Toxicity of tetrachlorwinfos to Rana temporaria l.

Comparative biochemistry and physiology. C: Comparative pharmacology Pub Date : 1993-06-01 DOI:10.1016/0742-8413(93)90209-4

K. Gromysz-Kałkowska, E. Szubartowska

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引用次数: 9

Abstract

1. Changes in the erythrocyte system of frogs poisoned with tetrachlorwinfos depend on the sex of the animals and the dose of pesticide applied. They are a result of the pathomorphological changes due to translocation of fluids from the tissues to the circulation and swelling of the blood cells.

2. Changes in the leucocyte system of frogs are caused by several mechanisms: lytic action of the pesticide on the blood cell membrane, the stressogenic effect of the agent and enhanced activity of the reticuloendothelial system.

3. The appearance of typical changes due to stress, after even the lowest dose of tetrachlorwinfos, and low ld₅₀ values indicate that this pesticide is highly toxic for frogs.

4. The relatively high susceptibility of frogs to intoxication with tetrachlorwinfos is probably the result of a high affinity of cholinesterase to this pesticide, because of the presence of the P=O bond in its molecule.

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四氯窗氟醚对天蚕的毒性研究。

1. 四氯winfos中毒的青蛙红细胞系统的变化取决于动物的性别和施用的农药剂量。它们是由于体液从组织转移到血液循环和血细胞肿胀而引起的病理形态学变化的结果。青蛙白细胞系统的变化是由几种机制引起的:农药对血细胞膜的溶解作用、药剂的应激作用和网状内皮系统活性的增强。即使在最低剂量的四氯氟后，由于应激而出现的典型变化，以及低ld50值表明这种杀虫剂对青蛙是剧毒的。青蛙对四氯winfos中毒的相对高易感性可能是由于胆碱酯酶对该农药的高亲和力，因为其分子中存在P=O键。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Comparative biochemistry and physiology. C: Comparative pharmacology

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