Encephalitis (Seoul, Korea)最新文献_第4页

Atypical occurrence of anti-Ma2-associated encephalitis after breast cancer surgery and COVID-19. 乳腺癌手术后抗ma2相关脑炎与COVID-19的不典型发生。

Encephalitis (Seoul, Korea) Pub Date : 2023-07-01 DOI: 10.47936/encephalitis.2023.00080

Jungyun Seo, Hong Nam Kim, Minsuk Kwon, Tae-Joon Kim

引用次数: 0

Optic neuritis associated with seronegative autoimmune encephalitis: a case report. 视神经炎合并血清阴性自身免疫性脑炎1例

Encephalitis (Seoul, Korea) Pub Date : 2023-07-01 DOI: 10.47936/encephalitis.2023.00024

Hyungseok Hah, Yonghyun Lee, Ho-Won Lee, Ji-Ye Jeon

{"title":"Optic neuritis associated with seronegative autoimmune encephalitis: a case report.","authors":"Hyungseok Hah, Yonghyun Lee, Ho-Won Lee, Ji-Ye Jeon","doi":"10.47936/encephalitis.2023.00024","DOIUrl":"https://doi.org/10.47936/encephalitis.2023.00024","url":null,"abstract":"Optic neuritis is an inflammatory demyelinating disorder that primarily affects the optic nerve and is often associated with multiple sclerosis. While it is rare for optic neuritis to be accompanied by autoimmune encephalitis, it can occur in some cases. A 65-year-old woman with bipolar disorder presented with a progressively altered mentality. Magnetic resonance imaging of the brain showed no definite abnormal findings. Electroencephalography revealed nonconvulsive status epilepticus. Cerebrospinal fluid study and autoimmune and paraneoplastic encephalitis antibodies were negative. The patient was diagnosed with seronegative autoimmune encephalitis and treated with methylprednisolone, intravenous immunoglobulin, and rituximab. Her condition gradually improved except for persistent blindness on the left side. This case highlights the importance of considering autoimmune encephalitis even in the absence of identifiable pathogenic antibodies when clinical manifestations and response to immunotherapy support such a diagnosis.","PeriodicalId":72904,"journal":{"name":"Encephalitis (Seoul, Korea)","volume":"3 3","pages":"94-96"},"PeriodicalIF":0.0,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e2/ad/encephalitis-2023-00024.PMC10368526.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9877420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peripheral blood inflammatory cytokines in prodromal and overt α-synucleinopathies: a review of current evidence. 外周血炎症因子在前驱和显性α-突触核蛋白病中的作用:目前证据的回顾。

Encephalitis (Seoul, Korea) Pub Date : 2023-07-01 DOI: 10.47936/encephalitis.2023.00031

Jin-Sun Jun, Ryul Kim

引用次数: 0

Intrathecal tigecycline is a safe and effective treatment for central nervous system infections. 鞘内替加环素是一种安全有效的治疗中枢神经系统感染的方法。

Encephalitis (Seoul, Korea) Pub Date : 2023-07-01 DOI: 10.47936/encephalitis.2023.00010

Antonio Mastroianni, Valeria Vangeli, Maria Vittoria Mauro, Filippo Urso, Roberto Manfredi, Sonia Greco

引用次数: 0

The importance of ruling out herpes simplex virus encephalitis in N-methyl-ᴅ-aspartate receptor encephalitis studies. 排除单纯疱疹病毒脑炎在n -甲基-夏-天冬氨酸受体脑炎研究中的重要性。

Encephalitis (Seoul, Korea) Pub Date : 2023-07-01 DOI: 10.47936/encephalitis.2023.00101

Esma'il Akade, Shahram Jalilian, Mohammad Bahadoram

引用次数: 0

Management of convulsive status epilepticus: recent updates. 惊厥癫痫持续状态的管理:最近的更新。

Encephalitis (Seoul, Korea) Pub Date : 2023-04-01 DOI: 10.47936/encephalitis.2022.00087

Jung-Ick Byun

引用次数: 1

The use of azithromycin and pyrimethamine for treatment of cerebral toxoplasmosis in human immunodeficiency virus-infected patients: a systematic review. 使用阿奇霉素和乙胺嘧啶治疗人类免疫缺陷病毒感染患者的脑弓形虫病:一项系统综述。

Encephalitis (Seoul, Korea) Pub Date : 2023-04-01 DOI: 10.47936/encephalitis.2022.00115

Mark Erving H Ramos, Steven G Villaraza

{"title":"The use of azithromycin and pyrimethamine for treatment of cerebral toxoplasmosis in human immunodeficiency virus-infected patients: a systematic review.","authors":"Mark Erving H Ramos, Steven G Villaraza","doi":"10.47936/encephalitis.2022.00115","DOIUrl":"https://doi.org/10.47936/encephalitis.2022.00115","url":null,"abstract":"Purpose: Toxoplasma gondii is a parasite that is widely distributed around the globe and can cause brain inflammation, particularly in immunosuppressed patients such as those diagnosed with human immunodeficiency virus (HIV). This paper reviews the efficacy of azithromycin and pyrimethamine combination therapy for cerebral toxoplasmosis in patients with HIV.Methods: The scope of the studies included in this review was limited from 1992 to 2022, with studies primarily being randomized, controlled clinical trials available on online scientific journal databases. The authors screened eligible records for review, removing those that did not fit the inclusion and exclusion criteria. The risk of bias of the extracted data was analyzed through the Cochrane risk-of-bias tool for randomized trials.Results: A broad search of major online databases such as PubMed, Medline, Google Scholar, and Cochrane using keywords, limit fields, and Boolean operators yielded 3,130 articles. After thoroughly screening the search results, two studies were included in this review. Results from the studies included in the review demonstrate that the combination therapy of azithromycin and pyrimethamine is favorable for cerebral toxoplasmosis. However, the net response is less effective than the standard treatment regimen (pyrimethamine and sulfadiazine).Conclusion: The combination therapy of azithromycin and pyrimethamine is less effective than the standard treatment regimen for maintenance therapy for cerebral toxoplasmosis; thus, administering these medications for this indication must be met with caution.","PeriodicalId":72904,"journal":{"name":"Encephalitis (Seoul, Korea)","volume":"3 2","pages":"64-70"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4d/61/encephalitis-2022-00115.PMC10295825.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9835134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroprotective effects of melatonin in neurodegenerative and autoimmune central nervous system diseases. 褪黑素在神经退行性和自身免疫性中枢神经系统疾病中的神经保护作用。

Encephalitis (Seoul, Korea) Pub Date : 2023-04-01 DOI: 10.47936/encephalitis.2022.00094

Jung-Won Shin

{"title":"Neuroprotective effects of melatonin in neurodegenerative and autoimmune central nervous system diseases.","authors":"Jung-Won Shin","doi":"10.47936/encephalitis.2022.00094","DOIUrl":"https://doi.org/10.47936/encephalitis.2022.00094","url":null,"abstract":"The suprachiasmatic nucleus (SCN) in the anterior hypothalamus is the major circadian pacemaker in humans. Melatonin is a key hormone secreted by the pineal gland in response to darkness. Light-induced stimuli are transmitted along the retinohypothalamic tract to the SCN. Activation of the SCN inhibits the production of melatonin by the pineal gland through a complex neural pathway passing through the superior cervical ganglion. Accordingly, when light is unavailable, the pineal gland secretes melatonin. The circadian rhythm modulates sleep-wake cycles as well as many physiological functions of the endocrine system, including core body temperature, pulse rate, oxygen consumption, hormone levels, metabolism, and gastrointestinal function. In neurodegenerative disorders, the sleep-wake cycle is disrupted and circadian regulation is altered, which accelerates disease progression, further disrupting circadian regulation and setting up a vicious cycle. Melatonin plays a critical role in the regulation of circadian rhythms and is a multifunctional pleiotropic agent with broad neuroprotective effects in neurodegenerative disorders, viral or autoimmune diseases, and cancer. In this review, I discuss the neuroprotective functions of melatonin in circadian regulation and its roles in promoting anti-inflammatory activity, enhancing immune system functions, and preventing alterations in glucose metabolism and mitochondrial dysfunction in neurodegenerative disorders and autoimmune central nervous system diseases.","PeriodicalId":72904,"journal":{"name":"Encephalitis (Seoul, Korea)","volume":"3 2","pages":"44-53"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/48/a3/encephalitis-2022-00094.PMC10295826.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9835131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protein biomarkers in multiple sclerosis. 多发性硬化症中的蛋白质生物标志物。

Encephalitis (Seoul, Korea) Pub Date : 2023-04-01 DOI: 10.47936/encephalitis.2022.00101

Jun-Soon Kim

{"title":"Protein biomarkers in multiple sclerosis.","authors":"Jun-Soon Kim","doi":"10.47936/encephalitis.2022.00101","DOIUrl":"https://doi.org/10.47936/encephalitis.2022.00101","url":null,"abstract":"This review aimed to elucidate protein biomarkers in body fluids, such as blood and cerebrospinal fluid (CSF), to identify those that may be used for early diagnosis of multiple sclerosis (MS), prediction of disease activity, and monitoring of treatment response among MS patients. The potential biomarkers elucidated in this review include neurofilament proteins (NFs), glial fibrillary acidic protein (GFAP), leptin, brain-derived neurotrophic factor (BDNF), chitinase-3-like protein 1 (CHI3L1), C-X-C motif chemokine 13 (CXCL13), and osteopontin (OPN), with each biomarker playing a different role in MS. GFAP, leptin, and CHI3L1 levels were increased in MS patient groups compared to the control group. NFs are the most studied proteins in the MS field, and significant correlations with disease activity, future progression, and treatment outcomes are evident. GFAP CSF level shows a different pattern by MS subtype. Increased concentration of CHI3L1 in the blood/CSF of clinically isolated syndrome (CIS) is an independent predictive factor of conversion to definite MS. BDNF may be affected by chronic progression of MS. CHI3L1 has potential as a biomarker for early diagnosis of MS and prediction of disability progression, while CXCL13 has potential as a biomarker of prognosis of CIS and reflects MS disease activity. OPN was an indicator of disease severity. A periodic detailed patient evaluation should be performed for MS patients, and broadly and easily accessible biomarkers with higher sensitivity and specificity in clinical settings should be identified.","PeriodicalId":72904,"journal":{"name":"Encephalitis (Seoul, Korea)","volume":"3 2","pages":"54-63"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/99/f2/encephalitis-2022-00101.PMC10295828.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9845007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Myelin oligodendrocyte glycoprotein antibody-associated encephalitis after severe acute respiratory syndrome coronavirus 2 infection: a case report and retrospective case reviews. 严重急性呼吸综合征冠状病毒2型感染后髓鞘少突胶质细胞糖蛋白抗体相关性脑炎1例报告及回顾性病例回顾

Encephalitis (Seoul, Korea) Pub Date : 2023-04-01 DOI: 10.47936/encephalitis.2022.00129

Yoonkyung Lee, Seon-Jae Ahn, Han-Sang Lee, Yongmoo Kim, Seolah Lee, Hyeyoung Park, Jangsup Moon, Sang Kun Lee, Kon Chu

引用次数: 0