Enfermedades infecciosas y microbiologia clinica (English ed.)最新文献

{"title":"Impact of infectious diseases consultation and oral sequential therapy in the management of post-surgical mediastinitis","authors":"Marta Represa ,&nbsp;Olalla Lima ,&nbsp;Marina Ávila ,&nbsp;Pablo Rubiñán ,&nbsp;Clara Torres ,&nbsp;Stefanie Sansón-León ,&nbsp;Julio Lugo ,&nbsp;Maximiliano Álvarez-Fernández ,&nbsp;Martin Rubianes ,&nbsp;Juan José Legarra ,&nbsp;María Teresa Pérez-Rodríguez","doi":"10.1016/j.eimce.2025.06.005","DOIUrl":"10.1016/j.eimce.2025.06.005","url":null,"abstract":"<div><h3>Introduction</h3><div>Post-cardiac surgery mediastinitis (PSM) is a serious, complex, and multifactorial complication of surgical procedures. Infectious diseases consultation (IDC) has demonstrated improvement in other complex infectious diseases. The objective of the study was to evaluate the impact of IDC in the management and outcome of patients with PSM.</div></div><div><h3>Methods</h3><div>Observational retrospective study, of adult patients with PSM between January 2010 and June 2021. After January 2016, IDC was performed in all the patients with PSM. The primary endpoint was clinical success, a composite variable of clinical cure, and absence of adverse events, or recurrence. Also, in-hospital stay, and clinical cure was evaluated in patients that received oral sequential therapy (OST).</div></div><div><h3>Results</h3><div>A total of 84 patients with PSM were included, 48 pre-IDC and 36 in IDC period. No differences in clinical success were observed between the two periods (pre-IDC 60% vs, IDC 77%, <em>p</em> <!-->=<!--> <!-->0.104). During the IDC period the rate of adequate targeted antibiotic treatment was higher (pre-IDC 71% vs. IDC 94%, <em>p</em> <!-->=<!--> <!-->0.016). Gram-negative bacilli infections (pre-IDC 42% vs. IDC 78%, <em>p</em> <!-->=<!--> <!-->0.002) and polymicrobial infections (pre-IDC 37% vs. IDC 63%, <em>p</em> <!-->=<!--> <!-->0.004) increased in the IDC period. Multivariate analysis did not show any variable associated with clinical success. OST was similar in both periods, and a shorter in-hospital stay was observed in the patients who underwent OST (no-OST, 70 days vs. OST, 44 days, <em>p</em> <!-->=<!--> <!-->0.003).</div></div><div><h3>Conclusions</h3><div>IDC was related with a higher adequate targeted antimicrobial therapy. We observed that OST offers a promising strategy in the management of this infection.</div></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 7","pages":"Pages 383-388"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144748908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhanced tick species identification in a tertiary care hospital using MALDI–TOF MS: The role of peak numbers","authors":"Antonio Beltrán-Rosel ,&nbsp;Ana M. Palomar ,&nbsp;Pilar Goñi ,&nbsp;Rafael Benito ,&nbsp;Beatriz López-Alonso ,&nbsp;Jorge Ligero-López ,&nbsp;Amparo Boquera-Albert ,&nbsp;María Ducons-Márquez ,&nbsp;Jose A. Oteo","doi":"10.1016/j.eimce.2024.12.017","DOIUrl":"10.1016/j.eimce.2024.12.017","url":null,"abstract":"<div><h3>Introduction</h3><div>Tick bites are a growing public health concern as ticks act as vectors for various pathogens. Accurate tick species identification is vital to assess disease exposure and determine prophylactic measures. MALDI–TOF MS has emerged as a promising tool for precise tick identification. This study evaluates the performance of MALDI–TOF MS in clinical tick identification, focusing on how the number of peaks present in the reference and sample spectra influences the accuracy of the identification process.</div></div><div><h3>Methods</h3><div>Between April 2022 and March 2024, 42 tick specimens sent to our hospital were identified using MALDI–TOF MS. The reference spectrum was created with 70 peaks and expanded to include versions with 40, 100, and 130 peaks using Compass Biotyper Explorer v4.1.1. Spectra were analyzed with Flex Analysis v3.4 software. Identification was performed by querying sample spectra against these libraries, with a log score value (LSV)<!--> <!-->≥<!--> <!-->1.70 considered accurate for species identification.</div></div><div><h3>Results</h3><div>Libraries with 40, 100, and 130 peaks improved identification scores for several species, though the degree varied. The highest scores were achieved in 64.3% of specimens. Combining all libraries as a single database yielded LSVs above the 1.70 threshold for all specimens.</div></div><div><h3>Conclusions</h3><div>The study highlights the species-specific nature of peak importance in spectra and underscores the potential of MALDI–TOF MS as a rapid and accurate tool for tick identification in clinical settings. Enhanced spectral libraries could further improve this technique, aiding timely clinical decisions and effective management of tick bites.</div></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 7","pages":"Pages 396-401"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of immunization strategies for preventing severe acute respiratory infection during the 2023/2024 season in a Spanish health department","authors":"Raíssa de Fátima Silva-Afonso ,&nbsp;Guillermo Platas-Abenza ,&nbsp;María Guerrero-Soler ,&nbsp;Pilar Gallardo-Rodríguez ,&nbsp;Francisco Gil-Sánchez ,&nbsp;Gonzalo Pérez-Paz ,&nbsp;Lidia Cartagena-Llopis ,&nbsp;Marina Fuster-Pérez ,&nbsp;María Sánchez-Valero ,&nbsp;Ana Esclapez-Martínez ,&nbsp;Noemí Solís-Aniorte ,&nbsp;Yamilet Fernández-Martínez ,&nbsp;Elena Ronda-Pérez ,&nbsp;Isabel Escribano-Cañadas ,&nbsp;Juan Carlos Rodríguez-Díaz ,&nbsp;Esperanza Merino De Lucas ,&nbsp;Pablo Chico-Sánchez ,&nbsp;José Sánchez-Payá ,&nbsp;Paula Gras-Valentí","doi":"10.1016/j.eimce.2025.03.017","DOIUrl":"10.1016/j.eimce.2025.03.017","url":null,"abstract":"<div><h3>Introduction</h3><div>A public funded immunization program targeting influenza, COVID-19 and respiratory syncytial virus (RSV), was introduced in Spain for the 2023/2024 season. Effective immunization strategies depend on product coverage and effectiveness.</div></div><div><h3>Objectives</h3><div>Estimate of the impact of three severe acute respiratory infections (SARI) immunization strategies, during the 2023/2024 respiratory illness season in a Spanish health department.</div></div><div><h3>Methods</h3><div>We conducted an ecological study to compare cumulative hospitalization rates of SARI between the 2022/2023 and 2023/2024 seasons. Subsequently, a cross-sectional study was conducted to describe immunization coverage. Three observational test-negative case–control studies were carried out to evaluate the vaccine effectiveness (VE) against influenza and COVID-19 and the effectiveness of immunization with nirsevimab.</div></div><div><h3>Results</h3><div>During the 2023/2024 season 2952 patients were hospitalized due to SARI, representing hospitalization rates of 322.6/100,000 inhabitants (RR<!--> <!-->=<!--> <!-->0.78), indicating a 21.8% (CI: 14.8–28.1) overall effectiveness of the immunization strategies (EIS) against SARI. The global EIS for influenza was 26.7% (CI: 15.2–36.7), with 5.9% (CI: −10.1–19.5) for influenza A and 94.0% (CI: 86.4–97.4) for influenza B. For COVID-19, the EIS was 19.3% (CI: 7.2–29.3). The EIS for RSV was 52.5% (CI: 35.4–65.0) in children &lt;1 year-old. For the 2023/2024 season, influenza vaccination in those aged &gt;64 decreased 7.9%, while COVID-19 vaccination fell by 40.6% in individuals &gt;60 years. Nirsevimab reached high coverage of 94.78%. The aVE was 28.2% (CI: 4.7–45.9) for influenza and 29.2% (CI: 7.1–46.0) for COVID-19. The overall adjusted effectiveness of nirsevimab was 63.8% (CI: 9.6–85.5).</div></div><div><h3>Conclusion</h3><div>The observed EIS was likely due to RSV immunization in infants’ high coverage with good effectiveness and low influenza B circulation.</div></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 7","pages":"Pages 435-443"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary T-cell lymphoma as a rare cause of nodular lung lesions in HIV-positive patient","authors":"Antonio Rosales-Castillo ,&nbsp;Antonio Bustos-Merlo ,&nbsp;Carmen Hidalgo-Tenorio","doi":"10.1016/j.eimce.2025.04.002","DOIUrl":"10.1016/j.eimce.2025.04.002","url":null,"abstract":"","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 7","pages":"Pages 454-455"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe invasive pulmonary aspergillosis caused by 2 different species of Aspergillus","authors":"Javier Romero López ,&nbsp;José María García de Lomas Guerrero ,&nbsp;Jesús Lancha Domínguez ,&nbsp;Francisco Javier Martínez Marcos","doi":"10.1016/j.eimce.2025.02.007","DOIUrl":"10.1016/j.eimce.2025.02.007","url":null,"abstract":"","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 7","pages":"Pages 448-449"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Norovirus GII.17 gastroenteritis outbreak in a nursing home","authors":"Paula Martín Bazarra ,&nbsp;Óscar Esparcia Rodríguez ,&nbsp;Angélica Gómez Martínez ,&nbsp;Regina Azancot Carballo ,&nbsp;Caridad Sainz de Baranda Camino ,&nbsp;Nerea García Ibáñez ,&nbsp;María Dolores Fernández García ,&nbsp;Rafael Carranza González","doi":"10.1016/j.eimce.2025.02.004","DOIUrl":"10.1016/j.eimce.2025.02.004","url":null,"abstract":"<div><h3>Introduction</h3><div>Gastrointestinal norovirus infections are highly prevalent, causing outbreaks especially in institutions such as nursing homes. We describe an outbreak caused by an emerging norovirus genotype.</div></div><div><h3>Material and methods</h3><div>We defined a case as a resident or worker of the centre with clinical signs and symptoms of AGE from 14 to 29 May 2022, with no underlying pathology to justify it. A clinical-epidemiological survey was carried out and stool samples were collected from patients with diarrhoea at the time of the study. Virological analysis was performed at the Microbiology Department of our hospital by antigenic detection (Certest®, Biotec SL) and/or multiplex PCR (AllplexTM GI-Virus Assay, Seegene®). Viral genotyping by sequencing was performed by the Centro Nacional de Microbiología (CNM).</div></div><div><h3>Results</h3><div>The outbreak totaled 114 cases (99 residents, 15 workers), extending over 16 days. The most frequent symptoms were vomiting and diarrhoea. The overall attack rate was 30.8% (in workers 12.7%). Cases increased rapidly in the first 48<!--> <!-->h, falling progressively over successive days. Food contamination was ruled out, with person-to-person transmission being the most likely. Those affected improved clinically in less than 72<!--> <!-->h, with no deaths. We tested 14 samples from residents, which were positive for norovirus GII. The CNM received 8 samples, detecting norovirus genogroup GII, genotype 17 [P17] in 6.</div></div><div><h3>Conclusions</h3><div>Outbreaks of norovirus GEA in nursing homes can affect numerous users. In our case, norovirus genotype GII.17 was the aetiological agent, confirming its widespread dissemination in the last decade worldwide.</div></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 7","pages":"Pages 378-382"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with glucocorticoid dosing in treating patients with noncritical COVID-19 pneumonia: Insights from an artificial intelligence-based CT imaging analysis","authors":"Jie Wang ,&nbsp;Chang He ,&nbsp;Yu Shi ,&nbsp;Kunkai Su ,&nbsp;Zhihui Huang ,&nbsp;Songli Du ,&nbsp;Xukun Li ,&nbsp;Wei Wu ,&nbsp;Jifang Sheng","doi":"10.1016/j.eimce.2025.06.004","DOIUrl":"10.1016/j.eimce.2025.06.004","url":null,"abstract":"<div><h3>Objective</h3><div>Glucocorticoids are vital in treating COVID-19, but standard dosage for noncritical patients remain controversial. To determine the optimal glucocorticoid dosage for noncritical COVID-19 patients, we analyzed factors influencing dosage and developed a predictive model.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed 273 noncritical COVID-19 pneumonia patients underwent pulmonary CT and treated with glucocorticoids in a tertiary hospital (12/2022–01/2023). Patients were divided into low and high glucocorticoid dosage groups based on a daily 40<!--> <!-->mg methylprednisolone or equivalent. Artificial intelligence (AI)-based deep learning was utilized to assess pulmonary CT images for accurate lesion area, which then analyzed through multivariable logistic regression to explore their correlation with glucocorticoid dosage. A predictive model was developed and validated for dosage prediction.</div></div><div><h3>Results</h3><div>The primary analysis included 243 patients, with 168 in the training set and 75 in the validation set. High-dose treatment was administered to 139 patients (82.7%) and low-dose to 29 patients (17.3%) in the training cohort. A predictive model incorporating normally inflated ratio, ground-glass opacity (GGO) ratio, and consolidation ratio accurately predicted selection of high- or low-dose, in both training (AUC<!--> <!-->=<!--> <!-->0.803) and validation cohorts (AUC<!--> <!-->=<!--> <!-->0.836), respectively. In 30 patients with post-CT adjusted dosages, the predicted dosages highly matched with the actual adjusted dosages.</div></div><div><h3>Conclusion</h3><div>Glucocorticoid dosages for noncritical COVID-19 pneumonia treatment are influenced by pulmonary CT features. Our predictive model can predict glucocorticoid dosage, however, should be validated by larger, prospective studies.</div></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 7","pages":"Pages 402-410"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Opportunities and challenges in the use of pool sampling for sexually transmitted infections","authors":"Laura Villa ,&nbsp;Fernando Vazquez","doi":"10.1016/j.eimce.2025.04.005","DOIUrl":"10.1016/j.eimce.2025.04.005","url":null,"abstract":"","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 7","pages":"Pages 371-373"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144749124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cost-effectiveness of cabotegravir versus tenofovir alafenamide plus emtricitabine versus tenofovir disoproxil fumarate plus emtricitabine for pre-exposure prophylaxis to prevent HIV-1 transmission in gay, bisexual and other men that have sex with men","authors":"Philip Erick Wikman-Jorgensen ,&nbsp;Marta Ruiz-Algueró ,&nbsp;Carlos Iniesta ,&nbsp;Federico Pulido ,&nbsp;Jara Llenas-García","doi":"10.1016/j.eimce.2024.12.014","DOIUrl":"10.1016/j.eimce.2024.12.014","url":null,"abstract":"<div><h3>Introduction</h3><div>This study aims to compare the cost-effectiveness of currently approved daily PrEP in Spain, with tenofovir disoproxil fumarate plus emtricitabine (TDF/FTC), in gay, bisexual and other men who have sex with men (GBMSM) versus newer alternatives like daily tenofovir alafenamide plus emtricitabine (TAF/FTC) or injectable cabotegravir every 2 months (CAB).</div></div><div><h3>Methods</h3><div>We fitted a dynamic compartmentalized Markov model that represents the dynamics of HIV-1 transmission in GBMSM in Spain. The model was calibrated to replicate the epidemiological data of the HIV epidemic in GBMSM in Spain from 2013 to 2018. We used the perspective of the national health system and applied a 40-year time horizon. Quality-adjusted life years (QALYs) were the health outcome variable, and the cost was accounted for in 2018 Euros (€). Our outcome variable was the incremental cost-effectiveness ratio (ICER) for PrEP. We used the 2018 gross domestic product per capita of Spain (€25,854) as the willingness-to-pay (WTP) threshold.</div></div><div><h3>Results</h3><div>The 2019 scenario with no PrEP in place would yield 17,424,891 QALYs and a cost of 2018 €17,345,310,254. The present scenario of daily TDF/FTC yields 18,615,325 QALYs, an increase of 1,190,434 QALYs at a cost of 2018 €15,354,878,534 (decrease of −2018 €1,990,431,719), generating an ICER of −2018 €1672 per QALY gained. The introduction of daily TAF/FTC in the present scenario would yield an increase in 449,392 QALYs at an additional cost of 2018 €13,634,260,217. The ICER would thus be 2018 €30,339 per QALY gained. Introducing CAB in the present scenario would yield an increase of 573,007 QALYs at an additional cost of 2018 €16,754,471,790 (average cost-effectiveness ratio<!--> <!-->=<!--> <!-->29,239). Compared to TAF, the increase in QALYs would be 123,614 at an additional cost of 2018 €5,707,367,590, yielding an ICER of 2018 €46,170/QALY gained. A one-way sensitivity analysis and a probabilistic sensitivity analysis was carried out.</div></div><div><h3>Conclusion</h3><div>The present Spanish policy of PrEP is a cost-saving strategy. TAF/FTC and CAB are not cost-effective at current market prices.</div></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 7","pages":"Pages 416-425"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of follow-up blood cultures in Escherichia coli and Klebsiella pneumoniae bacteremia in geriatric patients","authors":"Sinan Çetin,&nbsp;Ferah Öğüt,&nbsp;Ahmet Melih Şahin,&nbsp;Meltem Arzu Yetkin","doi":"10.1016/j.eimce.2024.12.016","DOIUrl":"10.1016/j.eimce.2024.12.016","url":null,"abstract":"<div><h3>Introduction</h3><div>We aimed to investigate the effect of obtaining follow-up blood cultures (FUBC) and persistent growth in FUBC on clinical outcomes in bacteremia cases caused by <em>Escherichia coli</em> and <em>Klebsiella pneumoniae</em> in the geriatric age group.</div></div><div><h3>Methods</h3><div>Patients over 65 years of age with <em>E. coli</em> or <em>K. pneumoniae</em> bacteremia were included in the study. Patients were grouped as those who obtained FUBC and those who did not. Patients with FUBC were grouped as persistent bacteremia or negative FUBC. Demographic, clinical characteristics and outcomes were compared between these groups.</div></div><div><h3>Results</h3><div>A total of 142 patients were included. FUBC were obtained in 79 patients (55.6%) and persistent bacteremia was detected in 23 (29.1%). There were no significant differences in demographic data and clinical characteristics between patients with and without FUBC. There was no statistical difference in the outcomes between patients with of without FUBC. Patients with persistent bacteremia had a higher prevalence of diabetes mellitus, and the interval between index blood culture and FUBC was shorter (2.9 days <em>versus</em> 4.2 days). There was no difference between patients with persistent bacteremia and patients with no growth on FUBC in terms of length of hospital stay, need for intensive care unit, intubation, vasopressor therapy, and 14, 30, 90-day all-cause mortality.</div></div><div><h3>Conclusion</h3><div>In patients over 65 years of age with <em>E. coli</em> or <em>K. pneumoniae</em> bacteremia, neither obtaining FUBC nor persistent bacteremia on FUBC showed any difference in terms of outcomes such as mortality and need for admission to an intensive care unit.</div></div>","PeriodicalId":72916,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica (English ed.)","volume":"43 7","pages":"Pages 389-395"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144748913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}