Frontiers in aging最新文献

{"title":"Individual differences in hearing decline predict region-specific brain and cognitive changes in healthy aging men.","authors":"Kamine Julie Jacobsen, Mostafa Mehdipour Ghazi, Reena Murmu Nielsen, Elaine Hoi Ning Ng, Nelly Shenton, Line Skødebjerg Kristensen, Olalla Urdanibia-Centelles, Sine Kongsbak Arvedsen, Henrik Bo Wiberg Larsson, Mark Bitch Vestergaard, Martin Lauritzen, Krisztina Benedek","doi":"10.3389/fragi.2026.1867663","DOIUrl":"10.3389/fragi.2026.1867663","url":null,"abstract":"<p><strong>Background: </strong>Cognitive decline in aging is heterogeneous and accelerates after approximately 60 years of age. Hearing decline is a common, potentially modifiable risk factor that may contribute to individual differences in cognitive aging and brain structural change. In addition to its cognitive consequences, hearing loss can impair communication and contribute to reduced social participation, loneliness, and poorer quality of life. However, the extent to which longitudinal changes in hearing predict cognitive performance and regional brain structure remains unclear.</p><p><strong>Methods: </strong>We assessed 51 healthy males from a longitudinal birth cohort extensively evaluated with cognitive testing and MRI across the lifespan. At ages 70 and 71 (recruited in 2024), participants completed four-frequency pure-tone audiometry (4PTA), audible contrast threshold (ACT), speech-in-noise tests (HINT), cognitive assessments, and structural MRI scans. All participants had a prior visit at age 63 ± 1 year (recruited in 2015-2018) with the same cognitive test battery. Previously, machine learning algorithm models were used to identify cognitive decline, and participants were clustered into four cognitive trajectories. These predefined clusters were used to examine whether hearing measures (4PTA, ACT, HINT) predicted cognitive outcomes and brain volume.</p><p><strong>Findings: </strong>The combination of PTA and HINT together showed the strongest contribution to classifying previously defined cognitive trajectory groups (p = 0.022). An XGBoost model with SHapley Additive exPlanations (SHAP) values identified bilaterally combined temporal lobe volume as key MRI feature influencing ACT, whereas cerebellum and fourth ventricle were key MRI features influencing HINT.</p><p><strong>Interpretation: </strong>These findings highlight complex hearing-cognition-brain interactions and support integrating diverse auditory measures into cognitive aging research.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"7 ","pages":"1867663"},"PeriodicalIF":4.9,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13461709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148726686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loneliness in older women: a multidimensional population-based study of social, health, and life-course factors.","authors":"Esther Cabrera, Meritxell Puyané, Marc Terradellas, Esther Limón, Ester Mateo, Enric Camón, Carme Planas, Rosario Delgado, Chaimae Lamrani, Carolina Chabrera","doi":"10.3389/fragi.2026.1858726","DOIUrl":"10.3389/fragi.2026.1858726","url":null,"abstract":"<p><strong>Introduction: </strong>Loneliness in older women is a major public health concern in ageing societies and a key determinant of healthy ageing. Despite its multidimensional nature, evidence on the relative contribution of social, health, and individual factors remains limited, particularly from a gender perspective.</p><p><strong>Methods: </strong>A cross-sectional population-based study was conducted in Catalonia using random sampling from the municipal census. Data were collected through face-to-face home interviews with 511 women. Loneliness was assessed with the 10-item Spanish version of the UCLA Loneliness Scale and analyzed as a binary outcome (moderate/severe vs. low or no loneliness). Explanatory variables were grouped into sociodemographic, social, clinical, functional, and quality-of-life domains. Crude and adjusted prevalence ratios were estimated using Poisson regression with robust variance.</p><p><strong>Results: </strong>Overall, 18.6% of participants reported moderate or severe loneliness. In crude analyses, loneliness was more frequent among women living alone, with lower income, weaker community belonging, greater social vulnerability, depressive symptoms, frailty, poorer physical performance, higher fall risk, and lower quality-of-life scores. In the fully adjusted model, living alone remained associated with higher loneliness prevalence (adjusted prevalence ratio 1.99, 95% confidence interval 1.13-3.50). Depressive symptoms showed the strongest associations, with adjusted prevalence ratios of 3.59 (95% confidence interval 2.27-5.68) for mild symptoms and 5.37 (95% confidence interval 2.72-10.61) for moderate symptoms, while other domains were not independently associated.</p><p><strong>Discussion: </strong>These findings suggest that emotional and social factors, particularly depressive symptoms and living alone, showed the strongest independent associations with loneliness among older women. These results provide evidence to inform the development of targeted and gender-sensitive strategies to prevent and address loneliness in later life.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"7 ","pages":"1858726"},"PeriodicalIF":4.9,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13461583/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148722058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondrial respiratory supercomplexes associated with longevity in mammals.","authors":"Shinichiro Suzuki, Kazuhiro Ikeda, Toshihiko Takeiwa, Kuniko Horie, Satoshi Inoue","doi":"10.3389/fragi.2026.1876149","DOIUrl":"10.3389/fragi.2026.1876149","url":null,"abstract":"<p><p>Because of population aging and morbidity expansion, extending healthspan has become a global challenge and it is required to elucidate molecular mechanisms underlying aging and age-related diseases. Mitochondrial dysfunction is a hallmark of aging, characterized by impaired oxidative phosphorylation, increased production of reactive oxygen species (ROS), and metabolic imbalance. Therefore, maintaining mitochondrial homeostasis is essential for healthspan. Mitochondrial respiratory chain complexes organize into higher-order assemblies known as supercomplexes (SCs), which enable to efficient energy or ATP production with repressed ROS generation. Notably, the assembly and stability of these SCs likely decline in aged mammals. In addition, factors such as COX7RP/SCAF1 and mitochondrial lipid cardiolipin have emerged as key regulators of SC assembly. In this review, we summarize the molecular assembly, physiological roles, and longevity implications of SC in healthy mammals. We further discuss emerging evidence supporting SC modulation as a potential strategy for promoting healthy aging.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"7 ","pages":"1876149"},"PeriodicalIF":4.9,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13461795/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148726763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Mechanistic redundancy and hierarchy of aging mechanisms: implications for strategies to extend healthspan and biomarker integration.","authors":"Maria Shvedova","doi":"10.3389/fragi.2026.1928559","DOIUrl":"https://doi.org/10.3389/fragi.2026.1928559","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.3389/fragi.2026.1776669.].</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"7 ","pages":"1928559"},"PeriodicalIF":4.9,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148714850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: User-centered approaches for designing assistive technologies to support older adults.","authors":"Samuel Olatunji, Neziha Akalin, Xiaomei Liu, Renato Ferreira Leitão Azevedo","doi":"10.3389/fragi.2026.1864923","DOIUrl":"10.3389/fragi.2026.1864923","url":null,"abstract":"","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"7 ","pages":"1864923"},"PeriodicalIF":4.9,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458185/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148714869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aging-related metabolic dysregulation in osteoporosis: mechanisms and therapeutic strategies.","authors":"Ruifeng Bai, Zishuai Huang, Xuan Tian, Yikai Liu, Yan Wang, Yu Su, Minjuan Li, Cheng Cheng, Jun Wu, Yejun Zha, Shuai Lu","doi":"10.3389/fragi.2026.1886673","DOIUrl":"10.3389/fragi.2026.1886673","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review aims to summarize recent advances in the mechanistic understanding of senile osteoporosis, with particular focus on the interconnected roles of cellular senescence, metabolic dysfunction, and systemic homeostatic imbalance in age-related skeletal degeneration.</p><p><strong>Recent findings: </strong>Emerging evidence indicates that senile osteoporosis is not driven solely by age-related hormonal decline, but by a complex network of biological processes involving senescence of bone marrow mesenchymal stem cells, accumulation of the senescence-associated secretory phenotype, mitochondrial dysfunction, oxidative stress, chronic low-grade inflammation, and disturbances in glucose and lipid metabolism. These alterations disrupt bone remodeling through key signaling pathways, including RANKL/OPG, Wnt/β-catenin, AMPK/SIRT1, NF-κB, and PI3K/Akt/mTOR. Together, these mechanisms impair osteogenesis, enhance osteoclastogenesis, deteriorate bone microarchitecture, and increase skeletal fragility. This broader pathophysiological framework may explain why conventional antiresorptive therapies, although effective in reducing bone resorption, often fail to fully restore the structural and functional deficits of the aging skeleton.</p><p><strong>Summary: </strong>Senile osteoporosis should be viewed as a systemic aging-related disorder involving both deterioration of the local bone microenvironment and whole-body metabolic dysregulation. Current evidence-based pharmacological treatments, including bisphosphonates, denosumab, teriparatide, abaloparatide, and romosozumab, remain central to fracture prevention and bone mass preservation. However, these interventions do not fully reverse the biological processes of skeletal aging. Emerging strategies targeting cellular senescence, the senescence-associated secretory phenotype, mitochondrial dysfunction, oxidative stress, nutrient-sensing pathways, and gut microbiota are under active investigation and may complement established therapies in the future. A clearer distinction between approved anti-osteoporotic drugs and experimental geroscience-based interventions is essential for translating mechanistic insights into clinically meaningful treatment strategies.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"7 ","pages":"1886673"},"PeriodicalIF":4.9,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13454395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148708831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms and management strategies for exacerbated bone loss following denosumab discontinuation.","authors":"Jiancheng Yang, Ming Yang, Yuhong Zeng","doi":"10.3389/fragi.2026.1886424","DOIUrl":"10.3389/fragi.2026.1886424","url":null,"abstract":"<p><p>Denosumab is a first-line therapy for osteoporosis, yet the rebound increase in bone turnover markers, rapid bone loss, and elevated fracture risk following its discontinuation have become major challenges in clinical management. This review systematically summarizes the potential mechanisms underlying exacerbated bone loss after denosumab withdrawal and the corresponding sequential treatment strategies. Current mechanistic studies have focused on several hypotheses, including the accumulation of osteomorphs and osteoclast precursors, imbalance in the RANKL/OPG ratio, uncoupling of bone remodeling, and osteocyte-mediated aberrant microdamage repair, which collectively contribute to the burst activation of bone resorption upon treatment cessation. To address this risk, international consensus recommends proactive sequential antiresorptive therapy for patients discontinuing denosumab. For short-term users (≤2.5 years), sequential administration of a single dose of zoledronic acid or alendronate can effectively preserve bone mineral density. For long-term users (>2.5 years), zoledronic acid should be initiated 6 months after the last dose, accompanied by intensive monitoring based on bone turnover markers and repeated dosing as needed. Additionally, emerging strategies such as early transition to romosozumab or alternating use with bisphosphonates have shown potential. Future studies are required to validate the underlying mechanisms in humans and to optimize sequential treatment regimens through prospective trials, thereby enabling individualized therapy and safe discontinuation.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"7 ","pages":"1886424"},"PeriodicalIF":4.9,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13447490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148690325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Machine learning-driven insights into cognitive aging and behavioral changes.","authors":"Jaiteg Singh, Amarjot Kaur Grewal, Sukhjit Singh Sehra, Sumeet Kaur Sehra","doi":"10.3389/fragi.2026.1919954","DOIUrl":"10.3389/fragi.2026.1919954","url":null,"abstract":"","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"7 ","pages":"1919954"},"PeriodicalIF":4.9,"publicationDate":"2026-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13447275/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148690250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loneliness and depression among older adults with cancer: an exploratory analysis of psychosocial constructs.","authors":"Addison Kitrel, Ellen Park, Elizabeth Schofield, Caraline Demirjian, Nisha Mehta, Erica Fortune, Christian Nelson, Rebecca Saracino","doi":"10.3389/fragi.2026.1821466","DOIUrl":"10.3389/fragi.2026.1821466","url":null,"abstract":"<p><strong>Introduction: </strong>Loneliness is a common and clinically significant concern among older adults with cancer (OACs; age ≥70), who often experience heightened psychological distress compounded by aging-related challenges. The current study sought to identify the nature and magnitude of the relationships between loneliness and other psychosocial variables.</p><p><strong>Methods: </strong>Data were drawn from the baseline assessment of an ongoing randomized controlled trial of psychotherapy for distressed OACs. Loneliness was assessed using the PROMIS Social Isolation measure. Depressive symptoms were measured using the Hospital Anxiety and Depression Scale-Depression subscale and the Center for Epidemiologic Studies Depression Scale. Psychosocial factors included attitudes toward aging, demoralization, and anxiety. Fully adjusted regression models were conducted to examine the independent associations of loneliness and psychosocial factors with depressive symptoms while accounting for demographic covariates.</p><p><strong>Results: </strong>Among 258 participants, social isolation was positively associated with depressive symptoms at the bivariate level (CES-D: r =.694; p <.001; HADS-D: r =.629, p <.001). In fully adjusted models, social isolation (p <.001), anxiety (p = 0.015), and demoralization (p = 0.001) were independently associated with depressive symptoms.</p><p><strong>Discussion: </strong>Findings suggest that loneliness is independently associated with depressive symptoms among distressed OACs, even when accounting for other psychosocial variables and demographic characteristics. Anxiety and demoralization showed stronger and more consistent associations with depressive symptoms than attitudes toward aging. Although causal direction cannot be inferred from cross-sectional data, results highlight potential psychosocial targets for intervention and underscore the need for longitudinal research to clarify the dynamic relationships among loneliness, psychosocial factors, and depression in OACs.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"7 ","pages":"1821466"},"PeriodicalIF":4.9,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13442528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148686843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Understanding the impact of loneliness and social isolation on the health of older adults with cancer.","authors":"Keith M Bellizzi, Rebecca M Saracino","doi":"10.3389/fragi.2026.1930051","DOIUrl":"https://doi.org/10.3389/fragi.2026.1930051","url":null,"abstract":"","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"7 ","pages":"1930051"},"PeriodicalIF":4.9,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13454724/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148708798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}