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Short Review on Fullerene-Containing Electrically Conducting Electron Beam Resist for Organic Biosensors with Nanostructures 纳米结构有机生物传感器用含富勒烯导电电子束阻胶的研究进展
Advanced techniques in biology & medicine Pub Date : 2018-01-01 DOI: 10.4172/2379-1764.1000257
A. Nakajima
{"title":"Short Review on Fullerene-Containing Electrically Conducting Electron Beam Resist for Organic Biosensors with Nanostructures","authors":"A. Nakajima","doi":"10.4172/2379-1764.1000257","DOIUrl":"https://doi.org/10.4172/2379-1764.1000257","url":null,"abstract":"This paper provides an overview of nanocomposite organic electron beam (EB) resist polymers from the viewpoint of advanced techniques for biology and medicine. An outstanding issue with organic devices is the difficulty of simultaneously controlling the lateral size and position of structures at submicron or nanometer scales. Nanocomposite EB organic resist of ZEP520a containing [6,6]-phenyl-C61 butyric acid methyl ester (PCBM) is an excellent electrically conductive material for nanometer lateral-scale organic electronic devices. The distribution of PCBM aggregations in the nanocomposite is examined. The results open the door to the simple fabrication of densely integrated sensitive biosensors with electrical nanowires and single-electron transistors for multiplexed and simultaneous diagnoses.","PeriodicalId":7277,"journal":{"name":"Advanced techniques in biology & medicine","volume":"31 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79830181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Pneumatic transport system for associative learning in Drosophila melanogaster 果蝇联想学习的气动输送系统
Advanced techniques in biology & medicine Pub Date : 2018-01-01 DOI: 10.4172/2379-1764.1000251
Austin J. Taylor, Jin Dai, Alexander Squires, P. Shen, Z. Tse
{"title":"Pneumatic transport system for associative learning in Drosophila melanogaster","authors":"Austin J. Taylor, Jin Dai, Alexander Squires, P. Shen, Z. Tse","doi":"10.4172/2379-1764.1000251","DOIUrl":"https://doi.org/10.4172/2379-1764.1000251","url":null,"abstract":"A widely used associative learning technique for biological studies involves introducing Drosophila larvae to two different odorants and associating one of the odorants with a stimulus. The experimental method requires transferring the larvae back and forth between two odor chambers. Each chamber contains a different odorant and one of the chambers contains an accompanying stimulus. By introducing the larvae to the two different odorants several times, the larvae are trained to commit the odorant associated with the stimulus to memory. We created a mechatronic system for transporting Drosophila larvae back and forth between two agar trays to reduce manual labor and enable a scalable platform for associative learning and related studies. Air was chosen as the means of transporting the larvae and a chamber was constructed for housing the two agar trays. Control electronics were implemented for creating a sweeping blowing motion to transport the larvae in a gentle manner. Computer aided design (CAD) software was employed in conjunction with a 3D printer to build nozzles which help to direct airflow. Flow analysis software was utilized to model computational fluid dynamic simulations for optimizing air nozzles. In this study, a pneumatic transport system was developed and tested. The experimental results showed a 90% success rate for the transportation of larval Drosophila across the chamber and an overall decrease in transportation time by 4.8 times compared to manual transportation.","PeriodicalId":7277,"journal":{"name":"Advanced techniques in biology & medicine","volume":"115 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85649767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Exposure Risk Assessment Follow-up in an Aluminium Salvage Plant 铝回收厂的暴露风险评估跟进
Advanced techniques in biology & medicine Pub Date : 2018-01-01 DOI: 10.4172/2379-1764.1000255
F. Deschamps, J. Salles, O. Laraqui, N. Manar, C. Laraqui
{"title":"Exposure Risk Assessment Follow-up in an Aluminium Salvage Plant","authors":"F. Deschamps, J. Salles, O. Laraqui, N. Manar, C. Laraqui","doi":"10.4172/2379-1764.1000255","DOIUrl":"https://doi.org/10.4172/2379-1764.1000255","url":null,"abstract":"Introduction: Workers who work in salvage plant industry are at risk of exposure to aluminum (Al). The objective of this study was to conduct a longitudinal quantitative health risk and bio monitoring assessment for workers exposed to Al. Methods: Al workers were compared to controls. A standardized medical examination and neurobehavioral tests and pulmonary assessment were achieved. The longitudinal study was based on repeated measurements (Airborne and urine Al evaluations). Results: Clinical results showed no evident adverse effects, only mild health impairings. Modification of industrial process to reduce Al exposure leaded paradoxically to increase Al peaks in airborne and urine samples. Conclusion: Hygienic and architectural measures taken to improve exposure and to reduce Al inhalation was a failure. Appropriate preventive measures should be carefully assessed before being applied to protect effectively exposed workers.","PeriodicalId":7277,"journal":{"name":"Advanced techniques in biology & medicine","volume":"1 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78414201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Using Gold Nanoparticles for Ultra trace Spectrophotometry Determination of Tolyltriazole in Aqueous Media 纳米金超痕量分光光度法测定水介质中甲苯三唑
Advanced techniques in biology & medicine Pub Date : 2018-01-01 DOI: 10.4172/2379-1764.1000264
N. Esmaile, M. Sohrabi, F. Motiee
{"title":"Using Gold Nanoparticles for Ultra trace Spectrophotometry Determination of Tolyltriazole in Aqueous Media","authors":"N. Esmaile, M. Sohrabi, F. Motiee","doi":"10.4172/2379-1764.1000264","DOIUrl":"https://doi.org/10.4172/2379-1764.1000264","url":null,"abstract":"In this study, the detection limit sensitivity to the level of μg L-1 was achieved. For this, by applying AuNPs signal fluctuations of high sensitivity was carefully monitored so that they become measureable with highest possible precision. The proposed method is capable of determining TTA over a range of 10-100 μgL-1 with a limit of detection 5 μg L-1. The relative standard deviation of the method was 3% and 1.5%. The obtained preliminary results from this study proved to be effectively successful in determination of TTA in water. A comparison between the proposed method and the previously published methods for TTA determination has also been made for the first time.","PeriodicalId":7277,"journal":{"name":"Advanced techniques in biology & medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89949376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Siddha Elixir and Aeitology of Polycystic Ovarian Syndrome 多囊卵巢综合征的Siddha酏剂与病因学
Advanced techniques in biology & medicine Pub Date : 2017-11-30 DOI: 10.4172/2379-1764.1000249
R. My, S. Suresh, K. Balagurusamy
{"title":"Siddha Elixir and Aeitology of Polycystic Ovarian Syndrome","authors":"R. My, S. Suresh, K. Balagurusamy","doi":"10.4172/2379-1764.1000249","DOIUrl":"https://doi.org/10.4172/2379-1764.1000249","url":null,"abstract":"Siddha medicine is a treatment which is followed by an Ancient Tamilians. It has no side effects and cost efficient. Polycystic ovarian syndrome is a hormonal disorder affecting many women nowadays. It is called as syndrome because it shows many symptoms. It is also named as polycystic ovary disease, stein Leventhal syndrome or hyper androgen anovulation syndrome. In this PCOS more than 12 tiny cysts present in the ovary. It may cause due to genetic problem or lifestyle factors. This review interrupts the solution to reduce the risk and ill effects of PCOS with help of siddha medicine which is the best, nil side effects, and cheapest medicinal system.","PeriodicalId":7277,"journal":{"name":"Advanced techniques in biology & medicine","volume":"26 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2017-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75390977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Advancements in Microarray Utility for Detection and Tracking of Foodborne Microbes in the Genomic Era 基因组时代用于食源性微生物检测和跟踪的微阵列应用进展
Advanced techniques in biology & medicine Pub Date : 2017-08-24 DOI: 10.4172/2379-1764.1000239
Baoguang Li, I. Patel, B. Tall, C. Elkins
{"title":"Advancements in Microarray Utility for Detection and Tracking of Foodborne Microbes in the Genomic Era","authors":"Baoguang Li, I. Patel, B. Tall, C. Elkins","doi":"10.4172/2379-1764.1000239","DOIUrl":"https://doi.org/10.4172/2379-1764.1000239","url":null,"abstract":"Outbreaks caused by foodborne microbes pose serious public health and food safety concerns worldwide. There is a great demand for rapid, sensitive and high-throughput methods to detect and track these pathogens in food, water and other environments. Recent advances in DNA genomic technology have enabled high-throughput analyses of strains by capturing total genomic content of strains and with concomitant comparative phylogenies. Microarrays are particularly adept for distilling large amounts of genomic DNA sequence information such as the gene(s) or genetic traits of hundreds of foodborne isolates in a single experiment. Hence, over the past two decades, microarray technology has advanced tremendously due to accessibility to thousands of complete and draft microbial genomes and this progress has led to the design and manufacturing of newer microarrays which can now identify gene sequence variations down to a single nucleotide polymorphism. DNA microarray remains a useful tool for rapid and refined genomic analysis of foodborne microbes. In this review, we will primarily focus our discussion on pathogen detection, serotype identification and tracking the genetic diversity and source of contamination of respective foodborne strains with our first-hand experience in using this technology.","PeriodicalId":7277,"journal":{"name":"Advanced techniques in biology & medicine","volume":"7 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2017-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88626000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Why is Lamin B Receptor Downregulated in Senescence 为什么纤层蛋白B受体在衰老过程中下调
Advanced techniques in biology & medicine Pub Date : 2017-08-10 DOI: 10.4172/2379-1764.1000237
E. Lukášová, A. Kovařík, S. Kozubek
{"title":"Why is Lamin B Receptor Downregulated in Senescence","authors":"E. Lukášová, A. Kovařík, S. Kozubek","doi":"10.4172/2379-1764.1000237","DOIUrl":"https://doi.org/10.4172/2379-1764.1000237","url":null,"abstract":"An important mechanism ensuring spatial organization of chromatin structure and genome function in eukaryotic nuclei consists in anchoring of specific heterochromatin regions to nuclear envelope by proteins of inner nuclear membrane (INM) that are able to recognize these regions and simultaneously bind either Lamin A/C or lamin B1. One of these proteins is lamin B receptor (LBR) that binds lamin B1 and tethers heterochromatin to INM in embryonic and undifferentiated cells. It is replaced by lamin A/C with specific lamin A/C binding proteins (especially LEM-domain proteins) at the beginning of cell differentiation. Our functional experiments in cancer cell lines show that heterochromatin in cancer cells is tethered to INM by LBR that is downregulated together with lamin B1 at the onset of cell transition to senescence. A coordinated regulation of these proteins is evidenced also by downregulation of LB1 in cells with LBR silenced by shRNA. The downregulation of these proteins in senescent cells leads to the detachment of centromeric heterochromatin from INM resulting in it distension in nucleoplasm. These changes in structure of constitutive heterochromatin may be the reason of a permanent loss of cell proliferation in senescence.","PeriodicalId":7277,"journal":{"name":"Advanced techniques in biology & medicine","volume":"26 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2017-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81394719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-coding Vibration in Circadian Oscillation 昼夜节律振荡中的非编码振动
Advanced techniques in biology & medicine Pub Date : 2017-08-09 DOI: 10.4172/2379-1764.1000236
U. Bhadra, Pradipta Patra, M. Pal‐Bhadra
{"title":"Non-coding Vibration in Circadian Oscillation","authors":"U. Bhadra, Pradipta Patra, M. Pal‐Bhadra","doi":"10.4172/2379-1764.1000236","DOIUrl":"https://doi.org/10.4172/2379-1764.1000236","url":null,"abstract":"Neuron driven physiological activities such as sleep, feeding, energy consumption are controlled by light sensitive central clock genes in the pacemaker neurons in the brain. Multiple epigenetic events including post-transcriptional regulation, splicing, polyadenylation, mature mRNA editing and stability of translation products are the main vibrators for circadian oscillation with the instructive role of various sets of non-coding small regulatory RNA. Here, we sum up the basic role of small regulatory RNA and their epigenetic circuits in brain clock activity.","PeriodicalId":7277,"journal":{"name":"Advanced techniques in biology & medicine","volume":"22 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2017-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83735015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
AIRE Gene Mutation in Chinese APS-1 Patients 中国APS-1患者AIRE基因突变
Advanced techniques in biology & medicine Pub Date : 2017-08-03 DOI: 10.4172/2379-1764.1000235
Wufei Zhu, Zhen Hu, Xiangyu Liao, Xing Chen, Zhaoyang Zeng
{"title":"AIRE Gene Mutation in Chinese APS-1 Patients","authors":"Wufei Zhu, Zhen Hu, Xiangyu Liao, Xing Chen, Zhaoyang Zeng","doi":"10.4172/2379-1764.1000235","DOIUrl":"https://doi.org/10.4172/2379-1764.1000235","url":null,"abstract":"Autoimmune polyendocrine syndrome type 1 (APS-1, OMIM 2403000) is a rare autosomal recessive disease that is caused by autoimmune regulator (AIRE) gene. The main symptoms of APS-1 are chronic mucocutaneous candidiasis, autoimmune adrenocortical insufficiency (Addison’s disease) and hypoparathyroidism. To date, more than 100 different mutations of the AIRE gene have been identified in APS-1 patients. These different mutations affect the structure and function of the AIRE protein in different ways, which eventually leads to the development of APS-1. So far, only five cases of APS-1 have been reported in the Chinese, and the main mutation sites are c. 769C>T (p.R257*), c.55G>A (p.A19T), c.463G>A (p.G155fsX203), c.622G>T (p.G208W) and c.206A>C (p.Q69P).","PeriodicalId":7277,"journal":{"name":"Advanced techniques in biology & medicine","volume":"15 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2017-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88509318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alpha 1 Microglobulin: A Potentially Paradoxical Anti-Oxidant Agent. α 1微球蛋白:一种潜在的矛盾抗氧化剂。
Advanced techniques in biology & medicine Pub Date : 2017-08-01 Epub Date: 2017-08-24 DOI: 10.4172/2379-1764.1000238
Richard A Zager
{"title":"Alpha 1 Microglobulin: A Potentially Paradoxical Anti-Oxidant Agent.","authors":"Richard A Zager","doi":"10.4172/2379-1764.1000238","DOIUrl":"https://doi.org/10.4172/2379-1764.1000238","url":null,"abstract":"<p><p>Alpha 1 microglobulin is a low molecular weight heme binding antioxidant protein with interesting, and potentially important, clinical applications. However, much remains to be learned about its in vivo effects. This invited review raises a number of physiologic issues regarding this compound as it pertains to clinical use.</p>","PeriodicalId":7277,"journal":{"name":"Advanced techniques in biology & medicine","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2379-1764.1000238","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35453040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
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