Comparative biochemistry and physiology. C: Comparative pharmacology最新文献_第4页

Erythrocyte membrane structural features that are critical for the lytic reaction of Spirographis spallanzani coelomic fluid hemolysin 对spallanzanspiro蝇体腔液体溶血素的溶解反应至关重要的红细胞膜结构特征

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-07-01 Epub Date: 2004-05-18 DOI: 10.1016/0742-8413(93)90078-Y

Calogero Canicatti , Philippe Roch

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引用次数: 3

Neurogenic inflammation in the chicken (Gallus gallus var domesticus) 鸡(Gallus Gallus var domesticus)的神经源性炎症

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-07-01 Epub Date: 2004-05-18 DOI: 10.1016/0742-8413(93)90086-Z

M.J. Gentle, L.N. Hunter

引用次数: 23

Toxic effects of mercury on the hard clam, Meretrix lusoria, in various salinities 汞在不同盐度下对硬蛤的毒性作用

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-07-01 Epub Date: 2004-05-18 DOI: 10.1016/0742-8413(93)90092-Y

Tzong-Shean Chin, Hon-Cheng Chen

{"title":"Toxic effects of mercury on the hard clam, Meretrix lusoria, in various salinities","authors":"Tzong-Shean Chin, Hon-Cheng Chen","doi":"10.1016/0742-8413(93)90092-Y","DOIUrl":"10.1016/0742-8413(93)90092-Y","url":null,"abstract":"<div>1. The 96-hr lc50 values for juvenile hard clams, Meretrix lusoria, were 328, 392 and 194 μg/l Hg in 10, 20 and 30 ppt salinities at 25 ± 1°C, respectively; for adult hard clams 341 and 140 μg/l Hg in 20 and 30 ppt salinities, respectively.2. Acclimatizing the adult clams to low salinity of 10 ppt lessened the toxicity of mercury. However, juvenile animals appeared to be more sensitive to mercury poisoning after 96 hr exposure in 10 ppt salinity.3. All embryos exposed to 40 μg/l Hg and above died within 30 hr. In the control, 44% of hatched embryos had developed into D-stage larvae, while those exposed to 20 μg/l Hg were still in the trochophore stage. Most of the retarded larvae developed into abnormal forms within 30 hr at 28°C in 15 ppt salinity.4. In order to maintain water quality and protect natural resources, the recommended safe level of mercury is 0.046 (0.039–0.053) μg/l Hg, based on the estimated 30-hr EC50 for the clam embryos, with an application factor of 0.01.</div>","PeriodicalId":72650,"journal":{"name":"Comparative biochemistry and physiology. C: Comparative pharmacology","volume":"105 3","pages":"Pages 501-507"},"PeriodicalIF":0.0,"publicationDate":"1993-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0742-8413(93)90092-Y","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54006522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

Role of GABA in hypoxia tolerance, metabolic depression and hibernation—Possible links to neurotransmitter evolution GABA在缺氧耐受、代谢抑制和冬眠中的作用——可能与神经递质进化有关

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-07-01 Epub Date: 2004-05-18 DOI: 10.1016/0742-8413(93)90069-W

G.E. Nilsson , P.L. Lutz

引用次数: 62

Cellular damage in the rat heart caused by caffeine or dinitrophenol 咖啡因或二硝基酚引起的大鼠心脏细胞损伤

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-06-01 Epub Date: 2004-05-18 DOI: 10.1016/0742-8413(93)90199-U

Stephanie Daniels, C.J. Duncan

引用次数: 11

Toxicity of tetrachlorwinfos to Rana temporaria l. 四氯窗氟醚对天蚕的毒性研究。

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-06-01 Epub Date: 2004-05-18 DOI: 10.1016/0742-8413(93)90209-4

K. Gromysz-Kałkowska, E. Szubartowska

引用次数: 9

Presynaptic block of transmission in the insect CNS by mono- and di-galactosyl analogues of vespulakinin 1, a wasp (Paravespula maculifrons) venom neurotoxin 黄蜂毒液神经毒素vespulakinin 1的单半乳糖和双半乳糖类似物在昆虫中枢神经系统中的突触前传导阻滞

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-06-01 Epub Date: 2004-05-18 DOI: 10.1016/0742-8413(93)90193-O

T. Piek , B. Hue , H. Le Corronc , P. Mantel , M. Gobbo , R. Rocchi

{"title":"Presynaptic block of transmission in the insect CNS by mono- and di-galactosyl analogues of vespulakinin 1, a wasp (Paravespula maculifrons) venom neurotoxin","authors":"T. Piek , B. Hue , H. Le Corronc , P. Mantel , M. Gobbo , R. Rocchi","doi":"10.1016/0742-8413(93)90193-O","DOIUrl":"10.1016/0742-8413(93)90193-O","url":null,"abstract":"<div>1. The pharmacological properties of four synthetic analogues of the wasp neurotoxin, Vespulakinin 1, were studied using a cascade of mammalian smooth muscle preparations and the synaptic transmission from the cockroach cereal nerves to a giant interneuron.2. All analogues have an extremely slow bradykinin-like effect on the smooth muscles. The carbohydrate-free and the two mono-glycosylated analogues are about equally active with bradykinin.3. The double glycosylated derivative is about 5 times more potent than bradykinin.4. All analogues have two different effects on synaptic transmission in the insect CNS—at first a direct and reversible block of excitatory nicotinic transmission with a concurrent activation of the inhibitory GABA-ergic system and, secondly, a delayed irreversible block of the transmission, comparable to the block described earlier for bradykinin and Thr6-bradykinin.5. For the synaptic transmission in the insect CNS the double glycosylated kinin is about 5 times more potent than bradykinin.</div>","PeriodicalId":72650,"journal":{"name":"Comparative biochemistry and physiology. C: Comparative pharmacology","volume":"105 2","pages":"Pages 189-196"},"PeriodicalIF":0.0,"publicationDate":"1993-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0742-8413(93)90193-O","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19096863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 15

The action of four proposed chloride movement modifiers on acetylcholine responses of central neurones of Helix aspersa 四种氯离子运动调节剂对螺旋树中枢神经元乙酰胆碱反应的影响

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-06-01 Epub Date: 2004-05-18 DOI: 10.1016/0742-8413(93)90213-5

N.J.D. Wright , R.J. Walker

{"title":"The action of four proposed chloride movement modifiers on acetylcholine responses of central neurones of Helix aspersa","authors":"N.J.D. Wright , R.J. Walker","doi":"10.1016/0742-8413(93)90213-5","DOIUrl":"https://doi.org/10.1016/0742-8413(93)90213-5","url":null,"abstract":"<div>1. Intracellular recordings were made from identified neurones in the visceral, (abdominal) ganglion of the snail, Helix aspersa. The hyperpolarising response of neurone E4 is a pure chloride event and has a reversal potential, (ECl), of −69.7 ± 1.7mV, (n = 4). This can be compared to depolarising responses of neurones E1 and E2 which are sodium mediated.2. Four membrane transport system antagonists, all thought to affect trans-membrane chloride movement, were investigated with respect to the two different acetylcholine responses described.3. Piretanide irreversibly blocks the hyperpolarising response in cell E4, (1–10 μM), increasing its inhibition with time but without changing ECl.4. Furosemide irreversibly blocks both types of acetylcholine responses at concentrations in the nanomolar range; no change in ECl or ENa was associated with the inhibition but the “passive” membrane resistance appeared to decrease. Inhibition increased with time, normally causing a significant effect after 10–30 min.5. S.I.T.S. and ethacrynic acid appear very similar in effect; both reversibly block the two responses to acetylcholine and recovery after washing is virtually complete. The onset of antagonism is rapid and both compounds are slightly more effective against the hyperpolarising (“H”), response than the depolarising (“D”) response (threshold ∼10−5 M compared to ∼ 10−4 M). No change in ECl or ENa was noted.6. Piretanide and furosemide probably exert their effect by interactions with the neuronal cell membrane, disrupting the integrity of this structure, whereas S.I.T.S. and ethacrynic acid may interact more specifically with the acetylcholine receptor protein.</div>","PeriodicalId":72650,"journal":{"name":"Comparative biochemistry and physiology. C: Comparative pharmacology","volume":"105 2","pages":"Pages 311-322"},"PeriodicalIF":0.0,"publicationDate":"1993-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0742-8413(93)90213-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136596942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Cadmium induced metallothionein in hepatopancreas of Procambarus clarkii: Quantification by a silver-saturation method 克氏原螯虾肝胰脏中镉诱导的金属硫蛋白:用饱和银法定量

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-06-01 Epub Date: 2004-05-18 DOI: 10.1016/0742-8413(93)90205-Y

Manuela Martínez , Amparo Torreblanca , Jose Del Ramo , Agustín Pastor , Javier Díaz-Mayans

引用次数: 34

Arachidonic acid, protein kinase C activators and bud formation in Hydra vulgaris 花生四烯酸、蛋白激酶C激活剂与水螅芽形成

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-06-01 Epub Date: 2004-05-18 DOI: 10.1016/0742-8413(93)90198-T

Luciano De Petrocellis , Vincenzo Di Marzo , Carmen Gianfrani , Rosario Minei

引用次数: 11