Encephalitis (Seoul, Korea)最新文献_第3页

The relationship between sleep and innate immunity. 睡眠与先天免疫力之间的关系。

Encephalitis (Seoul, Korea) Pub Date : 2024-10-01 Epub Date: 2024-05-21 DOI: 10.47936/encephalitis.2024.00017

Yoonkyung Lee, Kyung-Il Park

引用次数: 0

Understanding epileptogenesis from molecules to network alteration. 从分子到网络改变，了解癫痫发生。

Encephalitis (Seoul, Korea) Pub Date : 2024-07-01 Epub Date: 2024-06-18 DOI: 10.47936/encephalitis.2024.00038

Kyung-Il Park

引用次数: 0

Sleep and neuroimmunology: a narrative review. 睡眠与神经免疫学：叙述性综述。

Encephalitis (Seoul, Korea) Pub Date : 2024-07-01 Epub Date: 2024-06-25 DOI: 10.47936/encephalitis.2024.00024

Jin Myoung Seok, Kwang Ik Yang

引用次数: 0

Insights into adjunctive corticosteroid therapy in fulminant herpes simplex virus encephalitis: case analysis with contrasting outcomes. 对暴发性单纯疱疹病毒脑炎辅助皮质类固醇疗法的见解：结果截然不同的病例分析。

Encephalitis (Seoul, Korea) Pub Date : 2024-07-01 Epub Date: 2024-07-10 DOI: 10.47936/encephalitis.2024.00031

Hussein Algahtani, Bader Shirah, Hussam A Jamaluddin, Nawal Abdelghaffar

{"title":"Insights into adjunctive corticosteroid therapy in fulminant herpes simplex virus encephalitis: case analysis with contrasting outcomes.","authors":"Hussein Algahtani, Bader Shirah, Hussam A Jamaluddin, Nawal Abdelghaffar","doi":"10.47936/encephalitis.2024.00031","DOIUrl":"10.47936/encephalitis.2024.00031","url":null,"abstract":"Herpes simplex virus (HSV) encephalitis, predominantly caused by HSV-1, presents with significant morbidity and mortality challenges. This research investigates the particular role of adjunctive corticosteroid therapy in fulminant HSV encephalitis through in-depth analyses of two contrasting cases. Corticosteroids show potential benefits to improve an exaggerated immune response and limit viral dissemination within the brain. Daily assessments and frequent neuroimaging, particularly using magnetic resonance imaging, aid in the management of fulminant cases. Although existing evidence relies on limited case series and retrospective comparisons, the results of the present study emphasize the necessity for large-scale controlled trials to establish definitive guidelines. The discretion of the treating neurologist governs the decision to implement corticosteroids, emphasizing the imperative need for continued research and evidence-based strategies for this challenging neurological condition.","PeriodicalId":72904,"journal":{"name":"Encephalitis (Seoul, Korea)","volume":"4 3","pages":"62-68"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11237186/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141565311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chronic social stress in early life can predispose mice to antisocial maltreating behavior. 幼年时期的慢性社会压力会使小鼠容易产生反社会的虐待行为。

Encephalitis (Seoul, Korea) Pub Date : 2024-04-01 Epub Date: 2024-03-06 DOI: 10.47936/encephalitis.2023.00199

Daejong Jeon, Sangwoo Kim, Sang Kun Lee, Kon Chu

{"title":"Chronic social stress in early life can predispose mice to antisocial maltreating behavior.","authors":"Daejong Jeon, Sangwoo Kim, Sang Kun Lee, Kon Chu","doi":"10.47936/encephalitis.2023.00199","DOIUrl":"10.47936/encephalitis.2023.00199","url":null,"abstract":"Purpose: In our previous study, we developed an assay system to evaluate antisocial maltreating behavior of conspecific mice using a perpetrator-victim paradigm. We also generated a mouse model for the maltreating behavior by mimicking child maltreatment or abuse. Here, we further investigate the antisocial behavior using anti-aggressive and antipsychotic drugs.Methods: Model mice sequentially subjected to maternal separation (MS), social defeat (SD), and social isolation (SI) in that order (MS/SD/SI model) were subjected to a maltreating behavioral task. The MS/SD/SI mice were treated with oxytocin (OXY), clozapine (CLZ), haloperidol (HAL), and 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Western blotting and enzyme-linked immunosorbent assay were used for protein analysis.Results: A substantial portion of the MS/SD/SI model mice (46% of males and 40% of females) showed a higher number of nose pokes than the control. OXY or 8-OH-DPAT treatment reduced the high number of nose pokes by the MS/SD/SI mice, whereas HAL increased it. CLZ did not affect the number of nose pokes by the MS/SD/SI mice. Interestingly, although the OXY level in the MS/SD/SI mice was similar to that in the control, the amount of OXY receptor was lower in the MS/SD/SI mice. The amount of 5-HT1A receptor was also decreased in the MS/SD/SI mice.Conclusion: Chronic social stress in childhood might predispose a mouse to antisocial behavior. Our maltreating behavior assay system, including the MS/SD/SI model, is a good animal system for research on and drug screening for brain disorders associated with antisocial or psychotic behavior.","PeriodicalId":72904,"journal":{"name":"Encephalitis (Seoul, Korea)","volume":" ","pages":"23-30"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11007547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140041014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myelin oligodendrocyte glycoprotein antibody-associated disease presenting as unilateral cerebral cortical encephalitis: a case report. 表现为单侧大脑皮质脑炎的髓鞘少突胶质细胞糖蛋白抗体相关疾病：一份病例报告。

Encephalitis (Seoul, Korea) Pub Date : 2024-04-01 Epub Date: 2024-03-25 DOI: 10.47936/encephalitis.2023.00234

Ji-Yoon An, Soo-Im Jang, Seul-Gi Choi, Sae-Nal Lee, Eun-Ja Lee, Kwang-Ki Kim, Hang-Rai Kim

{"title":"Myelin oligodendrocyte glycoprotein antibody-associated disease presenting as unilateral cerebral cortical encephalitis: a case report.","authors":"Ji-Yoon An, Soo-Im Jang, Seul-Gi Choi, Sae-Nal Lee, Eun-Ja Lee, Kwang-Ki Kim, Hang-Rai Kim","doi":"10.47936/encephalitis.2023.00234","DOIUrl":"https://doi.org/10.47936/encephalitis.2023.00234","url":null,"abstract":"Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an autoimmune disorder with diverse clinical manifestations including myelitis, meningitis, encephalitis, and optic neuritis. MOGAD rarely presents with unilateral cerebral cortical encephalitis (CCE), rendering the diagnosis difficult in these cases. Furthermore, MOGAD is frequently accompanied by other autoimmune diseases such as thyroid disease or inflammatory bowel disease. Herein, we report a case of unilateral CCE with positive anti-myelin oligodendrocyte glycoprotein (MOG) antibodies. In addition, our patient presented with systemic symptoms as well as neurologic symptoms and was finally diagnosed with ulcerative colitis (UC). A 60-year-old female was admitted to the hospital with an acute onset of headache and fever. Neurological examination revealed left-sided homonymous hemianopsia with intermittent visual hallucinations as flickering red-circular spots in the left visual field. Brain magnetic resonance imaging showed focal hyperintensities and enhancement in the right temporo-parieto-occipital cortex. Electroencephalography indicated a focal seizure in the right occipital cortex. After the administration of an antiepileptic drug, the patient showed clinical and radiological improvements. She tested positive for serum anti-MOG antibodies and was diagnosed with anti-MOG-associated unilateral CCE. However, the gastrointestinal symptoms persisted, thus, a sigmoidoscopy was performed. The patient was diagnosed with comorbid UC. Steroids were administered to treat the UC and the gastrointestinal symptoms improved. To the best of our knowledge, this is the first case of MOGAD presenting as a unilateral CCE in Korea. This case highlights the clinical phenotypes of MOGAD and the need to assess comorbid autoimmune diseases in patients with MOGAD.","PeriodicalId":72904,"journal":{"name":"Encephalitis (Seoul, Korea)","volume":"4 2","pages":"35-39"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11007549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140868037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Herpes simplex encephalitis initially presenting without fever or cerebrospinal fluid pleocytosis and with typical neuroimaging findings: a case report. 最初表现为单纯疱疹性脑炎，无发热或脑脊液多细胞症，有典型的神经影像学检查结果。

Encephalitis (Seoul, Korea) Pub Date : 2024-04-01 Epub Date: 2024-03-05 DOI: 10.47936/encephalitis.2023.00220

Yoonjeong Na, Jung-Ju Lee, Byung Kun Kim, Woong-Woo Lee, Yong Soo Kim, Ilhan Yoo

{"title":"Herpes simplex encephalitis initially presenting without fever or cerebrospinal fluid pleocytosis and with typical neuroimaging findings: a case report.","authors":"Yoonjeong Na, Jung-Ju Lee, Byung Kun Kim, Woong-Woo Lee, Yong Soo Kim, Ilhan Yoo","doi":"10.47936/encephalitis.2023.00220","DOIUrl":"10.47936/encephalitis.2023.00220","url":null,"abstract":"Herpes simplex encephalitis (HSE) is a common viral encephalitis that can be fatal if not adequately treated. Fever, cerebrospinal fluid (CSF) pleocytosis, and typical neuroimaging findings are commonly observed in HSE cases. We encountered a patient with HSE who did not exhibit these classic clinical features. A 63-year-old male presented with his first-ever seizure. Fever did not develop until the fourth day of admission, and neither neuroimaging nor CSF analysis revealed abnormalities. Under suspicion of autoimmune encephalitis, methylprednisolone was administered. Subsequently, when the patient developed fever, a follow-up neuroimaging study was performed and revealed abnormalities consistent with HSE. The patient was promptly treated with acyclovir, which led to a full recovery. Diagnosing HSE in patients who present without fever or CSF pleocytosis and with typical neuroimaging findings poses a challenge. Therefore, prior to initiating immunosuppressive treatment, it is crucial to closely observe patients and to conduct follow-up tests, including neuroimaging and CSF analysis.","PeriodicalId":72904,"journal":{"name":"Encephalitis (Seoul, Korea)","volume":" ","pages":"31-34"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11007550/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140041015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Eosinophilic meningoencephalitis successfully treated with glucocorticoids and intravenous immunoglobulin: a case report. 用糖皮质激素和静脉注射免疫球蛋白成功治疗嗜酸性粒细胞脑膜脑炎：一份病例报告。

Encephalitis (Seoul, Korea) Pub Date : 2024-04-01 Epub Date: 2024-03-28 DOI: 10.47936/encephalitis.2024.00010

Soo Hyun Ahn, Seon-Jae Ahn, Seung Ae Kim, Han Sang Lee, Kon Chu

{"title":"Eosinophilic meningoencephalitis successfully treated with glucocorticoids and intravenous immunoglobulin: a case report.","authors":"Soo Hyun Ahn, Seon-Jae Ahn, Seung Ae Kim, Han Sang Lee, Kon Chu","doi":"10.47936/encephalitis.2024.00010","DOIUrl":"10.47936/encephalitis.2024.00010","url":null,"abstract":"Eosinophilic meningoencephalitis is a rare inflammatory condition of the central nervous system. As a limited number of cases has been reported, debate remains on the optimal treatment. We present a case of idiopathic eosinophilic meningoencephalitis successfully treated with glucocorticoids and intravenous immunoglobulin (IVIG). After extensive evaluation to rule out other possible causes, the patient was treated with intravenous (IV) dexamethasone and showed significant improvement within a few days. However, neurologic impairment persisted, and follow-up lumbar puncture results showed only a mild decrease in pleocytosis. Even after an additional 5 days of IV methylprednisolone, cerebrospinal fluid (CSF) pleocytosis persisted, and brain magnetic resonance imaging (MRI) showed an increase in enhanced lesions, implying persistent neuroinflammation. The patient was maintained on high-dose oral prednisolone for 2 months, and additional immune-modulatory effects were treated with IVIG. Follow-up MRI at 2 months showed a significant decrease in the extent of multiple enhanced lesions and a normalized CSF profile. The patient was maintained on regular maintenance doses of IVIG for an additional 6 months without any neurologic signs or symptoms. Inflammation is the key pathophysiology underlying neurological damage in eosinophilic meningoencephalitis. A literature review revealed that corticosteroid treatment is the only anti-inflammatory treatment used in cases of idiopathic meningoencephalitis, resulting in sufficient response in most patients but only partial response or death in a few cases. This is the first case report of IVIG use in idiopathic eosinophilic meningoencephalitis, suggesting the possibility of a new treatment modality for refractory cases.","PeriodicalId":72904,"journal":{"name":"Encephalitis (Seoul, Korea)","volume":" ","pages":"40-46"},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11007548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140308164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Encephalitis (Seoul, Korea) Pub Date : 2024-01-01 Epub Date: 2023-12-06 DOI: 10.47936/encephalitis.2023.00115

Reza Dehdab, Saif Afat

引用次数: 0

The association between autoimmune encephalitis mediated by N-methyl-ᴅ-aspartate receptor autoantibodies and COVID-19: a systematic review. N-甲基-ᴅ-天冬氨酸受体自身抗体介导的自身免疫性脑炎与COVID-19之间的关联：系统综述。

Encephalitis (Seoul, Korea) Pub Date : 2024-01-01 Epub Date: 2023-12-21 DOI: 10.47936/encephalitis.2023.00171

Ahmad Sawalha, Huda Alkilani, Rami Abdelaziz

引用次数: 0