Dementia and neurocognitive disorders最新文献_第8页

Amyloid Burden in Alzheimer's Disease Patients Is Associated with Alterations in Circadian Rhythm. 阿尔茨海默病患者的淀粉样蛋白负担与昼夜节律改变有关

Dementia and neurocognitive disorders Pub Date : 2021-10-01 Epub Date: 2021-10-31 DOI: 10.12779/dnd.2021.20.4.99

Jubin Kang, Hyung Jin Choi, Gary D Isaacs, Wonjae Sung, Hee-Jin Kim

{"title":"Amyloid Burden in Alzheimer's Disease Patients Is Associated with Alterations in Circadian Rhythm.","authors":"Jubin Kang, Hyung Jin Choi, Gary D Isaacs, Wonjae Sung, Hee-Jin Kim","doi":"10.12779/dnd.2021.20.4.99","DOIUrl":"https://doi.org/10.12779/dnd.2021.20.4.99","url":null,"abstract":"Background and purpose: In this study we evaluated the relationship between amyloid-beta (Aβ) deposition and 3 aspects of sleep quality in a group of clinically diagnosed Alzheimer's disease (AD) patients.Methods: We used self-report questionnaires to assess the quality of sleep using 3 previously established surveys: the Glasgow Sleep Effort Scale (GSES), the Pittsburgh Sleep Quality Index (PSQI), and the Morningness-Eveningness Questionnaire (MEQ). These questionnaires focused on the sleep effort, sleep efficiency, and circadian rhythm patterns of each participant. Also, we evaluated the regional distribution of Aβ in the brain by amyloid positron emission tomography-computed tomography (PET-CT) standardized uptake value ratios (SUVRs) in healthy normal (HN), mild cognitive impairment (MCI), and AD dementia groups. The MCI and AD dementia groups were combined to form the group with cognitive impairment due to AD (CIAD).Results: GSES and MEQ scores differed significantly between the HN, MCI, and AD dementia groups (p<0.037), whereas PSQI scores were similar across the groups (p=0.129). GSES and MEQ scores also differed between the HN and CIAD groups (p<0.018). Circadian rhythm scores positively correlated with amyloid PET-CT SUVR in posterior cingulate cortices (p<0.049).Conclusions: Sleep effort and abnormal shifts in circadian rhythm were more significant in the CIAD group than in the HN group. At the same time, HN subjects had minimal sleep disturbance, irrespective of clinical status. Thus, alterations in circadian rhythm may be indicative of neurodegeneration due to Aβ deposition.","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"20 4","pages":"99-107"},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4f/4f/dnd-20-99.PMC8585536.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39637940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Changes in Speech Range Profile Are Associated with Cognitive Impairment. 言语范围轮廓的改变与认知障碍有关。

Dementia and neurocognitive disorders Pub Date : 2021-10-01 Epub Date: 2021-10-31 DOI: 10.12779/dnd.2021.20.4.89

Alessandro De Stefano, Pamela Di Giovanni, Gautham Kulamarva, Francesca Di Fonzo, Tommaso Massaro, Agnese Contini, Francesco Dispenza, Claudio Cazzato

{"title":"Changes in Speech Range Profile Are Associated with Cognitive Impairment.","authors":"Alessandro De Stefano, Pamela Di Giovanni, Gautham Kulamarva, Francesca Di Fonzo, Tommaso Massaro, Agnese Contini, Francesco Dispenza, Claudio Cazzato","doi":"10.12779/dnd.2021.20.4.89","DOIUrl":"https://doi.org/10.12779/dnd.2021.20.4.89","url":null,"abstract":"Background and purpose: The aim of this study was to describe the variations in the speech range profile (SRP) of patients affected by cognitive decline.Methods: We collected the data of patients managed for suspected voice and speech disorders, and suspected cognitive impairment. Patients underwent an Ear Nose and Throat evaluation and Mini-Mental State Examination (MMSE). To obtain SRP, we asked the patients to read 18 sentences twice, at their most comfortable pitch and loudness as they would do in daily conversation, and recorded their voice on to computer software.Results: The study included 61 patients. The relationship between the MMSE score and SRP parameters was established. Increased severity of the MMSE score resulted in a statistically significant reduction in the average values of the semitones to the phonetogram, and the medium and maximum sound pressure levels (p<0.001). The maximum predictivity of MMSE was based on the highly significant values of semitones (p<0.001) and the maximum sound pressure levels (p=0.010).Conclusions: The differences in SRP between the various groups were analyzed. Specifically, the SRP value decreased with increasing severity of cognitive decline. SRP was useful in highlighting the relationship between all cognitive declines tested and speech.","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"20 4","pages":"89-98"},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ea/6a/dnd-20-89.PMC8585535.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39637470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repetitive and Stereotypic Vocalization in Dementia after Using Antipsychotics. 使用抗精神病药物后痴呆的重复和刻板化发声。

Dementia and neurocognitive disorders Pub Date : 2021-10-01 Epub Date: 2021-10-31 DOI: 10.12779/dnd.2021.20.4.116

Wonjae Sung, Hee-Jin Kim

引用次数: 0

A Comparison of Speech Features between Mild Cognitive Impairment and Healthy Aging Groups. 轻度认知障碍与健康老年人言语特征比较。

Dementia and neurocognitive disorders Pub Date : 2021-10-01 Epub Date: 2021-09-27 DOI: 10.12779/dnd.2021.20.4.52

Ko Woon Kim, Seung-Hoon Na, Young-Chul Chung, Byoung-Soo Shin

{"title":"A Comparison of Speech Features between Mild Cognitive Impairment and Healthy Aging Groups.","authors":"Ko Woon Kim, Seung-Hoon Na, Young-Chul Chung, Byoung-Soo Shin","doi":"10.12779/dnd.2021.20.4.52","DOIUrl":"https://doi.org/10.12779/dnd.2021.20.4.52","url":null,"abstract":"Background and purpose: Language dysfunction is a symptom common to patients with Alzheimer's disease (AD). Speech feature analysis may be a patient-friendly screening test for early-stage AD. We aimed to investigate the speech features of amnestic mild cognitive impairment (aMCI) compared to normal controls (NCs).Methods: Spoken responses to test questions were recorded with a microphone placed 15 cm in front of each participant. Speech samples delivered in response to four spoken test prompts (free speech test, Mini-Mental State Examination [MMSE], picture description test, and sentence repetition test) were obtained from 98 patients with aMCI and 139 NCs. Each recording was transcribed, with speech features noted. The frequency of the ten speech features assessed was evaluated to compare speech abilities between the test groups.Results: Among the ten speech features, the frequency of pauses (p=0.001) and mumbles (p=0.001) were significantly higher in patients with aMCI than in NCs. Moreover, MMSE score was found to negatively correlate with the frequency of pauses (r=-0.441, p<0.001) and mumbles (r=-0.341, p<0.001).Conclusions: Frequent pauses and mumbles reflect cognitive decline in aMCI patients in episodic and semantic memory tests. Speech feature analysis may prove to be a speech-based biomarker for screening early-stage cognitive impairment.","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"20 4","pages":"52-61"},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f3/c4/dnd-20-52.PMC8585532.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39637466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Validation of Four Methods for Converting Scores on the Montreal Cognitive Assessment to Scores on the Mini-Mental State Examination-2. 四种将蒙特利尔认知评估分数转换为简易精神状态考试分数的方法的验证-2。

Dementia and neurocognitive disorders Pub Date : 2021-10-01 Epub Date: 2021-09-27 DOI: 10.12779/dnd.2021.20.4.41

Sung Hoon Kang, Moon Ho Park

{"title":"Validation of Four Methods for Converting Scores on the Montreal Cognitive Assessment to Scores on the Mini-Mental State Examination-2.","authors":"Sung Hoon Kang, Moon Ho Park","doi":"10.12779/dnd.2021.20.4.41","DOIUrl":"https://doi.org/10.12779/dnd.2021.20.4.41","url":null,"abstract":"Background and purpose: There are many methods for converting scores from the Montreal Cognitive Assessment (MoCA) to those on the Mini-Mental State Examination (MMSE). In this study we aimed to validate 4 methods that convert the full score range (0-30 points) of the MoCA to an equivalent range for the MMSE.Methods: We examined the medical records of 506 subjects who completed the MoCA and MMSE-second edition (MMSE-2) on the same day. For the validation index, we calculated mean, median, and root-mean-squared error (RMSE) of the difference between true and equivalent MMSE-2 scores. We also calculated intraclass correlation coefficients (ICCs), the Bland-Altman plot, and the generalizability coefficient between true and equivalent MMSE-2 scores for reliability. We compared the ICCs according to age, sex, education, MMSE, and cognitive-status subgroups. For accuracy, we evaluated a ±2 point difference between the true and equivalent MMSE-2 scores.Results: The 4 conversion methods had a mean of -0.79 to -0.05, a median of -1 to 0, and an RMSE of 2.61-2.94 between true and equivalent MMSE-2 scores. All conversion methods had excellent reliability, with an ICC greater than 0.75 between true and equivalent MMSE-2 scores. These results were almost maintained in the subgroup analyses. These conversion methods provided more than 65% accuracy within ±2 points of the true MMSE-2 scores.Conclusions: We suggest that these 4 conversion methods are applicable for converting MoCA scores to MMSE-2 scores. They will greatly enhance the usefulness of existing cognitive data in clinical and research settings.","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"20 4","pages":"41-51"},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ee/ff/dnd-20-41.PMC8585534.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39637465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Comparison of RCF Scoring System to Clinical Decision for the Rey Complex Figure Using Machine-Learning Algorithm. 利用机器学习算法比较雷伊复杂图形的 RCF 评分系统与临床决策。

Dementia and neurocognitive disorders Pub Date : 2021-10-01 Epub Date: 2021-10-31 DOI: 10.12779/dnd.2021.20.4.70

Chanda Simfukwe, Seong Soo An, Young Chul Youn

{"title":"Comparison of RCF Scoring System to Clinical Decision for the Rey Complex Figure Using Machine-Learning Algorithm.","authors":"Chanda Simfukwe, Seong Soo An, Young Chul Youn","doi":"10.12779/dnd.2021.20.4.70","DOIUrl":"10.12779/dnd.2021.20.4.70","url":null,"abstract":"Background and purpose: Interpreting the Rey complex figure (RCF) requires a standard RCF scoring system and clinical decision by clinicians. The interpretation of RCF using clinical decision by clinicians might not be accurate in the diagnosing of mild cognitive impairment (MCI) or dementia patients in comparison with the RCF scoring system. For this reason, a machine-learning algorithm was used to demonstrate that scoring RCF using clinical decision is not as accurate as of the RCF scoring system in predicting MCI or mild dementia patients from normal subjects.Methods: The RCF dataset consisted of 2,232 subjects with formal neuropsychological assessments. The RCF dataset was classified into 2 datasets. The first dataset was to compare normal vs. abnormal and the second dataset was to compare normal vs. MCI vs. mild dementia. Models were trained using a convolutional neural network for machine learning. Receiver operating characteristic curves were used to compare the sensitivity, specificity, and area under the curve (AUC) of models.Results: The trained model's accuracy for predicting cognitive states was 96% with the first dataset (normal vs. abnormal) and 88% with the second dataset (normal vs. MCI vs. mild dementia). The model had a sensitivity of 85% for detecting abnormal with an AUC of 0.847 with the first dataset. It had a sensitivity of 78% for detecting MCI or mild dementia with an AUC of 0.778 with the second dataset.Conclusions: Based on this study, the RCF scoring system has the potential to present more accurate criteria than the clinical decision for distinguishing cognitive impairment among patients.","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"20 4","pages":"70-79"},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1d/dc/dnd-20-70.PMC8585537.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39637468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurosyphilis as a Rare Cause of Mild Cognitive Impairment and Depression: Two Case Reports and Literature Review. 神经梅毒是一种罕见的引起轻度认知障碍和抑郁的原因:两例报告和文献复习。

Dementia and neurocognitive disorders Pub Date : 2021-10-01 Epub Date: 2021-10-20 DOI: 10.12779/dnd.2021.20.4.112

Kyung Won Lee, Yun Jeong Hong, Si Baek Lee, Seong Hoon Kim, Yun Sang Oh, Yongbang Kim, Jeong Wook Park

引用次数: 1

A Comparison of the Performance between the 60- and 120-Second Conditions of the Korean-Color Word Stroop Test: Color Reading (K-CWST: CR). 韩文颜色词Stroop测验:颜色阅读(K-CWST: CR) 60秒和120秒条件下的表现比较

Dementia and neurocognitive disorders Pub Date : 2021-10-01 Epub Date: 2021-10-21 DOI: 10.12779/dnd.2021.20.4.62

Sun Hwa Lee, Yeonwook Kang, Minji Song, Geon Ha Kim, Jee Hyang Jeong

{"title":"A Comparison of the Performance between the 60- and 120-Second Conditions of the Korean-Color Word Stroop Test: Color Reading (K-CWST: CR).","authors":"Sun Hwa Lee, Yeonwook Kang, Minji Song, Geon Ha Kim, Jee Hyang Jeong","doi":"10.12779/dnd.2021.20.4.62","DOIUrl":"https://doi.org/10.12779/dnd.2021.20.4.62","url":null,"abstract":"Background and purpose: The Korean-Color Word Stroop Test: Color Reading (K-CWST: CR) included in the Seoul Neuropsychological Screening Battery, 2nd Edition (SNSB-II) examines inhibitory control deficit. It provides normative data for both 60- and 120-second conditions, but the validity of the 60-second condition has not yet been proven. This study examined the validity of the 60-second condition by observing concordance between the performances in cognitively normal, MCI, and mild dementia groups.Methods: There were 1,336 patients performed the SNSB-II, including the K-CWST: CR. Based on the cognitive test results, activities of daily living, and clinical interview, the patients were assigned to normal cognition (n=104), MCI (n=884), or mild dementia (n=348) groups. Abnormal performance on the K-CWST: CR was operationally defined as 1SD below the normative mean. The receiver operating characteristic curve analyses were conducted to compare the discriminability between the 60- and 120-second conditions.Results: The percentages of abnormal performance in the MCI group were 41.5% and 42.3%, and those in the mild dementia group were 82.7% and 82.4% for the 60- and 120-second conditions, respectively. The areas under the curve for the 60- and 120-seconds were as follows; 0.80 and 0.81 in differentiating normal from MCI; 0.95 and 0.96 in normal from mild dementia; and 0.77 and 0.77 in MCI from mild dementia.Conclusions: The 60-second condition of the K-CWST showed very similar results, not statistically different from the 120-second condition. Therefore, the 60-second condition could be used interchangeably with the 120-second condition in a clinical setting.","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"20 4","pages":"62-69"},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fb/70/dnd-20-62.PMC8585531.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39637467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On the Potential Benefit of Shunt Surgery in Idiopathic Normal-Pressure Hydrocephalus Patients with Alzheimer's Disease Pathology. 关于特发性常压脑积水合并阿尔茨海默病病理的分流手术的潜在益处。

Dementia and neurocognitive disorders Pub Date : 2021-10-01 Epub Date: 2021-09-07 DOI: 10.12779/dnd.2021.20.4.108

Kyunghun Kang, Ki-Su Park, Sang-Woo Lee, Ho-Won Lee, Myong Hun Hahm, Chi-Hun Kim, Uicheul Yoon, Shin Young Jeong

{"title":"On the Potential Benefit of Shunt Surgery in Idiopathic Normal-Pressure Hydrocephalus Patients with Alzheimer's Disease Pathology.","authors":"Kyunghun Kang, Ki-Su Park, Sang-Woo Lee, Ho-Won Lee, Myong Hun Hahm, Chi-Hun Kim, Uicheul Yoon, Shin Young Jeong","doi":"10.12779/dnd.2021.20.4.108","DOIUrl":"https://doi.org/10.12779/dnd.2021.20.4.108","url":null,"abstract":"Many institutions rule out shunt surgery for idiopathic normal-pressure hydrocephalus (INPH) patients with Alzheimer's disease (AD) pathology. However, we believe some INPH patients with AD pathology might benefit from shunt surgery. While some reports suggest AD pathology may not adversely affect improvement after shunt surgery in INPH patients,1 the predominant position today is that AD pathology will adversely affect shunt surgery outcomes.2-4 For example, Hamilton et al.3 reported that INPH patients with moderate to severe AD pathology were associated with worse post-shunt outcomes. And Patel et al.4 reported INPH patients with high phosphorylated tau/amyloid beta 1-42 ratios showed less improvement following shunt surgery. Based on these studies, Jang et al.5 used amyloid positivity on positron emission tomography (PET) to exclude INPH patients for shunt surgery. However, the view that INPH patients with amyloid pathology should not have shunt surgery is likely based on older studies with less reliable methods and shorter follow-ups. We believe further studies are warranted to investigate whether some INPH patients with AD pathology can benefit from shunt surgery.","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"20 4","pages":"108-111"},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/d9/20/dnd-20-108.PMC8585530.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39637941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Measurement of Subjective Cognitive Decline (SCD) Using Korean-Everyday Cognition (K-ECog) as a Screening Tool: a Feasibility Study. 韩国人日常认知(K-ECog)作为筛选工具测量主观认知衰退(SCD)的可行性研究

Dementia and neurocognitive disorders Pub Date : 2021-10-01 Epub Date: 2021-10-29 DOI: 10.12779/dnd.2021.20.4.80

Minji Song, Sun Hwa Lee, Seong Yoon Kim, Yeonwook Kang

{"title":"Measurement of Subjective Cognitive Decline (SCD) Using Korean-Everyday Cognition (K-ECog) as a Screening Tool: a Feasibility Study.","authors":"Minji Song, Sun Hwa Lee, Seong Yoon Kim, Yeonwook Kang","doi":"10.12779/dnd.2021.20.4.80","DOIUrl":"https://doi.org/10.12779/dnd.2021.20.4.80","url":null,"abstract":"Background and purpose: Everyday Cognition (ECog) has been widely used to differentiate individuals with mild cognitive impairment (MCI) and dementia from normal elderly individuals. It has also been used to assess subjective cognitive decline (SCD). This study investigated the feasibility of using ECog as a screening measure for SCD in community-dwelling elderly individuals.Methods: The participants included 84 older adults with and 93 without SCD living in the community. These 2 groups were classified based on their response (\"yes\" or \"no\") to the question \"Do you perceive memory or cognitive difficulties?\" All participants were evaluated using the Korean-Mini Mental State Examination (K-MMSE), Short form of the Geriatric Depression Scale (SGDS), and the Korean version of Everyday Cognition (K-ECog).Results: The scores of all participants were within the normal range on the K-MMSE and SGDS. The total K-MMSE score did not differ significantly between the 2 groups after controlling for age, education, and depression. The scores of SCD group were significantly higher than those of the non-SCD group for memory, language, and executive function: planning domains, as well as K-ECog total score. Receiver operating characteristic curve analysis revealed that the K-ECog total score was effective in moderately differentiating between subjects with and without SCD (area under the curve: 0.73).Conclusions: ECog is a feasible and useful screening measure for SCD in older adults living in the community, and can be used to assess the full spectrum of cognitive and functional deficits, ranging from SCD to MCI and dementia.","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"20 4","pages":"80-88"},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/70/35/dnd-20-80.PMC8585529.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39637469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3