Food safety (Tokyo, Japan)最新文献_第7页

Monepantel (Veterinary Medicinal Products). Monepantel(兽药产品)

Food safety (Tokyo, Japan) Pub Date : 2020-03-27 eCollection Date: 2020-03-01 DOI: 10.14252/foodsafetyfscj.D-20-00001

引用次数: 1

Dedication 奉献

Food safety (Tokyo, Japan) Pub Date : 2020-01-01 DOI: 10.1016/b978-0-12-818219-2.00014-4

引用次数: 0

Index 指数

Food safety (Tokyo, Japan) Pub Date : 2020-01-01 DOI: 10.1016/b978-0-12-818219-2.00021-1

引用次数: 0

Front matter 前页

Food safety (Tokyo, Japan) Pub Date : 2020-01-01 DOI: 10.1016/b978-0-12-818219-2.00012-0

引用次数: 0

Foreword 2 前言2

Food safety (Tokyo, Japan) Pub Date : 2020-01-01 DOI: 10.1016/b978-0-12-818219-2.00020-x

William “Bill” Marler

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Selected cases 选定的情况下

Food safety (Tokyo, Japan) Pub Date : 2020-01-01 DOI: 10.4337/9780857939562.00006

Darin S. Detwiler

引用次数: 0

Copyright 版权

Food safety (Tokyo, Japan) Pub Date : 2020-01-01 DOI: 10.1016/b978-0-12-818219-2.00013-2

引用次数: 0

Acknowledgments 致谢

Food safety (Tokyo, Japan) Pub Date : 2020-01-01 DOI: 10.1016/b978-0-12-818219-2.00017-x

引用次数: 0

Fosfomycin (Veterinary Medicinal Products): Summary. 磷霉素(兽药产品):综述。

Food safety (Tokyo, Japan) Pub Date : 2019-12-27 eCollection Date: 2019-12-01 DOI: 10.14252/foodsafetyfscj.D-19-00020

{"title":"Fosfomycin (Veterinary Medicinal Products): Summary.","authors":"","doi":"10.14252/foodsafetyfscj.D-19-00020","DOIUrl":"https://doi.org/10.14252/foodsafetyfscj.D-19-00020","url":null,"abstract":"The Food Safety Commission of Japan (FSCJ) conducted a risk assessment of fosfomycin (CAS No. 23155-02-4), using documents submitted for the ‟re-examination\" of veterinary medicinal products. The data used for the assessment include ADME of fosfomycin Ca, residue of fosfomycin Ca and of fosfomycin Na, acute toxicity of fosfomycin Ca and fosfomycin Na. Data on subacute toxicity, reproductive and developmental toxicity, genotoxicity and microbiological effect are also included. The lowest-observed-adverse-effect level (LOAEL) in these toxicity studies was 175 mg (titer)/kg body weight (bw) per day based on adverse effects including diarrhea, autopsy findings such as erosion, hyperplasia, and exfoliation of glandular stomach mucosa, and histopathological findings such as erosion of the stomach and ileum mucosa observed as adverse effects in the 35-day subacute toxicity study in rats. Fosfomycin was not teratogenic in rats and rabbits. FSCJ considered that fosfomycin is not a genotoxic carcinogen. The toxicological ADI of fosfomycin was established to be 0.175 mg/kg bw per day by applying a safety factor of 1000 based on the LOAEL of 175 mg (titer)/kg bw per day. On the other hand, the microbiological ADI was calculated to be 0.019 mg/kg bw per day, which is lower than the toxicological ADI. Thus, FSCJ established the ADI for fosfomycin as 0.019 mg/kg bw per day.","PeriodicalId":73044,"journal":{"name":"Food safety (Tokyo, Japan)","volume":"7 4","pages":"96-98"},"PeriodicalIF":0.0,"publicationDate":"2019-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.14252/foodsafetyfscj.D-19-00020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37592980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Citric Acid on Prolonging the Half-life of Dissolved Ozone in Water. 柠檬酸对延长水中溶解臭氧半衰期的影响。

Food safety (Tokyo, Japan) Pub Date : 2019-12-27 eCollection Date: 2019-12-01 DOI: 10.14252/foodsafetyfscj.D-19-00005

Yoshichika Hirahara, Kazuyoshi Iwata, Katsuhiko Nakamuro

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引用次数: 12