Fortune journal of health sciences最新文献

{"title":"County Mammogram Uptake can be Predicted from Social Determinants of Health, but Patterns Do Not Hold for Individual Patients.","authors":"Matthew Davis, Kit Simpson, Vanessa Diaz, Alexander V Alekseyenko","doi":"10.26502/fjhs.171","DOIUrl":"https://doi.org/10.26502/fjhs.171","url":null,"abstract":"<p><strong>Purpose: </strong>The objective of this study is to describe patterns in barriers to breast cancer screening uptake with the end goal of improving screening adherence and decreasing the burden of mortality due to breast cancer. This study looks at social determinants of health and their association to screening and mortality. It also investigates the extent that models trained on county data are generalizable to individuals.</p><p><strong>Methods: </strong>County level screening uptake and age adjusted mortality due to breast cancer are combined with the Centers for Disease Controls Social Vulnerability Index (SVI) to train a model predicting screening uptake rates. Patterns learned are then applied to de-identified electronic medical records from individual patients to make predictions on mammogram screening follow through.</p><p><strong>Results: </strong>Accurate predictions can be made about a county's breast cancer screening uptake with the SVI. However, the association between increased screening, and decreased age adjusted mortality, doesn't hold in areas with a high proportion of minority residents. It is also shown that patterns learned from county SVI data have little discriminative power at the patient level.</p><p><strong>Conclusion: </strong>This study demonstrates that social determinants in the SVI can explain much of the variance in county breast cancer screening rates. However, these same patterns fail to discriminate which patients will have timely follow through of a mammogram screening test. This study also concludes that the core association between increased screening and decreased age adjusted mortality does not hold in high proportion minority areas.</p><p><strong>Objective: </strong>The objective of this study is to describe patterns in social determinants of health and their association with female breast cancer screening uptake, age adjusted breast cancer mortality rate and the extent that models trained on county data are generalizable to individuals.</p>","PeriodicalId":73052,"journal":{"name":"Fortune journal of health sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11034937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140870394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology, Pathophysiology, and Treatment Strategies of Concussions: A Comprehensive Review.","authors":"Zubair Ahmed, Fihr Chaudhary, Marcel P Fraix, Devendra K Agrawal","doi":"10.26502/fjhs.178","DOIUrl":"https://doi.org/10.26502/fjhs.178","url":null,"abstract":"<p><p>A concussion is a particular manifestation of a traumatic brain injury, which is the leading cause of mortality and disabilities across the globe. The global prevalence of traumatic brain injury is estimated to be 939 instances per 100,000 individuals, with approximately 5.48 million people per year experiencing severe traumatic brain injury. Epidemiology varies amongst different countries by socioeconomic status with diverse clinical manifestations. Additionally, classifying concussions is an ambiguous process as clinical diagnoses are the only current classification method, and morbidity rates differ by demographic location as well as populations examined. In this article, we critically reviewed the pathophysiology of concussions, classification methods, treatment options available including both pharmacologic and nonpharmacologic intervention methods, etiologies as well as global etiologic differences associated with them, and clinical manifestations along with their associated morbidities. Furthermore, analysis of the current research regarding the incidence of concussion based traumatic brain injuries and future directions are discussed. Investigation on the efficacy of new therapeutic-related interventions such as exosome therapy and electromagnetic field stimulation are warranted to properly manage and treat concussion-induced traumatic brain injury.</p>","PeriodicalId":73052,"journal":{"name":"Fortune journal of health sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11067689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140872428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface Chemistry of Gold Nanoparticles Modulates Cytokines and Nanomechanical Properties in Pancreatic Cancer Cell Lines: A Correlative Study.","authors":"Tanmay Kulkarni, Ramcharan Singh Angom, Enfeng Wang, Debabrata Mukhopadhyay, Santanu Bhattacharya","doi":"10.26502/fjhs.170","DOIUrl":"10.26502/fjhs.170","url":null,"abstract":"<p><p>Surface chemistry of nanoparticles play significant role in their cellular interaction. Along with other group, we previously demonstrated that dynamic alteration of cell membrane during uptake of gold nanoparticles can be thoroughly probed by nanomechanical properties of cell membrane. Additionally, endocytosis influences intracellular cytokines expression that also impact membrane stiffness. Hence, we have hypothesized that surface chemistry of gold nanoparticles influences intracellular cytokines which in turn imparts dynamic alteration of nanomechanical properties of cellular membrane of pancreatic cancer cells. Various gold nanoparticles decorated with targeting peptide, polyethylene glycol or their combinations have been used to treat two pancreatic cancer cell lines, Panc-1 and AsPC1, for 1 and 24 hours. Atomic force microscope is used to measure linear and nonlinear nanomechanical properties of cell membrane. Intracellular cytokine has been measured using real time polymeric chain reaction. We evaluated several criteria such as receptor dependent vs independent, PEGylated vs non-PEGylated and different timepoints, to deduce correlations between cytokines and nanomechanical attributes. We have identified unique relationship pro-tumorigenic cytokines with both linear and non-linear nanomechanical properties of Panc-1 and AsPC1 cell membrane during uptake of pristine gold nanoparticles or for PEGylation and for targeting peptide conjugation at the nanoparticle surface.</p>","PeriodicalId":73052,"journal":{"name":"Fortune journal of health sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11065124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140860772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relevance of Cultural, Fatalistic and Psychosocial Factors in Breast Cancer Screening Behavior in Middle Age and Older Women","authors":"L. Cermignani, Martin E. Rabassa, María Virginia Croce","doi":"10.26502/fjhs.101","DOIUrl":"https://doi.org/10.26502/fjhs.101","url":null,"abstract":"","PeriodicalId":73052,"journal":{"name":"Fortune journal of health sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Data Driven vigiPoint Identification Study of Adverse Event Reporting Patterns for Zimbabwe Reports in VigiBase WHO Global Database of Individual Case Safety Reports for Medicines and Vaccines","authors":"Priscilla P.M. Nyambayo, Michael S. Gold, Ushma C. Mehta","doi":"10.26502/fjhs.121","DOIUrl":"https://doi.org/10.26502/fjhs.121","url":null,"abstract":"","PeriodicalId":73052,"journal":{"name":"Fortune journal of health sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Biochemical Parameters in COVID-19 and non-COVID-19 Individuals in Gandaki Province, Nepal","authors":"Anusha Thapa, Raksha Malla, Rebika Koirala, Sanjeeb Shrestha, Nischal Chimal, Sundar Adhikari, A. Nagila","doi":"10.26502/fjhs.122","DOIUrl":"https://doi.org/10.26502/fjhs.122","url":null,"abstract":"","PeriodicalId":73052,"journal":{"name":"Fortune journal of health sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Support of Patients Admitted with COVID-19 at Public Hospitals in South Africa by the Family Members","authors":"Lu Tr, Malwela T, Ndou Nd, Ramathuba Du, Maputle Ms, Mbedzi T","doi":"10.26502/fjhs.092","DOIUrl":"https://doi.org/10.26502/fjhs.092","url":null,"abstract":"","PeriodicalId":73052,"journal":{"name":"Fortune journal of health sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69347738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metastatic Dermatofibrosarcoma Protuberans in a Young African Lady: A Case Report","authors":"Motsepe TA, Maritz SM","doi":"10.26502/fjhs.146","DOIUrl":"https://doi.org/10.26502/fjhs.146","url":null,"abstract":"Dermatofibrosarcoma protuberans (DFSP) is a rare tumour that originates from the dermal fibroblasts. It is often a benign lesion with a low metastatic potential. However, if left untreated, it can become locally aggressive and infiltrate surrounding fascia, muscles and bones. Distant metastases, though uncommon, are usually to the lungs with lymph node involvement being extremely rare. Below is a case of a young African lady who at presentation had a locally advanced DFSP with extensive metastases to distant lymph nodes and the lungs.","PeriodicalId":73052,"journal":{"name":"Fortune journal of health sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135507262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contributing Factors to The Awareness of Health Risks of Geophagy Among Pregnant Women in Lubumbashi","authors":"Cham LC, Kayeme Z, Bokanya I, Tambwe MA, Bito V, Kakoma SZ","doi":"10.26502/fjhs.133","DOIUrl":"https://doi.org/10.26502/fjhs.133","url":null,"abstract":"Geophagy is widely practiced during pregnancy especially in Africa. In Lubumbashi geophagic material contains high levels of toxic metallic elements next to the eggs, larvae, or adult species of the geohelminths and micro toxins. Despite the health risks uncounted, pregnant women still consume clay. Whether pregnant geophagists are aware of the risks-related to geophagia is unknown. A case- control study of 104 geophagists and 107 no geophagists pregnant women was conducted from September 1st, 2022, to February 28th, 2023The pregnant women consecutively enlisted were attending the prenatal care in four medical institutions in Lubumbashi and completed an interview-based questionnaire. 51.7% of the study population were not aware of the health risks of geophagia and consumed large amounts of clay during the early stages of the pregnancy. Identified health risks related to geophagy were mainly helminthic infestation and anemia. The degree of awareness is related to the level of women education and societal/marital status. Our results demonstrate that despite the identified related health risks and the awareness of them, geophagia remains common practice during pregnancy in Lubumbashi. A holistic prevention approach should be implemented to reduce the consequences of geophagy among pregnant women.","PeriodicalId":73052,"journal":{"name":"Fortune journal of health sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135651090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"(-)-Agelastatin A is a Potent Modulator of Osteopontin Expression in Normal and Dystrophic Canine Myoblasts","authors":"Madison Feng, Sara Mata López, Peter P. Nghiem","doi":"10.26502/fjhs.143","DOIUrl":"https://doi.org/10.26502/fjhs.143","url":null,"abstract":"(-)-Agelastatin A [(-)-AA] is a naturally occurring alkaloid of marine sponge origin that is a potent modulator of osteopontin. The latter is a multifunctional cytokine expressed in many types of cells and is involved with several important cellular processes, including adhesion, proliferation, immune response stimulation, and so on. As such, modulating OPN could be of therapeutic benefit for various diseases. On that note, (-)-AA has been shown to reduce OPN in xenografted human tumors in nude mice. Additionally, an OPN genotype was associated loss of ambulation in Duchenne muscular dystrophy (DMD) boys and its expression associated with pathology. In this study, we analyzed OPN expression in normal and canine DMD stem cells (myoblasts) after AA treatment. When suspended in 1,2-propanediol (3-deoxy-DL-glycerol), (-)-AA elicited a dose-dependent decrease in OPN mRNA expression in canine DMD myoblasts at doses ranging from 0.01nM – 30nM. There was also a dose-dependent cell detachment after 24 hours of AA treatment with concentrations of 10nM and greater. Further studies are warranted to determine if (-)-AAis safe and can provide therapeutic benefit in animal models of DMD.","PeriodicalId":73052,"journal":{"name":"Fortune journal of health sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134888255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}