Ogbara, Maria Canellas Da Silva, AbryAnna Henderson, Yuan Liu, Steven J Prior, Sarah Kuzmiak-Glancy","doi":"10.3389/fragi.2025.1606110","DOIUrl":"10.3389/fragi.2025.1606110","url":null,"abstract":"<p><strong>Introduction: </strong>Skeletal and cardiac muscle mitochondria exist in a dynamic reticulum that is maintained by a balance of mitochondrial biogenesis, fusion, fission, and mitophagy. This balance is crucial for adequate ATP production, and alterations in skeletal muscle mitochondria have been implicated in aging-associated declines in mitochondrial function.</p><p><strong>Methods: </strong>We sought to determine whether age and biological sex affect mitochondrial content [Complex IV (CIV)], biogenesis (PGC-1ɑ), fusion (MFN2, OPA1), fission (DRP1, FIS1), and mitophagy (Parkin, Pink1) markers in skeletal and cardiac muscle by assessing protein expression in tibialis anterior (TA) and ventricular tissue from 16 young (≤6 months) and 16 old (≥20 months) male and female Sprague-Dawley rats.</p><p><strong>Results: </strong>In the TA, CIV expression was 40% lower in old vs. young rats (p < 0.001), indicating lower mitochondrial content, and coincided with higher expression of Parkin (+4-fold, p < 0.001). Further, MFN2 expression was higher (+2-fold, p < 0.005) and DRP1 expression was lower (-40%, p = 0.014) in older rats. In cardiac muscle, mitochondrial content was maintained in old vs. young rats, and this occurred concomitantly with higher expression of both PGC-1ɑ and Parkin. MFN2 and OPA1 expression were also 1.2-5-fold higher in older rats (p < 0.05 for all). Largely, protein expression did not differ between male and female rats, with the exception of Pink1 and FIS1 expression in the TA.</p><p><strong>Discussion: </strong>Collectively, older skeletal and cardiac muscle demonstrated higher expression of fusion and mitophagy proteins, which indicates age alters the balance of biogenesis, fission, fusion, and mitophagy. This may, in turn, affect the ability to provide ATP to these metabolically active tissues.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1606110"},"PeriodicalIF":3.3,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12237973/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144602358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrinsic capacity, functional and psychosocial aspects of older adults participating in a multicomponent physical exercise program.","authors":"Sarah Giulia Bandeira Felipe, Clarisse Bielh Printes, Fabiane de Oliveira Brauner, Douglas Katusohi Sato, Rafael Reimann Baptista","doi":"10.3389/fragi.2025.1562383","DOIUrl":"10.3389/fragi.2025.1562383","url":null,"abstract":"<p><strong>Introduction: </strong>In 2015, the WHO introduced intrinsic capacity (IC) as a health indicator with five domains to promote healthy aging. Multicomponent exercise programs are recommended to enhance IC, but research in Brazil on their comprehensive impact is limited. This study aimed to evaluate the effects of such a program on IC, functional, and psychosocial aspects in older adults.</p><p><strong>Methods: </strong>This pre- and post-study assessed older adults in Brazil enrolled in a multicomponent training program, evaluating IC as the main outcome using specific tests for each domain. Inclusion criteria were: aged 60+, completing assessments in five domains, attending the program at least twice a week, and participating in two exercise modalities per session for 90 min. Exclusion criteria included: history of stroke, Parkinson's or Alzheimer's, recent hand, hip, or knee surgery, or absence for more than 15 consecutive days. A total of 43 older adults were evaluated, and the score was calculated by summing the results of the five domains, yielding a total score ranging from 0 to 10 points. Subsequently, participants underwent a 12-week intervention involving multicomponent exercises and were reassessed.</p><p><strong>Results: </strong>After 12 weeks of intervention, there was a significant reduction in the proportion of participants with low IC, from 7.0% to 0.0%, and an increase in those with high IC, from 4.7% to 20.0% (p = 0.018). Improvements were seen in cognitive aspects, locomotor dimension (p < 0.001), vitality (p = 0.045) and functional classification (p < 0.001), with the greatest effect in the locomotor domain (es = 1.12). Significant gains were also observed in perceived health, quality of life, and physical activity (p < 0.002; p < 0.004; p < 0.001). Body composition showed improvements, including reduced body fat percentage, increased muscle mass, and better fat classification (p < 0.001), along with reductions in waist and abdominal circumferences (p < 0.001; p = 0.001).</p><p><strong>Conclusion: </strong>The multicomponent exercise program demonstrated a positive influence on composite IC, including functional and psychosocial aspects. These findings highlight the critical role of tailored and supervised exercise interventions in enhancing both physical and psychosocial dimensions of health, contributing to healthier aging trajectories.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1562383"},"PeriodicalIF":3.3,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preclinical models of mitochondrial dysfunction: mtDNA and nuclear-encoded regulators in diverse pathologies.","authors":"Dalia M Miller, Stephen L Archer, Kimberly J Dunham-Snary","doi":"10.3389/fragi.2025.1585508","DOIUrl":"10.3389/fragi.2025.1585508","url":null,"abstract":"<p><p>Mitochondrial-driven diseases encompass a diverse group of single-gene and complex disorders, all linked to mitochondrial dysfunction, with significant impacts on human health. While there are rare mitochondrial diseases in which the primary defect resides in mutations in mitochondrial DNA, it is increasingly clear that acquired mitochondrial dysfunction, both genetically- and epigenetically-mediated, complicates common complex diseases, including diabetes, cardiovascular disease and ischemia reperfusion injury, cancer, pulmonary hypertension, and neurodegenerative diseases. It is also recognized that mitochondrial abnormalities not only act by altering metabolism but, through effects on mitochondrial dynamics, can regulate numerous cellular processes including intracellular calcium handling, cell proliferation, apoptosis and quality control. This review examines the crucial role of preclinical models in advancing our understanding of mitochondrial genetic contributions to these conditions. It follows the evolution of models of mitochondrial-driven diseases, from earlier <i>in vitro</i> and <i>in vivo</i> systems to the use of more innovative approaches, such as CRISPR-based gene editing and mitochondrial replacement therapies. By assessing both the strengths and limitations of these models, we highlight their contributions to uncovering disease mechanisms, identifying therapeutic targets, and facilitating novel discoveries. Challenges in translating preclinical findings into clinical applications are also addressed, along with strategies to enhance the accuracy and relevance of these models. This review outlines the current state of the field, the future trajectory of mitochondrial disease modeling, and its potential impact on patient care.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1585508"},"PeriodicalIF":3.3,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12230096/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapamycin for longevity: the pros, the cons, and future perspectives.","authors":"Kelley M Roark, Philip H Iffland","doi":"10.3389/fragi.2025.1628187","DOIUrl":"10.3389/fragi.2025.1628187","url":null,"abstract":"<p><p>Rapamycin, an antibiotic discovered in the 1970s from <i>Streptomyces hygroscopicus</i> on Easter Island (Rapanui), has become a critical tool in biomedical research. Initially recognized for its potent antifungal and immunosuppressive properties, rapamycin has recently gained significant attention for anti-aging therapy and seizure treatment via mTOR pathway inhibition. The mechanistic target of the rapamycin (mTOR) pathway is an evolutionarily conserved metabolic signaling cascade that regulates cell division, growth, and survival. There is growing evidence that mTOR pathway activity accelerates aging and the development of age-related diseases including cancer, atherosclerosis, diabetes, and declining immune function. Therefore physicians and \"biohackers\" are using mTOR inhibition via rapamycin (and rapamycin analogs) off-label for prevention of age-related conditions despite not being widely recognized as a treatment by the broader clinical community. Currently, rapamycin (i.e., sirolimus and everolimus) is FDA approved for the prevention of transplant organ rejection and for anti-seizure therapy in Tuberous Sclerosis Complex (TSC; caused by variants in <i>TSC1</i> or <i>2</i>). We aim to summarize the mTOR pathway, the impact rapamycin has on the mTOR pathway, and the state of rapamycin use in the field of aging and longevity. Importantly, we will discuss the gaps in knowledge, pitfalls, and potential for the use of rapamycin to prevent aging/age-related disease and discuss the lessons learned from achieving FDA approval of evirolimus for TSC-related seizures after many years of off-label use.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1628187"},"PeriodicalIF":3.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gait analysis in older adults with mild cognitive impairment: a bibliometric analysis of global trends, hotspots, and emerging frontiers.","authors":"Yuan Zhong, Siqi Huang, Meixia Zou, Yiming Chen, Peifeng Shen, Yanan He, Yuanchao Li, Chunlong Liu, Zhibiao Chen","doi":"10.3389/fragi.2025.1592464","DOIUrl":"10.3389/fragi.2025.1592464","url":null,"abstract":"<p><strong>Background: </strong>Gait analysis has emerged as a critical non-invasive tool for early identification and monitoring of mild cognitive impairment (MCI) in aging populations, particularly given its potential to predict dementia progression. This bibliometric analysis synthesizes two decades of research to map the evolution of gait analysis in MCI, identify interdisciplinary collaborations, and highlight emerging frontiers in MCI-related mobility research.</p><p><strong>Methods: </strong>Literature related to gait analysis in MCI was retrieved from the Web of Science Core Collection. The search spanned publications from 2005 to 2024 and was executed in a single search session on 15 December 2024. CiteSpace and VOSviewer software were used to analyze publications, authorship, institutional affiliations, journals, keywords, and cited references. Burst detection and timeline analyses of keywords and references were conducted to identify emerging trends and temporal patterns.</p><p><strong>Results: </strong>A total of 1,223 articles were identified. Annual publication trends indicate sustained scholarly interest over the past 5 years. The United States contributed the most publications (392 articles, 32.05%), with Western University (Canada, 65 articles) as the leading institution. Journals publishing these studies primarily focus on Alzheimer's disease (AD), gerontology, and neurology, while prolific authors like Verghese J (USA) and Montero-odasso M(Canada) shaped the field's trajectory. Emerging research frontiers include dementia progression, AD, and Parkinson's disease, with 2024 priorities emphasizing \"dual-task walking\", \"digital biomarkers\" and \"working groups\". Additionally, validity and reliability assessments of gait analysis for MCI diagnosis and intervention represent a growing research trend.</p><p><strong>Conclusion: </strong>This study provides a comprehensive overview of the current landscape, hotspots, and trends in gait analysis for MCI management. By delineating its transformation from a descriptive tool to a predictive framework, we highlight persistent challenges such as methodological heterogeneity and small sample sizes. However, advances in machine learning and multicenter collaborations present opportunities to standardize protocols. Future high-quality studies are expected to establish gait-derived biomarkers as clinically actionable tools in MCI stratification and therapeutic monitoring.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1592464"},"PeriodicalIF":3.3,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12222084/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}