Dementia and neurocognitive disorders最新文献_第8页

Validity of the Montreal Cognitive Assessment (MoCA) Index Scores: a Comparison with the Cognitive Domain Scores of the Seoul Neuropsychological Screening Battery (SNSB). 蒙特利尔认知评估(MoCA)指数得分的效度:与首尔神经心理筛选组(SNSB)认知领域得分的比较。

Dementia and neurocognitive disorders Pub Date : 2021-07-01 Epub Date: 2021-07-27 DOI: 10.12779/dnd.2021.20.3.28

Haeyoon Kim, Kyung-Ho Yu, Byung-Chul Lee, Byeong-Chae Kim, Yeonwook Kang

{"title":"Validity of the Montreal Cognitive Assessment (MoCA) Index Scores: a Comparison with the Cognitive Domain Scores of the Seoul Neuropsychological Screening Battery (SNSB).","authors":"Haeyoon Kim, Kyung-Ho Yu, Byung-Chul Lee, Byeong-Chae Kim, Yeonwook Kang","doi":"10.12779/dnd.2021.20.3.28","DOIUrl":"https://doi.org/10.12779/dnd.2021.20.3.28","url":null,"abstract":"Background and Purpose A new approach was proposed to score the Montreal Cognitive Assessment (MoCA) index scores for 6 cognitive domains: orientation (OIS), attention (AIS), language (LIS), visuospatial function (VIS), memory (MIS), and executive function (EIS). This study investigated whether the MoCA index scores represent the functions of each cognitive domain by examining the correlations with the corresponding cognitive domain scores derived from conventional neuropsychological tests included in the Seoul Neuropsychological Screening Battery, 2nd Edition (SNSB-II). Methods The participants were 104 amnestic mild cognitive impairment (aMCI), 74 vascular mild cognitive impairment (VaMCI), 73 dementia of the Alzheimer's type (DAT), and 41 vascular dementia (VaD) patients. All participants were administered the Korean-MoCA and SNSB-II. Results Like the MoCA total score, the MoCA-OIS, MoCA-VIS, and MoCA-MIS showed differences between aMCI and AD groups and between VaMCI and VaD groups. The MoCA-AIS, MoCA-LIS, and MoCA-EIS showed significant differences between VaMCI and VaD groups, but no difference between aMCI and DAT groups. In the aMCI and VaMCI groups, all index scores of the MoCA showed significant correlations with the corresponding cognitive domain scores of the SNSB-II. Except for MoCA-MIS, the MoCA-AIS, MoCA-LIS, MoCA-VIS, and MoCA-EIS also showed significant correlations with the corresponding domain scores of the SNSB-II in the DAT and VaD groups. Conclusions These results indicate that all MoCA index scores, except for MoCA-MIS, which does not reflect the severity of memory impairment in dementia patients, provide highly valid information on the function of each cognitive domain in patients with mild cognitive impairment and dementia.","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/87/8c/dnd-20-28.PMC8326308.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39280695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Coronavirus Disease 2019 and Dementia: The Survey for Dementia Patients in COVID-19 Crisis. 2019冠状病毒病与痴呆:对2019冠状病毒病危机中痴呆患者的调查

Dementia and neurocognitive disorders Pub Date : 2021-04-01 Epub Date: 2021-04-27 DOI: 10.12779/dnd.2021.20.2.16

Hojin Choi, Jae-Sung Lim, Chan-Nyoung Lee, Jae-Won Jang, SangHak Yi, Seunghee Na, Nayoung Ryoo, Kun Woo Park, Yong S Shim

{"title":"Coronavirus Disease 2019 and Dementia: The Survey for Dementia Patients in COVID-19 Crisis.","authors":"Hojin Choi, Jae-Sung Lim, Chan-Nyoung Lee, Jae-Won Jang, SangHak Yi, Seunghee Na, Nayoung Ryoo, Kun Woo Park, Yong S Shim","doi":"10.12779/dnd.2021.20.2.16","DOIUrl":"https://doi.org/10.12779/dnd.2021.20.2.16","url":null,"abstract":"The coronavirus disease 2019 (COVID-19) crisis that began last year, has had a disruptive impact on our society.1 While the impact has affected society in general, it has affected certain groups of individuals disproportionately. Dementia patients are among the most vulnerable individuals in the society, and the COVID-19 crisis has further worsened their susceptibility. Notably, most of them are elderly patients who are vulnerable to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and COVID-19 complications.2,3 In order to prevent the spread of SARS-CoV-2 infection, most governments imposed mitigation measures including quarantine and movement restrictions. This confinement significantly limits physical, cognitive, and social activities and has consequently led to the rapid deteriorating of clinical symptoms in dementia patients.4 In addition, confinement is associated with several psychological effects, including depression, irritability, and anger, which are likely to have a negative impact on the already burdened caregivers both at home and nursing facilities. The Korean Dementia Association has been very concerned about the consequences of the pandemic on dementia patients and their families and has come up with two measures aimed at developing a strong support system; 1, developing care guidelines for dementia patients and caregivers, and 2, Conducting a survey to identify the extent of COVID-19 impact in dementia patients. The guidelines have already been published,5 herein, we report the findings of the survey.","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/66/99/dnd-20-16.PMC8093012.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38976555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Multiple Enhanced Lesions in the Brain MRI of a Patient with COVID-19. 1例COVID-19患者脑MRI多发强化病灶

Dementia and neurocognitive disorders Pub Date : 2021-04-01 Epub Date: 2021-04-08 DOI: 10.12779/dnd.2021.20.2.13

Yu Min Kang, Noh Hyuck Park, Min Jae Seong, Hyun Jeong Han, Young Hee Jung

{"title":"Multiple Enhanced Lesions in the Brain MRI of a Patient with COVID-19.","authors":"Yu Min Kang, Noh Hyuck Park, Min Jae Seong, Hyun Jeong Han, Young Hee Jung","doi":"10.12779/dnd.2021.20.2.13","DOIUrl":"https://doi.org/10.12779/dnd.2021.20.2.13","url":null,"abstract":"A 67-year-old-male was hospitalised for COVID-19-associated-pneumonia on April 2, 2020. His first symptoms consisted of myalgia and a cough. COVID-19 was diagnosed based on the detection of SARS-CoV-2 viral nucleic acid through a nasopharyngeal swab specimen using real-time polymerase-chain-reaction assay. Chest computerised tomography showed patchy areas of consolidation in the peribronchial and subpleural areas of both lungs, which was consistent with COVID-19-associated-pneumonia. He had diabetes, chronic kidney disease without dialysis, and alcoholic liver disease. The patient was not a smoker, but a heavy drinker. Lopinavir/ritonavir and antibiotic therapy were initiated. On the 5th day of illness, the patient was intubated due to desaturation. On the 14th day, multi-organ failure was diagnosed, and continuous-renal-replacement-therapy and extracorporeal-membraneoxygenation were administered. On the 25th day, he was released from quarantine due to the negative results of three consecutive COVID-19-tests. He had stupor, but diffusion, and MRI showed no abnormal findings. The response was not improved until 42nd day, although sedative was not used.","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1b/0b/dnd-20-13.PMC8093011.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38976554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glia-Like Cells from Human Mesenchymal Stem Cells Protect Neural Stem Cells in an In Vitro Model of Alzheimer's Disease by Reducing NLRP-3 Inflammasome. 来自人间充质干细胞的胶质样细胞通过减少NLRP-3炎性体保护阿尔茨海默病体外模型中的神经干细胞

Dementia and neurocognitive disorders Pub Date : 2021-01-01 Epub Date: 2020-11-27 DOI: 10.12779/dnd.2021.20.1.1

Mina Hwang, Se Hyeon Song, Mi-Sook Chang, Seong-Ho Koh

{"title":"Glia-Like Cells from Human Mesenchymal Stem Cells Protect Neural Stem Cells in an In Vitro Model of Alzheimer's Disease by Reducing NLRP-3 Inflammasome.","authors":"Mina Hwang, Se Hyeon Song, Mi-Sook Chang, Seong-Ho Koh","doi":"10.12779/dnd.2021.20.1.1","DOIUrl":"https://doi.org/10.12779/dnd.2021.20.1.1","url":null,"abstract":"Background and purpose: Neural stem cells (NSCs) have the ability to regenerate, proliferate, and differentiate, enabling them to play important roles in the recovery of the damaged nervous system. However, in neurodegenerative diseases such as Alzheimer's disease (AD), the NSCs are damaged as well. Glia-like cells from human mesenchymal stem cells (ghMSCs) are functionally enhanced adult stem cells. In the present study, we investigated whether ghMSCs could protect NSCs from amyloid beta (Aβ)-mediated toxicity.Methods: Rat NSCs were obtained from E13-14 fetal rat cortices. NSCs were seeded in pre-coated plates, and the next day, cells were simultaneously treated with 20 μM Aβ and 0.4 μm pore insert well-seeded ghMSCs. After 48 hours of co-treatment, cell viability and proliferation were evaluated. After 2 hours of co-treatment, western blotting was performed to measure inflammasome-related factors, such as NOD-like receptor family pyrin domain containing 3, caspase-1, and interleukin-1β.Results: The results showed that ghMSCs increased viability and proliferation and reduced the toxicity of NSCs injured by Aβ by reducing the NRLP3 inflammasome activation of NSCs induced by Aβ.Conclusions: In this study, we confirmed that ghMSCs could protect NSCs in an in vitro model of AD through the regulation of inflammatory response.","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c6/5f/dnd-20-1.PMC7847801.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25341903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Relationship between Retinal Nerve Fiber Layer Thickness and Cognitive Measures in Mild Cognitive Impairment Patients. 轻度认知障碍患者视网膜神经纤维层厚度与认知功能的关系。

Dementia and neurocognitive disorders Pub Date : 2021-01-01 Epub Date: 2021-01-05 DOI: 10.12779/dnd.2021.20.1.9

Heewon Bae, Tae Gu Kang, Min Ju Kang

引用次数: 0

A Comprehensive Visual Rating Scale for Predicting Progression from Mild Cognitive Impairment to Dementia in Patients with Alzheimer's Pathology or Suspected Non-Alzheimer's Pathology. 预测阿尔茨海默病病理或疑似非阿尔茨海默病病理患者从轻度认知障碍到痴呆进展的综合视觉评定量表

Dementia and neurocognitive disorders Pub Date : 2020-12-01 DOI: 10.12779/dnd.2020.19.4.129

Sang Won Park, Seongheon Kim, Jeonghoon Park, Jae Won Jang, SangYun Kim

{"title":"A Comprehensive Visual Rating Scale for Predicting Progression from Mild Cognitive Impairment to Dementia in Patients with Alzheimer's Pathology or Suspected Non-Alzheimer's Pathology.","authors":"Sang Won Park, Seongheon Kim, Jeonghoon Park, Jae Won Jang, SangYun Kim","doi":"10.12779/dnd.2020.19.4.129","DOIUrl":"https://doi.org/10.12779/dnd.2020.19.4.129","url":null,"abstract":"Background and purpose: To identify biomarkers for prediction of the progression to dementia in mild cognitive impairment (MCI) patients, evaluation of brain structure changes has been validated by a comprehensive visual grading scale (CVRS) through magnetic resonance imaging (MRI). In this study, we specifically elucidated for the cognitive change of MCI patients classified based on AT(N) pathological status classification during the follow-up period of 3 years through the CVRS.Methods: The 301 patients with initial MCI visited at least once for follow-up period. The data used in this study were obtained from the Alzheimer's disease (AD) Neuroimaging Initiative study. Brain atrophy was assessed by CVRS using MRI. AT(N) profiles were classified by cerebrospinal fluid abnormality. Based on the AT(N) assessment, all individuals in this study were divided into 3 groups (normal state biomarker, suspected non-Alzheimer's pathology [SNAP], or Alzheimer's continuum). The cox regression was used to analyze the hazard ratios of CVRS for progression to dementia.Results: Sixty-three progressed and 238 remained stable to dementia and the CVRS (mean±standard deviation) had significant difference between progressive MCI and stable MCI (p<0.001). Univariate and multivariate cox regression results (p<0.001) showed the independence of initial CVRS as a predictor for the progression to dementia. Moreover, comparing the classified AT(N) pathology group, SNAP and AD, effectiveness of CVRS as a predictor was verified only in Alzheimer's continuum.Conclusions: The initial CVRS score as a predictor of dementia progression was independently validated at the stage of Alzheimer's progression among AT(N) pathologically differentiated MCI.","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/66/f8/dnd-19-129.PMC7781734.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38763849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Vulnerable Strata to Non-Adherence and Overuse in Treatment for Patients with Cognitive Impairment. 认知障碍患者治疗中不依从性和过度使用的脆弱阶层。

Dementia and neurocognitive disorders Pub Date : 2020-12-01 DOI: 10.12779/dnd.2020.19.4.152

Yeonsil Moon, Jae Sung Lim, Chan Nyoung Lee, Hojin Choi

{"title":"Vulnerable Strata to Non-Adherence and Overuse in Treatment for Patients with Cognitive Impairment.","authors":"Yeonsil Moon, Jae Sung Lim, Chan Nyoung Lee, Hojin Choi","doi":"10.12779/dnd.2020.19.4.152","DOIUrl":"https://doi.org/10.12779/dnd.2020.19.4.152","url":null,"abstract":"Background and purpose: Appropriate medication treatment could enable both cognitively impaired patients and caregivers to hold on their cognitive functioning and quality of life. Thus, medication management and the factors influencing how management for this condition is carried out must be identified. In this study we aimed to evaluate the frequency of medication nonadherence (MNA) or drug overuse for cognitive impairment (DOC) and to extract significant variables, including the demographic and social characteristics, vascular risk factors, and cognitive status, for the diagnosis of MNA and DOC in Korean patients.Methods: We investigated patients aged over 50 years between March 2019 and June 2019 via the cognitive enHancement of patIents with acQuired cognitive impairment (HIQ) campaign. MNA was defined as a participant who was classified as having cognitive impairment but did not take any cognition-related drugs, whereas DOC was defined as a participant who had normal cognition but was taking cognition-related drugs.Results: We included 10,767 patients. The MNA group consisted of 337 participants, whereas the DOC group comprised 1,107 participants. The factors that could differentiate the MNA group from the normal-behavior group were age, education, sex, and the total Korean version of Mini-Mental State Examination (K-MMSE) score. The factors that could differentiate the DOC group from the normal medication-behavior group were age, sex, residential distinction, experience of a dementia screening test, and the total K-MMSE score.Conclusions: The underlying factors contributing to inadequate dementia-medication management must be understood, and intervention or support is needed to enable safe medication management.","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c3/25/dnd-19-152.PMC7781736.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38763280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Coronavirus Disease 2019 and Dementia: Recommendation of the Korean Dementia Association. 2019冠状病毒病与痴呆症:韩国痴呆症协会的建议。

Dementia and neurocognitive disorders Pub Date : 2020-12-01 DOI: 10.12779/dnd.2020.19.4.125

Jae Sung Lim, Yong S Shim, Chan Nyoung Lee, Jae Won Jang, Hojin Choi, SangHak Yi, Seunghee Na, Nayoung Ryoo, Kun Woo Park

引用次数: 3

The Effect of Seoul Dementia Healing Design Project on Cognition and Social Engagement. 首尔痴呆症治疗设计项目对认知和社会参与的影响。

Dementia and neurocognitive disorders Pub Date : 2020-12-01 DOI: 10.12779/dnd.2020.19.4.140

Min Young Chun, Jihye Hwang, Ji Young Yun, Geum Yun Sim, Gyoung Sil Choi, Geon Ha Kim, Jee Hyang Jeong

{"title":"The Effect of Seoul Dementia Healing Design Project on Cognition and Social Engagement.","authors":"Min Young Chun, Jihye Hwang, Ji Young Yun, Geum Yun Sim, Gyoung Sil Choi, Geon Ha Kim, Jee Hyang Jeong","doi":"10.12779/dnd.2020.19.4.140","DOIUrl":"https://doi.org/10.12779/dnd.2020.19.4.140","url":null,"abstract":"Background and purpose: Rapid population aging and an increase in the demented elderly became major social concerns in South Korea. Environmental design is increasingly recognized as an important aid for long-term care of patients with dementia as well as pharmacotherapy. We did a pilot study to investigate the effect of the Seoul Dementia Healing Design Project In-House Design (S-DHDP-IHD) in improving the quality of life of the cognitively impaired patients and of the S-DHDP Environmental Design (S-DHDP-ED) in increasing daily outdoor activities for cognitively impaired individuals and not cognitively impaired (NCI) elderly residents.Methods: We applied the S-DHDP-IHD to 2 households of patients with mild cognitive impairment (MCI) and early-stage vascular dementia (VD). We assessed the effectiveness of intervention by surveys and video recordings of daily tasks. Additionally, we applied the S-DHDP-ED to 5 community facilities and randomly selected 287 residents over 65 years old (32 dementia caregivers and 255 NCI elderly) to participate in surveys.Results: S-DHDP-IHD intervention showed improved instrumental activities in MCI patient and early-stage VD patient. Also, the satisfaction with an intervened home environment was increased. Following S-DHDP-ED intervention, non-demented residents engaged in more outdoor and social activities. They were also satisfied with the function and design of the installed facilities.Conclusions: S-DHDP encompassing both home and environmental improvements was effective in readapting cognitively impaired individuals and could achieve a customized, holistic approach to dementia caregiving by means of the improved design.","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/56/38/dnd-19-140.PMC7781737.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38763276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Delayed Post-Hypoxic Leukoencephalopathy Caused by Fentanyl Intoxication in a Healthy Woman. 芬太尼中毒致健康女性迟发性缺氧后脑白质病

Dementia and neurocognitive disorders Pub Date : 2020-12-01 DOI: 10.12779/dnd.2020.19.4.170

Jeongyeon Kim, Sung Wook Hyung, Junghee Seo, Heejin Lee, Hyun Jeong Yu, Mun Kyung Sunwoo

引用次数: 1