Ali Kudamba, Hussein M. Kafeero, M. Lubowa, Shaban A. Okurut, Hakimu Nsubuga, T. Abiti, Joweria Kayendeke, A. Walusansa, Jamilu E. Ssenku
{"title":"埃尔贡地区用于治疗癌症的黑荆、印楝和苔藻的植物化学特征","authors":"Ali Kudamba, Hussein M. Kafeero, M. Lubowa, Shaban A. Okurut, Hakimu Nsubuga, T. Abiti, Joweria Kayendeke, A. Walusansa, Jamilu E. Ssenku","doi":"10.26502/fjhs.073","DOIUrl":null,"url":null,"abstract":"Background: Cancer is one of the serious health burdens in the 21st century with a steady rise in cases and deaths. The current interventions used in cancer management are chemotherapy, radiation, and surgery, which have not only proved effective but also marred with several shortcomings. Preliminary studies indicated that residents in the Elgon sub-region highly rely on Albizia coriaria, Azadirachta indica & Tylosema fassoglensis as alternative cancer therapies to meet their cancer healthcare. But data are scarce on their phytochemical profiles as a basis for scientific backup in this regard. Therefore, our study documented the phytochemistry of Albizia coriaria, Azadirachta indica & Tylosema fassoglensis. Materials & Methods: We adopted an experimental study design. The collected plant materials were cleaned, air dried, ground into a coarse powder, and extracted by serial extract of aqueous and ethanol. Ultraviolet spectrometry and gravimetry methods were used to determine the phytochemical profiles and data was analyzed with MedCalc version 20.008. The current study revealed that the three plant species exhibited varied phytochemical constituents. The highest mean concentrations were 10174, 748, 17751 & 8060 mg/100ml for polyphenols, flavonoids, tannins, and alkaloids respectively. Flavonoids from root extracts of Tylosema fassoglensis and Albizia coriaria were insignificant (P= 0.1060 & P= 0.4983) respectively and the rest of the phytochemical compositions significantly (P < 0.0001) varied. Conclusions: The phytochemical profiles of plant species in the current study exhibited higher concentrations than the same species harvested in different parts of Uganda. Therefore, there is a need to carry out a study on the isolation & characterization of the phytochemical constituents; efficacy tests on anticancer activity against cancer cellline, and safety in animal models. Affiliation: 1Faculty of Health Sciences, Habib Medical School, Islamic University in Uganda, Kampala 2Faculty of Science, Department of Biological Sciences, Islamic University in Uganda, Mbale 3Faculty of Science, Department of Chemistry and Biochemistry, Islamic University in Uganda, Mbale 4Faculty of Science, Department of Chemistry, Muni University 5Faculty of Science, Department of Food Science and Nutrition, Islamic University in Uganda, Mbale *Corresponding author: Ali Kudamba, Faculty of Health Sciences, Habib Medical School, Islamic University in Uganda, Kampala. Citation: Ali Kudamba, Muhammad Lubowa, Hussein M. Kafeero, Shaban A. Okurut, Hakim Nsubuga, Twaha Abiti, Abdul Walusansa, Joweria Kayendeke, Hasifah Nanyingi, Muhamad S. Mubajje, and Jamilu E. Ssenku. Phytochemical Profiles of Albizia coriaria, Azadirachta indica, and Tylosema fassoglensis Used in the Management of Cancers in Elgon Sub-Region. Fortune Journal of Health Sciences 5 (2022): 461-471. Received: July 17, 2022 Accepted: July 28,2022 Published: August 20, 2022","PeriodicalId":73052,"journal":{"name":"Fortune journal of health sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Phytochemical Profiles of Albizia coriaria, Azadirachta indica, and Tylosema fassoglensis Used in the Management of Cancers in Elgon Sub-Region\",\"authors\":\"Ali Kudamba, Hussein M. Kafeero, M. Lubowa, Shaban A. Okurut, Hakimu Nsubuga, T. Abiti, Joweria Kayendeke, A. Walusansa, Jamilu E. 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The collected plant materials were cleaned, air dried, ground into a coarse powder, and extracted by serial extract of aqueous and ethanol. Ultraviolet spectrometry and gravimetry methods were used to determine the phytochemical profiles and data was analyzed with MedCalc version 20.008. The current study revealed that the three plant species exhibited varied phytochemical constituents. The highest mean concentrations were 10174, 748, 17751 & 8060 mg/100ml for polyphenols, flavonoids, tannins, and alkaloids respectively. Flavonoids from root extracts of Tylosema fassoglensis and Albizia coriaria were insignificant (P= 0.1060 & P= 0.4983) respectively and the rest of the phytochemical compositions significantly (P < 0.0001) varied. Conclusions: The phytochemical profiles of plant species in the current study exhibited higher concentrations than the same species harvested in different parts of Uganda. Therefore, there is a need to carry out a study on the isolation & characterization of the phytochemical constituents; efficacy tests on anticancer activity against cancer cellline, and safety in animal models. Affiliation: 1Faculty of Health Sciences, Habib Medical School, Islamic University in Uganda, Kampala 2Faculty of Science, Department of Biological Sciences, Islamic University in Uganda, Mbale 3Faculty of Science, Department of Chemistry and Biochemistry, Islamic University in Uganda, Mbale 4Faculty of Science, Department of Chemistry, Muni University 5Faculty of Science, Department of Food Science and Nutrition, Islamic University in Uganda, Mbale *Corresponding author: Ali Kudamba, Faculty of Health Sciences, Habib Medical School, Islamic University in Uganda, Kampala. Citation: Ali Kudamba, Muhammad Lubowa, Hussein M. Kafeero, Shaban A. Okurut, Hakim Nsubuga, Twaha Abiti, Abdul Walusansa, Joweria Kayendeke, Hasifah Nanyingi, Muhamad S. Mubajje, and Jamilu E. Ssenku. Phytochemical Profiles of Albizia coriaria, Azadirachta indica, and Tylosema fassoglensis Used in the Management of Cancers in Elgon Sub-Region. Fortune Journal of Health Sciences 5 (2022): 461-471. 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引用次数: 2
摘要
背景:癌症是21世纪严重的健康负担之一,病例和死亡人数稳步上升。目前用于癌症治疗的干预措施有化疗、放疗和手术,它们不仅被证明是有效的,但也存在一些缺点。初步研究表明,埃尔贡次区域的居民高度依赖马齿苋、印楝和铁虱作为替代癌症治疗方法来满足他们的癌症保健。但是,关于它们的植物化学特征的数据很少,无法作为这方面的科学依据。因此,本研究记录了茜草、印楝和苔草的植物化学成分。材料与方法:采用实验研究设计。收集到的植物材料经清洗、风干、磨成粗粉,经水提液和乙醇连续提取。采用紫外分光光度法和重量法测定植物化学特征,并使用MedCalc 20.008进行数据分析。目前的研究表明,这三种植物具有不同的植物化学成分。其中多酚类、黄酮类、单宁类和生物碱类的最高平均浓度分别为10174、748、17751和8060 mg/100ml。黄酮类化合物含量差异不显著(P= 0.1060和P= 0.4983),其余植物化学成分差异显著(P < 0.0001)。结论:在目前的研究中,植物物种的植物化学特征显示出比在乌干达不同地区收获的相同物种更高的浓度。因此,有必要对其植物化学成分的分离与表征进行研究;对癌细胞的抗癌活性及动物模型安全性的有效性试验。隶属单位:1乌干达伊斯兰大学哈比卜医学院健康科学系,坎帕拉2乌干达伊斯兰大学理学院,生物科学系,Mbale 3乌干达伊斯兰大学理学院,化学与生物化学系,Mbale 4穆尼大学理学院,化学系5乌干达伊斯兰大学理学院,食品科学与营养学系,Mbale *通讯作者:Ali Kudamba,坎帕拉乌干达伊斯兰大学哈比卜医学院健康科学系。引文:Ali Kudamba、Muhammad Lubowa、Hussein M. Kafeero、Shaban A. Okurut、Hakim Nsubuga、Twaha Abiti、Abdul Walusansa、Joweria Kayendeke、Hasifah Nanyingi、Muhammad S. Mubajje和Jamilu E. Ssenku。埃尔贡地区用于治疗癌症的黑荆、印楝和苔藻的植物化学特征。财富健康科学杂志5(2022):461-471。收稿日期:2022年7月17日收稿日期:2022年7月28日发表日期:2022年8月20日
Phytochemical Profiles of Albizia coriaria, Azadirachta indica, and Tylosema fassoglensis Used in the Management of Cancers in Elgon Sub-Region
Background: Cancer is one of the serious health burdens in the 21st century with a steady rise in cases and deaths. The current interventions used in cancer management are chemotherapy, radiation, and surgery, which have not only proved effective but also marred with several shortcomings. Preliminary studies indicated that residents in the Elgon sub-region highly rely on Albizia coriaria, Azadirachta indica & Tylosema fassoglensis as alternative cancer therapies to meet their cancer healthcare. But data are scarce on their phytochemical profiles as a basis for scientific backup in this regard. Therefore, our study documented the phytochemistry of Albizia coriaria, Azadirachta indica & Tylosema fassoglensis. Materials & Methods: We adopted an experimental study design. The collected plant materials were cleaned, air dried, ground into a coarse powder, and extracted by serial extract of aqueous and ethanol. Ultraviolet spectrometry and gravimetry methods were used to determine the phytochemical profiles and data was analyzed with MedCalc version 20.008. The current study revealed that the three plant species exhibited varied phytochemical constituents. The highest mean concentrations were 10174, 748, 17751 & 8060 mg/100ml for polyphenols, flavonoids, tannins, and alkaloids respectively. Flavonoids from root extracts of Tylosema fassoglensis and Albizia coriaria were insignificant (P= 0.1060 & P= 0.4983) respectively and the rest of the phytochemical compositions significantly (P < 0.0001) varied. Conclusions: The phytochemical profiles of plant species in the current study exhibited higher concentrations than the same species harvested in different parts of Uganda. Therefore, there is a need to carry out a study on the isolation & characterization of the phytochemical constituents; efficacy tests on anticancer activity against cancer cellline, and safety in animal models. Affiliation: 1Faculty of Health Sciences, Habib Medical School, Islamic University in Uganda, Kampala 2Faculty of Science, Department of Biological Sciences, Islamic University in Uganda, Mbale 3Faculty of Science, Department of Chemistry and Biochemistry, Islamic University in Uganda, Mbale 4Faculty of Science, Department of Chemistry, Muni University 5Faculty of Science, Department of Food Science and Nutrition, Islamic University in Uganda, Mbale *Corresponding author: Ali Kudamba, Faculty of Health Sciences, Habib Medical School, Islamic University in Uganda, Kampala. Citation: Ali Kudamba, Muhammad Lubowa, Hussein M. Kafeero, Shaban A. Okurut, Hakim Nsubuga, Twaha Abiti, Abdul Walusansa, Joweria Kayendeke, Hasifah Nanyingi, Muhamad S. Mubajje, and Jamilu E. Ssenku. Phytochemical Profiles of Albizia coriaria, Azadirachta indica, and Tylosema fassoglensis Used in the Management of Cancers in Elgon Sub-Region. Fortune Journal of Health Sciences 5 (2022): 461-471. Received: July 17, 2022 Accepted: July 28,2022 Published: August 20, 2022