Frontiers in aging最新文献

{"title":"The impact of age and frailty on hospitalization and survival in older liver transplant recipients: a longitudinal cohort study.","authors":"Matteo Valenti, Chiara Ceolin, Marco Rossato, Chiara Curreri, Maria Devita, Marta Tonon, Carlotta Campodall'Orto, Jessica Vanin, Martina Gambato, Umberto Cillo, Patrizia Burra, Paolo Angeli, Giuseppe Sergi, Marina De Rui","doi":"10.3389/fragi.2025.1539688","DOIUrl":"https://doi.org/10.3389/fragi.2025.1539688","url":null,"abstract":"<p><strong>Purpose: </strong>Frailty is a well-established risk factor for adverse outcomes, particularly in liver transplant candidates. This study investigates the impact of age and frailty on key clinical outcomes-hospitalizations, waitlist survival, and post-transplant mortality-in cirrhotic patients evaluated for liver transplantation.</p><p><strong>Methods: </strong>This study included older adults with chronic liver disease under consideration for transplantation. Data collected encompassed medical history, Model for End-Stage Liver Disease (MELD) and Child-Turcotte-Pugh (CTP) scores, Mini-Mental State Examination (MMSE), Mini Nutritional Assessment (MNA), and frailty status, assessed using both the Liver Frailty Index (LFI) and the Survey of Health, Ageing, and Retirement in Europe Frailty Index (SHARE-FI). Clinical outcomes, including mortality and hospitalizations, were tracked over a 24-month period.</p><p><strong>Results: </strong>Among 100 patients (67% male), those under 70 exhibited higher MNA, MMSE, and SHARE-FI scores. Based on frailty classification, 25 patients were frail, 28 pre-frail, and 47 robust. Younger patients experienced more hospitalizations during follow-up (p = 0.03) and had a higher probability of hospitalization within 24 months (p = 0.002). Although transplant-free survival did not differ significantly across groups, frail patients had a significantly higher mortality rate (p = 0.04). Overall, 24 patients underwent transplantation, while 26 died, including six post-transplant deaths. MELD and CTP scores were strong predictors of mortality, while among frailty measures, only SHARE-FI demonstrated significant predictive value. In multivariate Cox models, MELD [HR = 1.17, p = 0.001; HR = 1.11, p = 0.002], CTP [HR = 1.43, p = 0.003; HR = 1.41, p = 0.006], and LFI (HR = 1.69, p = 0.04) were significantly associated with mortality.</p><p><strong>Conclusion: </strong>Frailty, rather than age, emerges as a key predictor of mortality in liver transplant candidates. Further research is needed to validate these findings and enhance frailty assessment, ultimately improving candidate selection for transplantation.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1539688"},"PeriodicalIF":3.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tissue-specific effects of bacterial PncA overexpression on NAD⁺ metabolism and aging in mice: implications for tissue-specific aging interventions.","authors":"Fengjiao Huo, Meili Zhao, Yue Liu, Shuyao Lv, Shengyu Feng, Liuling Guo, Nan Wang, Shuaishuai Zhang, Qing Liu, Taotao Mi, Hao Wang, Jian-Kang Zhu, Hailiang Liu","doi":"10.3389/fragi.2025.1546017","DOIUrl":"https://doi.org/10.3389/fragi.2025.1546017","url":null,"abstract":"<p><strong>Background: </strong>As a critical molecule in biological systems, nicotinamide adenine dinucleotide (NAD⁺) influences the aging of mammals. Therefore, regulation of NAD⁺ synthesis and degradation may slow aging and mitigate related diseases.</p><p><strong>Results: </strong>This study investigated how mammalian tissues rely on different NAD⁺ synthesis pathways and prefer specific NAD⁺ precursors. Overexpressing the bacterial nicotinamidase PncA in mice increased NAD⁺ levels in the liver and kidneys but decreased levels in the heart and hippocampus. In aged mice (25 months old), this overexpression delayed aging indicators by boosting NAD⁺ levels in the liver and kidneys, indicating potential for PncA to improve age-related decline in these tissues. However, in younger mice (4 months old), PncA overexpression accelerates the senescence of cardiac cells, resulting in a reduction of NAD + levels, increased aging markers, and cognitive decline. These disparate results underscore the necessity of a nuanced, tissue-specific perspective when contemplating the use of NAD⁺ precursor supplementation as a means of addressing aging.</p><p><strong>Conclusion: </strong>Our study highlights the complexity of NAD⁺ metabolism and its effects on aging in various tissues. It suggests personalized interventions for aging and age-related diseases by showing how different tissues respond to NAD⁺ precursor manipulation, emphasizing the importance of targeted strategies for optimal therapeutic results with minimal side effects.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1546017"},"PeriodicalIF":3.3,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12066511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144008862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validity and reliability of Gripwise digital dynamometer in the assessment of handgrip strength in older adults.","authors":"Gabriela Benatti de Oliveira, Lara Vilar Fernandes, Teresa F Amaral, Ana Carolina Junqueira Vasques, Ligiana Pires Corona","doi":"10.3389/fragi.2025.1560097","DOIUrl":"https://doi.org/10.3389/fragi.2025.1560097","url":null,"abstract":"<p><strong>Introduction: </strong>With the advancement of studies on the importance of sarcopenia in the aging process, new technologies have been developed to assess muscle mass and function. However, most research on portable devices has not considered a wide range of ages and clinical conditions. This study aimed to evaluate the reliability of the Gripwise digital dynamometer in measuring handgrip strength in older Brazilian adults, comparing its performance with the widely used Saehan device.</p><p><strong>Methods: </strong>A cross-sectional study was conducted with 149 participants (32 men and 117 women), with an average age of 69.5 years. Handgrip strength was measured using both the Gripwise and Saehan dynamometers. Reliability was assessed using the intraclass correlation coefficient (ICC). Analyses considered three handgrip strength measurements from both devices, as well as the highest value obtained. The classification of dynapenia (low muscle strength) was compared using different cutoff points proposed by Villain et al. (2023), Spexoto et al. (2022), and Cruz-Jentoft et al. (2019).</p><p><strong>Results: </strong>Both dynamometers demonstrated excellent reliability, with ICC values above 0.90. However, significant differences in mean handgrip strength values were observed between the devices (approximately 3.5-four kgf). These variations impacted the classification of dynapenia, with the Gripwise identifying more cases of low muscle strength compared to Saehan.</p><p><strong>Conclusion: </strong>The lower values reported by the Gripwise may impact clinical decision-making in two ways. On one hand, lower values may lead to earlier detection of muscle weakness, allowing for quicker intervention in individuals with strength below typical thresholds. However, this could also result in an overestimation of the prevalence of dynapenia if the values do not accurately reflect true muscle strength, which could lead to unnecessary interventions. Therefore, it is crucial to consider the need for adjustments in the cutoff points when using Gripwise. These findings highlight the need to revise cutoff points for dynapenia classification, considering device variations and model differences in older age groups.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1560097"},"PeriodicalIF":3.3,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12062132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144051925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative analysis of binary and multi-class classification machine learning algorithms to detect current frailty status using the English longitudinal study of ageing (ELSA).","authors":"Charmayne Mary Lee Hughes, Yan Zhang, Ali Pourhossein, Terezia Jurasova","doi":"10.3389/fragi.2025.1501168","DOIUrl":"https://doi.org/10.3389/fragi.2025.1501168","url":null,"abstract":"<p><strong>Background: </strong>Physical frailty is a pressing public health issue that significantly increases the risk of disability, hospitalization, and mortality. Early and accurate detection of frailty is essential for timely intervention, reducing its widespread impact on healthcare systems, social support networks, and economic stability.</p><p><strong>Objective: </strong>This study aimed to classify frailty status into binary (frail vs. non-frail) and multi-class (frail vs. pre-frail vs. non-frail) categories. The goal was to detect and classify frailty status at a specific point in time. Model development and internal validation were conducted using data from wave 8 of the English Longitudinal Study of Ageing (ELSA), with external validation using wave 6 data to assess model generalizability.</p><p><strong>Methods: </strong>Nine classification algorithms, including Logistic Regression, Random Forest, K-nearest Neighbor, Gradient Boosting, AdaBoost, XGBoost, LightGBM, CatBoost, and Multi-Layer Perceptron, were evaluated and their performance compared.</p><p><strong>Results: </strong>CatBoost demonstrated the best overall performance in binary classification, achieving high recall (0.951), balanced accuracy (0.928), and the lowest Brier score (0.049) on the internal validation set, and maintaining strong performance externally with a recall of 0.950, balanced accuracy of 0.913, and F1-score of 0.951. Multi-class classification was more challenging, with Gradient Boosting emerging as the top model, achieving the highest recall (0.666) and precision (0.663) on the external validation set, with a strong F1-score (0.664) and reasonable calibration (Brier Score = 0.223).</p><p><strong>Conclusion: </strong>Machine learning algorithms show promise for the detection of current frailty status, particularly in binary classification. However, distinguishing between frailty subcategories remains challenging, highlighting the need for improved models and feature selection strategies to enhance multi-class classification accuracy.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1501168"},"PeriodicalIF":3.3,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12052818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144045652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multivariate analysis of immunosenescence data in healthy humans and diverse diseases.","authors":"Ana Laura Añé-Kourí, Jorge Luis Palomino, Patricia Lorenzo-Luaces, Lizet Sanchez, Nuris Ledon, Karla Pereira, Jenysbel de la Caridad Hernandez, Gisela María Suárez, Beatriz García, Amnely González, Danay Saavedra, Agustin Lage","doi":"10.3389/fragi.2025.1568034","DOIUrl":"https://doi.org/10.3389/fragi.2025.1568034","url":null,"abstract":"<p><strong>Introduction: </strong>Immunosenescence is a dynamic process, where both genetic and environmental factors account for the substantial inter-individual variability. This paper integrates all the data on immunosenescence markers generated in our laboratory and describes the differences and/or similarities between individuals based on their biological conditions (immunosenescence markers) and their associations with chronological age and health status.</p><p><strong>Materials and methods: </strong>The dataset consisted of immunological data from healthy donors, centenarians, patients diagnosed with chronic kidney disease, COVID-19 and non-small cell lung cancer (NSCLC), treatment-naïve or treated with platinum-based chemotherapy. To determine whether there are groups of immunologically different individuals despite their age or clinical condition, cluster analysis was performed. Canonical discriminant analysis was performed to determine which variables characterize each cluster.</p><p><strong>Results: </strong>There are differences in the expression of immunosenescence markers between healthy subjects and patients diagnosed with different pathological conditions, regardless of their age. Meanwhile, the distribution of the clusters indicates the presence of two separate groups of healthy participants, one of them characterized by a high frequency of naïve lymphocytes, and the other with high expression of terminally differentiated lymphocyte subsets. Advanced NSCLC treatment-naïve patients were in the same cluster as a group of healthy subjects. Additionally, centenarians belong to a different cluster than healthy subjects, suggesting they might have a unique immune signature.</p><p><strong>Conclusion: </strong>The distribution of clusters appears to be more appropriate than univariate associations of single markers for health and disease research. The present work reveals which immune markers are relevant in different physiological and pathological contexts and indicates the need for deeper studies on the biological age of the immune system.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1568034"},"PeriodicalIF":3.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040824/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the senescence secretome during zebrafish retina regeneration.","authors":"Gregory J Konar, Kyle T Vallone, Tu D Nguyen, James G Patton","doi":"10.3389/fragi.2025.1569422","DOIUrl":"https://doi.org/10.3389/fragi.2025.1569422","url":null,"abstract":"<p><strong>Introduction: </strong>Zebrafish possess the innate ability to regenerate any lost or damaged retinal cell type with Müller glia serving as resident stem cells. Recently, we discovered that this process is aided by a population of damage-induced senescent immune cells. As part of the Senescence Associated Secretory Phenotype (SASP), senescent cells secrete numerous factors that can play a role in the modulation of inflammation and remodeling of the retinal microenvironment during regeneration. However, the identity of specific SASP factors that drive initiation and progression of retina regeneration remains unclear.</p><p><strong>Materials and methods: </strong>We mined the SASP Atlas and publicly available RNAseq datasets to identify common, differentially expressed SASP factors after retina injury. These datasets included two distinct acute damage regimens, as well as two chronic, genetic models of retina degeneration. We identified overlapping factors between these models and used genetic knockdown experiments, qRT/PCR and immunohistochemical staining to test a role for one of these factors (<i>npm1a</i>).</p><p><strong>Results: </strong>We discovered an overlapping set of 31 SASP-related regeneration factors across all data sets and damage paradigms. These factors are upregulated after damage with functions that span the innate immune system, autophagic processing, cell cycle regulation, and cellular stress responses. From among these, we show that depletion of Nucleophosmin 1 (<i>npm1a</i>) inhibits retina regeneration and decreases senescent cell detection after damage.</p><p><strong>Discussion: </strong>Our data suggest that differential expression of SASP factors promotes initiation and progression of retina regeneration after both acute and chronic retinal damage. The existence of a common, overlapping set of 31 factors provides a group of novel therapeutic targets for retina regeneration studies.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1569422"},"PeriodicalIF":3.3,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12040975/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A scoping review of the feasibility, usability, and efficacy of digital interventions in older adults concerning physical activity and/or exercise.","authors":"Ethan C J Berry, Nicholas F Sculthorpe, Ashley Warner, James D Mather, Nilihan E M Sanal-Hayes, Lawrence D Hayes","doi":"10.3389/fragi.2025.1516481","DOIUrl":"https://doi.org/10.3389/fragi.2025.1516481","url":null,"abstract":"<p><strong>Background: </strong>The global population is aging, leading to significant health challenges among older adults, such as reduced muscle mass, increased risks of dementias, and chronic diseases. Physical activity (PA) is crucial for maintaining health and wellbeing in this demographic, yet participation tends to decrease with age due to various barriers. Digital technologies, including mobile health (mHealth) interventions, show promise in promoting PA among older adults, though their adoption remains limited due to intrinsic and extrinsic challenges.</p><p><strong>Objectives: </strong>This scoping review aimed to systematically map existing evidence on digital PA interventions for older adults, assessing feasibility, usability, and efficacy, whilst providing recommendations for future research and practice.</p><p><strong>Eligibility criteria: </strong>Original investigations concerning digital interventions in older adults (≥60 years of age) focusing on physical activity and/or exercise were considered. Sources of evidence: Four electronic databases [MEDLINE, CINAHL Ultimate, Scopus and Cochrane Central Register of Controlled Trials (CENTRAL)] were searched.</p><p><strong>Methods: </strong>A scoping review was conducted using the scoping review methodological framework. Review selection and characterisation were carried out by two independent reviewers.</p><p><strong>Results: </strong>The 34 included studies were published between 2005 and 2023 across Europe, North America, Asia, and Oceania. Participants varied from healthy to frail individuals, with some diagnosed with dementia or cognitive impairment. Interventions were most commonly delivered via exergames, tablet apps, and videoconferencing. The most common exercise program type was multicomponent. Most studies assessed efficacy, feasibility, and usability, with many using a combination of these measures. Reminders were commonly utilised to enhance engagement through various digital and non-digital methods.</p><p><strong>Conclusion: </strong>There was a notable lack of mobile health (mHealth) studies in the literature, with most research focusing on exergame and tablet interventions. More research on smartphone apps, particularly for muscle strengthening, is needed, and the growing ease of app development may drive innovation and research. Digital interventions are generally feasible, usable, and effective for older adults, offering a promising, scalable approach for promoting PA. This review identified several valuable lessons from the existent literature for future developments.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1516481"},"PeriodicalIF":3.3,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144029688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global research trends in inflammaging from 2005 to 2024: a bibliometric analysis.","authors":"Beier Jiang, Yi-Ni Dong, Yu Xiong, Chun-Xia Jiang, Jun Ping, Qi Wu, Liu-Jun Xu, Run-Zhe Shu, Dan-Dan Gao, Sheng-Mei Zhu, Wei-Dong Ye, Feng Zhang","doi":"10.3389/fragi.2025.1554186","DOIUrl":"https://doi.org/10.3389/fragi.2025.1554186","url":null,"abstract":"<p><strong>Background: </strong>Inflammaging, defined as chronic low-grade inflammation associated with aging, is considered a key factor in many age-related diseases. Despite growing research, comprehensive assessments of trends and focuses on this field over the past 2 decades remain lacking.</p><p><strong>Objective: </strong>To comprehensively analyze literature development trends, scientific priorities, and their evolution in the field of inflammaging from 2005 to 2024 using bibliometric analysis.</p><p><strong>Methods: </strong>Academic literature on inflammaging was retrieved from the Web of Science Core Collection. CiteSpace software was used as the bibliometric tool to analyze annual publication trends, contributing countries/regions, leading research institutions, primary journals, and keyword co-occurrence, including clustering and burst analysis in this field.</p><p><strong>Results: </strong>The study included 1,800 eligible articles, demonstrating a consistent growth in research publications over the past 20 years. The United States and Italy were the principal contributors. The University of Bologna had the highest publication. Professor Claudio Franceschi has been a leading figure in this field. Journal analysis shows that research themes predominantly focus on molecular biology/immunology and medicine/clinical fields. Keyword analysis identifies major research hotspots as \"inflammaging,\" \"Crohn's disease,\" \"periodontitis,\" \"immunosenescence,\" \"skeletal muscle,\" \"gut microbiota,\" and \"Parkinson's disease.\" Emerging term analysis indicates a shift from specific inflammatory diseases to broader aging and immune modulation studies.</p><p><strong>Conclusion: </strong>This first systematic assessment of literature trends in the field of inflammaging from 2005 to 2024 reveals sustained academic growth and an increasingly deep research focus.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1554186"},"PeriodicalIF":3.3,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12018403/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144064593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-defying swallowing.","authors":"María-Itatí Palacio, Rosa-María Bermejo, Ana-María Lucas-Ochoa, Ana-María González-Cuello, Emiliano Fernández-Villalba, María-Trinidad Herrero","doi":"10.3389/fragi.2025.1510257","DOIUrl":"https://doi.org/10.3389/fragi.2025.1510257","url":null,"abstract":"<p><p>Swallowing disorders, which are generally underdiagnosed, affect the elderly, leading to a decreased quality of life and complications, including aspiration pneumonia and death. Understanding the neurophysiology of swallowing and the causes of its dysfunction is a fundamental tool for the prevention, early diagnosis, and treatment of dysphagia. New technologies open a wide range of possibilities for the implementation of new care protocols for this disorder.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1510257"},"PeriodicalIF":3.3,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144059985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growth hormone and aging: a clinical review.","authors":"Luis E Fernández-Garza, Fernando Guillen-Silva, Marcos A Sotelo-Ibarra, Andrés Ely Domínguez-Mendoza, Silvia A Barrera-Barrera, Hugo A Barrera-Saldaña","doi":"10.3389/fragi.2025.1549453","DOIUrl":"https://doi.org/10.3389/fragi.2025.1549453","url":null,"abstract":"<p><p>Aging is a complex biological process characterized by functional decline, reduced quality of life, and increased vulnerability to diseases such as type 2 diabetes, cardiovascular conditions, neurodegeneration, and cancer. Advances in medical technology have introduced the concept of aging therapies, with growth hormone (GH) and its primary mediator, insulin-like growth factor 1 (IGF-1), receiving considerable attention for their potential to counteract age-related physiological and metabolic changes. GH plays a multifaceted role in the human body, primarily influencing body composition by increasing muscle mass, reducing fat tissue, promoting bone formation, and regulating the metabolism of proteins, lipids, and glucose. Additional effects have been noted on endothelial function, cognitive performance, and circadian rhythms. This review examines the molecular mechanisms of GH in aging, its potential as an anti-aging therapy, and findings from clinical trials involving these hormones for this purpose. It also addresses the associated adverse effects, limitations, and controversies. While some studies report significant benefits, these therapies' long-term safety and efficacy in promoting healthy aging remain uncertain, highlighting the need for further research.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"6 ","pages":"1549453"},"PeriodicalIF":3.3,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009952/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144044280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}