Dementia and neurocognitive disorders最新文献_第7页

Transient Epileptic Amnesia With Amygdala Enlargement Presenting to a Dementia Clinic. 一过性癫痫性健忘症伴杏仁核增大到痴呆诊所。

Dementia and neurocognitive disorders Pub Date : 2022-07-01 Epub Date: 2022-07-26 DOI: 10.12779/dnd.2022.21.3.103

Yebin Ahn, Keun Lee, Eun Bin Park, Sun Min Lee, So Young Moon

引用次数: 0

Is Telomere Length Shortening a Risk Factor for Neurodegenerative Disorders? 端粒缩短是神经退行性疾病的危险因素吗?

Dementia and neurocognitive disorders Pub Date : 2022-07-01 Epub Date: 2022-07-21 DOI: 10.12779/dnd.2022.21.3.83

Hyun-Jung Yu, Seong-Ho Koh

{"title":"Is Telomere Length Shortening a Risk Factor for Neurodegenerative Disorders?","authors":"Hyun-Jung Yu, Seong-Ho Koh","doi":"10.12779/dnd.2022.21.3.83","DOIUrl":"https://doi.org/10.12779/dnd.2022.21.3.83","url":null,"abstract":"Telomeres are located at the end of chromosomes. They are known to protect chromosomes and prevent cellular senescence. Telomere length shortening has been considered an important marker of aging. Many studies have reported this concept in connection with neurodegenerative disorders. Considering the role of telomeres, it seems that longer telomeres are beneficial while shorter telomeres are detrimental in preventing neurodegenerative disorders. However, several studies have shown that people with longer telomeres might also be vulnerable to neurodegenerative disorders. Before these conflicting results can be explained through large-scale longitudinal clinical studies on the role of telomere length in neurodegenerative disorders, it would be beneficial to simultaneously review these opposing results. Understanding these conflicting results might help us plan future studies to reveal the role of telomere length in neurodegenerative disorders. In this review, these contradictory findings are thoroughly discussed, with the aim to better understand the role of telomere length in neurodegenerative disorders.","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"21 3","pages":"83-92"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3f/0e/dnd-21-83.PMC9340245.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40696990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Rapidly Progressive Behavioral Syndrome Without Spastic Paraplegia in a Patient With SPAST p.Pro26Thr Variant SPAST p.Pro26Thr变异患者无痉挛性截瘫的快速进行性行为综合征

Dementia and neurocognitive disorders Pub Date : 2022-04-01 DOI: 10.12779/dnd.2022.21.2.79

F. Arshad, S. Alladi, Karthik Kulanthaivelu

引用次数: 0

Translocator Protein (18 kDa) Polymorphism (rs6971) in the Korean Population 韩国人群易位蛋白(18kda)多态性(rs6971

Dementia and neurocognitive disorders Pub Date : 2022-04-01 DOI: 10.12779/dnd.2022.21.2.71

Hyon Lee, Y. Noh, Woo-Ram Kim, Ha-Eun Seo, Hyeon-Mi Park

{"title":"Translocator Protein (18 kDa) Polymorphism (rs6971) in the Korean Population","authors":"Hyon Lee, Y. Noh, Woo-Ram Kim, Ha-Eun Seo, Hyeon-Mi Park","doi":"10.12779/dnd.2022.21.2.71","DOIUrl":"https://doi.org/10.12779/dnd.2022.21.2.71","url":null,"abstract":"Background and Purpose The expression of the 18-kDA mitochondrial translocator protein (TSPO) in the brain is an attractive target to study neuroinflammation. However, the binding properties of TSPO ligands are reportedly dependent on genetic polymorphism of the TSPO gene (rs6971). The objective of this study is to investigate the rs6971 gene polymorphism in the Korean population. Methods We performed genetic testing on 109 subjects including patients with mild cognitive impairment, Alzheimer’s disease (AD) dementia, non-AD dementia, and cognitively unimpaired participants. Magnetic resonance imaging scans and detailed neuropsychological tests were also performed, and 29 participants underwent 18F-DPA714 PET scans. Exon 4 of the TSPO gene containing the polymorphism rs6971 (Ala or Thr at position 147) was polymerase chain reaction amplified and sequenced using the Sanger method. The identified rs6971 genotype codes (C/C, C/T, or T/T) of the TSPO protein generated high-, mixed-, or low-affinity binding phenotypes (HABs, MABs, and LABs), respectively. Results We found that 96.3% of the study subjects were HAB (105 out of 109 subjects), and 3.7% of the subjects were MAB (4 out of 109 subjects). 18F-DPA-714 PET scans showed nonspecific binding to the thalamus and brainstem, and increased tracer uptake throughout the cortex in cognitively impaired patients. The participant with the MAB polymorphism had a higher DPA714 signal throughout the cortex. Conclusions The majority of Koreans are HAB (aprox. 96%). Therefore, the polymorphism of the rs6971 gene would have a smaller impact on the availability of second-generation TSPO PET tracers.","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"97 1","pages":"71 - 78"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78228238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Executive Summary of the 2021 International Conference of Korean Dementia Association: A Report From the Academic Committee of the Korean Dementia Association 《2021年韩国痴呆症协会国际会议纪要:韩国痴呆症协会学术委员会报告》

Dementia and neurocognitive disorders Pub Date : 2022-03-14 DOI: 10.12779/dnd.2022.21.2.45

K. Park, Jae-Won Jang, Jeewon Suh, SangHak Yi, J. Bae, Jae-Sung Lim, Hyon Lee, J. Chin, Young Ho Park, Y. Hong, G. Kim

{"title":"Executive Summary of the 2021 International Conference of Korean Dementia Association: A Report From the Academic Committee of the Korean Dementia Association","authors":"K. Park, Jae-Won Jang, Jeewon Suh, SangHak Yi, J. Bae, Jae-Sung Lim, Hyon Lee, J. Chin, Young Ho Park, Y. Hong, G. Kim","doi":"10.12779/dnd.2022.21.2.45","DOIUrl":"https://doi.org/10.12779/dnd.2022.21.2.45","url":null,"abstract":"Recently, aducanumab, a beta amyloid targeted immunotherapy, has been approved by the US Food and Drug Administration for the treatment of Alzheimer’s dementia (AD). Although many questions need to be answered, this approval provides a promising hope for the development of AD drugs that could be supported by new biomarkers such as blood-based ones and composite neuropsychological tests that can confirm pathologic changes in early stages of AD. It is important to elucidate the complexity of AD which is known to be associated with other factors such as vascular etiologies and neuro-inflammation. Through the second international conference of the Korean Dementia Association (KDA), researchers from all over the world have participated in the exchange of opinions with KDA members on the most up-to-date topics. The Academic Committee of the KDA summarizes lectures to provide the depth of the conference as well as discussions. This will be an important milestone to widen the latest knowledge in the research of AD’s diagnosis, therapeutics, pathogenesis that can lead to the establishment of future directions.","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"28 1","pages":"45 - 58"},"PeriodicalIF":0.0,"publicationDate":"2022-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80697000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Application of Plasma Neurofilament Light Chain in a Memory Clinic: A Pilot Study 血浆神经丝轻链在记忆临床应用的初步研究

Dementia and neurocognitive disorders Pub Date : 2022-03-14 DOI: 10.12779/dnd.2022.21.2.59

YongSoo Shim

{"title":"Clinical Application of Plasma Neurofilament Light Chain in a Memory Clinic: A Pilot Study","authors":"YongSoo Shim","doi":"10.12779/dnd.2022.21.2.59","DOIUrl":"https://doi.org/10.12779/dnd.2022.21.2.59","url":null,"abstract":"Background and Purpose Neurofilament light chain (NfL) has been considered as a biomarker for neurodegenerative diseases including Alzheimer’s disease (AD). We measured plasma NfL levels in older adults with cognitive complaints and evaluated their clinical usefulness in AD. Methods Plasma levels of NfL, measured by using the single molecule array method, were acquired in a total of 113 subjects consisting of subjective cognitive decline (SCD; n=14), mild cognitive impairment (MCI; n=37), or dementia of Alzheimer type (DAT; n=62). Plasma NfL level was compared among three groups, and its association with cognitive and functional status was also analyzed. Results After adjusting for age, plasma NfL level was higher in subjects with DAT (65.98±84.96 pg/mL), compared to in subjects with SCD (16.90±2.54 pg/mL) or MCI (25.53±10.42 pg/mL, p=0.004). NfL levels were correlated with scores of the mini-mental state examination (r=−0.242, p=0.021), clinical dementia rating (CDR) (r=0.291, p=0.005), or CDR-sum of boxes (r=0.276, p=0.008). Just for participants who performed amyloid positron emission tomography (PET), the levels were different between subjects with PET (−) (n=17, 25.95±13.25 pg/mL) and PET (+) (n=16, 63.65±81.90 pg/mL, p=0.010). Additionally, plasma NfL levels were different between vascular dementia and vascular MCI, and between Parkinson’s disease- dementia and no dementia. Conclusions This pilot study shows that in subjects with DAT, plasma NfL levels increase. Plasma NfL level correlated with cognitive and functional status. Further longitudinal studies may help to apply the plasma NfL levels to AD, as a potential biomarker for the diagnosis and predicting progression.","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"42 1","pages":"59 - 70"},"PeriodicalIF":0.0,"publicationDate":"2022-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82332126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Exploring Factors Associated With Successful Nonpharmacological Interventions for People With Dementia. 探索与痴呆患者成功非药物干预相关的因素。

Dementia and neurocognitive disorders Pub Date : 2022-01-01 Epub Date: 2021-12-29 DOI: 10.12779/dnd.2022.21.1.1

HyounKyoung Grace Park, Suzanne E Perumean-Chaney, Alfred A Bartolucci

{"title":"Exploring Factors Associated With Successful Nonpharmacological Interventions for People With Dementia.","authors":"HyounKyoung Grace Park, Suzanne E Perumean-Chaney, Alfred A Bartolucci","doi":"10.12779/dnd.2022.21.1.1","DOIUrl":"https://doi.org/10.12779/dnd.2022.21.1.1","url":null,"abstract":"Background and purpose: We investigated existing nonpharmacological programs for people with dementia (PWD) to explore critical factors related to the effectiveness of these types of programs.Methods: We conducted a qualitative systematic literature review to identify nonpharmacological intervention programs developed for PWD and reviewed 36 randomized controlled trials. Among several outcomes reported in each study, we focused on the most common outcomes including quality of life (QoL), neuropsychiatric symptoms, depression, agitation, and cognition for further review.Results: Several factors were identified that might affect the outcomes of nonpharmacological interventions for PWD including study design, characteristics of the intervention, maintaining research participants, heterogeneity issues, and implementation fidelity. About half of studies in this review reported positive program effects on their targeted outcomes such as Well-being and Health for PWD on improving quality of life, neuropsychiatric symptoms and agitation; cognitive stimulation therapy on QoL, neuropsychiatric symptoms and cognition; and a stepwise multicomponent intervention on neuropsychiatric symptoms, depression and agitation.Conclusions: We found some programs even with a rigorous study design did not produce expected outcomes while other programs with poor designs reported positive outcomes, which necessitates further investigation on the validity of the assessments. Factors such as individual tailored and customized interventions, promoting social interactions, ease of administration and compatibility of interventions, and developing program theory need to be considered when developing nonpharmacological intervention programs.","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":" ","pages":"1-16"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3c/aa/dnd-21-1.PMC8811205.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39776609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

A Comparison Between the Performances of Verbal and Nonverbal Fluency Tests in Discriminating Between Mild Cognitive Impairments and Alzheimer's Disease Patients and Their Brain Morphological Correlates. 言语和非言语流畅性测试在轻度认知障碍和阿尔茨海默病患者鉴别中的表现及其脑形态学相关性的比较

Dementia and neurocognitive disorders Pub Date : 2022-01-01 DOI: 10.12779/dnd.2022.21.1.17

Seyul Kwak, Seong A Shin, Hyunwoong Ko, Hairin Kim, Dae Jong Oh, Jung Hae Youn, Jun-Young Lee, Yu Kyeong Kim

{"title":"A Comparison Between the Performances of Verbal and Nonverbal Fluency Tests in Discriminating Between Mild Cognitive Impairments and Alzheimer's Disease Patients and Their Brain Morphological Correlates.","authors":"Seyul Kwak, Seong A Shin, Hyunwoong Ko, Hairin Kim, Dae Jong Oh, Jung Hae Youn, Jun-Young Lee, Yu Kyeong Kim","doi":"10.12779/dnd.2022.21.1.17","DOIUrl":"https://doi.org/10.12779/dnd.2022.21.1.17","url":null,"abstract":"Background and purpose: Verbal and nonverbal fluency tests are the conventional methods for examining executive function in the elderly population. However, differences in impairments result in fluency tests in patients with mild cognitive impairments (MCIs) and Alzheimer's disease (AD) and in neural correlates underlying the tests still necessitate concrete evidence.Methods: We compared the test performances in 27 normal controls, 28 patients with MCI, and 20 with AD, and investigated morphological changes in association with the test performances using structural magnetic imaging.Results: Patients with AD performed poorly across all the fluency tests, and a receiver operating characteristics curve analysis revealed that only category fluency test discriminated all the 3 groups. Association, category, and design fluency tests involved temporal and frontal regions, while letter fluency involved the cerebellum and caudate.Conclusions: Category fluency is a reliable measure for screening patients with AD and MCI, and this efficacy might be related to morphological correlates that underlie semantic and executive processing.","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"21 1","pages":"17-29"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/31/b6/dnd-21-17.PMC8811206.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9506135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Association Between Body Mass Index and Cognitive Function in Mild Cognitive Impairment Regardless of APOE ε4 Status. 与APOE ε4状态无关的轻度认知障碍患者体重指数与认知功能的关系

Dementia and neurocognitive disorders Pub Date : 2022-01-01 Epub Date: 2022-01-12 DOI: 10.12779/dnd.2022.21.1.30

Ye Sol Mun, Hee Kyung Park, Jihee Kim, Jiyoung Yeom, Geon Ha Kim, Min Young Chun, Hye Ah Lee, Soo Jin Yoon, Kyung Won Park, Eun-Joo Kim, Bora Yoon, Jae-Won Jang, Jin Yong Hong, Seong Hye Choi, Jee Hyang Jeong

{"title":"Association Between Body Mass Index and Cognitive Function in Mild Cognitive Impairment Regardless of APOE ε4 Status.","authors":"Ye Sol Mun, Hee Kyung Park, Jihee Kim, Jiyoung Yeom, Geon Ha Kim, Min Young Chun, Hye Ah Lee, Soo Jin Yoon, Kyung Won Park, Eun-Joo Kim, Bora Yoon, Jae-Won Jang, Jin Yong Hong, Seong Hye Choi, Jee Hyang Jeong","doi":"10.12779/dnd.2022.21.1.30","DOIUrl":"https://doi.org/10.12779/dnd.2022.21.1.30","url":null,"abstract":"Background and purpose: In this study we aimed to find the association between neuropsychological performance and body mass index (BMI) in patients with mild cognitive impairment (MCI). In addition, we investigated the effects of the apolipoprotein E (APOE) genotype in the relationship between the BMI and cognition in MCI.Methods: We enrolled a cohort of 3,038 subjects with MCI aged 65-90 from the Clinical Research Center for Dementia of South Korea and a dementia cohort of the Ewha Womans University Mokdong Hospital. MCI patients were classified into three subgroups according to the Asian standard of BMI. We compared cognitive performances between groups by one-way analysis of variance. To investigate the effects of the APOE genotype, we used multivariate linear regression models after adjusting for possible confounders.Results: Even though normal BMI groups were younger, had more females, and had less comorbidities, the higher BMI groups had better cognitive functions. Among subjects with APOE ε4 carriers, there was a positive relationship between the BMI and the memory task alone.Conclusions: Our findings suggested that higher BMI in patients with MCI were associated with better cognitive performance. The effects of the APOE ε4 genotype in the associations between BMI and cognition were distinguishing. Therefore, according to physical status, APOE ε4 genotype-specific strategies in the assessments and treatments may be necessary in elderly patients with MCI.","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":" ","pages":"30-41"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/05/45/dnd-21-30.PMC8811203.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39776610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Clinical Practice Guideline for Dementia (Diagnosis and Evaluation): 2021 Revised Edition. 痴呆临床实践指南(诊断和评估):2021修订版。

Dementia and neurocognitive disorders Pub Date : 2022-01-01 Epub Date: 2022-01-21 DOI: 10.12779/dnd.2022.21.1.42

Jin San Lee, Geon Ha Kim, Hee-Jin Kim, Hee Jin Kim, Seunghee Na, Kee Hyung Park, Young Ho Park, Jeewon Suh, Joon Hyun Shin, Seong-Il Oh, Bora Yoon, Hak Young Rhee, Jae-Sung Lim, Jae-Won Jang, Juhee Chin, Yun Jeong Hong, YongSoo Shim

引用次数: 5