Frontiers in aging最新文献

{"title":"Ulcerative colitis (UC) in the elderly: diagnostic and therapeutic considerations.","authors":"Łucja Wróbel, Ewa Małecka-Wojciesko","doi":"10.3389/fragi.2026.1815043","DOIUrl":"https://doi.org/10.3389/fragi.2026.1815043","url":null,"abstract":"<p><p>Ulcerative colitis (UC) demonstrates a bimodal incidence distribution, with a significant second peak and the highest prevalence observed in individuals aged ≥60 years. The pathogenesis of elderly UC involves immunosenescence-manifested by Th17/Treg imbalance and the accumulation of cells with a pro-inflammatory senescence-associated secretory phenotype (SASP)-alongside age-related dysbiosis, increased intestinal permeability, and mitochondrial dysfunction that impairs mucosal regeneration. Clinically, older patients more frequently present with left-sided colitis, characterized by anemia and weight loss, while abdominal pain is less common. Managing geriatric UC is challenging due to inadequate colonoscopy preparation and complex differential diagnosis (e.g., colorectal cancer, ischemic colitis). Furthermore, older adults face a fivefold increased risk of <i>Clostridioides difficile</i> infection and a sharply rising risk of colorectal cancer if diagnosed after 70 years of age. While 5-aminosalicylic acid remains the first-line therapy, it requires renal monitoring. Conversely, steroids increase infection and osteoporosis risks, thiopurines are restricted due to myelotoxicity and malignancy risks, and among biologics, vedolizumab offers better safety than anti-TNF agents. Ultimately, managing UC in older adults requires a comprehensive, multidisciplinary approach that accounts for multimorbidity, polypharmacy, nutritional status, and mental health to optimize pharmacotherapy and mitigate high-risk surgical interventions.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"7 ","pages":"1815043"},"PeriodicalIF":4.9,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13481447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148802190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of anesthesia induction with ciprofol, propofol, and etomidate in elderly patients undergoing gastrointestinal endoscopy: a single center, prospective, double blind randomized controlled trial.","authors":"Yingchao Guan, Gang Zhou, Conghui Wang, Yusong Lin, Minghong Ju, Wen He, Xiaodong Wang","doi":"10.3389/fragi.2026.1842800","DOIUrl":"https://doi.org/10.3389/fragi.2026.1842800","url":null,"abstract":"<p><strong>Background: </strong>We compared benefits and adverse effects of anesthesia induction with ciprofol, propofol, and etomidate in elderly patients undergoing gastrointestinal endoscopy anesthesia.</p><p><strong>Methods: </strong>A total of 391 patients who underwent painless gastrointestinal endoscopy; age ≥ 60 years; ASA I-III were involved between April 30 and 30 December 2025. The primary outcome was hypoxemia or apnea during anesthesia. Secondary outcomes included systolic blood pressure (SBP), diastolic blood pressure (DBP), mean blood pressure (MBP), heart rate (HR), respiratory rate (RR), SpO₂ during surgery, and adverse reactions such as coughing dizziness and agitation.</p><p><strong>Results: </strong>No differences were found in hypoxemia and apnea. Except for RR, other hemodynamic and respiratory parameters were significantly different among the groups (p < 0.05), and the degree of blood pressure decline in group E was smaller than groups C and P. Group E patients had lower intraoperative hypotension (p = 0.007) and lower demand for vasoactive drugs (p = 0.006). The injection pain scores in groups C and E were lower, but patients in group E had a higher incidence of myoclonus, and the proportion of coughing and hiccups during endoscopy was higher in group E. The incidence of dizziness was lower in Group C.</p><p><strong>Conclusion: </strong>No significant differences were observed in the incidence of hypoxemia and apnea among three groups. Etomidate has the advantage of stable hemodynamics; however, the incidence of myoclonus, bucking, and hiccups is high. Injection pain occurred less frequently with ciprofol and etomidate, while ciprofol was associated with a low incidence of postoperative dizziness.</p><p><strong>Clinical trail registration: </strong>https://www.chictr.org.cn/showproj.html?proj=269837, identifier ChiCTR2500101280.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"7 ","pages":"1842800"},"PeriodicalIF":4.9,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13478072/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Promoting physical activity and physical functioning among residents in nursing homes - lessons learnt by the PROGRESS project.","authors":"Vera Belkin, Berit K Labott, Claudia Voelcker-Rehage","doi":"10.3389/fragi.2026.1793208","DOIUrl":"https://doi.org/10.3389/fragi.2026.1793208","url":null,"abstract":"<p><strong>Introduction: </strong>Nursing home residents show high sedentary behavior and limited physical functioning, while structural constraints hinder sustainable prevention. This study examined how group-based physical exercise and environmental interventions, such as activity-promoting materials and interior design, can be integrated into everyday care to promote a physical activity-promoting culture in nursing homes and identified key organizational and individual determinants of sustainable implementation.</p><p><strong>Methods: </strong>PROGRESS was a participatory, cluster-randomized cross-over trial conducted in seven nursing homes in the Münster area in Germany. Residents received two of four guided or non-guided exercise (n = 62) and/or environmental interventions (e.g., activity posters, a seated bike ergometer, walking brochures/routes; n = 65). Data from attendance logs, participatory workshops, and a follow-up questionnaire at t4 (the fourth and final measurement time point, approximately 50 weeks after baseline assessment; n = 73) were analyzed using descriptive statistics and structured content analysis for open-ended feedback. Based on these findings, the PROGRESS pyramid was developed as a framework for sustainable implementation of physical activity into everyday care.</p><p><strong>Results: </strong>Of the 73 participants, 90.4% attended at least one guided intervention session. Participation was highest in the exercise intervention, with most residents reporting weekly engagement. In contrast, engagement with environmental interventions was more variable and strongly dependent on staff support, with 63.0% of residents reporting no independent use of physical activity opportunities. Comparisons between self-reported participation and attendance records revealed substantial discrepancies, particularly for environmental interventions. Overall satisfaction with the project was high (mean = 2.7 ± 2.5 on a 0 = happy to 10 = angry scale). Most participants supported continuation of the interventions (86.0%), and 64.0% reported perceived personal benefits. Organizational and individual determinants jointly shaped participation.</p><p><strong>Conclusion: </strong>In order to promote physical activity and functioning sustainably in nursing homes, it is necessary to address organizational conditions and individual needs in a coordinated manner. The PROGRESS pyramid translates these findings into a practical framework comprising organizational and communicational foundations, resident participation, education, and staff qualification to guide the long-term integration of exercise and environmental interventions into daily routine.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"7 ","pages":"1793208"},"PeriodicalIF":4.9,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13478141/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Guided positional stabilization: a hypothesis on the role of targeted interfaces in enhancing upright stability among frail older adults.","authors":"Mayur Bhatt, Harikrashna Bhatt","doi":"10.3389/fragi.2026.1886928","DOIUrl":"https://doi.org/10.3389/fragi.2026.1886928","url":null,"abstract":"<p><p>Elderly adults are at a higher risk of falls due to many reasons including issues in balance, coordination and overall sensory responsiveness. Falls ultimately threaten health and result in the fear of falling this causes restricted mobility and further decrease in health. Although there are traditional interventions such as railings, walkers or balance therapy which aim to reduce falls, they often function on compensatory mechanisms with little for postural regulation. We hypothesize that Guided Positional Stabilization (GZ) which use light strategically situated contact interfaces, can improve upright stability in frail elderly individuals by stimulating proprioceptive and tactile pathways. GZ is not a support aid rather a neurosensory framework that engages the nervous system in reactive and anticipatory balance corrections. Learning from concepts in biomechanics, neuroscience and geriatrics, this article presents the design requirements, theory, and possible clinical applications of GZ in fall prevention. We also put forward a pilot research agenda for testing the effectiveness of GZ in real world environments.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"7 ","pages":"1886928"},"PeriodicalIF":4.9,"publicationDate":"2026-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13478680/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148801766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Chinese medicine for frailty and sarcopenia in aging populations: a bibliometric and visualized analysis of research trajectories and emerging frontiers.","authors":"Xiaoshuo He, Lisha Sun, Huizhen Chen, Qiu Chen","doi":"10.3389/fragi.2026.1854710","DOIUrl":"https://doi.org/10.3389/fragi.2026.1854710","url":null,"abstract":"<p><strong>Background: </strong>By 2050, the proportion of people aged 65 and older is projected to reach 16% globally, up from roughly 10% in 2022. Frailty and sarcopenia are among the most clinically consequential age-related conditions, independently associated with falls, hospitalization, and death. Traditional Chinese medicine (TCM)-encompassing herbal formulas, acupuncture, tai chi, and qigong-has shown therapeutic potential for both conditions, yet no systematic bibliometric overview of this research area exists.</p><p><strong>Methods: </strong>Publications on TCM interventions for frailty and sarcopenia were retrieved from the Web of Science Core Collection on 14 March 2026. After a four-phase screening (identification, document-type screening, title/abstract relevance screening, and inclusion), 405 publications were retained. Bibliometric and visualization analyses were performed using CiteSpace (6.2.R6), VOSviewer (1.6.20), and the R package bibliometrix (4.3.0). To avoid tautological bias, all Boolean search terms were removed from the keyword field before every keyword-based analysis (co-occurrence, growth, burst detection, thematic mapping, and thematic evolution).</p><p><strong>Results: </strong>A total of 405 publications from 2011 to 2026 were included. Annual output grew sharply after 2019 and peaked at 77 publications in 2025. China was the overwhelmingly dominant contributor (910 author appearances), followed by the USA (152) and Japan (131). With search terms excluded, keyword co-occurrence resolved into interpretable clusters: exercise/physical activity/aging; randomized controlled trials of muscle strength and physical function; falls, balance and rehabilitation; evidence synthesis (systematic review/meta-analysis); and cachexia/nutrition/skeletal-muscle inflammation. Burst detection showed early activity in falls, balance, elderly, and exercise (2011-2018) shifting toward network pharmacology, molecular docking, ninjin'yoeito, and nutrition (2020-2026). Co-citation analysis identified the seminal frailty-phenotype study as the foundational reference, with a strong tai-chi fall-prevention trial base and the EWGSOP/AWGS sarcopenia consensus definitions as intellectual pillars.</p><p><strong>Conclusion: </strong>TCM research on frailty and sarcopenia has grown substantially, particularly since 2019, with China as the primary driver and Japan and the USA as secondary contributors. Network pharmacology, nutrition-based intervention science, and oxidative-stress/inflammation mechanisms represent the most promising emerging frontiers. These findings provide a structured evidence map for prioritizing future research and translational efforts in TCM-based geriatric care.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"7 ","pages":"1854710"},"PeriodicalIF":4.9,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13473409/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preliminary assessment of sarcopenic obesity risk after sleeve gastrectomy using dual-modality imaging: a six-month MRI and DXA pilot study in women.","authors":"Matej Pekar, Veronika Horka, Denisa Hyvlova, Radovan Jirik, Jaroslav Uchytil, Marketa Rygelova, Petr Kutac, Hana Tomaskova, Dominik Vilimek, Pavol Holeczy, Jan Maca, Marek Buzga","doi":"10.3389/fragi.2026.1913282","DOIUrl":"https://doi.org/10.3389/fragi.2026.1913282","url":null,"abstract":"<p><strong>Introduction: </strong>Sarcopenic obesity (SO) is characterized by excess adiposity combined with skeletal muscle loss, but the absence of standardized diagnostic criteria makes interpretation of muscle tissue changes after bariatric surgery difficult, and different diagnostic indices can yield markedly different conclusions about the same patients.</p><p><strong>Methods: </strong>This preliminary analysis from the SarxOb trial (NCT04617392) compared several body-composition indices for detecting SO risk in eleven female patients undergoing laparoscopic sleeve gastrectomy, prospectively followed for six months using dual-modality imaging - magnetic resonance imaging (MRI) and dual-energy X-ray absorptiometry (DXA).</p><p><strong>Results: </strong>Lean body mass (LBM) decreased significantly from 56.3 ± 6.2 kg to 47.6 ± 6.0 kg (p < 0.001), while LBM as a percentage of total body weight increased from 50.4 ± 3.2% to 57.9 ± 4.3% (p = 0.003), reflecting a disproportionately greater loss of fat mass than lean mass. Appendicular skeletal muscle mass (ASM) decreased from 24.5 ± 3.3 kg to 20.1 ± 2.9 kg (p < 0.001). Critically, the choice of diagnostic index changed the apparent prevalence of SO risk entirely: by the ASM and ASM/height² indices, no patient met criteria for SO risk at any timepoint, whereas by the weight-adjusted ASM/weight index recommended by the 2022 ESPEN/EASO consensus statement, ten of eleven patients met SO-risk criteria at baseline and at one month postoperatively, decreasing to four of eleven by six months. MRI-based quantification of the right lower limb corroborated the DXA findings, showing a parallel increase in the muscle-to-adipose tissue ratio.</p><p><strong>Conclusion: </strong>These results indicate that weight-adjusted indices detect a substantially higher burden of SO risk than traditional height-adjusted indices in this population, and that the choice of diagnostic index, not only the imaging modality used, is a major source of disagreement in reported SO risk prevalence after bariatric surgery. Given the small sample size inherent to this interim analysis of an ongoing trial, these findings should be considered exploratory and hypothesis-generating rather than confirmatory. As functional muscle assessment was not available in this interim report, these findings should be interpreted as SO risk by body-composition criteria rather than a complete EWGSOP2/ESPEN-EASO diagnosis.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"7 ","pages":"1913282"},"PeriodicalIF":4.9,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13473381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional association between functional difficulty and multimorbidity among older adults in India.","authors":"Priyanka Patel, Harihar Sahoo, Ravi Prakash Jha, Krittika Bhattacharyya, Mayank Singh","doi":"10.3389/fragi.2026.1871767","DOIUrl":"https://doi.org/10.3389/fragi.2026.1871767","url":null,"abstract":"<p><strong>Introduction: </strong>The demographic landscape of India is rapidly transforming as the population ages, with projections indicating a substantial in elderly individuals by 2050.</p><p><strong>Methods: </strong>This study delves into the bidirectional association between functional difficulty and multimorbidity among older adults, utilizing data from the Longitudinal Ageing Study in India (LASI) 2017-18. Covering 31,902 participants aged 60 and above, the research examines the prevalence and impact of multiple chronic conditions and their association with functional abilities categorized into Activities of Daily Living (ADL) and Instrumental Activities of Daily Living (IADL).</p><p><strong>Results: </strong>The findings reveal a significant association between multimorbidity and functional limitations. Functional difficulty, both in ADL and IADL, is shown to be positively associated with an increase in likelihood of multimorbidity. The incidence of severe ADL difficulties, for instance, corresponds with a 3.97 times higher likelihood (Confidence Interval CI: 3.47-4.54) of multimorbidity. Severe difficulties in IADL were associated with 2.92 times increase (CI: 2.65-3.20) in multimorbidity risk. Similarly, the presence of multimorbidity escalates the probability of encountering functional difficulties. Participants with multimorbidity showed a 3.89 times increased risk (CI: 3.40-4.45) of severe ADL limitations and a 2.84 times increased risk (CI: 2.58-3.11) for severe IADL limitations.</p><p><strong>Conclusion: </strong>This research underscores the critical need for integrated health interventions that concurrently address chronic disease management and functional ability to enhance the quality of life for India's aging population.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"7 ","pages":"1871767"},"PeriodicalIF":4.9,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13473446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148765474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advances in anti-aging Drug research leveraging multi-omics and artificial intelligence.","authors":"Lijuan Gao, Yongsheng Qin, Yudai Xu, Ju Su, Zhicheng Cai, Zhongyu Hu, Ruohu Shi, Xinyi Mu, Shiying Cen, Chanchan Xiao, Guobing Chen","doi":"10.3389/fragi.2026.1868486","DOIUrl":"https://doi.org/10.3389/fragi.2026.1868486","url":null,"abstract":"<p><p>The intensifying global population aging has rendered the development of anti-aging drugs a core challenge in the life sciences domain. Traditional models struggle to address the systemic and networked nature of aging. Multi-omics technologies provide a panoramic perspective for deciphering molecular networks of aging, while Artificial Intelligence (AI) has demonstrated significant advantages in target discovery, drug screening, and clinical trial optimization. This review systematically elaborates on the pathological characteristics and molecular mechanisms of aging, analyzes the application paradigms of multi-omics in biomarker screening, mechanism elucidation, and high-throughput screening, and discusses the core value and technical bottlenecks of AI in target prediction, virtual screening, and trial design. Simultaneously, this paper addresses critical challenges including ethical controversies and data standardization currently confronting the field, and explores the prospects of precision anti-aging drug development and personalized treatment strategies driven by deep integration of multi-omics and AI. This approach offers novel theoretical frameworks and practical pathways for extending human healthspan.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"7 ","pages":"1868486"},"PeriodicalIF":4.9,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13469437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148761507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of resistance training on the cognitive health of older adults: a narrative review.","authors":"Marie Pullerits, Ivi Vaher","doi":"10.3389/fragi.2026.1872457","DOIUrl":"https://doi.org/10.3389/fragi.2026.1872457","url":null,"abstract":"<p><strong>Background: </strong>Population aging is associated with an increased risk of cognitive decline, highlighting the need for effective and accessible interventions to support cognitive health in older adults. Resistance training has emerged as a promising non-pharmacological strategy; however, the role of training intensity in optimizing cognitive outcomes remains unclear.</p><p><strong>Methods: </strong>This narrative review synthesizes 28 peer-reviewed publications, representing 24 independent study samples, published between 2014 and 2024 that examined the effects of resistance training intensity on cognitive function and related physiological markers in older adults.</p><p><strong>Results: </strong>Evidence indicates that low-, moderate-, and high-intensity resistance training can improve cognitive performance and markers of overall brain and physiological health, including neurotrophic factors, inflammation, and cerebral blood flow. Reported benefits include improvements in executive function, memory, processing speed, and spatial abilities. Moderate-intensity resistance training (approximately 60%-79% of one-repetition maximum) showed the most consistent benefits across studies, though direct intensity comparisons remain limited.</p><p><strong>Conclusions: </strong>Resistance training, particularly at moderate intensity, appears to be a feasible and effective strategy for supporting cognitive health in older adults, although further research is needed to determine optimal training prescriptions and long-term effects.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"7 ","pages":"1872457"},"PeriodicalIF":4.9,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13469083/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148765834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary factors and MRI-Defined synovial inflammation progression in knee osteoarthritis: a longitudinal mixed-effects analysis from the osteoarthritis initiative.","authors":"Yin Wang, Ming Chen","doi":"10.3389/fragi.2026.1877396","DOIUrl":"10.3389/fragi.2026.1877396","url":null,"abstract":"<p><strong>Background: </strong>Dietary factors have been implicated in the development and progression of knee osteoarthritis (KOA), yet their role in modulating synovial inflammation remains unclear, particularly when assessed using quantitative MRI. This study aimed to investigate the cross-sectional and longitudinal associations between dietary intake and MRI-defined effusion-synovitis (ES) in knees at risk of KOA.</p><p><strong>Methods: </strong>This was a secondary analysis based on the Pivotal OAI MR Imaging Analyses incidence OA (POMA_INCOA) sub-cohort. Dietary exposures were derived from the Block Brief 2000 food frequency questionnaire. The primary outcomes were baseline ES volume and 12-month change in ES volume (ΔES). Linear mixed-effects models with participant-specific random intercepts were used to account for within-subject correlation due to bilateral knees. Models were adjusted for age, sex, body mass index, baseline ES volume (for longitudinal models), and Kellgren-Lawrence grade (KLG). Sensitivity analyses included additional adjustment for physical activity and diabetes, as well as alternative outcome specifications (winsorization and categorical progression models).</p><p><strong>Results: </strong>A total of 659 knees from 620 participants were analyzed. In cross-sectional analyses, a higher intake of meat, fish, poultry, eggs, and legumes was significantly associated with a larger baseline ES volume (β = 0.452, 95% CI: 0.075 to 0.829, p = 0.019), though this association did not retain statistical significance after stringent FDR correction (FDR-adjusted p > 0.050). In longitudinal analyses, no dietary variables, including percentage of energy from fat (β = -0.005, 95% CI: -0.150 to 0.006, p = 0.383), demonstrated a statistically significant association with 12-month ΔES. This lack of longitudinal association remained consistent across all sensitivity analyses, including models adjusted for physical activity and diabetes, and those using winsorized or binary progression outcomes (all p > 0.05).</p><p><strong>Conclusion: </strong>While specific protein-rich food groups are cross-sectionally linked to baseline synovial inflammation volume, dietary factors are not robustly associated with the short-term progression of effusion-synovitis in knees at risk of KOA. These findings suggest that dietary intake may correlate with the inflammatory \"set-point\" of the joint but has limited influence on active 12-month inflammatory fluctuations, highlighting the complexity of inflammatory mechanisms in early KOA.</p>","PeriodicalId":73061,"journal":{"name":"Frontiers in aging","volume":"7 ","pages":"1877396"},"PeriodicalIF":4.9,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13461594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148726107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}