Frontiers in aging最新文献

{"title":"Editorial: Aging and the microbiome.","authors":"Claudia Villicaña, Chiara H Moretti, Franck Carbonero","doi":"10.3389/fragi.2024.1522703","DOIUrl":"https://doi.org/10.3389/fragi.2024.1522703","url":null,"abstract":"","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"5 ","pages":"1522703"},"PeriodicalIF":3.3,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular senescence in acute human infectious disease: a systematic review.","authors":"William C Miller, Stephanie Wallace, William Kamm, Erin Reardon, Nicole Theis-Mahon, Matthew J Yousefzadeh, Elizabeth L Schmidt, Laura J Niedernhofer, Michael A Puskarich","doi":"10.3389/fragi.2024.1500741","DOIUrl":"https://doi.org/10.3389/fragi.2024.1500741","url":null,"abstract":"<p><strong>Introduction: </strong><i>Acute infectious disease represents a significant cause of mortality and morbidity in elderly individuals admitted to the hospital. In its extreme, it presents as sepsis, a systematic inflammatory and immunologic response responsible for self-injurious organ injury. As individuals age, a unique set of factors including immunosenescence predispose them to acquiring an infection and a worse clinical prognosis.</i> This systematic review explores the relationship between cellular senescence, an age-related inflammatory phenomenon, with acute human infectious disease.</p><p><strong>Methods: </strong>Embase via OVID, Scopus, Web of Science, Global Index Medicus, Cochrane Library via Wiley, and ClinicalTrials.gov were queried. Included studies must have compared at least one of the following measures of cellular senescence between patients with an infection and without an infection: cell cycle inhibition measured via levels of <i>p16</i> ^<i>INK4a</i> and/or <i>p21</i> ^<i>CIP1</i> , short telomere length, DNA damage via ɣH2AX, high senescence-associated β galactosidase activity, and inflammation via the detection of senescence associated secretory phenotype (SASP). Manuscripts were screened and data collected via two independent reviewers.</p><p><strong>Results: </strong>A total of 15,828 studies were screened after duplicates were removed. One hundred and fifty-three full-text articles were assessed for eligibility and a total of 16 original articles were included in analysis. Of the 16 original articles included, 12 (75%) articles were centered on SARS-CoV-2, 2 (12.5%) articles utilized patients infected with <i>Leishmania braziliensis</i>, 1 (6.25%) with <i>Plasmodium falciparum</i>, and 1 (6.25%) with Hepatitis C.</p><p><strong>Conclusion: </strong>Current literature demonstrates robust upregulation of markers of cellular senescence in the setting of acute SARS-CoV-2, <i>P. falciparum</i>, <i>L. braziliensis</i>, and hepatitis C virus, and that markers of senescence correlate with disease severity and persist for months after resolution. Limitations in the number and types of infectious organisms studied, low sample sizes, modest longitudinal sampling, and a lack of consistency in markers measured, the method of measurement, and the definition of normal values represent ongoing gaps in the literature.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=421473, Identifier CRD42023421473.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"5 ","pages":"1500741"},"PeriodicalIF":3.3,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11604623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of anti-aging approaches in managing hypogonadism in sedentary older males.","authors":"Khaled A Abdel-Sater","doi":"10.3389/fragi.2024.1514438","DOIUrl":"10.3389/fragi.2024.1514438","url":null,"abstract":"<p><strong>Introduction: </strong>With thirty percent of the world's population not getting enough exercise, Worldwide, physical inactivity ranks as one of the most common causes of premature mortality. Rapid drops in physical activity, decreased mobility, and early morbidity are aging characteristics. As the population over 80 continues to rise, aging raises the danger of age-related illnesses and changes in hormone release.</p><p><strong>Aim: </strong>Understanding the aging process is useful in developing pharmacological therapies and identifying therapeutic targets for age-related testosterone deficiency. Therefore, this study's purpose is to present a thorough evaluation of the effects of anti-aging strategies on testosterone levels in older, inactive men.</p><p><strong>Methods: </strong>A literature search was completed for clinical and preclinical studies published in English between 2014 and 2024 related to age, sedentary life, testosterone, and anti-aging strategies.</p><p><strong>Results: </strong>A sedentary lifestyle and low testosterone are linked to a vicious cycle. A sedentary lifestyle lowers testosterone levels, which leads to depression, exhaustion, low energy, and weakened bone and muscle strength. These effects exacerbate the detrimental consequences of aging and physical inactivity. Anti-aging techniques can prevent and treat age-related diseases, including calorie restriction, a balanced diet, regular exercise, weight control, diabetes management, and quitting smoking. Regular exercise raises total testosterone, free testosterone, and muscle steroidogenesis. In older men, testosterone replacement treatment increases bone density, cholesterol, protein synthesis, strength, erectile function, sexual desire, and general cognitive performance. However, some studies suggest dehydroepiandrosterone supplementation may provide health improvements without negative effects, potentially reversing arterial aging and reducing cardiovascular disease risk.</p><p><strong>Conclusion: </strong>This article evaluates the prospects for anti-aging procedures to assist in reducing the adverse effects of aging and physical inactivity in men.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"5 ","pages":"1514438"},"PeriodicalIF":3.3,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11602875/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistent elevation of plasma markers of cellular senescence after hip fracture: a pilot longitudinal study.","authors":"Eric J Lenze, Ginger E Nicol, George A Kuchel, Michael S Avidan, Breno S Diniz","doi":"10.3389/fragi.2024.1477528","DOIUrl":"10.3389/fragi.2024.1477528","url":null,"abstract":"<p><strong>Introduction: </strong>Hip fractures may result from and contribute to accelerated biological aging. We aimed to evaluate the impact of hip fracture and its surgery on the senescence-associated secretory phenotype (SASP) index, a composite of peripheral protein markers where higher scores are thought to indicate greater levels of cellular senescence and accelerated aging.</p><p><strong>Methods: </strong>We examined the SASP index in plasma over 12 weeks post-surgery and its prediction of long-term post-surgical functional outcomes. We included 60 older adults: 20 recruited immediately after hip fracture surgery, and 40 comparison individuals who were either healthy or suffering chronic psychosocial stress (caregiving). We assessed 22 SASP biomarkers and calculated the SASP index score for each hip fracture participant immediately following fracture surgery and 4 and 12 weeks later. Functional recovery was assessed at 12, 26, and 52 weeks after hip replacement surgery.</p><p><strong>Results: </strong>The hip fracture group had higher SASP index scores than the comparison groups, after adjusting for potential confounding variables (<i>p</i> = 0.021). SASP index scores in hip fracture patients increased further by week 4 after surgery (<i>p</i> < 0.001), declining by week 12 but remaining elevated overall. However, the SASP index scores were not significantly associated with functional recovery after hip replacement surgery at 26 or 52 weeks after surgery. In conclusion, after hip fracture surgery SASP scores are elevated, continue to rise over time, and do not return to normal by 12 weeks post-surgery.</p><p><strong>Discussion: </strong>Our findings support the need to investigate this phenomenon of post-operative senescence, including whether novel interventions such as senolytics would help older adults facing major surgery.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"5 ","pages":"1477528"},"PeriodicalIF":3.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588694/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142735046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How can robots facilitate physical, cognitive, and social engagement in skilled nursing facilities?","authors":"Rhian C Preston, Madison R Shippy, Carolyn M Aldwin, Naomi T Fitter","doi":"10.3389/fragi.2024.1463460","DOIUrl":"10.3389/fragi.2024.1463460","url":null,"abstract":"<p><p>As people live longer, the population of older adults in need of support continues to expand relative to the available workforce of caregivers, necessitating new solutions to supplement caregiver availability for the physical, cognitive, and social needs of older adults. Robotics and automation present strong possible solutions. Past solutions have typically supported short-term rehabilitation and aging in place, yet many older adults live in skilled nursing facilities (SNFs), a setting reached by relatively little research to date. In this paper, we examine the unique needs of staff and residents at SNFs, after which we begin an iterative design process of robot-mediated wellness activities for the SNF space. We worked closely with domain experts in exercise science and physical therapy for older adults and a local SNF to design and test a series of robot-mediated activity prototypes with residents, visitors, and staff. We found that while both residents and staff highly value physical activity, there are nuanced challenges associated with supporting resident activity (one important element of overall wellbeing). As a result, we considered and tested a wide range of intervention options from usual approaches (e.g., mirroring movements) to creative approaches (e.g., social engagement via lewd humor). Our final design insights can inform practitioners who wish to use robots to support resident wellbeing in SNFs.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"5 ","pages":"1463460"},"PeriodicalIF":3.3,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142735043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age and sex-related differences in elastic properties of the gastrocnemius muscle-tendon unit: an observational prospective study.","authors":"Zhijie Zhang, Wenjing Wang, Feng Li, Jiayi Guo","doi":"10.3389/fragi.2024.1455404","DOIUrl":"10.3389/fragi.2024.1455404","url":null,"abstract":"<p><strong>Introduction: </strong>Changes in the mechanical properties of the gastrocnemius muscle-tendon unit can lead to abnormal biomechanics of lower limbs, which is a risk factor for the development of many diseases. However, fewer studies have explored physiological changes in the gastrocnemius muscle-tendon unit stiffness. This study aimed to investigate the age- and sex-related differences in the gastrocnemius muscle-tendon unit stiffness.</p><p><strong>Methods: </strong>The study included 20 older women, 20 young women, and 20 older men. Shear wave elastography (SWE) was used to measure the stiffness of the medial gastrocnemius (MG), lateral gastrocnemius (LG), and Achilles tendon (AT) in all subjects in relaxed, neutral, and standing positions.</p><p><strong>Results: </strong>The results showed no significant differences in the MG, LG, and AT stiffness between the dominant and non-dominant sides (<i>p</i> > 0.05). The MG, LG, and AT stiffness changed with positions (<i>p</i> < 0.05). The LG stiffness in older women was lower than in older men and young women in any position (<i>p</i> < 0.05). The MG stiffness in older men was greater than that in older women in any position, and age-related changes were found only in the relaxed and standing positions (<i>p</i> < 0.05). The AT stiffness was higher in older men only in the relaxed position (<i>p</i> < 0.05). There was no significant difference in AT stiffness between older and younger women at any position (<i>p</i> > 0.05).</p><p><strong>Discussion: </strong>These results suggest that the bilateral gastrocnemius muscle-tendon unit stiffnesses were similar regardless of sex, age, and position. The stiffness of the gastrocnemius in women decreased with age. However, the effect of aging on AT stiffness was slight. Men have greater gastrocnemius stiffness in older adults.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"5 ","pages":"1455404"},"PeriodicalIF":3.3,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586365/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142717775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attitudes towards geroprotection: measuring willingness, from lifestyle changes to drug use.","authors":"Sam J Brouwers, Georges E Janssens, Tali Spiegel","doi":"10.3389/fragi.2024.1440661","DOIUrl":"10.3389/fragi.2024.1440661","url":null,"abstract":"<p><strong>Introduction: </strong>Geroprotection is an emerging field of research focused on devising strategies for combating the mechanisms of ageing. This study held three aims: 1) to explore the willingness to utilise five different geroprotective measures (i.e., exercise, supplements, intermittent fasting, metformin, and rapamycin use), 2) to explore whether the willingness differs based on respondents' sociodemographic characteristics and 3) to explore the association between trust in medical institutions and willingness to utilise different geroprotective measures.</p><p><strong>Methods: </strong>A questionnaire was used to assess the attitudes of a sample of the Dutch population by way of both convenience and snowball sampling (final N = 178). Descriptive data and bivariate correlations were used in the analyses.</p><p><strong>Results: </strong>Relatively high social acceptance of both exercise (66%) and supplements (82%) was found, whereas intermittent fasting (30%), metformin (26%), and rapamycin (10%) were less supported. Males were significantly more likely to be open to exercise and women to supplement use. Trust in medical institutions correlated significantly with the willingness to start metformin.</p><p><strong>Discussion: </strong>Exploratory research can only provide a first step in understanding the social acceptance of geroprotection measures. Nevertheless, this study clearly illustrates more well-known measures promoted by public health policy are also more accepted and used. Public health campaigns could consider the sex differences in the uptake of exercise and supplements, and future research may want to delve deeper into the role of facilitating trust relations between medical institutions and the public in promoting the use of geroprotective drugs.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"5 ","pages":"1440661"},"PeriodicalIF":3.3,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11573782/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142677741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telomere length and cognitive changes in 7,877 older UK adults of European ancestry.","authors":"Amy Packer, Leena Habiballa, Esteban Tato-Barcia, Gerome Breen, Helen Brooker, Anne Corbett, Ryan Arathimos, Clive Ballard, Adam Hampshire, Abbie Palmer, Danai Dima, Dag Aarsland, Byron Creese, Margherita Malanchini, Timothy R Powell","doi":"10.3389/fragi.2024.1480326","DOIUrl":"10.3389/fragi.2024.1480326","url":null,"abstract":"<p><strong>Background: </strong>Telomere length (TL) has been linked to cognitive function, decline and dementia. This study aimed to explore whether both measured TL and genetic disposition for TL predict dimensions of cognitive performance in a longitudinal sample of older UK adults.</p><p><strong>Methods: </strong>We analysed data from PROTECT study participants aged ≥50 years without a dementia diagnosis, who had completed longitudinal cognitive testing. We calculated polygenic scores for telomere length (PGS-TL) for 7,877 participants and measured relative telomere length (RTL) in a subgroup of 846 participants using DNA extracted from saliva samples collected within 6 months either side of their baseline cognitive testing. Latent growth models were used to examine whether RTL and PGS-TL predict both baseline and longitudinal changes in cognitive performance (4 time-points, annually).</p><p><strong>Results: </strong>In the whole sample, we did not observe significant associations between either measure of telomere length and initial or longitudinal changes in cognitive performance. Stratifying by median age, in older adults (≥ ∼62 years), longer baseline RTL showed a nominal association with poorer baseline verbal reasoning performance (<i>n</i> = 423, <i>M</i> _{<i>intercept</i>} = 47.58, <i>B</i> = -1.05, <i>p</i> = .011) and PGS-TL was associated with performance over time (<i>n</i> = 3,939; slope factor, <i>M</i> _<i>slope</i> = 3.23, <i>B</i> = -0.45, <i>p</i> = .001; <i>slope</i> ^<i>2</i> factor, <i>M</i> _<i>slope</i> ^<i>2</i> = 0.21, <i>B</i> = 0.13, <i>p</i> = .002).</p><p><strong>Conclusion: </strong>Our findings suggest either the absence of a significant relationship between telomere length (RTL and PGS-TL) and cognitive performance (baseline and change over time), or possibly a weak age-dependent and domain-specific relationship, in older adults of European ancestry. More research is needed in representative and ancestrally diverse samples over a longer assessment period. Alternative biological ageing indicators may still provide utility in the early detection of individuals at risk for cognitive decline (e.g., pace-of ageing epigenetic clocks).</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"5 ","pages":"1480326"},"PeriodicalIF":3.3,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11564160/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduction in the olfactory ability in aging <i>Mitf</i> mutant mice without evidence of neurodegeneration.","authors":"Fatich Mechmet, Eiríkur Steingrímsson, Petur Henry Petersen","doi":"10.3389/fragi.2024.1462900","DOIUrl":"https://doi.org/10.3389/fragi.2024.1462900","url":null,"abstract":"<p><p>Age-related decline occurs in most brain structures and sensory systems. An illustrative case is olfaction. The olfactory bulb (OB) undergoes deterioration with age, resulting in reduced olfactory ability. A decline in olfaction is also associated with early symptoms of neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). However, the underlying reasons are unclear. The microphthalmia-associated transcription factor (MITF) is expressed in the projection neurons (PNs) of the OB-the mitral and tufted (M/T) cells. Primary M/T cells from <i>Mitf</i> mutant mice show hyperactivity, potentially attributed to the reduced expression of a key potassium channel subunit, <i>Kcnd3</i>/Kv4.3. This influences intrinsic plasticity, an essential mechanism involving the non-synaptic regulation of neuronal activity. As neuronal hyperactivity often precedes neurodegenerative conditions, the current study aimed to determine whether the absence of <i>Mitf</i> causes degenerative effects during aging. Aged <i>Mitf</i> mutant mice showed reduced olfactory ability without inflammation. However, an increase in the expression of potassium channel subunit genes in the OBs of aged <i>Mitf</i> ^{<i>mi-vga9/mi-vga9</i>} mice suggests that during aging, compensatory mechanisms lead to stabilization.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"5 ","pages":"1462900"},"PeriodicalIF":3.3,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11543575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global burden of inflammatory bowel disease in the elderly: trends from 1990 to 2021 and projections to 2051.","authors":"Ying Liu, Ju Li, Guangxia Yang, Deqian Meng, Xianming Long, Kai Wang","doi":"10.3389/fragi.2024.1479928","DOIUrl":"https://doi.org/10.3389/fragi.2024.1479928","url":null,"abstract":"<p><strong>Background: </strong>This study aims to analyze the historical trends of inflammatory bowel disease (IBD) burden in the elderly from 1990 to 2021 and forecast future trends up to 2051.</p><p><strong>Methods: </strong>Data from the Global Burden of Disease Study 2021 were utilized. Age-standardized rates (ASR) for incidence, prevalence, mortality, and disability-adjusted life years (DALYs) were calculated. Estimated annual percentage changes (EAPCs) were computed to quantify temporal trends. A Bayesian Age-Period-Cohort model was employed to project future trends.</p><p><strong>Results: </strong>From 1990 to 2021, the global number of elderly IBD increased from 573,500 to 1,278,190. The age-standardized incidence rate (ASIR) rose from 8.01 to 8.77 per 100,000, while the age-standardized prevalence rate (ASPR) slightly decreased from 118.14 to 117.29 per 100,000. Death number increased from 14,400 to 33,490, but the age-standardized mortality rate decreased from 3.21 to 2.84 per 100,000. DALYs increased from 324,100 to 683,750, with the age-standardized DALYs rate declining from 68.78 to 60.88 per 100,000. Significant geographical variations were observed, with high Socio-demographic Index regions showing the highest burden. Projections suggest that by 2051, elderly IBD prevalence number may reach 2,316,000, with ASIR and ASPR potentially rising after 2035 and 2042, respectively. Deaths and DALYs are projected to increase to 75,000 and 1,401,000 respectively, despite continued declines in ASRs.</p><p><strong>Conclusion: </strong>The absolute burden of IBD in the elderly population is projected to increase substantially by 2051, despite decreasing ASRs. These findings underscore the need for tailored healthcare strategies and resource allocation to address the growing challenge of elderly IBD globally.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"5 ","pages":"1479928"},"PeriodicalIF":3.3,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11540814/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}