Prevalence of various psychotic disorders among patients with type 2 diabetes: Real-world evidence from Shanghai, China

IF 1 Q4 ENDOCRINOLOGY & METABOLISM

Diabetes epidemiology and management Pub Date : 2025-04-01 DOI:10.1016/j.deman.2025.100259

Yunxi Ji , Ping He , Yingxia Zhou , Huayan Yao , Yanbin Xue , Renjie Jing , Tingyu Zhang , Wen Sun , Ping Lu , Bin Cui , Weiqing Wang

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Abstract

Aims

Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder that significantly impacts psychotic health, leading to increased incidence and mortality. We aim to explore the status of patients with T2DM and the issue of comorbid psychotic disorders.

Methods

Our study estimated the characteristics of 836,120 patients with T2DM from 2019 to 2023 based on electronic health records from the Shanghai Link Database (SHLD). We calculated the prevalence of the four major psychotic disorders in patients with T2DM, including depression, anxiety, dementia, and schizophrenia. The data was also stratified by age, sex, and other factors. Additionally, the association between diabetes complications and various psychotic disorders was investigated.

Results

We observed that the age group of 55-80 counted for about 68.15% of the total population with T2DM. There were more male patients with T2DM than females, but females exhibited a higher overall prevalence of psychotic disorders compared to males. For patients with T2DM, anxiety had the highest prevalence (3.97%), followed by depression (2.33%), dementia (2.04%), and schizophrenia (0.16%). There was a significant relationship between psychotic disorders and various diabetes complications.

Conclusions

The high prevalence of psychotic disorders among patients with T2DM highlights the importance of considering the impact of their comorbid psychotic illnesses when treating T2DM. Developing high-quality diabetes healthcare and implementing targeted treatment and management plans are essential in addressing these issues.

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2型糖尿病患者中各种精神障碍的患病率：来自中国上海的真实世界证据

目的：2型糖尿病（T2DM）是一种慢性代谢紊乱，严重影响精神健康，导致发病率和死亡率增加。我们的目的是探讨T2DM患者的状况和共病性精神障碍的问题。方法基于上海Link数据库（SHLD）的电子健康记录，对2019 - 2023年836,120例T2DM患者的特征进行估计。我们计算了T2DM患者中四种主要精神障碍的患病率，包括抑郁、焦虑、痴呆和精神分裂症。数据还按年龄、性别和其他因素分层。此外，还研究了糖尿病并发症与各种精神障碍之间的关系。结果55 ~ 80岁年龄组占T2DM患者总数的68.15%。男性2型糖尿病患者多于女性，但女性精神障碍的总体患病率高于男性。在T2DM患者中，焦虑患病率最高（3.97%），其次是抑郁（2.33%）、痴呆（2.04%）和精神分裂症（0.16%）。精神障碍与各种糖尿病并发症之间存在显著相关性。结论T2DM患者中精神疾病的高发突出了在治疗T2DM时考虑其合并症精神疾病影响的重要性。发展高质量的糖尿病保健和实施有针对性的治疗和管理计划对于解决这些问题至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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