Diabetes epidemiology and management最新文献

{"title":"Anthropometric measures of obesity as risk indicators for prediabetes. A systematic review and meta-analysis","authors":"Víctor Juan Vera-Ponce ,&nbsp;Fiorella E. Zuzunaga-Montoya ,&nbsp;Luisa Erika Milagros Vásquez-Romero ,&nbsp;Joan A. Loayza-Castro ,&nbsp;Cori Raquel Iturregui Paucar ,&nbsp;Carmen Inés Gutiérrez De Carrillo ,&nbsp;Mario J. Valladares-Garrido ,&nbsp;Maritza Placencia Medina","doi":"10.1016/j.deman.2024.100230","DOIUrl":"https://doi.org/10.1016/j.deman.2024.100230","url":null,"abstract":"<div><h3>Introduction</h3><p>Several previous studies have provided evidence that obesity is a significant risk factor for the increase in prediabetes, but there are discrepancies regarding whether all the classic ways of measuring obesity, the body mass index (BMI), the waist circumference (WC) or the Waist to height ratio (WHtR) present the same level of risk.</p></div><div><h3>Objective</h3><p>to carry out a systematic review (SR) with meta-analysis to determine the association between indicators of obesity and prediabetes.</p></div><div><h3>Methods</h3><p>A systematic review (SR) with a meta-analysis of observational studies was performed. The search was conducted in four databases: Pubmed/Medline, SCOPUS, Web of Science, and EMBASE. Association measures were presented as odds ratios (OR), relative risk (RR), or hazard ratio (HR), together with their 95% confidence intervals (95% CI).</p></div><div><h3>Results</h3><p>Of the total number of manuscripts chosen, 12 had an analytical cross-sectional design, and 4 were cohort studies. For the cross-sectional studies, together they presented a statistically significant association for BMI (OR: 1.99; 95% CI 1.65 – 1.34), WC (OR: 1.41; 95% CI 1.30 – 1.54), and WHtR (OR: 2.47 IC 95 % 1.50 – 4.06). In the meta-analysis of the cohort studies, an association was found with WC (RR: 4.95; 95% CI 3.42 – 7.17) but not with BMI (HR: 1.22; 95% CI 0.81 – 1.85). There were no studies with WHtR.</p></div><div><h3>Conclusions</h3><p>According to the results, considering cohort studies, WC could be the best risk indicator for prediabetes. There is a high degree of heterogeneity between the studies about the way obesity is measured, including the cut-off points used, so further longitudinal studies are needed to evaluate the association and confirm the results found.</p></div>","PeriodicalId":72796,"journal":{"name":"Diabetes epidemiology and management","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666970624000350/pdfft?md5=f6755fe212739b3c2af790ce9df1b1af&pid=1-s2.0-S2666970624000350-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141483267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between serum high-density lipoprotein and hemoglobin A1c in T2DM: Evidence from a nationwide cross-sectional study in diabetic patients","authors":"Methavee Poochanasri ,&nbsp;Sethapong Lertsakulbunlue ,&nbsp;Chutawat Kookanok ,&nbsp;Ram Rangsin ,&nbsp;Wisit Kaewput ,&nbsp;Boonsub Sakboonyarat ,&nbsp;Mathirut Mungthin ,&nbsp;Parinya Samakkarnthai","doi":"10.1016/j.deman.2024.100232","DOIUrl":"https://doi.org/10.1016/j.deman.2024.100232","url":null,"abstract":"<div><h3>Introduction</h3><p>The prevalence of Type 2 Diabetes Mellitus (T2DM) is expected to rise, increasing the risk of cardiovascular disease. This study explores the relationship between high-density lipoprotein cholesterol (HDL) and glycemic control in T2DM patients, measured by hemoglobin A1c (HbA1c). While HDL is known to confer cardiovascular benefits, its impact on glycemic control remains unclear.</p></div><div><h3>Methods</h3><p>This cross-sectional study analyzed 30,195 Thai adults with T2DM data from the 2018 Thailand DM/HT database. Well-controlled HbA1c was defined as less than 53 mmol/mol (7 %). The study utilized multivariable linear, piecewise linear, and logistic regression analyses to investigate the relationship between HDL levels and glycemic control.</p></div><div><h3>Results</h3><p>The impact of HDL on HbA1c levels was nonlinear, showing a U-shaped relationship among the study participants with an HDL inflection point of 59 mg/dl. In females, a U-shaped relationship was also observed at the same inflection point, where increased HDL above this level was associated with a rise in HbA1c (Adjusted β = 0.205, <em>P</em> &lt; 0.001). In contrast, a linear model better explained the consistent negative relationship between HDL and HbA1c in males (Adjusted β = –0.076, <em>P</em> &lt; 0.001). Furthermore, in the poorly controlled HbA1c group, a significant U-shaped pattern was observed with an inflection point at 59 mg/dl.</p></div><div><h3>Conclusion</h3><p>This study found a nonlinear, gender-specific relationship between HDL and HbA1c in T2DM patients. Males with higher HDL are more likely to achieve glycemic control, while a U-shaped relationship is observed in females. Further research is needed to understand the differing correlation between well-controlled and poorly controlled groups.</p></div>","PeriodicalId":72796,"journal":{"name":"Diabetes epidemiology and management","volume":null,"pages":null},"PeriodicalIF":1.0,"publicationDate":"2024-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666970624000374/pdfft?md5=6925a89cb7b18007b10d54f8ce35a2c3&pid=1-s2.0-S2666970624000374-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141483328","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the Amharic version of the summary of diabetes self-care activity scale among type 2 diabetes patients in Addis Ababa, Ethiopia, 2023","authors":"Molla Gashu ,&nbsp;Yimer Seid Yimer ,&nbsp;Ayele Belachew ,&nbsp;Berhanu Semra Mulat","doi":"10.1016/j.deman.2024.100222","DOIUrl":"https://doi.org/10.1016/j.deman.2024.100222","url":null,"abstract":"<div><h3>Introduction</h3><p>Measuring what it tends to measure makes a tool powerful and useful for decision-making. As the Amharic version summary of the diabetes self-care activity scale construct hasn't yet been validated, there is an urgent need for validation. This study aims to validate the Amharic version of the summary of the diabetes self-care activity scale among type 2 diabetes mellitus patients in Addis Ababa hospitals.</p></div><div><h3>Methods</h3><p>A facility-based cross-sectional study design was used to recruit 600 participants. The data was collected using open-data-kit and exported to SPSS and STATA for analysis. Both exploratory and confirmatory factor analysis was performed on 300 randomly allocated separate samples.</p></div><div><h3>Result</h3><p>A total of four factors with an eigenvalue greater than one, constituting nine items, were identified. The average variance executed (AVE) becomes 0.78, with a composite reliability of 0.97. Hence there is convergence between the items and the new construct. The overall internal consistency of the new construct was 0.853, which is greater than 0.7, affirming the reliability of the construct.</p></div><div><h3>Conclusion</h3><p>We can conclude that this 4-factor structure with a 9-item Amharic version of SDSCA is highly valid and reliable. Researchers and clinicians are highly recommended to use this validated tool.</p></div>","PeriodicalId":72796,"journal":{"name":"Diabetes epidemiology and management","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666970624000271/pdfft?md5=3df0dd8d7783f38fad0cda1707374a4d&pid=1-s2.0-S2666970624000271-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141264003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation of ABC goal attainment with insulin resistance/sensitivity in Syrian type 2 diabetes patients","authors":"Samer Younes","doi":"10.1016/j.deman.2024.100221","DOIUrl":"10.1016/j.deman.2024.100221","url":null,"abstract":"<div><h3>Background</h3><p>The rising prevalence of type 2 diabetes (T2D) in Syria emphasizes the urgent requirement for effective management approaches. The ABC goals, which include maintaining glycated hemoglobin levels below 7 %, blood pressure below 140/90 mmHg, and low-density lipoprotein cholesterol levels below 100 mg/dl, serve as crucial benchmarks for managing T2D and its associated comorbidities.</p></div><div><h3>Methods</h3><p>In this cross-sectional study, the achievement of ABC goals was retrospectively examined among 681 clinically diagnosed T2D patients (not on Insulin) who participated in a six-year online lifestyle intervention program for diabetes management at the Freedom from Diabetes Clinic in Syria between January 2016 and December 2022.</p></div><div><h3>Results</h3><p>Out of the participants, 152 (22.3 %) successfully achieved all three ABC goals, while 306 (45.0 %) and 183 (26.9 %) achieved two or one goal(s) respectively. The factors influencing the attainment of all three ABC goals revealed a significant association with older age (&gt;50 years), lower body mass index (&lt;25 kg/m2), and lower insulin resistance (Homeostatic Model Assessment of Insulin Resistance &lt; 2.5). Furthermore, patients who successfully achieved all three ABC goals exhibited lower insulin resistance, improved lipid profiles, and higher insulin sensitivity and beta cell function.</p></div><div><h3>Conclusion</h3><p>This study offers new insights into the relationship between insulin resistance/sensitivity and the achievement of ABC goals in the Syrian population with T2D, underscoring the necessity for tailored strategies to enhance comprehensive diabetes management.</p></div>","PeriodicalId":72796,"journal":{"name":"Diabetes epidemiology and management","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266697062400026X/pdfft?md5=f5fd82ac6f31fec02870d126545664a8&pid=1-s2.0-S266697062400026X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141025367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hospital prevalence of diabetes mellitus among under 15 children in Butembo: A retrospective study at the University Clinics of Graben","authors":"Roland Muyisa ,&nbsp;Emile Watumwa ,&nbsp;Apollinaire SaaSita ,&nbsp;Judith Kithonga ,&nbsp;Judith Malembe ,&nbsp;Wivine Kitasuvirwa ,&nbsp;Ghyslaine Kalivanda ,&nbsp;Mupenzi Mumbere ,&nbsp;Francois Mbahweka ,&nbsp;Soly Kamwira","doi":"10.1016/j.deman.2024.100218","DOIUrl":"https://doi.org/10.1016/j.deman.2024.100218","url":null,"abstract":"<div><h3>Introduction</h3><p>Mellitus diabetes is an endocrine trouble characterized by chronic high glycemia caused by a relative or absolute insulin deficiency. It is a public health problem because of its frequency associated with high morbi-mortality. The objective of this research was to determine the frequency of mellitus diabetes in under 15-year-old patients in Butembo Town.</p></div><div><h3>Method</h3><p>it was a cross-sectional descriptive study realized at the University Clinics of Graben from January 1st, 2017 to December 31st, 2021.</p></div><div><h3>Results</h3><p>Between 2017 and 2021, 3,681 children and adolescents were hospitalized at the University Clinics of the Graben Pediatrics Department. Out of them, 49 were diagnosed with mellitus diabetes, which indicates a prevalence of 1.331 %. The majority of patients were males, with high frequencies observed between the ages of 2 to 12 years. Common complaints included coma, polyurea-polydipsia, vision troubles, fever, weight loss, and growth retardation. Complications in infants and adolescents with diabetes included retinopathies, neuropathies, coma, infection, and ketoacidosis. The patients were admitted with extreme glycemia, with many suffering from hypoglycemia. Forty-three out of the 49 patients received insulin, and five of them died.</p></div><div><h3>Conclusion</h3><p>Mellitus diabetes in young remains a health problem in Butembo. Effective healthcare must include medical professionals, the population, and the state.</p></div>","PeriodicalId":72796,"journal":{"name":"Diabetes epidemiology and management","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666970624000234/pdfft?md5=3983443ffc27baa3220ce1f0574b1df0&pid=1-s2.0-S2666970624000234-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140649591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epidemiology of isolated impaired fasting glucose among Asian Indians","authors":"Sathish Thirunavukkarasu","doi":"10.1016/j.deman.2024.100219","DOIUrl":"https://doi.org/10.1016/j.deman.2024.100219","url":null,"abstract":"","PeriodicalId":72796,"journal":{"name":"Diabetes epidemiology and management","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666970624000246/pdfft?md5=0b764abe89c0fb35014317b553ad8f8a&pid=1-s2.0-S2666970624000246-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140637941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of non-fasting patients with diabetes type 2 in the DAR global surveys of 2020 and 2022","authors":"Bachar Afandi ,&nbsp;Khadija Hafidh ,&nbsp;Rachid Malek ,&nbsp;M Yakoob Ahmedani ,&nbsp;Inass Shaltout ,&nbsp;Reem Alamoudi ,&nbsp;Zanariah Hussein ,&nbsp;Mohamed Hassanein","doi":"10.1016/j.deman.2024.100217","DOIUrl":"https://doi.org/10.1016/j.deman.2024.100217","url":null,"abstract":"<div><h3>Introduction</h3><p>The decision to fast or not is quite complex. Personal, medical and religious matters may influence it for individuals with diabetes. However, a diagnosis of diabetes does not constitute an automatic exemption from Ramadan fasting. We aimed to evaluate the characteristics of the non-fasting cohort and explore the potential reasons during Ramadan through the global Ramadan surveys of 2020 and 2022.</p></div><div><h3>Method</h3><p>The Diabetes and Ramadan (DaR) Global Study is an observational retrospective survey conducted between 2020 and 2022, which included adult patients (18 and older) who fasted and those who opted not to fast. The survey captured demographic data and patient characteristics (co-morbidities, duration and type of diabetes, diabetes-related complications and medications, development of acute complications during Ramadan, hospitalisations and ER visits) for both groups.</p></div><div><h3>Results</h3><p>Of 12,059 patients, 1822 (14.5 %) did not fast during Ramadan; that population leaned towards females (54.6 %). They had an average age of 60.58 years (SD=12.12) with a statistically significant difference from the fasting population, averaging 54.29±11.45 (<em>p</em> = 0.000). Also of note was the more significant average duration of diabetes in the non-fasting cohort (12.54 years vs 9.44). There are notable regional differences in rates of fasting that ranged between 6.3 % and up to 51.2 % of patients opting not fast in certain regions (Chart 1). The risk factors that showed apparent differences of high statistical significance (<em>p</em> ≤ 0.001) included: long duration of diabetes of over ten years, age above 60+ years, HbA1c value over 9 %, use of insulin therapy, and being affected by one or more vascular complications (these include CKD, CVD, and diabetic foot problems).</p></div><div><h3>Conclusions</h3><p>Many factors and comorbidities might influence patients’ decisions when planning Ramadan fasting. The non-fasting population's demographic and clinical profiles reveal distinctive features, emphasising a need for tailored risk assessments. Furthermore, regional disparities in the decision to fast underscore the multifaceted nature of this decision-making process. The new IDF-DAR risk assessment tool can help to stratify patients’ risk during Ramadan fasting and bridge the gap among different populations and cultures.</p></div>","PeriodicalId":72796,"journal":{"name":"Diabetes epidemiology and management","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666970624000222/pdfft?md5=4eb5e3f489f47bab3d4af0c5dbecd660&pid=1-s2.0-S2666970624000222-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140558176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phase angle associated is with low ankle-brachial index in type 2 diabetes patients in Ghana","authors":"Jennifer Adjepong Agyekum ,&nbsp;Kwame Yeboah","doi":"10.1016/j.deman.2024.100216","DOIUrl":"https://doi.org/10.1016/j.deman.2024.100216","url":null,"abstract":"<div><h3>Background</h3><p>Type 2 diabetes (T2DM) is associated with high burden of atherosclerotic macrovascular disease which could be diagnosed with ankle-brachial index (ABI). Phase angle (PhA) from bioelectric impedance analysis is associated with the development of cardiovascular diseases. We investigated the association between low ABI and phase angle in T2DM patients in Ghana.</p></div><div><h3>Method</h3><p>In a cross-sectional study, 462 T2DM patients were systematically recruited for the study. ABI was measured using an 8 Hz continuous Doppler and ABI≤0.9 was considered to be low ABI. PhA was obtained from resistance and reactance from Bioelectric impedance analysis.</p></div><div><h3>Results</h3><p>The prevalence of low ABI was 16 % in the study population. T2DM patients with low ABI have decreased PhA (7.5 ± 1.9 vs 8.3 ± 2.2 units, <em>p</em> = 0.004) compared to those with normal ABI. An increase in phase angle by 1° was associated with a decrease in odds of having low ABI in unadjusted [OR (95 % CI) = 0.79 (0.48 – 0.95), <em>p</em> = 0.007] and adjusted models [0.88 (0.43 – 0.98), <em>p</em> = 0.036].</p></div><div><h3>Conclusion</h3><p>The prevalence of low ABI in T2DM patients in this study was 16 %. Also, PhA was lower in patients with low ABI compared to those with normal ABI.</p></div>","PeriodicalId":72796,"journal":{"name":"Diabetes epidemiology and management","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666970624000210/pdfft?md5=20ec669293ad684e8b07be6d669947a6&pid=1-s2.0-S2666970624000210-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140180046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of prediabetes with stroke in young metabolically healthy tobacco users: A population-based analysis","authors":"Advait Vasavada ,&nbsp;Arankesh Mahadevan ,&nbsp;Manisha Jain ,&nbsp;Subramanian Gnanaguruparan ,&nbsp;Rupak Desai","doi":"10.1016/j.deman.2024.100210","DOIUrl":"https://doi.org/10.1016/j.deman.2024.100210","url":null,"abstract":"<div><h3>Background</h3><p>Diabetes and tobacco use are well-established risk factors for stroke. However, the intersection of prediabetes, tobacco use, and stroke among young individuals remains underexplored. This study aims to investigate the association between pre-diabetes and stroke risk in young tobacco users.</p></div><div><h3>Methods</h3><p>Using the National Inpatient Sample (2019) and relevant ICD-10 codes, we identified young patients with tobacco use disorder and pre-diabetes. Regression analysis considered risk factors (gender, demographics, income, comorbidities) to assess stroke odds.</p></div><div><h3>Results</h3><p>Among 1,017,540 stroke hospitalizations, 1.9 % were pre-diabetic. Pre-diabetics were often older (median age 36 vs. 31), male (59.4 %), Black (33.8 %), and Hispanic (12.2 %), with higher rates of comorbidities, including drug abuse, alcohol abuse, COPD, and CKD (<em>p</em> &lt; 0.001). They also exhibited higher rates of stroke events (1.9 % vs. 0.5 %, <em>p</em> &lt; 0.001). Multivariable analysis after adjusting for confounders, young metabolically healthy smokers with pre-diabetes had a higher risk of stroke (aOR 3.31, 95 % CI [1.67–6.55], <em>p</em> &lt; 0.001).</p></div><div><h3>Conclusion</h3><p>Prediabetes could potentially triple stroke risk in young tobacco smokers. Prospective research is warranted to explore the causal association between pre-diabetes and stroke in the setting of tobacco use.</p></div>","PeriodicalId":72796,"journal":{"name":"Diabetes epidemiology and management","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666970624000155/pdfft?md5=a95efa544ec5b5f638e4cf57c191dc00&pid=1-s2.0-S2666970624000155-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140191303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early diagnosis of Charcot neuro-osteoarthropathy using MRI and its effect on patient outcomes: A seven-year retrospective audit","authors":"Laksh Lukkhoo ,&nbsp;Sharlene Vu ,&nbsp;Joanna Scheepers ,&nbsp;Deborah Schoen","doi":"10.1016/j.deman.2024.100208","DOIUrl":"https://doi.org/10.1016/j.deman.2024.100208","url":null,"abstract":"<div><h3>Background</h3><p>There remains a paucity of research comparing the diagnostic and therapeutic outcomes between Magnetic Resonance Imaging (MRI) and x-ray modalities for Charcot neuro-osteoarthropathy CNO. This retrospective study investigates the use of offloading devices, duration of offloading and final footwear outcomes dependent on imaging at diagnosis.</p></div><div><h3>Methods</h3><p>Medical records from a secondary hospital high-risk foot clinic in Perth, Western Australia, were systematically reviewed. Data collected included baseline medical history, location of CNO, Eichenholtz stage or Chantelau and Grutznel grade at diagnosis, type and duration of offloading, and final footwear outcomes.</p></div><div><h3>Results</h3><p>Twenty-eight patients met the inclusion criteria. All had diabetes and peripheral neuropathy. All patients received either an MRI (43%) or x-ray (57%) to confirm the diagnosis of active CNO. Five (17.9%) patients who were diagnosed on MRI had grade 0 CNO whilst 23 (82.1%) patients who were diagnosed on x-ray had stage 1 CNO. No statistical significance was found between the type and duration of offloading, resolution of CNO, footwear and transtibial amputation (TTA) outcomes across those diagnosed with MRI or x-ray.</p></div><div><h3>Conclusion</h3><p>No statistical significance in patient outcomes was found between those diagnosed with grade 0 on MRI and those diagnosed with stage 1 on x-ray.</p></div>","PeriodicalId":72796,"journal":{"name":"Diabetes epidemiology and management","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666970624000131/pdfft?md5=2b43b95910ef45809f0883f0f651baf3&pid=1-s2.0-S2666970624000131-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140180047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}