Dementia and neurocognitive disorders最新文献

{"title":"Improving Medication Adherence in Isolated Patients With Cognitive Impairment Using Automated Telephone Reminders.","authors":"Moon Jeong Kim,&nbsp;Jeong Yun Song,&nbsp;Jae-Won Jang,&nbsp;Seo-Young Lee,&nbsp;Jin Hyeong Jhoo,&nbsp;Gi Hwan Byeon,&nbsp;Yeshin Kim","doi":"10.12779/dnd.2022.21.4.117","DOIUrl":"https://doi.org/10.12779/dnd.2022.21.4.117","url":null,"abstract":"<p><strong>Background and purpose: </strong>Medication adherence is essential for effective medical treatment. However, it is challenging for cognitively impaired patients. We investigated whether an automated telephone reminder service improves medication adherence and reduces the decline of cognitive function in isolated patients with cognitive impairment.</p><p><strong>Methods: </strong>This was a single-center, randomized clinical trial. We enrolled mild cognitive impairment (MCI) or Alzheimer's disease (AD) patients who lived alone or with a cognitively impaired spouse. We provided an automated telephone reminder service for taking medication to the intervention group for 6 months. The control group was provided with general guidelines for taking the medication every month. The participants underwent neuropsychological assessment at the beginning and end of the study. Statistical significance was tested using nonparametric Wilcoxon rank sum and Wilcoxon matched-pairs signed-rank tests.</p><p><strong>Results: </strong>Thirty participants were allocated randomly to groups, and data for 29 participants were analyzed. The mean age was 79.6 (standard deviation, 6.0) years and 79.3% of the participants were female. There was no significant difference in medication adherence between the 2 groups. However, a subgroup analysis among participants with more than 70% response rates showed better medication adherence compared to the control group (intervention: 94.6%; control: 90.2%, <i>p</i>=0.0478). There was no significant difference in the change in cognitive function between the 2 groups.</p><p><strong>Conclusions: </strong>If a patient's compliance is good, telephone reminders might be effective in improving medication adherence. It is necessary to develop reminder tools that can improve compliance for cognitively impaired patients.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"21 4","pages":"117-125"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a4/eb/dnd-21-117.PMC9644062.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40698319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroencephalography for Early Detection of Alzheimer's Disease in Subjective Cognitive Decline.","authors":"YongSoo Shim,&nbsp;Dong Won Yang,&nbsp;SeongHee Ho,&nbsp;Yun Jeong Hong,&nbsp;Jee Hyang Jeong,&nbsp;Kee Hyung Park,&nbsp;SangYun Kim,&nbsp;Min Jeong Wang,&nbsp;Seong Hye Choi,&nbsp;Seung Wan Kang","doi":"10.12779/dnd.2022.21.4.126","DOIUrl":"https://doi.org/10.12779/dnd.2022.21.4.126","url":null,"abstract":"<p><strong>Background and purpose: </strong>Early detection of subjective cognitive decline (SCD) due to Alzheimer's disease (AD) is important for clinical research and effective prevention and management. This study examined if quantitative electroencephalography (qEEG) could be used for early detection of AD in SCD.</p><p><strong>Methods: </strong>Participants with SCD from 6 dementia clinics in Korea were enrolled. ¹⁸F-florbetaben brain amyloid positron emission tomography (PET) was conducted for all the participants. qEEG was performed to measure power spectrum and source cortical activity.</p><p><strong>Results: </strong>The present study included 95 participants aged over 65 years, including 26 amyloid PET (+) and 69 amyloid PET (-). In participants with amyloid PET (+), relative power at delta band was higher in frontal (<i>p</i>=0.025), parietal (<i>p</i>=0.005), and occipital (<i>p</i>=0.022) areas even after adjusting for age, sex, and education. Source activities of alpha 1 band were significantly decreased in the bilateral fusiform and inferior temporal areas, whereas those of delta band were increased in the bilateral cuneus, pericalcarine, lingual, lateral occipital, precuneus, posterior cingulate, and isthmus areas. There were increased connections between bilateral precuneus areas but decreased connections between left rostral middle frontal area and bilateral frontal poles at delta band in participants with amyloid PET (+) showed. At alpha 1 band, there were decreased connections between bilateral entorhinal areas after adjusting for covariates.</p><p><strong>Conclusions: </strong>SCD participants with amyloid PET (+) showed increased delta and decreased alpha 1 activity. qEEG is a potential means for predicting amyloid pathology in SCD. Further longitudinal studies are needed to confirm these findings.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"21 4","pages":"126-137"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/95/1d/dnd-21-126.PMC9644061.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40698322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study Design and Baseline Results in a Cohort Study to Identify Predictors for the Clinical Progression to Mild Cognitive Impairment or Dementia From Subjective Cognitive Decline (CoSCo) Study.","authors":"SeongHee Ho,&nbsp;Yun Jeong Hong,&nbsp;Jee Hyang Jeong,&nbsp;Kee Hyung Park,&nbsp;SangYun Kim,&nbsp;Min Jeong Wang,&nbsp;Seong Hye Choi,&nbsp;SeungHyun Han,&nbsp;Dong Won Yang","doi":"10.12779/dnd.2022.21.4.147","DOIUrl":"https://doi.org/10.12779/dnd.2022.21.4.147","url":null,"abstract":"<p><strong>Background and purpose: </strong>Subjective cognitive decline (SCD) refers to the self-perception of cognitive decline with normal performance on objective neuropsychological tests. SCD, which is the first help-seeking stage and the last stage before the clinical disease stage, can be considered to be the most appropriate time for prevention and treatment. This study aimed to compare characteristics between the amyloid positive and amyloid negative groups of SCD patients.</p><p><strong>Methods: </strong>A cohort study to identify predictors for the clinical progression to mild cognitive impairment (MCI) or dementia from subjective cognitive decline (CoSCo) study is a multicenter, prospective observational study conducted in the Republic of Korea. In total, 120 people aged 60 years or above who presented with a complaint of persistent cognitive decline were selected, and various risk factors were measured among these participants. Continuous variables were analyzed using the Wilcoxon rank-sum test, and categorical variables were analyzed using the χ² test or Fisher's exact test. Logistic regression models were used to assess the predictors of amyloid positivity.</p><p><strong>Results: </strong>The multivariate logistic regression model indicated that amyloid positivity on PET was related to a lack of hypertension, atrophy of the left temporal lateral and entorhinal cortex, low body mass index, low waist circumference, less body and visceral fat, fast gait speed, and the presence of the apolipoprotein E ε4 allele in amnestic SCD patients.</p><p><strong>Conclusions: </strong>The CoSCo study is still in progress, and the authors aim to identify the risk factors that are related to the progression of MCI or dementia in amnestic SCD patients through a two-year follow-up longitudinal study.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"21 4","pages":"147-161"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b9/67/dnd-21-147.PMC9644060.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40698320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of East Asian Brain Age using Machine Learning Algorithms Trained With Community-based Healthy Brain MRI.","authors":"Chanda Simfukwe,&nbsp;Young Chul Youn","doi":"10.12779/dnd.2022.21.4.138","DOIUrl":"https://doi.org/10.12779/dnd.2022.21.4.138","url":null,"abstract":"<p><strong>Background and purpose: </strong>Magnetic resonance imaging (MRI) helps with brain development analysis and disease diagnosis. Brain volumes measured from different ages using MRI provides useful information in clinical evaluation and research. Therefore, we trained machine learning models that predict the brain age gap of healthy subjects in the East Asian population using T1 brain MRI volume images.</p><p><strong>Methods: </strong>In total, 154 T1-weighted MRIs of healthy subjects (55-83 years of age) were collected from an East Asian community. The information of age, gender, and education level was collected for each participant. The MRIs of the participants were preprocessed using FreeSurfer(https://surfer.nmr.mgh.harvard.edu/) to collect the brain volume data. We trained the models using different supervised machine learning regression algorithms from the scikit-learn (https://scikit-learn.org/) library.</p><p><strong>Results: </strong>The trained models comprised 19 features that had been reduced from 55 brain volume labels. The algorithm BayesianRidge (BR) achieved a mean absolute error (MAE) and r squared (R²) of 3 and 0.3 years, respectively, in predicting the age of the new subjects compared to other regression methods. The results of feature importance analysis showed that the right pallidum, white matter hypointensities on T1-MRI scans, and left hippocampus comprise some of the essential features in predicting brain age.</p><p><strong>Conclusions: </strong>The MAE and R² accuracies of the BR model predicting brain age gap in the East Asian population showed that the model could reduce the dimensionality of neuroimaging data to provide a meaningful biomarker for individual brain aging.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"21 4","pages":"138-146"},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8f/43/dnd-21-138.PMC9644058.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40698321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of a High-Intensity Interval Physical Exercise Program on Cognition, Physical Performance, and Electroencephalogram Patterns in Korean Elderly People: A Pilot Study.","authors":"Sun Min Lee,&nbsp;Muncheong Choi,&nbsp;Buong-O Chun,&nbsp;Kyunghwa Sun,&nbsp;Ki Sub Kim,&nbsp;Seung Wan Kang,&nbsp;Hong-Sun Song,&nbsp;So Young Moon","doi":"10.12779/dnd.2022.21.3.93","DOIUrl":"https://doi.org/10.12779/dnd.2022.21.3.93","url":null,"abstract":"<p><strong>Background and purpose: </strong>The effects of high-intensity interval training (HIIT) interventions on functional brain changes in older adults remain unclear. This preliminary study aimed to explore the effect of physical exercise intervention (PEI), including HIIT, on cognitive function, physical performance, and electroencephalogram patterns in Korean elderly people.</p><p><strong>Methods: </strong>We enrolled six non-dementia participants aged >65 years from a community health center. PEI was conducted at the community health center for 4 weeks, three times/week, and 50 min/day. PEI, including HIIT, involved aerobic exercise, resistance training (muscle strength), flexibility, and balance. Wilcoxon signed rank test was used for data analysis.</p><p><strong>Results: </strong>After the PEI, there was improvement in the 30-second sit-to-stand test result (16.2±7.0 times vs. 24.8±5.5 times, <i>p</i>=0.027), 2-minute stationary march result (98.3±27.2 times vs. 143.7±36.9 times, <i>p</i>=0.027), T-wall response time (104.2±55.8 seconds vs.71.0±19.4 seconds, <i>p</i>=0.028), memory score (89.6±21.6 vs. 111.0±19.1, <i>p</i>=0.028), executive function score (33.3±5.3 vs. 37.0±5.1, <i>p</i>=0.046), and total Literacy Independent Cognitive Assessment score (214.6±30.6 vs. 241.6±22.8, <i>p</i>=0.028). Electroencephalography demonstrated that the beta power in the frontal region was increased, while the theta power in the temporal region was decreased (all <i>p</i><0.05).</p><p><strong>Conclusions: </strong>Our HIIT PEI program effectively improved cognitive function, physical fitness, and electroencephalographic markers in elderly individuals; thus, it could be beneficial for improving functional brain activity in this population.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"21 3","pages":"93-102"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/70/2a/dnd-21-93.PMC9340247.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40616562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transient Epileptic Amnesia With Amygdala Enlargement Presenting to a Dementia Clinic.","authors":"Yebin Ahn,&nbsp;Keun Lee,&nbsp;Eun Bin Park,&nbsp;Sun Min Lee,&nbsp;So Young Moon","doi":"10.12779/dnd.2022.21.3.103","DOIUrl":"https://doi.org/10.12779/dnd.2022.21.3.103","url":null,"abstract":"Transient epileptic amnesia (TEA) is a distinct syndrome of late-onset limbic epilepsy of unknown cause, typically occurring in old age. It is an important cause of memory loss in older people because it could be treatable. However, it is often mistaken for neurodegenerative disease, transient global amnesia (TGA), cerebrovascular disease, and functional amnesia because amnesia is the only manifestation in some patients, unaccompanied by symptoms such as olfactory hallucination, motor automatisms, or brief unresponsiveness.1 In some patients with TEA, suspected causative abnormalities are detected by magnetic resonance imaging (MRI). These most commonly involve the mesial temporal lobes,2 which might provide some hints to clinicians in dementia clinics for diagnosing TEA. Here, we report the case of a patient with TEA accompanied by amygdala enlargement who presented to a dementia clinic.","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"21 3","pages":"103-106"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/4b/0e/dnd-21-103.PMC9340246.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40616563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Telomere Length Shortening a Risk Factor for Neurodegenerative Disorders?","authors":"Hyun-Jung Yu,&nbsp;Seong-Ho Koh","doi":"10.12779/dnd.2022.21.3.83","DOIUrl":"https://doi.org/10.12779/dnd.2022.21.3.83","url":null,"abstract":"<p><p>Telomeres are located at the end of chromosomes. They are known to protect chromosomes and prevent cellular senescence. Telomere length shortening has been considered an important marker of aging. Many studies have reported this concept in connection with neurodegenerative disorders. Considering the role of telomeres, it seems that longer telomeres are beneficial while shorter telomeres are detrimental in preventing neurodegenerative disorders. However, several studies have shown that people with longer telomeres might also be vulnerable to neurodegenerative disorders. Before these conflicting results can be explained through large-scale longitudinal clinical studies on the role of telomere length in neurodegenerative disorders, it would be beneficial to simultaneously review these opposing results. Understanding these conflicting results might help us plan future studies to reveal the role of telomere length in neurodegenerative disorders. In this review, these contradictory findings are thoroughly discussed, with the aim to better understand the role of telomere length in neurodegenerative disorders.</p>","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"21 3","pages":"83-92"},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3f/0e/dnd-21-83.PMC9340245.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40696990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapidly Progressive Behavioral Syndrome Without Spastic Paraplegia in a Patient With SPAST p.Pro26Thr Variant","authors":"F. Arshad, S. Alladi, Karthik Kulanthaivelu","doi":"10.12779/dnd.2022.21.2.79","DOIUrl":"https://doi.org/10.12779/dnd.2022.21.2.79","url":null,"abstract":"pulse=74/min). Neurological examination revealed echolalia, utilization behavior, prominent frontal release signs (bilateral palmo-mental reflex, glabellar tap, and snout reflex), inattention, executive","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"256 1","pages":"79 - 82"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73129977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translocator Protein (18 kDa) Polymorphism (rs6971) in the Korean Population","authors":"Hyon Lee, Y. Noh, Woo-Ram Kim, Ha-Eun Seo, Hyeon-Mi Park","doi":"10.12779/dnd.2022.21.2.71","DOIUrl":"https://doi.org/10.12779/dnd.2022.21.2.71","url":null,"abstract":"Background and Purpose The expression of the 18-kDA mitochondrial translocator protein (TSPO) in the brain is an attractive target to study neuroinflammation. However, the binding properties of TSPO ligands are reportedly dependent on genetic polymorphism of the TSPO gene (rs6971). The objective of this study is to investigate the rs6971 gene polymorphism in the Korean population. Methods We performed genetic testing on 109 subjects including patients with mild cognitive impairment, Alzheimer’s disease (AD) dementia, non-AD dementia, and cognitively unimpaired participants. Magnetic resonance imaging scans and detailed neuropsychological tests were also performed, and 29 participants underwent 18F-DPA714 PET scans. Exon 4 of the TSPO gene containing the polymorphism rs6971 (Ala or Thr at position 147) was polymerase chain reaction amplified and sequenced using the Sanger method. The identified rs6971 genotype codes (C/C, C/T, or T/T) of the TSPO protein generated high-, mixed-, or low-affinity binding phenotypes (HABs, MABs, and LABs), respectively. Results We found that 96.3% of the study subjects were HAB (105 out of 109 subjects), and 3.7% of the subjects were MAB (4 out of 109 subjects). 18F-DPA-714 PET scans showed nonspecific binding to the thalamus and brainstem, and increased tracer uptake throughout the cortex in cognitively impaired patients. The participant with the MAB polymorphism had a higher DPA714 signal throughout the cortex. Conclusions The majority of Koreans are HAB (aprox. 96%). Therefore, the polymorphism of the rs6971 gene would have a smaller impact on the availability of second-generation TSPO PET tracers.","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"97 1","pages":"71 - 78"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78228238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Executive Summary of the 2021 International Conference of Korean Dementia Association: A Report From the Academic Committee of the Korean Dementia Association","authors":"K. Park, Jae-Won Jang, Jeewon Suh, SangHak Yi, J. Bae, Jae-Sung Lim, Hyon Lee, J. Chin, Young Ho Park, Y. Hong, G. Kim","doi":"10.12779/dnd.2022.21.2.45","DOIUrl":"https://doi.org/10.12779/dnd.2022.21.2.45","url":null,"abstract":"Recently, aducanumab, a beta amyloid targeted immunotherapy, has been approved by the US Food and Drug Administration for the treatment of Alzheimer’s dementia (AD). Although many questions need to be answered, this approval provides a promising hope for the development of AD drugs that could be supported by new biomarkers such as blood-based ones and composite neuropsychological tests that can confirm pathologic changes in early stages of AD. It is important to elucidate the complexity of AD which is known to be associated with other factors such as vascular etiologies and neuro-inflammation. Through the second international conference of the Korean Dementia Association (KDA), researchers from all over the world have participated in the exchange of opinions with KDA members on the most up-to-date topics. The Academic Committee of the KDA summarizes lectures to provide the depth of the conference as well as discussions. This will be an important milestone to widen the latest knowledge in the research of AD’s diagnosis, therapeutics, pathogenesis that can lead to the establishment of future directions.","PeriodicalId":72779,"journal":{"name":"Dementia and neurocognitive disorders","volume":"28 1","pages":"45 - 58"},"PeriodicalIF":0.0,"publicationDate":"2022-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80697000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}