Diabetes epidemiology and management最新文献

{"title":"Autoantibodies in type 1 diabetes: Prevalence and clinical profiles","authors":"Raja Hazime ,&nbsp;Saad Lamjadli ,&nbsp;Morad Guennouni ,&nbsp;Mounir Belkrachni ,&nbsp;Fatima-Ezzohra Eddehbi ,&nbsp;Ider Oujamaa ,&nbsp;Lahcen Elmoumou ,&nbsp;Aicha Bourrahouate ,&nbsp;Imane Ait Sab ,&nbsp;Hicham Baizri ,&nbsp;Nawal El Ansari ,&nbsp;Brahim Admou","doi":"10.1016/j.deman.2024.100246","DOIUrl":"10.1016/j.deman.2024.100246","url":null,"abstract":"<div><div>Type 1 diabetes mellitus (T1D) is one of the most common chronic diseases in children and is associated with acute and serious chronic complications. T1D is characterized by the destruction of insulin-producing beta cells in the pancreas, with the emergence of circulating autoantibodies (a-Abs) targeting β cell antigens. Identifying autoantibodies can help predict the onset of T1D and associated autoimmune disorders, enhancing patient management strategies.</div><div>We aimed to determine the prevalence of T1D autoantibodies and their clinical significance in the pediatric and adult populations. A multicenter cross-sectional study was carried out on 276 patient-first with T1D, including 167 pediatric (60.5 %) and 109 adult (39.5 %) cases, of which 144 were female and 132 were male (sex ratio= 0.91),with an average age of 14.1 ± 8.0 years. The immunological investigation was based on the detection of T1D related a-Abs, including anti-insulin, anti-glutamic acid decarboxylase (GAD65), anti-insulinoma-associated antigen 2 (IA2), and anti-zinc transporter 8 (ZnT8) specificities. The results revealed an overall autoantibody seropositivity rate of 75.36 % (n= 208). Among the positive cases, GAD65 antibodies were the most prevalent at 37.31 %, followed by anti-insulin and anti-ZnT8 antibodies, each at 36.59 %, and anti-IA2 at 28.62 %. Additionally, 45,67 % of patients had one a-Abs, 28.36 % had a two, 21.15 % had three, and 4.8 % had all four a-Abs.</div><div>A statistically significant difference was observed between the seropositive and seronegative groups regarding the presence of associated autoimmune diseases (p = 0.005). These findings align with the existing literature, highlighting the importance and scientific value of detecting a-Abs in patients with T1D.</div></div>","PeriodicalId":72796,"journal":{"name":"Diabetes epidemiology and management","volume":"17 ","pages":"Article 100246"},"PeriodicalIF":1.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142657375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to increase in diabetic deaths during COVID-19 pandemic. Some comments","authors":"Camilla Mattiuzzi,&nbsp;Giuseppe Lippi","doi":"10.1016/j.deman.2024.100240","DOIUrl":"10.1016/j.deman.2024.100240","url":null,"abstract":"","PeriodicalId":72796,"journal":{"name":"Diabetes epidemiology and management","volume":"17 ","pages":"Article 100240"},"PeriodicalIF":1.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142527393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High prevalence of prediabetes and type 2 diabetes, and identification of associated factors, in high-risk adults in Vietnam: A cross-sectional study","authors":"Tran Bao Vuong ,&nbsp;Triet Minh Tran ,&nbsp;Nam Quang Tran","doi":"10.1016/j.deman.2024.100239","DOIUrl":"10.1016/j.deman.2024.100239","url":null,"abstract":"<div><h3>Objectives</h3><div>The prevalences of diabetes and prediabetes have increased rapidly in recent years in emerging nations such as Vietnam, particularly in the population at high risk of diabetes. This study aimed to investigate the prevalence of prediabetes and undiagnosed diabetes in individuals at high risk of type 2 diabetes (T2D), as well as the related risk factors.</div></div><div><h3>Methods</h3><div>This cross-sectional study at the clinics of the University Medical Center in Ho Chi Minh City included 360 patients who were 18 years of age or older, and were at risk of developing T2D. The diagnosis of prediabetes and diabetes relied on measurements of fasting plasma glucose, HbA1c, and 2-hour plasma glucose after a 75 g oral glucose tolerance test.</div></div><div><h3>Results</h3><div>The prevalence of prediabetes was 60.6 % (95 % CI: 55.3–65.6 %), and the prevalence of diabetes was 18.3 % (95 % CI: 14.6–22.8 %). Older age (OR = 1.06), obesity (OR = 3.89), hypertension (OR = 5.71), and dyslipidemia (OR = 2.01) were factors associated with increasing frequencies of undiagnosed T2D and prediabetes.</div></div><div><h3>Conclusion</h3><div>The prevalences of prediabetes and undiagnosed diabetes were significantly higher among people with a high-risk of dysglycemia in Vietnam. There is a need for screening programs for such high-risk individuals.</div></div>","PeriodicalId":72796,"journal":{"name":"Diabetes epidemiology and management","volume":"17 ","pages":"Article 100239"},"PeriodicalIF":1.0,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142434305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increase in diabetic deaths during COVID-19 pandemic. Some comments","authors":"Salvatore Chirumbolo","doi":"10.1016/j.deman.2024.100238","DOIUrl":"10.1016/j.deman.2024.100238","url":null,"abstract":"","PeriodicalId":72796,"journal":{"name":"Diabetes epidemiology and management","volume":"17 ","pages":"Article 100238"},"PeriodicalIF":1.0,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142427573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of vitamin D status in obese and non-obese patients: A case-control study","authors":"Salma Derbel ,&nbsp;Lamiae Zarraa ,&nbsp;Imane Assarrar ,&nbsp;Nisrine Bouichrat ,&nbsp;Siham Rouf ,&nbsp;Hanane Latrech","doi":"10.1016/j.deman.2024.100237","DOIUrl":"10.1016/j.deman.2024.100237","url":null,"abstract":"<div><h3>Background</h3><p>Vitamin D is an essential component of healthy bones and its deficiency is widespread in obese patients. Through our study, we aimed to look into vitamin D status in obese and non-obese patients and determine its association with hypertension, glucose levels, and lipid profiles.</p></div><div><h3>Patients and methods</h3><p>A case-control study was laid out to compare serum Vitamin D levels between obese patients and controls. Obese patients (<em>n</em>= 67) over 18 years old were recruited from our Endocrinology-Diabetology and Nutrition department between March 2018 and September 2023. Controls (<em>n</em> = 60) were randomly assigned and were matched for age, sex, glycated hemoglobin, ethnicity, and geographic area. The levels of Vitamin D in the serum were determined in obese patients and non-obese controls.</p></div><div><h3>Results</h3><p>Average serum Vitamin D concentration was established in both groups, reaching 10,41±4,2 ng/ml in obese patients and 15,14±6,1 ng/ml in the control group. The mean serum Vitamin D was significantly lower in the obese group (<em>p</em> = 0,000). A positive correlation was noticed between body fat and serum Vitamin D (<em>p</em> &lt; 0,05). A significant correlation between vitamin D status and glycated hemoglobin in the obese group (<em>p</em> = 0,047) was found, whereas it was insignificant in the control group (<em>p</em> = 0,966). In addition, the correlation between vitamin D, blood pressure, and body mass index was significant (<em>p</em> <em>=</em> 0.004) as well as between vitamin D and triglycerides (<em>p</em> <em>=</em> 0.015) and cholesterol (<em>p</em> <em>=</em> 0.014).</p></div><div><h3>Conclusion</h3><p>Vitamin D deficiency is common in obese patients, as highlighted by our study, which is in line with other findings. This may be explained by the fact that vitamin D must be supplied at a greater volume in obese patients. A significant correlation between BMI, vitamin D, glycated hemoglobin, blood pressure, triglycerides, and total cholesterol was found. The pathophysiology behind this association is complex. Further research is needed to clarify the relationship between vitamin D, adipose tissue, and the other components of metabolic syndrome.</p></div>","PeriodicalId":72796,"journal":{"name":"Diabetes epidemiology and management","volume":"17 ","pages":"Article 100237"},"PeriodicalIF":1.0,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666970624000416/pdfft?md5=6312261234fdc2e5e815735d8c34c4e9&pid=1-s2.0-S2666970624000416-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142239733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of the COVID-19 pandemic on diabetes-related mortality","authors":"Camilla Mattiuzzi,&nbsp;Giuseppe Lippi","doi":"10.1016/j.deman.2024.100236","DOIUrl":"10.1016/j.deman.2024.100236","url":null,"abstract":"","PeriodicalId":72796,"journal":{"name":"Diabetes epidemiology and management","volume":"17 ","pages":"Article 100236"},"PeriodicalIF":1.0,"publicationDate":"2024-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666970624000404/pdfft?md5=a532904d865fc649ee8f0692d0d710cd&pid=1-s2.0-S2666970624000404-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141961092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes in pregnancy: Anxious minds precarious times","authors":"Ahmed Hasan,&nbsp;Almas Zafar","doi":"10.1016/j.deman.2024.100235","DOIUrl":"10.1016/j.deman.2024.100235","url":null,"abstract":"<div><p>Gestational diabetes is a prevalent condition that affects up to 24.2 % of women in South-East Asia. A study conducted in Iran highlighted the correlation between gestational diabetes and anxiety/depression. Improvements can be made by conducting a cohort study to better establish the causality between the compounding factors of mental health and gestational diabetes. Additionally, conducting a follow-up study in a region with a higher incidence of gestational diabetes, such as South-East Asia, can broaden the geographic distribution of the available data. We must promote awareness campaigns highlighting this correlation to improve holistic healthcare strategies.</p></div>","PeriodicalId":72796,"journal":{"name":"Diabetes epidemiology and management","volume":"16 ","pages":"Article 100235"},"PeriodicalIF":1.0,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666970624000398/pdfft?md5=fec62aa64c34fd7b15ca81914bd6bdbf&pid=1-s2.0-S2666970624000398-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141843525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary care monitoring of HbA1c tests in type 2 diabetic patients in Northern France and impact of the successive COVID-19 pandemic containments","authors":"Dr. Julie Demoule ,&nbsp;Dr. Paul Quindroit ,&nbsp;Dr. Camille Frévent ,&nbsp;Prof. Dr. Claire Collins ,&nbsp;Prof. Dr. Emmanuel Chazard ,&nbsp;Prof. Dr. Jean-Baptiste Beuscart ,&nbsp;Prof. Dr. Christophe Berkhout ,&nbsp;Dr. Matthieu Calafiore ,&nbsp;Dr. François Quersin","doi":"10.1016/j.deman.2024.100233","DOIUrl":"https://doi.org/10.1016/j.deman.2024.100233","url":null,"abstract":"<div><h3>Background</h3><p>French health authorities recommend the testing of HbA1c every 3 to 6 months in patients with diabetes. The successive containments linked to the SARSCoV-2 pandemic may have had a profound impact on the follow-up of diabetic patients in primary care. The objective of this study was to investigate the effect of containments on the volume of HbA1c assays and on HbA1c values of type 2 diabetic patients monitored in primary care in Northern France compared to usual seasonal variations.</p></div><div><h3>Methods</h3><p>Epidemiological study of a multicentre retrospective cohort, collecting the number and the value of HbA1c assays from type 2 diabetic patients, carried out in 73 private medical analysis laboratories in Northern France region between October 1, 2018 and October 31, 2022.</p></div><div><h3>Results</h3><p>A total of 196,744 patients and 828,037 tests were included. The first and third containments were associated with a significant decrease in the mean number of performed HbA1c tests, the decrease in the 2nd containment did not reach significance. We observed a significant decrease in HbA1c testing during the winter holiday season and the summer months. The variations in HbA1c values were not substantial compared to seasonal variations.</p></div>","PeriodicalId":72796,"journal":{"name":"Diabetes epidemiology and management","volume":"16 ","pages":"Article 100233"},"PeriodicalIF":1.0,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666970624000386/pdfft?md5=cd9b06e986a7d80d6a6750bae1c21f51&pid=1-s2.0-S2666970624000386-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141540065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a Support Tool for Diabetes Control in primary care – A Qualitative study with primary care staff","authors":"Ricko Damberg Nissen,&nbsp;Jesper Bo Nielsen","doi":"10.1016/j.deman.2024.100228","DOIUrl":"https://doi.org/10.1016/j.deman.2024.100228","url":null,"abstract":"<div><h3>Background</h3><p>In Denmark, the primary responsibility for treatment of patients with diabetes has shifted from hospitals to primary care. Thus, general practice has assumed responsibility for a complex and multifaceted disease. To address this situation a stratification tool to assist the nurses in primary care in their work with diabetes patients was developed.</p></div><div><h3>Aim</h3><p>In the present study we evaluated this stratification tool.</p></div><div><h3>Method</h3><p>The evaluation was based on 18 semi-structured interviews conducted with nurses employed in primary care across Denmark, and who had experience with the stratification tool. The data was subsequently analyzed by content and thematic analyses.</p></div><div><h3>Results</h3><p>The interviewees were generally positive towards the stratification tool. The analyses established three themes 1. Treatment, 2. Resources, and 3. Points of critique.</p></div><div><h3>Conclusions</h3><p>Our study indicates that a combined tool for risk stratification of patients with T2D and for subsequent risk communication is perceived as positive and supportive for quality in care. It is seen to potentially reduce the resources presently allocated to well-regulated and stable T2D patients. These resources will eventually be available for other patients. The positive reception by nurses supports that tools like the Diabetes Control Support Tool could be developed and implemented in general practice.</p></div>","PeriodicalId":72796,"journal":{"name":"Diabetes epidemiology and management","volume":"16 ","pages":"Article 100228"},"PeriodicalIF":1.0,"publicationDate":"2024-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666970624000337/pdfft?md5=9c4c5a22cb9a7b99acc7e735767daafd&pid=1-s2.0-S2666970624000337-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141540064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ramadan fasting among adults with type 2 diabetes in five geographically different regions of the world: The DAR 2020 global survey","authors":"Mohamed Hassanein ,&nbsp;M Yakoob Ahmedani ,&nbsp;Inass Shaltout ,&nbsp;Majid Alabbood ,&nbsp;Mehmet Akif Buyukbese ,&nbsp;Khadija Hafidh ,&nbsp;Shehla Shaikh ,&nbsp;Lobna F. El Toony ,&nbsp;Rakesh Kumar Sahay ,&nbsp;Mohammed Ali Batais ,&nbsp;Eman Alfadhli ,&nbsp;Md Farid Uddin ,&nbsp;Abdulaziz F Alfadhly ,&nbsp;Mohan T Shenoy ,&nbsp;Adibah Salleh ,&nbsp;Naweed Alzaman ,&nbsp;Eman Sheshah ,&nbsp;Benabed Kebira ,&nbsp;Reem Alamoudi ,&nbsp;Zanariah Hussein","doi":"10.1016/j.deman.2024.100229","DOIUrl":"https://doi.org/10.1016/j.deman.2024.100229","url":null,"abstract":"<div><h3>Aims</h3><p>The DAR 2020 survey summarised fasting practices and complications in people with type 2 diabetes (T2D) who fasted during Ramadan, and impact of pre-Ramadan diabetes education towards controlling the complications.</p></div><div><h3>Methods</h3><p>Eight week post-Ramadan, Muslim people with T2D from 13 countries of five regions (South Asia, Southeast Asia, Gulf Nations, Middle East and North Africa) consented to answer questionnaire on breaking fast, hypoglycaemia, hyperglycaemia, Ramadan-focused diabetes education and self-monitoring of blood glucose (SMBG).</p></div><div><h3>Results</h3><p>Among 4889 participants who observed Ramadan fast (&gt;25 days), 51.1 % were females. Hypoglycaemia and hyperglycaemia was recorded mostly in North Africa (25.2 %) and Gulf Nations (30.2 %), respectively. In Middle East, 2.5 % and 3.1 % people required hospitalisation following hypoglycaemia and hyperglycaemia respectively. In South Asia, lowest incidents of hypoglycaemia (8.4 %) and hyperglycaemia (7.0 %) were noted. Pre-Ramadan diabetic education was received by total 45.9 % participants. SMBG was performed more frequently in North Africa (19.5 %). Metformin, Sulfonylureas and basal insulin were used most commonly in all regions.</p></div><div><h3>Conclusions</h3><p>Fasting complications occurred in each region, but well-managed by the participants, physicians and family members amidst difficult time of COVID-19. The findings promote the necessity of patient education programmes for more people with diabetes to ensure safe fasting during Ramadan.</p></div>","PeriodicalId":72796,"journal":{"name":"Diabetes epidemiology and management","volume":"16 ","pages":"Article 100229"},"PeriodicalIF":1.0,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2666970624000349/pdfft?md5=9c2db7d84c8876d6f20cadf5fff7d45d&pid=1-s2.0-S2666970624000349-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141483329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}