Fortune journal of health sciences最新文献

{"title":"Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency in Neonates Presenting with Indirect Hyperbilirubinemia in Neonatal Intensive Care Unit of Tertiary Health Care Center of Pakistan: Is the Trend Changing with Change in Consanguineous Marriages?","authors":"A. Jamali, Aasma Kayani, Anam Zubair, R. Noreen, S. Fatima","doi":"10.26502/fjhs.077","DOIUrl":"https://doi.org/10.26502/fjhs.077","url":null,"abstract":"Introduction: G6PD is an X-linked enzyme that catalyzes the first step in the HMP pathway to produces NADPH which is required for regeneration of the reduced form of glutathione (GSH). GSH is essential for the detoxification of hydrogen peroxide, especially in RBCs, which rely only on this pathway. There has been some declining trend in consanguineous marriages since last 3 decades in Pakistan, so we are conducting this study to find out whether this change lead to decrease in the frequency of G6PD deficiency in the country. Materials and Methods: This was a prospective cross-sectional study, using non-probability consecutive sampling technique, conducted at the Neonatal Unit of Civil Hospital, Karachi during 2016-17, on 144 neonates with indirect hyperbilirubinemia. The study was approved by the Ethical Review Committee of the Civil Hospital, Dow University of Health Sciences Karachi. Results: The mean age ± SD of neonates was 10.63±3.48 days and the majority were males (68%). The majority of neonates presented after the 5th day of their life i.e. 87.5%. G6PD deficiency was present in 8.3% of the neonates with indirect hyperbilirubinemia. Consanguinity was present in around 50% of the neonates who presented with neonatal jaundice. The overall mean total serum bilirubin, hemoglobin, hematocrit and reticulocyte count were 15.57±2.87 (mg/dl), 14.22±0.48 g/dl, 45.57±3.31%, and 0.84±0.32 % respectively. Most of the mothers (22.2%) have blood groups AB +ve and B +ve and the most babies (28.5%) have A +ve blood group. Conclusion: Male gender and age 5 days or less had significantly high G6PD deficiency. Although consanguineous marriages have decreased only slightly, no significant effect on G6PD deficiency is found.","PeriodicalId":73052,"journal":{"name":"Fortune journal of health sciences","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Married Annual Income Threshold for Survival Days among Both Elderly Suburban and Rural Dwellers","authors":"T. Hoshi, Sayuri Kodama, Sugako Kurimori, K. Fujita","doi":"10.26502/fjhs.082","DOIUrl":"https://doi.org/10.26502/fjhs.082","url":null,"abstract":"Objective: The purpose of this study was to make clear the relationship the survival days and the threshold of yearly marital income for both the suburban and rural elderly dwellers. Method: A total number of 13,195(response rate of 80.2%) living the suburban city of Tokyo. On the ei ther hand a total number of 5,320(response rate of 89.2%) living the rural town located in the middle of Kyusyu Island. Data were collected through self-administered questionnaires, with informed consent including marital yearly income. All of participants were followed and checked their survival status for 2,160 days. Data were analyzed by using SPSS28.0J for Windows. Results: In results of this analyses, survival days are significantly correlated with yearly marital income for both fields and sexes. 2.5 million yen for both sexes may be pointed out as a threshold marital yearly income for the rural elderly dwellers. On the other hand, 4.5 million yen may be pointed out as a threshold marital yearly income for the suburban elderly dwellers for both sexes. Elderly living in the rural area had a lower annual family income of about 0.83 to 1.5 million yen lower than those in the suburbs, but the length of survival day was almost similar. Conclusion: In results of this analyses, survival days are significantly correlated with yearly marital income for both fields and sexes. Future research is needed to make clear the relationships between equivalent income and survival days for both another areas and generations and also make clear the causal structure relationship.","PeriodicalId":73052,"journal":{"name":"Fortune journal of health sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of a Polyherbal Unani drug as an Adjuvant Therapy in type-2 diabetes mellitus: a double blind, Randomized, Placebo Controlled Study","authors":"Y. Shamsi, Manju Sharma, A. Jabeen, Wasi Akhtar","doi":"10.26502/fjhs.045","DOIUrl":"https://doi.org/10.26502/fjhs.045","url":null,"abstract":"Efficacy and Safety of a Polyherbal Unani drug as an Adjuvant Therapy in type-2 diabetes mellitus: a double-blind, Abstract Background This double‑blind, randomized, placebo‑controlled study was conducted to assess the efficacy and safety of a polyherbal Unani drug as adjuvant therapy in Patients with Type-2 Diabetes who were inadequately controlled with Metformin monotherapy. Methods Patients who had inadequate glycaemic control (HbA1c between 7% to 10%) despite Metformin therapy were randomized into Unani Adjuvant therapy (n=40) and placebo (n = 38) groups. Patients were administered either Unani drug or Placebo at a dose of Compared with the Placebo group, Unani drug significantly decreased fasting plasma glucose levels (-26. 34 ± 11.73, p= 0.002 vs -4.82 ± 2.63 mg/dl, p= 0.089) and postprandial plasma glucose (-60.02 ± 10.18 mg/dl, p= 0.001 vs -18.70 ± 2.06 mg/dl, p= 0.039). Conclusion Unani polyherbal drug as an add on therapy to Metformin in patients with type 2 diabetes who were not at their goal for glycaemic control with Metformin monotherapy produced significant reduction in HbA1c, FPG and PPG levels. Unani drug (or Placebo) add on therapy with Metformin was well tolerated, and showed an overall safety profile similar to placebo.","PeriodicalId":73052,"journal":{"name":"Fortune journal of health sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69346926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Seasonality of Human Coronaviruses and Future Implications for SARS-CoV-2","authors":"Alan T. Evangelista, A. Abdalla","doi":"10.26502/fjhs.048","DOIUrl":"https://doi.org/10.26502/fjhs.048","url":null,"abstract":"The seasonality of influenza viruses and endemic human coronaviruses was tracked over an 8-year period (2013-2020) to assess key epidemiologic reduction points in disease incidence for an urban area in the northeast United States. Patients admitted to a pediatric hospital with worsening respiratory symptoms were tested using a multiplex PCR assay from nasopharyngeal swabs. The additive seasonal effects of outdoor temperatures and indoor relative humidity (RH) were evaluated. The 8-year average peak activity of human coronaviruses occurred in the first week of January, when droplet, aerosol, and contact transmission was enabled by the low indoor RH of 20-30%. Previous studies have shown that an increase in RH from 30% to 50% has been associated with markedly reduced viability and transmission of influenza virus and animal coronaviruses. As disease incidence was reduced by 50% in early March, to 75% in early April, to greater than 99% at the end of April, a relationship was observed from colder outdoor temperatures in January with a low indoor RH to a gradual increase in outdoor temperatures in April with an indoor RH up to 50%. As a lipid-bound, enveloped virus with similar size characteristics to endemic human coronaviruses, SARS-CoV-2 should be subject to the same dynamics of reduced viability and transmission with the seasonal increase in indoor relative humidity. Major factors in the reduction of community SARS-CoV-2 can be attributed to vaccination, acquired natural immunity post-infection, indoor mask-wearing, social distancing, and contact tracing. In addition to these factors, the seasonal effect of the transitioning from lower to higher indoor RH with increasing outdoor temperatures could contribute to the future seasonality of SARS-CoV-2 Fortune J Health Sci 2022; 5 (1): 98-109 DOI: 10.26502/fjhs.048 Fortune Journal of Health Sciences Vol. 5 No. 1 Mar 2022. 99 cases. Over the 8-year period of this study, human coronavirus activity displayed a greater than 99% incidence reduction in the months of June through September, and the future implication would be that SARS-Cov-2 may follow a similar pattern.","PeriodicalId":73052,"journal":{"name":"Fortune journal of health sciences","volume":"2021 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69346979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Web-Based Student Internship Portal for Students of Health Colleges","authors":"Abdulellah Modhi ALSOLAIS","doi":"10.26502/fjhs.072","DOIUrl":"https://doi.org/10.26502/fjhs.072","url":null,"abstract":"Introduction: Information technology is used as a communication tool in colleges of applied medical sciences, but its optimal use in internship program is still low. Aim and objectives: This study aims to develop a web-based information system for student internships and to provide students with nursing information, skills and experience necessary to qualify them as highly competent nurses. Methods: The system is built using interactive website technology based on four main components, namely students, supervisors, industry and coordinators. The web-based student placement system includes information functions, schedules, enrolments, portfolio reports, completion reports, database backup and guidance systems. PHP, Bootstrap, CSS, HTML, JavaScript, MySQL database and Apache web server are the technologies used to develop the web-based internship information system. Results: The results show that the resulting system can be used to support the student internship program for all parties involved. Conclusion: This system can help students, supervisors and coordinators in running internship program. ,","PeriodicalId":73052,"journal":{"name":"Fortune journal of health sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma Prolidase Level is a Reliable Biomarker to Predict Polycystic Ovary Syndrome","authors":"A. M., Rahman Akms, Patwary T, Jahan Li, T. R","doi":"10.26502/fjhs.086","DOIUrl":"https://doi.org/10.26502/fjhs.086","url":null,"abstract":"","PeriodicalId":73052,"journal":{"name":"Fortune journal of health sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intimate Partner Violence among Pregnant Women and Associated Factors in Negelle Borena Town Guji Zone, South Oromia","authors":"Kebebush Worku, H. Lami, G. Arero","doi":"10.26502/fjhs.075","DOIUrl":"https://doi.org/10.26502/fjhs.075","url":null,"abstract":"Background : Intimate partner violence is an important public health and human rights issue. Intimate partner violence during pregnancy has been found to be associated with fatal and non-fatal adverse health outcomes for the pregnant woman and her baby. The aim of this study is to determine the magnitude of intimate partner violence among pregnant mothers and associated factors. Objective : To assess Intimate partner violence among pregnant women and associated factors in Negelle Borena town in the selected public health facility 2020. Methods : Facility based cross-sectional study was carried out from Oct15 –Dec15/2020. Face to face interviews were conducted using a pre-tested structured questionnaire. The collected data was entered into Epi info version 7.2.1.0 and then exported into Statical package for social science version 20 for analysis. Descriptive statistics were conducted. Bivariate analysis was done to select candidate variable for multivariate analysis. Finally, variables which had significant associations with intimate violence during pregnancy were identified on the basis of p-value<0.05 and AOR with 95% CI. Result : About 44.3% (95% CI 44.2-44.4) of pregnant women had faced at least one form of intimate partner violence during the current pregnancy. Psychological Sexual physical were forms of the respondents was encountered.","PeriodicalId":73052,"journal":{"name":"Fortune journal of health sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Associated with the Low Immunization Coverage in the Second Year of Life in the Central Region of Burkina Faso","authors":"Daniel Koala, Marie-Laure Kleme, I. Ouédraogo","doi":"10.26502/fjhs.089","DOIUrl":"https://doi.org/10.26502/fjhs.089","url":null,"abstract":"Introduction: The second year of life immunization is the administration of vaccines to a child between 12 and 24 months of age. After seven years of implementation of this immunization, the coverage remains low. This study was to understand the factors associated with low immunization coverage in the second year of life in Burkina Faso. Methods: The LQAS method was used to conduct a cross-sectional household survey of children aged 24 to 35 months in two health districts in the Central region. A two-level random sampling was used. Eighteen health facilities were randomly selected and then in each health facility, 1 to 4 villages were randomly selected for the study. The households were visited to collect the data. In the selected health facilities, the EPI manager and health facilities manager were questioned about vaccination during the second year of life. Results: Forgetting to vaccinate the child (25.1%), lack of time to go to health facilities on immunization day (23.3%), long waiting time in health facilities (11.0%) and far distance from the health facilities (11.0%) are the reasons given by mothers whose children did not receive MR2. Multiparous mothers were vaccinated with MR2 than Primiparous mothers (aOR = 2.4 et CI 95%=1.5 – 4.0). According to health workers, the main reasons were the lack of vaccine in 29.6% of cases and that there were not enough children to open 10 doses vial of the vaccine in 18.5% of cases. Conclusion: Targeted interventions are needed to address these contributing factors to poor immunization coverage.","PeriodicalId":73052,"journal":{"name":"Fortune journal of health sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Cardio Exercise, Resistance Training, or Combined Exercising on Cardiovascular Disease Risk Factors in Type 2 Diabetes Patients","authors":"Jyoti Prakash Lal Karn, N. Kumar","doi":"10.26502/fjhs.078","DOIUrl":"https://doi.org/10.26502/fjhs.078","url":null,"abstract":"Type 2 diabetes (T2D) and cardiovascular disease (CVD) complications are among the leading causes of mortality today. Since the two conditions are comorbidities, there are also high chances of them shortening the lives of patients. Despite them being leading causes of mortality, they can be easily controlled by integrating interventions. Strength training and cardio are some of the recommended exercises for the management of these conditions. Cardio exercises are considered effective in reducing body weight, while strength training is considered effective in increasing lean body mass. When combined, a person can enjoy both benefits in improving health. This study was designed to assess the impacts of strength training, aerobic exercises, and a mixture of exercises plus other interventions in managing T2D. In a retrospective study involving 320 patients, the results showed that even though one category of exercise alone had a significant impact in improving the management of the conditions, combined exercises plus other interventions had more positive impacts.","PeriodicalId":73052,"journal":{"name":"Fortune journal of health sciences","volume":"99 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Diversity of Plasmodium falciparum before and after intensive and massive relocation of populations into Yaoundé, Cameroon","authors":"Akindeh Mbuh Nji, A. Ekollo Mbange, Abdel Aziz Selly-Ngaloumo","doi":"10.26502/fjhs.065","DOIUrl":"https://doi.org/10.26502/fjhs.065","url":null,"abstract":"massive Abstract The introduction of new, genetically diverse and divergent populations of Plasmodium falciparum parasites into a given location, due to population influx, may have serious public health consequences. This study compared the genetic diversity (GD) of P. falciparum amongst Cameroonian populations sampled before (2014) and after (2018) intensive and massive relocations due to civil unrest, from affected regions with different malaria dynamics to the capital city Yaounde. For each time point, a subset of 50 samples was retrieved from a pool of samples collected from participant children aged between 6 months and 18 years and adults attending the hospital for outpatient consultation. To precisely assess the breadth of P. falciparum diversity, genotyping was performed using 2 PCR-based techniques which were further evaluated for their performance: nested-PCR targeting the merozoite surface protein 2 ( msp2 ) gene and Random Amplified Polymorphic DNA (RAPD-PCR) . Three of the 6 RAPD primers used (R8, E8, L12) yielded useful polymorphic patterns with higher genotyping rates (91-95%) than nested-PCR (67%). There was a significant difference between the 4 (3RAPD and msp2) primers used (ANOVA; P<0.001 ). Based on msp2 , the Multiplicity of Infection in 2014 was greater than in 2018 (2.28 vs. 1.97). The calculated mean of GD parameters across years and markers showed RAPD-R8 had the highest index of GD (Shannon’s Index, Unbiased Nei-GD) except for the Percentage of Polymorphic Loci. These indices, based on RAPD-R8, confirmed the comparatively higher trend of GD in 2014 compared to 2018, respectively - 0.294 vs 0.246; 0.179 vs 0.156; 88.64 vs 75.0. Clustering analysis was also used as a proxy for population structure, with the msp2 -based UPGMA distance-tree depicting intermixed and epidemiologically related clonal populations of 2014 and 2018 across sub-trees. Interestingly, the distance-tree based on RAPD-R8 primer revealed 2 clearly distinct unrelated clusters for 2014 alone, suggesting different genetic backgrounds from the rest of intermixed populations. These observations warrant in-depth investigation into how human migration redistributes malaria diversity and the interest of targeting populations with different genetic background for diagnostic purpose.","PeriodicalId":73052,"journal":{"name":"Fortune journal of health sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}