Enfermedades infecciosas y microbiologia clinica (English ed.)最新文献

{"title":"How can we optimize the diagnostic and therapeutic approach of pneumonia? Expert opinion-based recommendations. Authors' reply","authors":"Mario Fernández-Ruiz , Juan José Castón , José Luis del Pozo , José María Aguado , en representación de los miembros del Grupo OPENIN (“Optimización de procesos clínicos para el diagnóstico y tratamiento de infecciones”)","doi":"10.1016/j.eimce.2024.11.002","DOIUrl":"10.1016/j.eimce.2024.11.002","url":null,"abstract":"","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 2","pages":"Pages 121-122"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dalbavancin as consolidation antibiotic treatment in infective endocarditis, cardiac implantable electronic devices infection and bacteremia: Clinical experience of 7 years","authors":"Alejandro Salinas-Botrán ,&nbsp;Carmen Olmos-Blanco ,&nbsp;David Fernández de Velasco-Pérez ,&nbsp;Alicia Guzmán-Carreras ,&nbsp;Alejandro Morales-Rosas ,&nbsp;Daniel Gómez-Ramírez","doi":"10.1016/j.eimce.2024.05.009","DOIUrl":"10.1016/j.eimce.2024.05.009","url":null,"abstract":"<div><h3>Introduction</h3><div>Dalbavancin<span><span><span> (DBV), a novel lipoglycopeptide with activity against Gram-positive bacterial infections, is approved for the treatment of acute bacterial skin and skin structure infections (ABSSSIs). It has linear dose-related </span>pharmacokinetics allowing a prolonged interval between doses. It would be a good option for the treatment of patients with Gram-positive </span>cardiovascular infections.</span></div></div><div><h3>Methods</h3><div>Retrospective analysis of patients with cardiovascular infection (infective endocarditis, bacteremia, implantable electronic device infection) treated with DBV at Hospital Clínico San Carlos (Madrid) for 7 years (2016–2022). Patients were divided in two study groups: 1) Infective endocarditis (IE), 2) Bacteremia. Epidemiological, clinical, microbiological and therapeutic data were analyzed.</div></div><div><h3>Results</h3><div><span>A total of 25 patients were treated with DBV for cardiovascular infection. IE was the most common indication (68%), followed by bacteremia (32%) with male predominance in both groups (64% vs 62%) and median age of 67,7 and 57,5 years, respectively. 100% of blood cultures were positive to Gram-positive microorganisms (</span><em>Staphylococcus</em> spp., <span><span>Streptococcus</span></span> spp. or <span><span>Enterococcus</span></span><span><span><span> spp.) in both study groups. Previously to DBV, all patients received other antibiotic therapy, both in the group of IE (median: 80 days) as in bacteremia (14,8 days). The main reason for the administration of DBV was to continue intravenous antimicrobial therapy outside the hospital in both the </span>EI group (n = 15) and the bacteremia group (n = 8). DBV was used as consolidation therapy in a once- or twice-weekly regimen. Microbiological and clinical successes were reached in 84% of cases (n = 21), 76,4% in IE group and 100% in bacteremia group. No patient documented </span>adverse effects during long-term dalbavancin treatment.</span></div></div><div><h3>Conclusion</h3><div>DBV is an effective and safety treatment as consolidation antibiotic therapy in IE and bacteremia produced by Gram-positive microorganisms.</div></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 2","pages":"Pages 71-79"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141066247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dalbavancin: A new milestone in the treatment of Gram-positive infections","authors":"Arístides de Alarcón González","doi":"10.1016/j.eimce.2024.12.007","DOIUrl":"10.1016/j.eimce.2024.12.007","url":null,"abstract":"","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 2","pages":"Pages 61-63"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusually high incidence of pneumonia in Navarre, Spain, 2023–2024","authors":"Camino Trobajo-Sanmartín ,&nbsp;María Eugenia Portillo ,&nbsp;Ana Navascués ,&nbsp;Iván Martínez-Baz ,&nbsp;Carmen Ezpeleta ,&nbsp;Jesús Castilla","doi":"10.1016/j.eimce.2024.08.007","DOIUrl":"10.1016/j.eimce.2024.08.007","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the pneumonia incidence in Navarre, Spain, in the 2023–2024 season.</div></div><div><h3>Methods</h3><div>Using electronic medical records, we evaluated the incidence of clinical pneumonia, positive pneumococcal antigen cases and <em>Mycoplasma pneumoniae</em> positive PCR cases by age groups from 2017–2018 to 2023–2024 season.</div></div><div><h3>Results</h3><div>Compared to the average of the 2017–2018 and 2018–2019 seasons, in the 2023–2024 season, pneumonia incidence rate increased by 73% overall and multiplied by 4.43 in the age group of 5–14 years. The rate of confirmed pneumococcal pneumonia increased by 63%, and that of <em>M. pneumoniae</em> multiplied by 19.</div></div><div><h3>Conclusion</h3><div>Pneumonia incidence was unusually high in all ages in the 2023–2024 season and was related to upsurges in pneumococcal and <em>Mycoplasma</em> diseases.</div></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 2","pages":"Pages 93-96"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143163796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erythema induratum of Bazin—A cutaneous manifestation of tuberculosis","authors":"Maria Ana Quadros Flores ,&nbsp;Gustavo Almeida Silva ,&nbsp;Paulo Filipe ,&nbsp;Sérgio Eduardo Paulo","doi":"10.1016/j.eimce.2024.06.010","DOIUrl":"10.1016/j.eimce.2024.06.010","url":null,"abstract":"","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 2","pages":"Pages 110-112"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143165030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Which corticosteroid should be used in severe pneumonia?","authors":"Javier Velasco Montes ,&nbsp;María Victoria Pardo Gutiérrez ,&nbsp;Carlos Hernando Martín ,&nbsp;Silvia González Díez","doi":"10.1016/j.eimce.2024.11.001","DOIUrl":"10.1016/j.eimce.2024.11.001","url":null,"abstract":"","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 2","pages":"Page 121"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143076708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of UV-C disinfection and copper plating on healthcare-associated infections in a NICU with high ESBL infections","authors":"Daniela de la Rosa-Zamboni,&nbsp;Mónica Villa-Guillén,&nbsp;Anaíd Bustos-Hamdan,&nbsp;María Isabel Rosas-Mateos,&nbsp;Marisol Medina-Pelcastre,&nbsp;Margarita Torres-García,&nbsp;María Isabel Franco-Hernández,&nbsp;María del Carmen Castellanos-Cruz,&nbsp;Israel Parra-Ortega,&nbsp;Edmedt Fest-Parra,&nbsp;María Citlalli Casillas-Casillas,&nbsp;Ana Carmen Guerrero-Díaz","doi":"10.1016/j.eimce.2024.02.014","DOIUrl":"10.1016/j.eimce.2024.02.014","url":null,"abstract":"<div><h3>Introduction</h3><div>Healthcare-associated infections (HCAIs) in neonates are frequent and highly lethal, in particular those caused by extended spectrum beta-lactamase (ESBL) producing bacteria. We evaluated the beneficial effects of ultraviolet C (UV-C) disinfection and copper adhesive plating on HCAIs in the Neonatal Intensive Care Unit (NICU) of a third level paediatric hospital in Mexico City, both in combination of hand-hygiene (HH) and prevention bundles.</div></div><div><h3>Methods</h3><div>All NICU patients were included. There were 4 periods (P): P1: HH monitoring and prevention bundles; P2: P1<!--> <!-->+<!--> <!-->UV-C disinfection; P3: P2<!--> <!-->+<!--> <!-->Copper adhesive plating on frequent-contact surfaces and P4: Monitoring of P3 actions.</div></div><div><h3>Results</h3><div>552 neonates were monitored during 15,467 patient days (PD). HCAI rates decreased from 11.03/1000 PD in P1 to 5.35/1000 PD in P4 (<em>p</em> <!-->=<!--> <!-->0.006). HCAIs with bacterial isolates dropped from 5.39/1000 PD in PI to 1.79/1000 PD in P4 (<em>p</em> <!-->=<!--> <!-->0.011). UV-C and copper were associated with significant HCAI prevention (RR 0.49, CI_95% 0.30–0.81, <em>p</em> <!-->=<!--> <!-->0.005) and with lesser HCAIs with bacterial isolates (RR 0.33, CI_95% 0.14–0.77, <em>p</em> <!-->=<!--> <!-->0.011).</div></div><div><h3>Conclusions</h3><div>Copper adhesive plating combined with UV-C disinfection were associated with a drop in HCAI rates and with the elimination of ESBL-caused HCAIs. Hence, we propose that these strategies be considered in MDRO proliferation preventions.</div></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 2","pages":"Pages 64-70"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140867811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-life application of a stratification model for HIV care","authors":"Miguel Suárez-Robles ,&nbsp;Clara Crespillo Andújar ,&nbsp;Sandra Chamorro-Tojeiro ,&nbsp;Begoña Monge-Maillo ,&nbsp;Francesca Norman ,&nbsp;Ignacio Peña ,&nbsp;Martina Corral ,&nbsp;Cristina Arcas ,&nbsp;Santiago Moreno ,&nbsp;Jose A. Pérez-Molina","doi":"10.1016/j.eimce.2024.05.008","DOIUrl":"10.1016/j.eimce.2024.05.008","url":null,"abstract":"<div><h3>Introduction</h3><div>HIV infection<span> has become a chronic disease with a good long-term prognosis, necessitating a change in the care model. For this study, we applied a proposal for an Optimal Care Model (OCM) for people with HIV (PHIV), which includes tools for assessing patient complexity and their classification into profiles to optimize care provision.</span></div></div><div><h3>Methods</h3><div>Observational, cross-sectional, and retrospective study. Adult PHIV treated at the Tropical Medicine consultations at Ramón y Cajal Hospital from January 1 to June 30, 2023, were included. The complexity calculation and the stratification into profiles for each patient were done according to the OCM.</div></div><div><h3>Results</h3><div>Ninety-four participants were included, 76.6% cisgender men, with a median age of 41 years (range 23−76). Latin America and Africa were the main regions of origin (72.4%). 98% had an undetectable HIV viral load. The degree of complexity was 78.7% low, 11.7% medium, 1% high, and 8.5% extreme. The predominant profile was blue (64.9%), followed by lilac (11.7%), purple (6.3%), and green (4.3%). 7.4% were unclassifiable, of whom 57.2% had high/extreme complexity. Among the unclassifiable, mental health problems were the most common.</div></div><div><h3>Conclusions</h3><div>The OCM tools for People Living with HIV (PLWH) allow for the classification and stratification of most patients in a consultation with a non-standard population. Patients who did not fit into the pre-established profiles presented high complexity. Creating a profile focused on mental health or mixed profiles could facilitate the classification of more patients.</div></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 2","pages":"Pages 80-85"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141066253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dalbavancin as sequential therapy in infective endocarditis: Real-life experience in elder and comorbid patients","authors":"Eduardo Aparicio-Minguijón ,&nbsp;Jorge Boán ,&nbsp;Antonio Terrón ,&nbsp;Carlos Heredia ,&nbsp;Cristina Puente ,&nbsp;Asunción Pérez-Jacoiste Asín ,&nbsp;M. Ángeles Orellana ,&nbsp;Laura Domínguez ,&nbsp;José Manuel Caro ,&nbsp;M. Jesús López-Gude ,&nbsp;Eva María Aguilar-Blanco ,&nbsp;Andrea Eixerés-Esteve ,&nbsp;Francisco López-Medrano","doi":"10.1016/j.eimce.2024.04.012","DOIUrl":"10.1016/j.eimce.2024.04.012","url":null,"abstract":"<div><h3>Objectives</h3><div>This study aimed to evaluate the effectiveness of dalbavancin as sequential therapy in patients with infective endocarditis (IE) due to gram positive bacteria (GPB) in a real-life heterogenous cohort with comorbid patients.</div></div><div><h3>Methods</h3><div>A single center retrospective cohort study including all patients with definite IE treated with dalbavancin between January 2017 and February 2022 was developed. A 6-month follow-up was performed. The main outcomes were clinical cure rate, clinical and microbiological relapse, 6-month mortality, and adverse effects (AEs) rate.</div></div><div><h3>Results</h3><div>The study included 61 IE episodes. The median age was 78.5 years (interquartile range [IQR] 63.2–85.2), 78.7% were male, with a median Charlson comorbidity index of 7 (IQR 4–9) points. Overall, 49.2% suffered native valve IE. The most common microorganism was <span><span>Staphylococcus aureus</span></span> (26.3%) followed by <span><span>Enterococcus faecalis</span></span> (21.3%). The median duration of initial antimicrobial therapy and dalbavancin therapy were 27 (IQR 20–34) and 14 days (IQR 14–28) respectively. The total reduction of hospitalization was 1090 days. The most frequent dosage was 1500<!--> <!-->mg of dalbavancin every 14 days (96.7%). An AE was detected in 8.2% of patients, only one (1.6%) was attributed to dalbavancin (infusion reaction). Clinical cure was achieved in 86.9% of patients. One patient (1.6%) with <em>Enterococcus faecalis</em> IE suffered relapse. The 6-month mortality was 11.5%, with only one IE-related death (1.6%).</div></div><div><h3>Conclusion</h3><div>This study shows a high efficacy of dalbavancin in a heterogeneous real-world cohort of IE patients, with an excellent safety profile. Dalbavancin allowed a substantial reduction of in-hospital length of stay.</div></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 2","pages":"Pages 86-92"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141433530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute bacterial peritonitis due to methicillin resistant Staphylococcus lugdunensis","authors":"David Roa Alonso ,&nbsp;Víctor Antón Berenguer ,&nbsp;Alberto Orejas Gallego ,&nbsp;Ricardo Díaz Abad","doi":"10.1016/j.eimce.2024.12.001","DOIUrl":"10.1016/j.eimce.2024.12.001","url":null,"abstract":"","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 2","pages":"Pages 115-116"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}