{"title":"A multidimensional astrocytic framework links serum biomarkers to depression subtypes cognition and sleep EEG.","authors":"Zi-Jie Ma, Tian-Tian Zou, Yu-Shun Zhou, Xue-Yan Li, Zhen-Yu Hu, Gao-Xia Liu, Lan Xia, Gui-Hai Chen","doi":"10.1007/s44192-026-00467-8","DOIUrl":"https://doi.org/10.1007/s44192-026-00467-8","url":null,"abstract":"<p><strong>Objective: </strong>To investigate changed levels of serum astrocytic biomarkers, including glial cell line-derived neurotrophic factor (GDNF), aldehyde dehydrogenase (ALDH) and connexin-26, and the correlations with depression subtypes, cognitive dysfunction and electroencephalogram measures in patients with depression disorder (DD).</p><p><strong>Methods: </strong>Seventy-three patients and 46 healthy subjects (HC) were enrolled. Questionnaires, Nine Box Maze Test (NBMT) were used to assess sleep and neuropsychology. Serum biomarkers were evaluated with enzyme-linked immunosorbent assay. Partial subjects (45 DD and 10 HC) completed polysomnography.</p><p><strong>Results: </strong>Compared to the HC, the patients had lower levels of GDNF, ALDH and connexin-26, and increased errors in NBMT tasks, including spatial/object working memory (SWM/OWM) and spatial/object reference memory (SRM/ORM). The connexin-26 concentration was higher in recurrent depression relative to dysthymia and bipolar depression; and GDNF concentrations was higher in the first episode depression compared to the recurrent depression and bipolar depression, with the lowest concentration in dysthymia. Partial correlation analysis for patients showed that the GDNF positively associated with N3% and power of delta wave; ALDH positively associated with MMSE score and OWM error; and connexin-26 negatively correlated with ORM and SRM errors.</p><p><strong>Conclusion: </strong>Depressive patients had decreased serum levels of GDNF, ALDH and CX26, with subtype-specific difference in GDNF and CX26, which were associated with impaired cognition and slow wave power of electroencephalogram.</p>","PeriodicalId":72827,"journal":{"name":"Discover mental health","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147824242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Scoping Review of Interventions for the Management of Nomophobia.","authors":"Vardhini Krishnamurthy, Surekha Chukkali, Kasi Mayan Pavithrakshmi","doi":"10.1007/s44192-026-00466-9","DOIUrl":"https://doi.org/10.1007/s44192-026-00466-9","url":null,"abstract":"<p><p>Nomophobia, or \"no-mobile-phone-phobia\", refers to the anxiety and apprehension arisingfrom the inability to have constant access to mobile phones due to various reasons. In a worldwhere digital modes of communication and socialisation are becoming the norm and people are finding it increasingly difficult to survive without their phones, nomophobia is emerging as one severe consequence. This scoping review seeks to understand the breadth of the existing literature surrounding the interventions for nomophobia, along with understanding its formats, components, scales used, theoretical framework and outcomes. The search included studies published in English from 2008 to 2025 that assessed nomophobia as an outcome using standardised measures. A total of 4,828 records were identified, of which 12 articles met the inclusion criteria. The authors adopted the JBI framework to structure the scoping review. The included studies primarily focused on the young adult population. The interventions were grouped into mindfulness-based, psychoeducation, app-based, and multi-component, combining various techniques. Most of the interventions were administered in groups and in-person formats. The Nomophobia Questionnaire (NMQ) was the most commonly used tool. Results revealed the need for designing primary and secondary preventive measures and long-term follow-ups. The review highlights the critical need for interventions focused on nomophobia since it is still nascent. The interventions are focused on limited populations and are limited in scope. Given the public mental implications of this increasingly pressing concern, this study shows the urgent need for culturally adaptable interventions to foster healthier digital habits and overall well-being.</p>","PeriodicalId":72827,"journal":{"name":"Discover mental health","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147824218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A review of occupational health stress and mental health outcomes among informal metal fabrication workers in Southern Africa.","authors":"Thandekile Mirriam Mkosana, Steven Jerie","doi":"10.1007/s44192-026-00463-y","DOIUrl":"https://doi.org/10.1007/s44192-026-00463-y","url":null,"abstract":"<p><p>Occupational stress is a pervasive issue globally among informal metal fabrication employees, with significant consequences for mental health. The review aims to understand occupational health stress and its psychological outcomes among informal metal fabrication workers in Southern Africa. Literature used during the review was wrangled from databases which included Google scholar, Scopus and PubMed. The review used PRISMA methodology for inclusion and exclusion criteria for selection of articles were 82 articles were found relevant. The review did an in-depth analysis of the contributing factors of occupational stress which included high job demands, inconsistent remuneration, inadequate resources and interpersonal conflicts. Furthermore, the study examined the effects of occupational stress that included behavioral outcomes, physical outcomes, emotional outcomes and cognitive outcomes with specific focus on mental health conditions such as anxiety, depression and burnout. Practical interventions to manage occupational stress employee focused interventions, workplace focused interventions, policy and community level interventions. Various laws governing worker well-being which included Factories and Works Acts from different countries in Southern Africa, Labour Acts and Occupational Health and Safety Policies. The review made recommendations for the informal metal fabrication industries to prioritize worker safety so as to ensure worker well-being, including mental health through offering training, safe work environments and personal protective equipment. Southern African governments and policy makers should make policies specifically tailored for the informal metal fabrication industries to ensure worker safety and address psychological hazards. There is a need for governments to fund occupational stress-related research and development (RD) to cover the dearth of literature on mental health in the informal metal fabrication industries.</p>","PeriodicalId":72827,"journal":{"name":"Discover mental health","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147790567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A bibliometric review of depression among cancer patients in low- and middle-income countries.","authors":"Tay Zar Lin, Nguyen Thi Thanh Tuyen, Fadhlin Binti Abd Hamid","doi":"10.1007/s44192-026-00390-y","DOIUrl":"https://doi.org/10.1007/s44192-026-00390-y","url":null,"abstract":"","PeriodicalId":72827,"journal":{"name":"Discover mental health","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147790635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Psychological and cognitive indicators of Takotsubo syndrome.","authors":"Afaf Hussein, Ali Abd Rabbo","doi":"10.1007/s44192-026-00438-z","DOIUrl":"10.1007/s44192-026-00438-z","url":null,"abstract":"<p><strong>Background: </strong>Takotsubo syndrome (broken-heart syndrome) is considered a cardiac disorder typically associated with exposure to severe psychological or physical stress, and it clinically resembles acute coronary syndrome. The literature indicates its association with elevated levels of anxiety and depression among patients, in addition to the potential impairment of cognitive functions.</p><p><strong>Aims: </strong>This study aims to identify the differences in psychological indicators (anxiety & depression) and cognitive functions between patients with Takotsubo syndrome (TTS) and healthy Controls.</p><p><strong>Methods: </strong>A case-control cross-sectional design was employed. The study sample consisted of twenty patients who were selected from the Health Insurance Hospital in Zagazig, Al-Sharqia Governorate, aged (35.8 ± 8.4) years, and twenty healthy Controls aged (36 ± 9.7) years, who were matched with the patient group in terms of demographic characteristics, including gender, age, educational level, and mental state variables. The study instruments included an initial clinical interview for data collection, the Perceived Stress Scale (PSS-10), Raven's Progressive Matrices Test, the Hospital Anxiety and Depression Scale (HADS), and the Montreal Cognitive Assessment (MoCA).</p><p><strong>Results: </strong>The study revealed a significant increase in anxiety and depression levels, along with cognitive impairment in patients with TTS compared to healthy controls, manifested particularly in executive functions, memory, and attention, thereby reflecting a unique interaction between the brain and the heart in this syndrome.</p><p><strong>Conclusions: </strong>The findings indicate that the psychological and cognitive indicators in patients with TTS are multifactorial in nature, involving an interplay of Cerebral Hypoperfusion, Neurohormonal alterations, and dysfunction of brain networks.</p>","PeriodicalId":72827,"journal":{"name":"Discover mental health","volume":"6 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13129059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147790751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Gender differences in the association between discrimination, mental health, and peer support among ethnic/racial minority adolescents.","authors":"Kyle Lorenzo, Tiffany Yip","doi":"10.1007/s44192-026-00457-w","DOIUrl":"https://doi.org/10.1007/s44192-026-00457-w","url":null,"abstract":"","PeriodicalId":72827,"journal":{"name":"Discover mental health","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147790573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevalence and factors associated with the symptoms of depression, anxiety, and stress among freelancers in Bangladesh.","authors":"Avijit Mondal, Md Sanaul Haque Mondal","doi":"10.1007/s44192-026-00450-3","DOIUrl":"https://doi.org/10.1007/s44192-026-00450-3","url":null,"abstract":"","PeriodicalId":72827,"journal":{"name":"Discover mental health","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147790692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Asef Raj, Md Siddiqul Islam, Md Alamgir Hossain, Mohammad Masud Parves, Md Rabiul Islam
{"title":"Prevalence and associated risk factors for social networking addiction among the young generation in Bangladesh.","authors":"Asef Raj, Md Siddiqul Islam, Md Alamgir Hossain, Mohammad Masud Parves, Md Rabiul Islam","doi":"10.1007/s44192-026-00460-1","DOIUrl":"https://doi.org/10.1007/s44192-026-00460-1","url":null,"abstract":"","PeriodicalId":72827,"journal":{"name":"Discover mental health","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147790689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Exploring the associations between intersectional discrimination, shame, coping and trauma among Muslim women in Canada.","authors":"Manzar Zare, Monnica T Williams","doi":"10.1007/s44192-026-00459-8","DOIUrl":"https://doi.org/10.1007/s44192-026-00459-8","url":null,"abstract":"","PeriodicalId":72827,"journal":{"name":"Discover mental health","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147790563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}