Frontiers in aging最新文献_第3页

Application of laboratory frailty index in predicting delirium in elderly patients with community-acquired pneumonia. 实验室虚弱指数在预测社区获得性肺炎老年患者谵妄中的应用。

IF 3.3

Frontiers in aging Pub Date : 2024-12-16 eCollection Date: 2024-01-01 DOI: 10.3389/fragi.2024.1478355

Jingxian Liao, Xiaozhu Shen, Zhiqiang Du, Lei Miao

{"title":"Application of laboratory frailty index in predicting delirium in elderly patients with community-acquired pneumonia.","authors":"Jingxian Liao, Xiaozhu Shen, Zhiqiang Du, Lei Miao","doi":"10.3389/fragi.2024.1478355","DOIUrl":"10.3389/fragi.2024.1478355","url":null,"abstract":"Background: With the global aging population, community-acquired pneumonia and delirium are increasingly critical health issues among the elderly. The Laboratory Frailty Index provides an objective measure of frailty. This study explores its capacity in predicting delirium and examines the interplay between frailty and nutritional status in elderly patients with community-acquired pneumonia.Methods and materials: This retrospective study included 481 elderly patients aged 75 and above diagnosed with community-acquired pneumonia. The Laboratory Frailty Index was calculated by dividing the sum of abnormal indicator scores by the total number of test indicators, resulting in a score ranging from 0 to 1, with higher values indicating greater frailty.Results: Higher Laboratory Frailty Index scores were associated with an increased risk of delirium. The index's predictive accuracy improved when combined with nutritional assessments. Patients experiencing malnutrition alongside higher frailty scores exhibited a higher risk of adverse outcomes. Nutritional status mediated the relationship between frailty and delirium, underlining the significance of addressing both variables.Conclusion: The Laboratory Frailty Index is a robust predictor of delirium in elderly patients with community-acquired pneumonia. These findings provide valuable insights for the early identification and intervention of delirium in clinical settings.","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"5 ","pages":"1478355"},"PeriodicalIF":3.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683053/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Critical review of aging clocks and factors that may influence the pace of aging. 对衰老时钟和可能影响衰老速度的因素的评述。

IF 3.3

Frontiers in aging Pub Date : 2024-12-13 eCollection Date: 2024-01-01 DOI: 10.3389/fragi.2024.1487260

Mildred Min, Caitlin Egli, Ajay S Dulai, Raja K Sivamani

{"title":"Critical review of aging clocks and factors that may influence the pace of aging.","authors":"Mildred Min, Caitlin Egli, Ajay S Dulai, Raja K Sivamani","doi":"10.3389/fragi.2024.1487260","DOIUrl":"10.3389/fragi.2024.1487260","url":null,"abstract":"Background and objectives: Aging clocks are computational models designed to measure biological age and aging rate based on age-related markers including epigenetic, proteomic, and immunomic changes, gut and skin microbiota, among others. In this narrative review, we aim to discuss the currently available aging clocks, ranging from epigenetic aging clocks to visual skin aging clocks.Methods: We performed a literature search on PubMed/MEDLINE databases with keywords including: \"aging clock,\" \"aging,\" \"biological age,\" \"chronological age,\" \"epigenetic,\" \"proteomic,\" \"microbiome,\" \"telomere,\" \"metabolic,\" \"inflammation,\" \"glycomic,\" \"lifestyle,\" \"nutrition,\" \"diet,\" \"exercise,\" \"psychosocial,\" and \"technology.\"Results: Notably, several CpG regions, plasma proteins, inflammatory and immune biomarkers, microbiome shifts, neuroimaging changes, and visual skin aging parameters demonstrated roles in aging and aging clock predictions. Further analysis on the most predictive CpGs and biomarkers is warranted. Limitations of aging clocks include technical noise which may be corrected with additional statistical techniques, and the diversity and applicability of samples utilized.Conclusion: Aging clocks have significant therapeutic potential to better understand aging and the influence of chronic inflammation and diseases in an expanding older population.","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"5 ","pages":"1487260"},"PeriodicalIF":3.3,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of track and field training on dynapenia: gender differences in age-related decline of vertical jump performance among older adults. 田径训练对运动障碍的影响：老年人垂直跳远成绩年龄相关性下降的性别差异。

IF 3.3

Frontiers in aging Pub Date : 2024-12-12 eCollection Date: 2024-01-01 DOI: 10.3389/fragi.2024.1504789

Eneko Fernández-Peña, Eugenio Formiglio, Marco Gervasi, Piero Benelli, Alexander Bertuccioli, Giuseppe Russo, Valerio Giustino, Antonino Patti

{"title":"The impact of track and field training on dynapenia: gender differences in age-related decline of vertical jump performance among older adults.","authors":"Eneko Fernández-Peña, Eugenio Formiglio, Marco Gervasi, Piero Benelli, Alexander Bertuccioli, Giuseppe Russo, Valerio Giustino, Antonino Patti","doi":"10.3389/fragi.2024.1504789","DOIUrl":"10.3389/fragi.2024.1504789","url":null,"abstract":"Introduction: Alongside sarcopenia, the age-related loss of muscle strength and power, known as dynapenia, increases the risk of functional disability and mortality in older adults. However, engaging in sporting activities during old age appears to enhance functional capacity. The differences in effects between athletes and sedentary individuals, as well as between genders, have yet to be fully clarified.Methods: The vertical jump test is recognized as a measure of lower limb performance with almost no learning effect. In the present study, we quantified age-related countermovement jump (CMJ) height loss in 120 subjects over 58 years old among both master athletes and sedentary counterparts, and analysed gender differences.Results: Both male and female master athletes showed significantly higher jump heights results than their sedentary counterparts (male athletes 28.5 ± 4.3 cm vs. male sedentaries 15.1 ± 5.2 cm; p < 0.01; female athletes 22.7 ± 2.5 cm vs. female sedentaries 8.2 ± 3.3 cm; p < 0.01). Female athletes were found to have higher CMJ performance than even sedentary men (p < 0.01). The rate of decline in jumping ability was the same for male athletes and non-athletes, but female athletes had the shallower rate of decline of all the groups observed (2.78 cm per decade).Discussion: Sporting activity in the older age allows both men and women to perform at a higher level, with the latter also benefiting from a slower rate of decline, which can have a positive impact on functional ability and quality of life.","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"5 ","pages":"1504789"},"PeriodicalIF":3.3,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11672781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142904290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heightened cholesterol 25-hydroxylase expression in aged lung during Streptococcus pneumoniae. 老年肺炎链球菌感染时肺部胆固醇25-羟化酶表达增高。

IF 3.3

Frontiers in aging Pub Date : 2024-12-09 eCollection Date: 2024-01-01 DOI: 10.3389/fragi.2024.1480886

David G Thomas, Jianjun Yang, Soo Jung Cho, Heather Stout-Delgado

{"title":"Heightened cholesterol 25-hydroxylase expression in aged lung during Streptococcus pneumoniae.","authors":"David G Thomas, Jianjun Yang, Soo Jung Cho, Heather Stout-Delgado","doi":"10.3389/fragi.2024.1480886","DOIUrl":"10.3389/fragi.2024.1480886","url":null,"abstract":"Introduction: Alveolar macrophages (AM) are critical effectors of the immune response and are essential for host responses to Streptococcus pneumoniae. Changes in lipid metabolism in AM can alter cellular function and biology. Impaired metabolism can contribute to excessive lipid accumulation and pro-inflammatory signaling. Our current study was designed to examine the role of cholesterol 25-hydroxylase (Ch25h), a redox enzyme that catalyzes the oxidation of cholesterol to 25-hydroxycholesterol (25-HC), in modulating AM responses in the aged lung during S. pneumoniae infection.Methods: To observe the impact of aging on Ch25h expression in AM during infection, in vitro and in vivo murine models of S. pneumoniae were used.Results: At baseline and in response to infection, cholesterol metabolism significantly altered in aged AM, which corresponded with increased lipid droplet formation. In vitro, treatment of aged macrophages with Ch25 h-specific siRNA improved S. pneumoniae clearance and enhanced phagocytic receptor expression. In vivo siRNA targeting significantly reduced Ch25h expression in aged lungs and improved clinical parameters during S. pneumoniae infection. Reduction of Ch25h was associated with changes in phagocytosis and antibacterial signaling, correlated with changes in cholesterol metabolism, and increased S. pneumoniae clearance.Discussion: The results of our current study demonstrate that Ch25h plays an essential role in modulating aged AM responses to S. pneumoniae.","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"5 ","pages":"1480886"},"PeriodicalIF":3.3,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11663934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chaperone-mediated autophagy as a modulator of aging and longevity. 伴侣介导的自噬作为衰老和长寿的调节剂。

IF 3.3

Frontiers in aging Pub Date : 2024-12-02 eCollection Date: 2024-01-01 DOI: 10.3389/fragi.2024.1509400

S Joseph Endicott

{"title":"Chaperone-mediated autophagy as a modulator of aging and longevity.","authors":"S Joseph Endicott","doi":"10.3389/fragi.2024.1509400","DOIUrl":"10.3389/fragi.2024.1509400","url":null,"abstract":"Chaperone-mediated autophagy (CMA) is the lysosomal degradation of individually selected proteins, independent of vesicle fusion. CMA is a central part of the proteostasis network in vertebrate cells. However, CMA is also a negative regulator of anabolism, and it degrades enzymes required for glycolysis, de novo lipogenesis, and translation at the cytoplasmic ribosome. Recently, CMA has gained attention as a possible modulator of rodent aging. Two mechanistic models have been proposed to explain the relationship between CMA and aging in mice. Both of these models are backed by experimental data, and they are not mutually exclusionary. Model 1, the \"Longevity Model,\" states that lifespan-extending interventions that decrease signaling through the INS/IGF1 signaling axis also increase CMA, which degrades (and thereby reduces the abundance of) several proteins that negatively regulate vertebrate lifespan, such as MYC, NLRP3, ACLY, and ACSS2. Therefore, enhanced CMA, in early and midlife, is hypothesized to slow the aging process. Model 2, the \"Aging Model,\" states that changes in lysosomal membrane dynamics with age lead to age-related losses in the essential CMA component LAMP2A, which in turn reduces CMA, contributes to age-related proteostasis collapse, and leads to overaccumulation of proteins that contribute to age-related diseases, such as Alzheimer's disease, Parkinson's disease, cancer, atherosclerosis, and sterile inflammation. The objective of this review paper is to comprehensively describe the data in support of both of these explanatory models, and to discuss the strengths and limitations of each.","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"5 ","pages":"1509400"},"PeriodicalIF":3.3,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11647017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the utility of epigenetic clocks for health prediction in South Korean. 评估韩国表观遗传时钟对健康预测的效用。

IF 3.3

Frontiers in aging Pub Date : 2024-12-02 eCollection Date: 2024-01-01 DOI: 10.3389/fragi.2024.1493406

Dong Jun Kim, Joon Ho Kang, Ji-Woong Kim, Sun Bin Kim, Young Kee Lee, Myeong Jae Cheon, Byung-Chul Lee

{"title":"Assessing the utility of epigenetic clocks for health prediction in South Korean.","authors":"Dong Jun Kim, Joon Ho Kang, Ji-Woong Kim, Sun Bin Kim, Young Kee Lee, Myeong Jae Cheon, Byung-Chul Lee","doi":"10.3389/fragi.2024.1493406","DOIUrl":"10.3389/fragi.2024.1493406","url":null,"abstract":"Epigenetic clocks have been developed to track both chronological age and biological age, which is defined by physiological biomarkers and the risk of adverse health outcomes. Epigenetic age acceleration (EAA) has been found to predict various diseases, aging-related factors, and mortality. However, epigenetic clocks have predominantly been developed with individuals of European or Hispanic ancestry, and their association with health outcomes and environmental factors has not been sufficiently assessed in East Asian populations. Here, we investigated nine epigenetic clocks: five trained on chronological age (first-generation) and four on biological age (second-generation), using DNA methylation data from blood samples of South Koreans. EAAs of second-generation epigenetic clocks reflected the risk of chronic diseases (type 2 diabetes and hypertension), levels of health-related blood markers (alanine aminotransferase, aspartate aminotransferase, high density lipoprotein, triglyceride, and high sensitivity C-reactive protein), and lung functions (percentage of predicted FEV1 and percentage of predicted FVC), while EAAs of first generation clocks did not. Using follow-up data, we also found that EAAs of second-generation clocks were associated with the time to onset risks of chronic diseases. Health behavior factors (drinking, smoking, exercise, body mass index, and waist-hip ratio), socioeconomic status (income level and educational attainment), and psychosocial status were associated with EAAs of second-generation clocks, while only smoking status was associated with EAAs of first-generation clocks. We conducted validation analyses in an independent South Korean cohort and replicated the association of EAAs with health outcomes and environmental factors. Age acceleration of epigenetic clocks is influenced by various environmental factors and can serve as an effective predictor of health in South Korea.","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"5 ","pages":"1493406"},"PeriodicalIF":3.3,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial: Frailty- and age-associated diseases: possibilities for intervention. 社论：虚弱和年龄相关疾病：干预的可能性。

IF 3.3

Frontiers in aging Pub Date : 2024-11-28 eCollection Date: 2024-01-01 DOI: 10.3389/fragi.2024.1522451

Cristina Mas-Bargues, Jose Viña, Consuelo Borrás

引用次数: 0

Climbing the longevity pyramid: overview of evidence-driven healthcare prevention strategies for human longevity. 攀登长寿金字塔：人类长寿循证医疗预防策略概述。

IF 3.3

Frontiers in aging Pub Date : 2024-11-26 eCollection Date: 2024-01-01 DOI: 10.3389/fragi.2024.1495029

Anđela Martinović, Matilde Mantovani, Natalia Trpchevska, Eva Novak, Nikolay B Milev, Leonie Bode, Collin Y Ewald, Evelyne Bischof, Tobias Reichmuth, Rebecca Lapides, Alexander Navarini, Babak Saravi, Elisabeth Roider

{"title":"Climbing the longevity pyramid: overview of evidence-driven healthcare prevention strategies for human longevity.","authors":"Anđela Martinović, Matilde Mantovani, Natalia Trpchevska, Eva Novak, Nikolay B Milev, Leonie Bode, Collin Y Ewald, Evelyne Bischof, Tobias Reichmuth, Rebecca Lapides, Alexander Navarini, Babak Saravi, Elisabeth Roider","doi":"10.3389/fragi.2024.1495029","DOIUrl":"10.3389/fragi.2024.1495029","url":null,"abstract":"Longevity medicine is an emerging and iterative healthcare discipline focusing on early detection, preventive measures, and personalized approaches that aim to extend healthy lifespan and promote healthy aging. This comprehensive review introduces the innovative concept of the \"Longevity Pyramid.\" This conceptual framework delineates progressive intervention levels, providing a structured approach to understanding the diverse strategies available in longevity medicine. At the base of the Longevity Pyramid lies the level of prevention, emphasizing early detection strategies and advanced diagnostics or timely identification of potential health issues. Moving upwards, the next step involves lifestyle modifications, health-promoting behaviors, and proactive measures to delay the onset of age-related conditions. The Longevity Pyramid further explores the vast range of personalized interventions, highlighting the importance of tailoring medical approaches based on genetic predispositions, lifestyle factors, and unique health profiles, thereby optimizing interventions for maximal efficacy. These interventions aim to extend lifespan and reduce the impact and severity of age-related conditions, ensuring that additional years are characterized by vitality and wellbeing. By outlining these progressive levels of intervention, this review offers valuable insights into the evolving field of longevity medicine. This structured framework guides researchers and practitioners toward a nuanced strategic approach to advancing the science and practice of healthy aging.","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"5 ","pages":"1495029"},"PeriodicalIF":3.3,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11628525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic signatures of combined exercise and fasting: an expanded perspective on previous telomere length findings. 结合运动和禁食的代谢特征：对先前端粒长度发现的扩展视角。

IF 3.3

Frontiers in aging Pub Date : 2024-11-20 eCollection Date: 2024-01-01 DOI: 10.3389/fragi.2024.1494095

Shamma Almuraikhy, Khaled Naja, Najeha Anwardeen, Maha Sellami, Hadaia Saleh Al-Amri, Haya Al-Sulaiti, Sara S Bashraheel, Amina Ali Aden, Mohamed A Elrayess

{"title":"Metabolic signatures of combined exercise and fasting: an expanded perspective on previous telomere length findings.","authors":"Shamma Almuraikhy, Khaled Naja, Najeha Anwardeen, Maha Sellami, Hadaia Saleh Al-Amri, Haya Al-Sulaiti, Sara S Bashraheel, Amina Ali Aden, Mohamed A Elrayess","doi":"10.3389/fragi.2024.1494095","DOIUrl":"10.3389/fragi.2024.1494095","url":null,"abstract":"Introduction: Aging is a complex process marked by a gradual decline in physiological function and increased susceptibility to diseases. Telomere length is frequently regarded as one of the primary biomarkers of aging. Metabolic profiles are key features in longevity and have been associated with both age and age-related diseases. We previously reported an increase in the telomere length in healthy female subjects when Ramadan fasting was combined with physical training. This study aims to characterize the metabolic signature differentiating the combined effects of exercise and fasting from exercise alone and explore the correlations with the previously reported telomere length changes.Methods: Twenty-nine young, non-obese, and healthy female subjects were previously randomized into two groups: one group followed a 4-week exercise program, while the other group followed the same 4-week exercise program but also fasted during Ramadan. Metabolic profiles were assessed pre- and post-intervention using untargeted metabolomics.Results and discussion: Our results showed a significant decrease in many lipid metabolites in the exercise-while-fasting group, particularly ceramides. Our study sheds light on the dynamic changes in lipid metabolism and its potential role in inflammation and age-related diseases, and contributes to the broader understanding of how lifestyle factors can influence cellular aging and metabolic health.","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"5 ","pages":"1494095"},"PeriodicalIF":3.3,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11615071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142781898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mesenchymal stem cells and their exosomes mitigate osteoarthritis by restoring the balance between proinflammatory Teffs and Tregs. 间充质干细胞及其外泌体通过恢复促炎Teffs和Tregs之间的平衡来减轻骨关节炎。

IF 3.3

Frontiers in aging Pub Date : 2024-11-19 eCollection Date: 2024-01-01 DOI: 10.3389/fragi.2024.1509014

Tianhao Liu, Chunxiao Ran, Dewei Zhao, Fan Yang, Qiang Guo, Jiahui Yang, Xiuzhi Zhang

{"title":"Mesenchymal stem cells and their exosomes mitigate osteoarthritis by restoring the balance between proinflammatory Teffs and Tregs.","authors":"Tianhao Liu, Chunxiao Ran, Dewei Zhao, Fan Yang, Qiang Guo, Jiahui Yang, Xiuzhi Zhang","doi":"10.3389/fragi.2024.1509014","DOIUrl":"10.3389/fragi.2024.1509014","url":null,"abstract":"Osteoarthritis (OA) is a degenerative joint disease caused by chronic inflammation that damages articular cartilage. In addition to the wear and tear of joints, aberrant remodelling driven by a significant presence of inflammatory mediators within the joint is one of the key mechanisms in the pathogenesis of OA. Among these factors, hyperactivation of Teffs subsets plays a crucial role in promoting this pathological process. The immune imbalance between proinflammatory CD4+ effector T cells (proinflammatory Teffs) and Tregs could be a crucial factor in the pathogenesis of OA. Therefore, correcting the imbalance of Tregs/proinflammatory Teffs may slow or inhibit the occurrence and development of OA, which could be a potential target for the treatment of OA. Mesenchymal stem cells (MSCs) possess anti-inflammatory and immunomodulatory properties, regulating both adaptive and innate immunity through mechanisms involving soluble factors such as IDO, PGE2, and TGF-β, as well as cell-to-cell contact and exosomes. Correcting the imbalance between Tregs and proinflammatory Teffs may be one of the mechanisms of MSCs in the treatment of OA. Therefore, this review aims to summarize the relationship between OA and the immune imbalance between Tregs and proinflammatory Teffs, the immunoregulatory role of Tregs in OA, and the role of MSCs and their exosomes in correcting the imbalance between Tregs and proinflammatory Teffs.","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"5 ","pages":"1509014"},"PeriodicalIF":3.3,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11611854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0