细胞自体克隆是实现真正年轻化的途径。

IF 3.3 Q2 GERIATRICS & GERONTOLOGY
Frontiers in aging Pub Date : 2024-07-29 eCollection Date: 2024-01-01 DOI:10.3389/fragi.2024.1429156
Lev Salnikov
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引用次数: 0

摘要

文章简要介绍了目前已知的老年保护和返老还童方法,介绍了其主要机制和局限性。为了克服返老还童过程的主要局限性,可以使用一种名为 "细胞自体免疫接种 "的过程。所建议的年轻化方法的原理如下:在细胞基因组中启动一个周期性的细胞核自体克隆过程,形成一个不稳定的子拷贝,随后自我消除。在这种情况下,细胞分裂过程会在细胞核分化阶段停止,而细胞本身不会随之发生物理分离。这一点对有丝分裂后的细胞尤为重要,因为在这种情况下,本体发生程序的 "单向 "线循环成一个 "环",就意味着它们将转变为可再生细胞。自体克隆机制的原型可能是已经知道的细胞适应其损伤量随时间不断增加的方式。它们是多倍体和非对称细胞分裂,依靠这两种方式可以获得细胞核分裂的可再生过程,即分裂后只剩下原来的细胞核。虽然这不是一项简单的任务,但利用分子和细胞生物学以及遗传学领域的现代知识,还是有可能找到解决这一问题的途径。要实现这一目标,需要做大量的工作,但预期结果证明这是正确的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cell autocloning as a pathway to their real rejuvenation.

The article gives a brief description of geroprotection and rejuvenation methods known to date, presenting their main mechanisms and limitations. To overcome the main limitations of the process of rejuvenation, it is possible to use a process called "cell autocloning." The principle of the proposed method of rejuvenation is as follows: a periodic process of autocloning of the cell nucleus is initiated in the cellular genome with the formation of one unstable daughter copy and its subsequent self-elimination. In this case, the process of cell division stops in the phase of nuclei divergence without subsequent physical separation of the cell itself. This is especially important for postmitotic cells, where the looping of the "unidirectional" line of the ontogenesis program into a "ring" will mean their transition into renewable cells. The prototype for autocloning mechanisms could be the already known ways in which cells adapt to the increasing amount of their damage over time. These are polyploidy and asymmetric cell division, relying on which it is possible to obtain a renewable process of cell nuclei division, when only the original nucleus remains as a result of division. Although this is not a simple task, there are possible pathways to its solution using approaches that can suggest modern knowledge from the field of molecular and cell biology and genetics. The realization of such a goal will require a lot of work, but the expected result justifies it.

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CiteScore
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