Advanced Materials Technologies最新文献

{"title":"Portable, Rapid, Label-Free Sensors for Early Detection of Prostate Cancer Biomarkers: An Approach Toward Point-of-Care Diagnosis","authors":"Bolivia Konthoujam,&nbsp;Ruma Ghosh","doi":"10.1002/admt.71094","DOIUrl":"https://doi.org/10.1002/admt.71094","url":null,"abstract":"<div>\u0000 \u0000 <p>Prostate cancer (PCa) is among the most common and fatal malignancies in men. Early diagnosis greatly improves prognosis, but current diagnostic methods like serum prostate-specific antigen (PSA) assays, digital rectal examination (DRE), and biopsy are invasive, costly, or lack specificity and sensitivity, emphasizing the need for accurate, non-invasive alternatives. Biomarkers research beyond PSA targeting PCA3, VEGF, PCAT14, SChLAP1, SPINK1, and various RNAs has expanded to enhance diagnostic precision. However, most protein and RNA detection methods remain laboratory-bound, hindering translation to point-of-care applications, which is crucial for early detection of PCa. This review highlights advances in three portable biosensor classes—electrochemical, field-effect transistor (FET), and resistive sensors that convert biomolecular interactions into electronic signals. It focuses on (1) nanomaterial-based transducer layers, which result in enhanced sensitivity, (2) bioreceptors (antibodies, nucleic acid probes) providing specificity, and (3) miniaturized, low-noise electronics enabling portable and low-power readouts.</p>\u0000 </div>","PeriodicalId":7292,"journal":{"name":"Advanced Materials Technologies","volume":"11 17","pages":""},"PeriodicalIF":6.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mimicry of Tumor-Promoting Factors in 3D In Vitro Breast Cancer Models: AI-Driven Opportunities for Model Design and Biological Data Analysis","authors":"Unnati Modi,&nbsp;Satya Omprabha,&nbsp;Raghu Solanki,&nbsp;Rajesh Vasita,&nbsp;Dhiraj Bhatia","doi":"10.1002/admt.202501440","DOIUrl":"https://doi.org/10.1002/admt.202501440","url":null,"abstract":"<div>\u0000 \u0000 <p>With the growing need to accurately recapitulate tumor pathophysiology in vitro, 3D culture systems have emerged as superior to standard 2D models. 3D cell culture systems overcome key limitations of 2D cultures, including insufficient cell-to-cell and cell-to-matrix interactions, lack of cellular heterogeneity, and absence of structural complexity. Physiologically relevant modeling of cancer can only be achieved by adequately mimicking critical tumor promoting factors such as hypoxia, cancer stemness, metastatic potential, and drug resistance—features that are effectively captured by in vitro 3D tumor models developed using scaffold-free or scaffold-based platforms. Scaffold-based systems are particularly valuable, as they provide extracellular matrix (ECM)-mimicking physical, chemical, and spatiotemporal cues, thereby supporting the formation of robust and pertinent 3D in vitro cancer models. With the fact that breast cancer (BC) is widely growing as a life threatening cancer amongst women, advancing 3D in vitro breast cancer models is crucial for developing biologically relevant and reliable platforms to evaluate drug candidates and treatment regimens. Such platforms offer significant potential for the effective translation of anticancer therapies and personalized medicine. This perspective discusses scaffold-free and scaffold-based cell culture platforms employed to mimic breast tumors and investigate key tumor promoting factors. With special attention to hydrogels within scaffold-based systems, this review highlights recent advancements driven by artificial intelligence in the design, development, and scalability of hydrogel-assisted 3D in vitro tumor models, as well as in the detailed investigation of tumor promoting factors. These developments underscore the growing potential of 3D in vitro models as viable alternatives to animal models, influencing translational anticancer strategies, therapeutic innovation, and broader biomedical research.</p>\u0000 </div>","PeriodicalId":7292,"journal":{"name":"Advanced Materials Technologies","volume":"11 17","pages":""},"PeriodicalIF":6.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of Graphene Aerogel–Flyash Composite Sheets for Enhanced Radar Absorption in Drone Stealth Applications","authors":"Srinu budumuru,&nbsp;Lakshman Pappula,&nbsp;Allu gayatri,&nbsp;S Srinivasa rao,&nbsp;B Ravi kiran,&nbsp;Y Madhu babu","doi":"10.1002/admt.71093","DOIUrl":"https://doi.org/10.1002/admt.71093","url":null,"abstract":"<div>\u0000 \u0000 <p>This work aims to develop a new composite material with low absorption loss, high strength, and low weight for various stealth and radar-absorbing operations. The material chosen here is graphene aerogel and fly ash. The graphene aerogel reinforced with flyash at different levels, such as 5%, 10%, and 15%, to improve radar wave absorption in the X-band frequency range (8–12 GHz). Here, analysis was conducted for different thicknesses, including 1, 2, and 3 mm, and absorption loss was measured for oblique incidence of electromagnetic waves. The improvement in the dielectric constant enhances the attenuation for the propagated electromagnetic wave when flyash is reinforced with graphene aerogel. As the thickness of the composite increases, the amount of EM energy absorption increases for the given X-band. There should be a trade off between absorption loss and mechanical strength; it can be balanced in a composite with 10%–15% flyash reinforcement. Finally, the combination of graphene aerogel and flyash composite offers good absorption of EM waves, is lightweight, and is cost-effective for stakeholder operations involving drones and other radar-absorbing systems.</p>\u0000 </div>","PeriodicalId":7292,"journal":{"name":"Advanced Materials Technologies","volume":"11 17","pages":""},"PeriodicalIF":6.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148871872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Guided-Wave Inspired Reconfigurable Intelligent Surface With Independent Continuous Control of Reflection Amplitude and Phase for Wireless Communications","authors":"Rui Liu,&nbsp;Hongyu Shi,&nbsp;Xiaoming Chen,&nbsp;Juan Chen,&nbsp;Jianjia Yi,&nbsp;Haiwen Liu,&nbsp;Anxue Zhang","doi":"10.1002/admt.71031","DOIUrl":"https://doi.org/10.1002/admt.71031","url":null,"abstract":"<div>\u0000 \u0000 <p>In this article, a guided-wave-inspired reconfigurable intelligent surface (RIS) with independent continuous amplitude and phase control ability is proposed. The designed RIS unit cell mainly consists of a top square patch, a middle metal ground, and a bottom reconfigurable attenuator-phase shifter cascade structure. By applying different bias voltages, the proposed RIS achieves a continuous amplitude modulation of 0.2–0.78 and a continuous phase modulation of 410° at 4.9 GHz. As a validation, a RIS array consisting of 12 × 12 elements is fabricated and measured, generating dual beams with independent beam pointing and required power intensity allocation. Correspondingly, a RIS-assisted wireless communication system is constructed, and the performance of the proposed RIS is verified through image information transmission. In addition, a sub-bias network that can be flexibly extended according to the scale of the RIS array is designed to solve the problem of the increasing complexity of bias network arrangement caused by independent modulation of amplitude and phase. The proposed RIS has great application potential in RIS-assisted wireless communication systems, especially in scenarios where power intensities of the beams are allocated based on the data transmission rate requirements of different devices.</p>\u0000 </div>","PeriodicalId":7292,"journal":{"name":"Advanced Materials Technologies","volume":"11 17","pages":""},"PeriodicalIF":6.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wearable Radiative Cooling Fabrics for Personal Thermal Management","authors":"Linan Feng,&nbsp;Kangkang Wang,&nbsp;Aike Xi,&nbsp;Zhenyu Guo,&nbsp;Xinnong Wang,&nbsp;Ya Huang,&nbsp;Zhuojing Zhao,&nbsp;Siming Zhao,&nbsp;Rufan Zhang","doi":"10.1002/admt.202501351","DOIUrl":"https://doi.org/10.1002/admt.202501351","url":null,"abstract":"<p>Radiative cooling, a zero-energy-consumption passive cooling technology, enables spontaneous heat dissipation, reducing energy use and pollution, and provides an innovative solution for personal thermal management (PTM). This review thoroughly summarizes recent advances in radiative cooling fabrics, detailing the fundamental model of human body heat exchange and the essential cooling mechanism based on simultaneous high solar reflectivity and mid-infrared (MIR) emissivity. Strategies for material spectral design, fabrication processes, and structural optimization techniques are systematically analyzed. Key performance metrics are analyzed alongside multifunctional integrations such as evaporative–radiative coupling and thermal-moisture management. Emerging applications in adaptive thermoregulation and health monitoring are explored, highlighting the versatility of technology. Finally, current challenges are discussed, and future research directions are outlined to stimulate deeper investigation and accelerate the industrialization and widespread application of this sustainable technology.</p>","PeriodicalId":7292,"journal":{"name":"Advanced Materials Technologies","volume":"11 17","pages":""},"PeriodicalIF":6.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress Dissipation in Stretchable Organic Field-Effect Transistors: Evaluation Metrics and Pathways","authors":"Long Cao,&nbsp;Jin Cao,&nbsp;Yuguang Feng,&nbsp;Ti Wu","doi":"10.1002/admt.71114","DOIUrl":"https://doi.org/10.1002/admt.71114","url":null,"abstract":"<div>\u0000 \u0000 <p>The rapid advancement of the Internet of Things (IoT) and artificial intelligence (AI) has fueled increasing interest in stretchable organic field-effect transistors (SOFETs), which serve as essential building blocks for flexible electronic systems, such as wearable sensors and bio-integrated devices. Despite their promising applications, achieving efficient stress dissipation while maintaining electrical performance under mechanical deformation remains a major challenge. This review systematically examines the impact of mechanical stress on the operational stability and integrity of SOFETs, with a focused discussion on key evaluation metrics and underlying mechanistic principles. By elucidating fundamental pathways for stress-dissipation, this paper aims to provide design guidelines for developing highly durable and electrically robust SOFETs, thereby advancing their integration into next-generation soft electronics.</p>\u0000 </div>","PeriodicalId":7292,"journal":{"name":"Advanced Materials Technologies","volume":"11 17","pages":""},"PeriodicalIF":6.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Testing and Simulation of Multilayer Polyvinylidene Fluoride-Based Piezoelectric Energy Harvester Devices","authors":"Hamdi Ezzin,&nbsp;Silvia Monchetti,&nbsp;Paolo Emilio Puddu,&nbsp;Luciano Teresi,&nbsp;Antonio DeSimone,&nbsp;Roberto Brighenti","doi":"10.1002/admt.71087","DOIUrl":"https://doi.org/10.1002/admt.71087","url":null,"abstract":"<p>Power supply challenges for implantable medical devices, including pacemakers and health sensors, require device miniaturization for safe and minimally invasive implantation, as well as advancements in energy supply and storage technologies, such as high-density batteries and wireless power transmission. Traditional piezoelectric energy harvesters (EH) often exhibit high electrical impedances, which can restrict their use in energy harvesting systems. To address this limitation, a polymer-based multilayer flexible energy harvesting device composed of alternating dielectric and piezoelectric β-phase polyvinylidene fluoride (PVDF) layers is introduced. A theoretical mechanical model based on large-displacement beam theory is developed to quantify the stress experienced by the piezoelectric layer, and parametric simulations of the generated energy are conducted. Experimental results are compared with simulation outcomes. Furthermore, using real human heart kinematics obtained from epicardium surface measurements, the voltage and energy obtainable from the proposed devices are evaluated. Compared to the single-layer configuration, the multilayer PVDF device demonstrates an increased maximum output voltage and capacitance, along with reduced impedance. The proposed EH multilayer PVDF-based provides significant advantages due to its simple and expandable architecture, indicating strong potential for supplying energy to small-scale devices for biomedical applications.</p>","PeriodicalId":7292,"journal":{"name":"Advanced Materials Technologies","volume":"11 17","pages":""},"PeriodicalIF":6.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/admt.71087","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stacked Variable Structure Gripper Based on Dielectric Elastomer Minimum Energy Structures","authors":"Xinwei He,&nbsp;Shengyang Xi,&nbsp;Ye Chen,&nbsp;Yijing Niu,&nbsp;Guanyao Qiao,&nbsp;Chaoqun Xiang","doi":"10.1002/admt.71098","DOIUrl":"https://doi.org/10.1002/admt.71098","url":null,"abstract":"<div>\u0000 \u0000 <p>To address the insufficient clamping force and narrow adjustable opening range of existing flexible grippers, we propose a stacked variable structure gripper based on dielectric elastomer minimum energy structures (SVSDEG, DEMES). Through modular stacked of variable structure and clamping dielectric elastomer actuators (DEAs), functional decoupling of caliber adjustment and force output is achieved. The symmetric structure adopts double-layer very high bond (VHB) films as the core driving layer and polyethylene terephthalate (PET) rigid frames for structural stability. Experimental results show that under 0–7 kV driving voltage, SVS-DEG realizes 0–25 mm continuous opening adjustment, stably clamping 0.465–8.452 g objects of diverse shapes non-destructively. It exhibits excellent reliability with 7.5% clamping force attenuation and 4% opening recovery rate decrease after 100 cycles. Integrated with an automated control system, it completes precise “variable structure-positioning-clamping-transfer-release” operations. This structural design improves mechanical adaptability and reliability under the tested conditions, providing a feasible solution for soft robotics, automated manufacturing, and biomedical manipulation.</p>\u0000 </div>","PeriodicalId":7292,"journal":{"name":"Advanced Materials Technologies","volume":"11 17","pages":""},"PeriodicalIF":6.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148871827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Additive-Manufactured, Multifunctional Bioreactor Technology for Dynamic Culture of 3D Bioprinted Tissue Models","authors":"Lys Sprenger,&nbsp;Johann Schorzmann,&nbsp;Hsuan-Heng Lu,&nbsp;Muhammad Osama,&nbsp;Julian Bauer,&nbsp;Michael Haug,&nbsp;Oliver Friedrich,&nbsp;Aldo R. Boccaccini,&nbsp;Frank Döpper,&nbsp;Sahar Salehi","doi":"10.1002/admt.202502635","DOIUrl":"https://doi.org/10.1002/admt.202502635","url":null,"abstract":"<p>Bioreactors in biofabrication and tissue engineering enable dynamic cell and tissue culture under controlled conditions while applying external stimuli such as mechanical or electrical signals. Together, these features mimic the in vivo environment and support functional tissue formation for implantation or model systems. Most current bioreactors focus on medium perfusion and mechanical or electrical stimulation, but often lack real-time monitoring, which is essential for quality control. To address this gap, this work presents an additively manufactured bioreactor that integrates dynamic perfusion, electrical stimulation, and in-line microscopy and sensor monitoring for culturing 3D-bioprinted constructs. Three bioinks containing C2C12 myoblasts were 3D-printed and cultured in the system, with continuous tracking of pH and temperature and comparison to static controls. Laminar perfusion improved cell viability and spreading in GelMA and ADA-GEL bioinks, with faster myoblast alignment observed in ADA-GEL after 3 days. Platinum-coated copper electrodes embedded in the design produced electric fields of at least 10 V·cm⁻¹. As a proof of principle, isolated murine <i>interossei plantares</i> myofibers were placed in the chamber and electrically stimulated to induce twitching. Overall, this bioreactor demonstrates strong potential as a platform for real-time tissue monitoring and studying customized stimuli during tissue development.</p>","PeriodicalId":7292,"journal":{"name":"Advanced Materials Technologies","volume":"11 17","pages":""},"PeriodicalIF":6.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/admt.202502635","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148871965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"At Home Detection of Ovarian Health Biomarker in Menstruation Blood","authors":"Lucas Dosnon,&nbsp;Thomas Rduch,&nbsp;Salma Sherif Azer,&nbsp;Inge K. Herrmann","doi":"10.1002/admt.71077","DOIUrl":"https://doi.org/10.1002/admt.71077","url":null,"abstract":"<p>Blood-based biomarkers are central to diagnostics, yet current approaches depend on invasive sampling and centralized laboratory infrastructure. At the same time, women's reproductive health remains severely under-monitored: most clinically relevant biomarkers are rarely measured outside fertility clinics, leaving millions without accessible, continuous insight into their reproductive lifespan. Anti-Müllerian hormone (AMH), a key indicator of ovarian reserve and overall reproductive function, still requires venous blood collection and specialized analysis, creating a major barrier to early detection, routine monitoring, and population-level screening. Here, we present a lateral flow assay (LFA) enabling direct AMH detection in unprocessed menstrual blood. The assay uses covalently conjugated 150 nm gold nanoshells to achieve sensitive colorimetric detection within the clinically relevant 0–10 ng/mL range. Results can be visually interpreted by naked-eye detection or quantified via a smartphone-based machine-learning algorithm for semi-quantitative assessment. The LFA performance correlates strongly with clinical chemistry lab-based analyses and can be seamlessly integrated into point-of-care formats, including wearable menstruation pads as well as simple dipstick tests. This technology demonstrates the feasibility of a non-invasive and affordable approach for decentralized ovarian health assessment.</p>","PeriodicalId":7292,"journal":{"name":"Advanced Materials Technologies","volume":"11 17","pages":""},"PeriodicalIF":6.0,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/admt.71077","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148872128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}