昼夜节律振荡中的非编码振动

U. Bhadra, Pradipta Patra, M. Pal‐Bhadra
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引用次数: 0

摘要

神经元驱动的生理活动,如睡眠、进食、能量消耗,是由大脑中起搏器神经元中的光敏中央时钟基因控制的。转录后调控、剪接、聚腺苷化、成熟mRNA编辑和翻译产物稳定性等多种表观遗传事件是昼夜节律振荡的主要振子,各种非编码小调控RNA具有指导作用。在此,我们总结了小调控RNA及其表观遗传回路在脑时钟活动中的基本作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Non-coding Vibration in Circadian Oscillation
Neuron driven physiological activities such as sleep, feeding, energy consumption are controlled by light sensitive central clock genes in the pacemaker neurons in the brain. Multiple epigenetic events including post-transcriptional regulation, splicing, polyadenylation, mature mRNA editing and stability of translation products are the main vibrators for circadian oscillation with the instructive role of various sets of non-coding small regulatory RNA. Here, we sum up the basic role of small regulatory RNA and their epigenetic circuits in brain clock activity.
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