Development & reproduction最新文献_第7页

Expression and Functional Analysis of cofilin1-like in Craniofacial Development in Zebrafish cofilin1-like在斑马鱼颅面发育中的表达及功能分析

Development & reproduction Pub Date : 2022-03-01 DOI: 10.12717/DR.2022.26.1.23

Sil Jin, Haewon Jeon, Chong Pyo Choe

{"title":"Expression and Functional Analysis of cofilin1-like in Craniofacial Development in Zebrafish","authors":"Sil Jin, Haewon Jeon, Chong Pyo Choe","doi":"10.12717/DR.2022.26.1.23","DOIUrl":"https://doi.org/10.12717/DR.2022.26.1.23","url":null,"abstract":"Abstract Pharyngeal pouches, a series of outgrowths of the pharyngeal endoderm, are a key epithelial structure governing facial skeleton development in vertebrates. Pouch formation is achieved through collective cell migration and rearrangement of pouch-forming cells controlled by actin cytoskeleton dynamics. While essential transcription factors and signaling molecules have been identified in pouch formation, regulators of actin cytoskeleton dynamics have not been reported yet in any vertebrates. Cofilin1-like (Cfl1l) is a fish-specific member of the Actin-depolymerizing factor (ADF)/Cofilin family, a critical regulator of actin cytoskeleton dynamics in eukaryotic cells. Here, we report the expression and function of cfl1l in pouch development in zebrafish. We first showed that fish cfl1l might be an ortholog of vertebrate adf, based on phylogenetic analysis of vertebrate adf and cfl genes. During pouch formation, cfl1l was expressed sequentially in the developing pouches but not in the posterior cell mass in which future pouch-forming cells are present. However, pouches, as well as facial cartilages whose development is dependent upon pouch formation, were unaffected by loss-of-function mutations in cfl1l. Although it could not be completely ruled out a possibility of a genetic redundancy of Cfl1l with other Cfls, our results suggest that the cfl1l expression in the developing pouches might be dispensable for regulating actin cytoskeleton dynamics in pouch-forming cells.","PeriodicalId":72791,"journal":{"name":"Development & reproduction","volume":"26 1","pages":"23 - 36"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45624002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Response of Pituitary Cells and Tissues to Neurokinin B and F in the Nile tilapia 尼罗罗非鱼垂体细胞和组织对神经激肽B和F的反应

Development & reproduction Pub Date : 2022-03-01 DOI: 10.12717/DR.2022.26.1.13

Seong Hee Mun, H. J. Oh, J. Kwon

{"title":"Response of Pituitary Cells and Tissues to Neurokinin B and F in the Nile tilapia","authors":"Seong Hee Mun, H. J. Oh, J. Kwon","doi":"10.12717/DR.2022.26.1.13","DOIUrl":"https://doi.org/10.12717/DR.2022.26.1.13","url":null,"abstract":"Abstract Neurokinin B (NKB) is a neuropeptide involved in the regulation of reproductive endocrine system of vertebrate animals, including fish. However, the pathway of NKB action in fish has not been clearly elucidated. In order to clarify the effect of NKB and NKF (neurokinin F) on gonadotropic hormone (GTH) gene expression in the pituitary, we studied the changes of LHβ and FSHβ gene expressions by using two different pituitary culture methods (whole pituitary culture or dispersed pituitary cell culture). Pituitaries were removed from mature female and male Nile tilapia. Changes of LHβ and FSHβ gene expressions were measured and compared after the treatment with NKB or NKF peptides at concentrations 0 to 1,000 nM. Expression of GTH genes in the whole pituitary cultures treated with NKB or NKF peptides did not show significant difference except in female at one concentration when treated with NKF. On the contrary, there were significant changes of GTH gene expressions in the dispersed pituitary cell cultures when treated with NKB and NKF peptides. These results suggest that dispersed pituitary cell culture is more relevant than whole pituitary culture in studying the function of pituitary, and that NKB and NKF could act directly on the pituitary to regulate the expression of GTH genes.","PeriodicalId":72791,"journal":{"name":"Development & reproduction","volume":"26 1","pages":"13 - 21"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47001329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Chronic-Low-Dose Exposing of DEHP with OECD TG 443 Altered the Histological Characteristics and Steroidogeic Gene Expression of Adrenal Gland in Female Mice. 慢性低剂量暴露DEHP与OECD TG 443改变了雌性小鼠肾上腺的组织学特征和类固醇基因表达。

Development & reproduction Pub Date : 2021-12-01 Epub Date: 2021-12-31 DOI: 10.12717/DR.2021.25.4.257

Bo Young Lee, Jeong Bin Jo, Donchan Choi, Sung-Ho Lee, Yong-Pil Cheon

{"title":"A Chronic-Low-Dose Exposing of DEHP with OECD TG 443 Altered the Histological Characteristics and Steroidogeic Gene Expression of Adrenal Gland in Female Mice.","authors":"Bo Young Lee, Jeong Bin Jo, Donchan Choi, Sung-Ho Lee, Yong-Pil Cheon","doi":"10.12717/DR.2021.25.4.257","DOIUrl":"https://doi.org/10.12717/DR.2021.25.4.257","url":null,"abstract":"Phthalates and their metabolites are well-known endocrine disrupting chemicals. Di-(2-ethylhexyl) phthalate (DEHP) has been widely used in industry and the exposing possibility to adult is high. In this study, DEHP was treated (133 μg/L and 1,330 μg/L in drinking water) according to the OECD test guideline 443 to mature female mice and their adrenal gland were examined for histological characteristics and steroidogenic gene expression. The wet weight of the adrenal gland was increased in all administrated groups compared to control. The diameter of zona fasciculata (ZF) was increased by DEHP in both outer ZF and inner ZF but there was no difference in morphology of the cells and arrangements into zona between groups. In addition, the arrangement of extracellular matrix was not different between control and DEHP groups. CYP11B1 was mainly localized at ZF and the intensity was not different between groups. DAX1 was localized in zona glomerulosa (ZG) and ZF, and its expression levels were decreased by DEHP administration. Its level was lower in DEHP133 group than DEHP1330 group. On the other hand, CYP17A1 was localized in ZG of DEHP1330 group. These results suggest that chronic low-dose DEHP exposing may modify the microstructure and function of the adrenal cortical cortex.","PeriodicalId":72791,"journal":{"name":"Development & reproduction","volume":"25 4","pages":"257-268"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/01/05/dr-25-4-257.PMC8807134.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39767381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Impairment of Thyroid Hormones Homeostasis after Short-Term Exposure to Di(2-ethylhexyl)phthalate in Adolescent Male Rats. 短期接触邻苯二甲酸二(2-乙基己基)对青春期雄性大鼠甲状腺激素稳态的损害。

Development & reproduction Pub Date : 2021-12-01 Epub Date: 2021-12-31 DOI: 10.12717/DR.2021.25.4.293

Sang-Yon Kim, Yeon-Pyo Hong, Yun-Jung Yang

{"title":"The Impairment of Thyroid Hormones Homeostasis after Short-Term Exposure to Di(2-ethylhexyl)phthalate in Adolescent Male Rats.","authors":"Sang-Yon Kim, Yeon-Pyo Hong, Yun-Jung Yang","doi":"10.12717/DR.2021.25.4.293","DOIUrl":"https://doi.org/10.12717/DR.2021.25.4.293","url":null,"abstract":"Di(2-ethylhexyl)phthalate (DEHP) could induce metabolic disorders through interfering with thyroid homeostasis. Therefore, we evaluated the effects of short term to environmental relevant doses of DEHP on thyroid hormones. Four week old Sprague-Dawley (SD) rats were treated with vehicle (corn oil), and DEHP 0.75, 7.5, and 150 mg/kg/day. The rats were treated with once daily by oral gavage and were sacrificed with after 1 week. They were measured body weight and relative thyroid weight, serum thyroid hormones and histological changes of thyroid. There was no difference in body weight between the control and DEHP exposed rats. Relative thyroid weight in DEHP 150 mg/kg/day treated group was significantly lower than control. Serum thyroxine levels was decreased in rats exposed to 0.75 and 150 mg/kg/day DEHP. No histological changes were observed in the thyroid of rats administered DEHP compared to control. Exposure to DEHP at environmental relevant levels, even short-term exposure, can cause hypothyroidism in adolescent rats even the exposure period is relative short.","PeriodicalId":72791,"journal":{"name":"Development & reproduction","volume":"25 4","pages":"293-298"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a7/99/dr-25-4-293.PMC8807126.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39781492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Gonadal Changes during the Annual Reproductive Cycle of the Ascidian Halocynthia aurantium (Pallas). 海鞘(Halocynthia aurantium)年生殖周期中性腺的变化。

Development & reproduction Pub Date : 2021-12-01 Epub Date: 2021-12-31 DOI: 10.12717/DR.2021.25.4.299

Wang Jong Lee, Gil Jung Kim

{"title":"Gonadal Changes during the Annual Reproductive Cycle of the Ascidian Halocynthia aurantium (Pallas).","authors":"Wang Jong Lee, Gil Jung Kim","doi":"10.12717/DR.2021.25.4.299","DOIUrl":"https://doi.org/10.12717/DR.2021.25.4.299","url":null,"abstract":"The ascidian Halocynthia aurantium (sea peach), a marine invertebrate, belongs to the same genus of the phylum Chordata along with the ascidian Halocynthia roretzi (sea pineapple), which is one of the model animals in the field of developmental biology. The characteristics of development and reproduction of H. aurantium are not yet known in detail. In order to find out the spawning period of H. aurantium, we investigated development of the gonads during the annual reproductive cycle. Testis and ovary were both in the bisexual gonads (ovotestes) of H. aurantium, which is a hermaphrodite like H. roretzi. In H. aurantium, the right gonad was longer and slightly larger than the left gonad throughout the year. In each gonad, the number of the testis gonoducts was slightly higher than that of the ovary gonoducts. These features were similarly observed in H. roretzi. However, the number of the testis gonoducts and the ovary gonoducts in each gonad of H. aurantium was about half that of H. roretzi. The gonads of H. aurantium contracted during the winter and summer seasons. The gonads decreased to the smallest size around February, and then started to increase again in March. The gonads were most developed in September of the year. Therefore, it is estimated that the spawning of H. aurantium begins around this period.","PeriodicalId":72791,"journal":{"name":"Development & reproduction","volume":"25 4","pages":"299-303"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a6/cd/dr-25-4-299.PMC8807128.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39781493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Deficiency of Formyl Peptide Receptor 2 Retards Hair Regeneration by Modulating the Activation of Hair Follicle Stem Cells and Dermal Papilla Cells in Mice. 甲酰基肽受体2缺乏通过调节小鼠毛囊干细胞和真皮乳头细胞的激活来延缓毛发再生。

Development & reproduction Pub Date : 2021-12-01 Epub Date: 2021-12-31 DOI: 10.12717/DR.2021.25.4.279

Jinsol Han, Chanbin Lee, Youngmi Jung

{"title":"Deficiency of Formyl Peptide Receptor 2 Retards Hair Regeneration by Modulating the Activation of Hair Follicle Stem Cells and Dermal Papilla Cells in Mice.","authors":"Jinsol Han, Chanbin Lee, Youngmi Jung","doi":"10.12717/DR.2021.25.4.279","DOIUrl":"https://doi.org/10.12717/DR.2021.25.4.279","url":null,"abstract":"Hair loss is one of the most common chronic diseases, with a detrimental effect on a patient's psychosocial life. Hair loss results from damage to the hair follicle (HF) and/or hair regeneration cycle. Various damaging factors, such as hereditary, inflammation, and aging, impair hair regeneration by inhibiting the activation of hair follicle stem cells (HFSCs) and dermal papilla cells (DPCs). Formyl peptide receptor 2 (FPR2) regulates the inflammatory response and the activity of various types of stem cells, and has recently been reported to have a protective effect on hair loss. Given that stem cell activity is the driving force for hair regeneration, we hypothesized that FPR2 influences hair regeneration by mediating HFSC activity. To prove this hypothesis, we investigated the role of FPR2 in hair regeneration using Fpr2 knockout (KO) mice. Fpr2 KO mice were found to have excessive hair loss and abnormal HF structures and skin layer construction compared to wild-type (WT) mice. The levels of Sonic hedgehog (Shh) and β-catenin, which promote HF regeneration, were significantly decreased, and the expression of bone morphogenetic protein (Bmp)2/4, an inhibitor of the anagen phase, was significantly increased in Fpr2 KO mice compared to WT mice. The proliferation of HFSCs and DPCs was significantly lower in Fpr2 KO mice than in WT mice. These findings demonstrate that FPR2 impacts signaling molecules that regulate HF regeneration, and is involved in the proliferation of HFSCs and DPCs, exerting a protective effect on hair loss.","PeriodicalId":72791,"journal":{"name":"Development & reproduction","volume":"25 4","pages":"279-291"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ff/94/dr-25-4-279.PMC8807127.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39767383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Lin28 and Imp are Required for Stability of Bowl Transcripts in Hub Cells of the Drosophila Testis. 睾丸果蝇中心细胞碗状转录本的稳定性需要Lin28和Imp。

Development & reproduction Pub Date : 2021-12-01 Epub Date: 2021-12-31 DOI: 10.12717/DR.2021.25.4.313

Van To, Hyun Ju Kim, Wijeong Jang, Perinthottathil Sreejith, Changsoo Kim

引用次数: 0

Effects of Repeated Ovarian Stimulation on Ovarian Function and Aging in Mice. 反复卵巢刺激对小鼠卵巢功能及衰老的影响。

Development & reproduction Pub Date : 2021-12-01 Epub Date: 2021-12-31 DOI: 10.12717/DR.2021.25.4.213

Jihye Whang, Cheyoung Ahn, Soohyun Kim, Eunji Seok, Yunjeong Yang, Goeun Han, Haeun Jo, Hyunwon Yang

{"title":"Effects of Repeated Ovarian Stimulation on Ovarian Function and Aging in Mice.","authors":"Jihye Whang, Cheyoung Ahn, Soohyun Kim, Eunji Seok, Yunjeong Yang, Goeun Han, Haeun Jo, Hyunwon Yang","doi":"10.12717/DR.2021.25.4.213","DOIUrl":"https://doi.org/10.12717/DR.2021.25.4.213","url":null,"abstract":"Controlled ovarian hyperstimulation (COH) is routinely used in the in vitro fertilization and embryo transfer (IVF-ET) cycles to increase the number of retrieved mature oocytes. However, the relationship between repeated COH and ovarian function is still controversial. Therefore, we investigated whether repeated ovarian stimulation affects ovarian aging and function, including follicular development, autophagy, and apoptosis in follicles. Ovarian hyperstimulation in mice was induced by intraperitoneal injection with pregnant mare serum gonadotropin (PMSG) and human chorionic gonadotropin (hCG). Mice subjected to ovarian stimulation once were used as a control group and 10 times as an experimental group. Repeated injections with PMSG and hCG significantly reduced the number of primary follicles compared to a single injection. The number of secondary and antral follicles increased slightly, while the number of corpus luteum increased significantly with repeated injections. On the other hand, repeated injections did not affect apoptosis in follicles associated with follicular atresia. The expression of autophagy-related genes Atg5, Atg12, LC3B, and Beclin1, cell proliferation-related genes mTOR, apoptosis-related genes Fas, and FasL was not significantly different between the two groups. In addition, the expression of the aging-related genes Dnmt1, Dnmt3a, and AMH were also not significantly different. In this study, we demonstrated that repeated ovarian stimulation in mice affects follicular development, but not autophagy, apoptosis, aging in ovary. These results suggest that repetition of COH in the IVF-ET cycle may not result in ovarian aging, such as a decrease in ovarian reserve in adult women.","PeriodicalId":72791,"journal":{"name":"Development & reproduction","volume":"25 4","pages":"213-223"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5f/b4/dr-25-4-213.PMC8807135.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39767376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Analysis of Tissue-Specific Interferon Regulatory Factor 3 (IRF3) Gene Expression against Viral Infection in Paralichthys olivaceus. 组织特异性干扰素调节因子3 (IRF3)基因在橄榄鲆抗病毒感染中的表达分析。

Development & reproduction Pub Date : 2021-12-01 Epub Date: 2021-12-31 DOI: 10.12717/DR.2021.25.4.235

Kyung-Hee Kim, Sanghyun Lee, Jong-Won Park, Hyo Sun Jung, Julan Kim, Hyerim Yang, Jeong-Ho Lee, Dain Lee

{"title":"Analysis of Tissue-Specific Interferon Regulatory Factor 3 (IRF3) Gene Expression against Viral Infection in Paralichthys olivaceus.","authors":"Kyung-Hee Kim, Sanghyun Lee, Jong-Won Park, Hyo Sun Jung, Julan Kim, Hyerim Yang, Jeong-Ho Lee, Dain Lee","doi":"10.12717/DR.2021.25.4.235","DOIUrl":"https://doi.org/10.12717/DR.2021.25.4.235","url":null,"abstract":"Interferon Regulatory Factor 3 (IRF3) is a member of interferon-regulated transcription factor family and is known to play an important role in the innate immune response against viral infections. In this study, the expression of IRF3 in different tissues, developmental stages, and stocking densities of olive flounder was investigated. The expression of IRF3 was observed to gradually increase in early-stage juvenile fish. The highest expression was observed in later-stage juvenile fish when immune tissues were formed. High IRF3 expression was observed in the muscles and the brain tissues. The expression of IRF3 was observed in fish at different stocking densities after viral hemorrhagic septicemia virus (VHSV) infection. It yielded an interesting expression pattern in the muscles and the brain tissues of fish stocked at low density. These observations can be used as basic data for the study of the expression of immune response-related genes against viruses based on stocking density and immune systems in other fish species.","PeriodicalId":72791,"journal":{"name":"Development & reproduction","volume":"25 4","pages":"235-244"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/be/bd/dr-25-4-235.PMC8807130.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39767379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Expressional Modulation of Aquaporin 1 and 9 in the Rat Epididymis by an Anabolic-Androgenic Steroid, Nandrolone Decanoate. 合成代谢雄激素类固醇癸酸诺龙对大鼠附睾水通道蛋白1和9表达的调节。

Development & reproduction Pub Date : 2021-12-01 Epub Date: 2021-12-31 DOI: 10.12717/DR.2021.25.4.245

Ki-Ho Lee

{"title":"Expressional Modulation of Aquaporin 1 and 9 in the Rat Epididymis by an Anabolic-Androgenic Steroid, Nandrolone Decanoate.","authors":"Ki-Ho Lee","doi":"10.12717/DR.2021.25.4.245","DOIUrl":"https://doi.org/10.12717/DR.2021.25.4.245","url":null,"abstract":"The spermatozoa become mature in the epididymis which is divided into initial segment and caput, corpus, and cauda epididymis. The water movement across the epididymal epithelium is important for creating luminal microenvironment for sperm maturation. Aquaporins (Aqps) are water channel proteins, and expression of Aqps is regulated by androgens. The current research was focused to examine expressional regulation of Aqp1 and Aqp9 by an androgenic-anabolic steroid, nandrolone decanoate (ND). The ND at the low dose (2 mg/ kg body weight/week) or high dose (10 mg) was subcutaneously administrated into male rats for 2 or 12 weeks. Transcript levels of Aqp1 and Aqp9 were determined by quantitative real-time polymerase chain reaction (PCR) analyses. In the initial segment, level of Aqp1 was decreased with 12 week-treatment, while Aqp9 level was decreased by the high dose treatment for 12 weeks. In the caput epididymis, Aqp9 expression was decreased by the low dose treatment. The 2 week-treatment resulted in an increase of Aqp1 level but a decrease of Aqp9 expression in the corpus epididymis. In the corpus epididymis, the 12 week-treatment at the low dose caused the reduction of Aqp1 and Aqp9 levels, but the high dose treatment resulted in an increase of Aqp1 expression and a decrease of Aqp9 level. In the cauda epididymis, Aqp1 expression was decreased by 2 and 12 week-treatments, while increases of Aqp9 levels was detected with the high dose treatment for 2 weeks and with 12 week-treatment. These findings indicate differential regulation of Aqp1 and Aqp9 expression among epididymal segments by ND.","PeriodicalId":72791,"journal":{"name":"Development & reproduction","volume":"25 4","pages":"245-255"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f3/80/dr-25-4-245.PMC8807133.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39767380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0