Clinical nutrition research最新文献_第8页

The Association Between Dietary Diversity Score and Cardiovascular Risk Factors Among Patients With Pemphigus Vulgaris: A Cross Sectional Study. 寻常型天疱疮患者饮食多样性评分与心血管危险因素的相关性:一项横断面研究

Clinical nutrition research Pub Date : 2022-10-24 eCollection Date: 2022-10-01 DOI: 10.7762/cnr.2022.11.4.289

Atefeh Seifollahi, Mahboubeh Rezaei Fazl, Leila Setayesh, Mohammad Hassan Javanbakht, Maryam Daneshpazhooh, Sakineh Shab-Bidar, Mehdi Yaseri

{"title":"The Association Between Dietary Diversity Score and Cardiovascular Risk Factors Among Patients With Pemphigus Vulgaris: A Cross Sectional Study.","authors":"Atefeh Seifollahi, Mahboubeh Rezaei Fazl, Leila Setayesh, Mohammad Hassan Javanbakht, Maryam Daneshpazhooh, Sakineh Shab-Bidar, Mehdi Yaseri","doi":"10.7762/cnr.2022.11.4.289","DOIUrl":"https://doi.org/10.7762/cnr.2022.11.4.289","url":null,"abstract":"This study was conducted to evaluate the associations between dietary diversity score (DDS) and cardiovascular risk factors in this population. In this cross-sectional study, 187 patients, aged 18-65 years with pemphigus vulgaris were included. DDS was assessed by a 24-hour dietary recall method. Anthropometric measures and biochemical parameters assessed according to standard protocols. Multivariate linear regression analyses used for detecting any associations between DDS and cardiovascular risk factors. The mean ± standard deviation age and body mass index of studied participants were (46.71 ± 11.49 years) and (27.83 ± 4.39 kg/m2) respectively. Our findings showed that a higher DDS intake was related with higher consumption of vegetables (p = 0.001), dairy products (p < 0.001), cereals (p = 0.002), red and processed meat (p < 0.001), sweets and desserts (p < 0.001). After controlling for confounding variables, the results showed positive associations between DDS and high-density lipoprotein cholesterol (HDL-C, β = 1.87, 95% confidence interval [CI], 0.30-3.45, p = 0.02) and total cholesterol (TC) levels (β = 6.41, 95% CI, 1.62-11.03, p = 0.02) (β = 1.75, 95% CI, 0.20-3.30, p = 0.02). However, there were no associations between DDS and prevalence of obesity and glucose homeostasis. The results of this cross-sectional study showed that DDS might be associated with increased HDL-C and TC. However, further prospective studies are needed to prove these findings.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"11 4","pages":"289-301"},"PeriodicalIF":0.0,"publicationDate":"2022-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/58/21/cnr-11-289.PMC9633973.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40687679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pre-treatment Nutritional Risk Assessment by NRS-2002 Predicts Prognosis in Patients With Advanced Biliary Tract Cancer: A Single Center Retrospective Study. NRS-2002治疗前营养风险评估预测晚期胆道癌患者预后:一项单中心回顾性研究

Clinical nutrition research Pub Date : 2022-07-28 eCollection Date: 2022-07-01 DOI: 10.7762/cnr.2022.11.3.183

Se Eung Oh, Juong Soon Park, Hei-Cheul Jeung

{"title":"Pre-treatment Nutritional Risk Assessment by NRS-2002 Predicts Prognosis in Patients With Advanced Biliary Tract Cancer: A Single Center Retrospective Study.","authors":"Se Eung Oh, Juong Soon Park, Hei-Cheul Jeung","doi":"10.7762/cnr.2022.11.3.183","DOIUrl":"https://doi.org/10.7762/cnr.2022.11.3.183","url":null,"abstract":"We investigated the predictors of survival in patients with advanced BTC according to their baseline nutritional status estimated by the Nutritional Risk Screening (NRS)-2002. From September 2006 to July 2017, we reviewed the data of 601 inpatients with BTC. Data on demographic and clinical parameters was collected from electronic medical records, and overall survival (OS) and progression-free survival were analyzed using the Kaplan-Meier method and the stepwise Cox regression analysis. Patients with an NRS-2002 score of ≤ 2, 3, and ≥ 4 were respectively classified as \"no risk,\" \"moderate risk,\" \"high risk.\" Following initial NRS-2002 score, 333 patients (55%) were classified as \"no-risk,\" 109 patients (18%) as \"moderate-risk,\" and 159 patients (27%) as \"high-risk.\" Survival analysis demonstrated significant differences in the median OS: \"no-risk\": 12.6 months (95% confidence interval [CI], 11.5-13.7); \"moderate-risk\": 6.1 months (95% CI, 4.3-8.0); and \"high-risk\": 3.9 months (95% CI, 3.2-4.6) (p < 0.001). NRS-2002 score was an independent factor for OS (hazard ratio [HR], 1.616 for \"moderate-risk\", 95% CI, 1.288-2.027, p < 0.001; HR, 2.121 for \"high-risk\", 95% CI, 1.722-2.612, p < 0.001), along with liver metastasis, peritoneal seeding, white blood cell count, platelet count, neutrophil-to-lymphocyte ratio, cholesterol, carcinoembryonic antigen, and carbohydrate antigen 19-9. In conclusion, baseline NRS-2002 is an appropriate method for discriminating those who are already malnourished and who have poor prognosis in advanced BTC patient. Significance of these results merit further validation to be integrated in the routine practice to improve quality of care in BTC patients.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"11 3","pages":"183-193"},"PeriodicalIF":0.0,"publicationDate":"2022-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b9/e7/cnr-11-183.PMC9348911.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40616573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Anti-hypertensive Effects of Artichoke Supplementation in Adults: A Systematic Review and Dose-response Meta-analysis of Randomized Controlled Trials. 成人补充洋蓟的降压作用:随机对照试验的系统评价和剂量反应荟萃分析。

Clinical nutrition research Pub Date : 2022-07-26 eCollection Date: 2022-07-01 DOI: 10.7762/cnr.2022.11.3.214

Mohammad Reza Amini, Fatemeh Sheikhhossein, Mohsen Alvani, Seyyed Morteza Seyyed Shoura, Asma Sohrabnavi, Ehsan Heidarian, Azita Hekmatdoost

{"title":"Anti-hypertensive Effects of Artichoke Supplementation in Adults: A Systematic Review and Dose-response Meta-analysis of Randomized Controlled Trials.","authors":"Mohammad Reza Amini, Fatemeh Sheikhhossein, Mohsen Alvani, Seyyed Morteza Seyyed Shoura, Asma Sohrabnavi, Ehsan Heidarian, Azita Hekmatdoost","doi":"10.7762/cnr.2022.11.3.214","DOIUrl":"https://doi.org/10.7762/cnr.2022.11.3.214","url":null,"abstract":"Despite controversies, no earlier study has systematically summarized findings from earlier studies on the effect of artichoke supplementation on blood pressure. Therefore, current systematic review and meta-analysis was done on the effect of artichoke supplementation on systolic blood pressure (SBP) and diastolic blood pressure (DBP) in adults. Five databases were searched from inception to January 2022 using relevant keywords. All randomized clinical trials investigating the impact of oral artichoke supplementation on any of the blood pressure parameters including SBP or/and DBP were included. Out of 1,507 citations, 7 trials that enrolled 472 subjects were included. Artichoke supplementation resulted in significant reduction in SBP (weighted mean difference [WMD], -2.01 mmHg; 95% confidence interval [CI], -3.78, -0.24; p = 0.026) and DBP (WMD, -1.45 mmHg; 95% CI, -2.81, -0.08; p = 0.038). Greater effects on SBP were detected in trials using ≤ 500 mg artichoke, lasted > 8 weeks, participants aged < 50 years' old and sample size ≤ 70. There was also a similar impact of artichoke on DBP. However, significant non-linear associations were found between artichoke supplementation dosage and study duration with both SBP (for dosage: pnon-linearity = 0.002, for duration: pnon-linearity = 0.016) and DBP (for dosage: pnon-linearity = 0.005, for duration: pnon-linearity = 0.003). We found a significant reduction in both SBP and DBP following artichoke supplementation in adults. It could be proposed as a hypotensive supplement in hypertension management.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"11 3","pages":"214-227"},"PeriodicalIF":0.0,"publicationDate":"2022-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/13/5c/cnr-11-214.PMC9348915.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40616574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutritional Intervention for a Critically Ill Trauma Patient: A Case Report. 创伤重症患者的营养干预1例。

Clinical nutrition research Pub Date : 2022-07-25 eCollection Date: 2022-07-01 DOI: 10.7762/cnr.2022.11.3.153

Seong Hyeon Kim, Sun Jung Kim, Woojeong Kim

{"title":"Nutritional Intervention for a Critically Ill Trauma Patient: A Case Report.","authors":"Seong Hyeon Kim, Sun Jung Kim, Woojeong Kim","doi":"10.7762/cnr.2022.11.3.153","DOIUrl":"https://doi.org/10.7762/cnr.2022.11.3.153","url":null,"abstract":"Critically ill trauma patients generally show good nutritional status upon initial hospitalization. However, they have a high risk of malnutrition due to hyper-metabolism during the acute phase. Hence, suitable nutritional support is essential for the optimal recovery of these patients; therefore, outcomes such as preservation of fat-free mass, maintenance of immune functions, reduction in infectious complications, and prevention of malnutrition can be expected. In this report, we present the experience of a patient subjected to 40 days of nutritional interventions during postoperative intensive care unit (ICU) care. Although the patient was no malnutrition at ICU admission, enteral nutrition (EN) was delayed for > 2 weeks because of several postoperative complications. Subsequently, while receiving parenteral nutrition (PN), the patient displayed persistent hypertriglyceridemia. As a result, his prescription of PN were converted to lipid-free PN. On postoperative day (POD) #19, the patient underwent jejunostomy and started standard EN. A week later, the patient was switched to a high-protein, immune-modulating formula for postoperative wound recovery. Thereafter, PN was stopped, while EN was increased. In addition, because of defecation issues, a fiber-containing formula was administered with previous formula alternately. Despite continuous nutritional intervention, the patient experienced a significant weight loss and muscle mass depletion and was diagnosed with severe malnutrition upon discharge from the ICU. To conclude, this case report highlights the importance of nutrition interventions in critically ill trauma patients with an increased risk of malnutrition, indicating the need to promptly secure an appropriate route of feeding access for active nutritional support of patients in the ICU.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"11 3","pages":"153-158"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/be/32/cnr-11-153.PMC9348913.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40697006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Evaluation of Serum Omentin-1, Vaspin, Leptin, Adiponectin Levels in Obese/Overweight Children and Their Relationship With Non-Alcoholic Fatty Liver Disease. 肥胖/超重儿童血清Omentin-1、Vaspin、Leptin、脂联素水平的评价及其与非酒精性脂肪肝的关系

Clinical nutrition research Pub Date : 2022-07-25 eCollection Date: 2022-07-01 DOI: 10.7762/cnr.2022.11.3.194

Esra Akyüz Özkan, Allahverdi Sadigov, Osman Öztürk

{"title":"Evaluation of Serum Omentin-1, Vaspin, Leptin, Adiponectin Levels in Obese/Overweight Children and Their Relationship With Non-Alcoholic Fatty Liver Disease.","authors":"Esra Akyüz Özkan, Allahverdi Sadigov, Osman Öztürk","doi":"10.7762/cnr.2022.11.3.194","DOIUrl":"https://doi.org/10.7762/cnr.2022.11.3.194","url":null,"abstract":"To investigate adipokines (vaspin, omentin-1, adiponectin and leptin) and their correlation with hepatosteatosis degree in obese/overweight (O/O) children. We analyzed adipokine levels of 81 children (49 O/O, [body mass index (BMI) > 95th] and 32 non-obese (BMI = 5-85th) admitted to the pediatric outpatient clinic. Serum triglyceride, glucose, low density lipoprotein-cholesterol, total cholesterol, high density lipoprotein-cholesterol, alanine aminotransferase, aspartate aminotransferase (AST), insulin, HbA1c levels and leptin, omentin-1, vaspin, adiponectin levels were studied. O/O children with hepatosteatosis were divided into grades 1, 2 and 3 according to the degree of hepatosteatosis determined by ultrasonography. While AST (p = 0.001), triglyceride (p = 0.006), BMI percentile (p = 0.000), HOMA index (p = 0.002), systolic blood pressure (p = 0.02), leptin (p = 0.001), omentin-1 (p = 0.001), adiponectin (p = 0.001) levels were higher, vaspin level was lower (p = 0.008) in the (O/O) group compared to the controls. There was a positive correlation between HDL and vaspin, and a negative correlation between HDL and omentin-1 in the O/O group. Also it was observed that as the degree of hepatosteotosis increased, leptin (p = 0.004), omentin-1 (p = 0.001) levels were increased. There was no significant change in vaspin level (p = 0.128). The high levels of omentin-1, leptin and adiponectin have an association with the development of hepatosteatosis in O/O children.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"11 3","pages":"194-203"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ce/c3/cnr-11-194.PMC9348910.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40616577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Positive Association Between Nutrient Adequacy and Waist Circumference: Results of a Cross-Sectional Study. 营养充足与腰围正相关:一项横断面研究的结果。

Clinical nutrition research Pub Date : 2022-07-25 eCollection Date: 2022-07-01 DOI: 10.7762/cnr.2022.11.3.204

Aliyu T Jibril, Parivash Ghorbaninejad, Fatemeh Sheikhhossein, Sakineh Shab-Bidar

{"title":"Positive Association Between Nutrient Adequacy and Waist Circumference: Results of a Cross-Sectional Study.","authors":"Aliyu T Jibril, Parivash Ghorbaninejad, Fatemeh Sheikhhossein, Sakineh Shab-Bidar","doi":"10.7762/cnr.2022.11.3.204","DOIUrl":"https://doi.org/10.7762/cnr.2022.11.3.204","url":null,"abstract":"Metabolic syndrome (MetS) is a multifactorial disease with its exact causes not completely clear. Micronutrients such as vitamin A, vitamin D, zinc, and magnesium have been associated with MetS components. Our objective was to investigate the association of nutrient adequacy (NA) with MetS components. The present cross-sectional study consisted of 850 adults between 18-59 years from Tehran, Iran. Dietary intake, socio-demographic data, medical history, and anthropometric indices were collected by trained personnel. NA was calculated as the mean intake ratio to the recommended amount of 16 micronutrients. MetS were defined by the consensus of National Cholesterol Education Program-Adult Treatment Panel III criteria. The association between NA and MetS was examined using linear regression analyses after controlling potential confounders. More participants in the highest quartile were obese in terms of general obesity (p = 0004) and abdominal obesity (p = 0.003) compared with subjects in the least quartile. A significant positive correlation was found between waist circumference (WC) and NA even after controlling for all potential confounders (p < 0.001). NA was positively associated with WC among adults living in Tehran.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"11 3","pages":"204-213"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/76/29/cnr-11-204.PMC9348912.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40617022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Nutrition Education Using MyPlate on Lipid Profiles, Glycemic Indices, and Inflammatory Markers in Diabetic Patients. 利用我的餐盘进行营养教育对糖尿病患者血脂、血糖指数和炎症标志物的影响

Clinical nutrition research Pub Date : 2022-07-25 eCollection Date: 2022-07-01 DOI: 10.7762/cnr.2022.11.3.171

Mehrnoosh Zakerkish, Shima Shahmoradi, Fatemeh Haidari, Seyed Mahmoud Latifi, Majid Mohammadshahi

{"title":"The Effect of Nutrition Education Using MyPlate on Lipid Profiles, Glycemic Indices, and Inflammatory Markers in Diabetic Patients.","authors":"Mehrnoosh Zakerkish, Shima Shahmoradi, Fatemeh Haidari, Seyed Mahmoud Latifi, Majid Mohammadshahi","doi":"10.7762/cnr.2022.11.3.171","DOIUrl":"https://doi.org/10.7762/cnr.2022.11.3.171","url":null,"abstract":"As a result of a nutrition transition, chronic diseases, including diabetes, have increased in Iran. Nutrition education is a cost-effective method for modifying diet and controlling diabetes. This study aimed to examine the effect of nutrition education using MyPlate recommendations on glycemic and lipid profiles and inflammatory markers in Iranian adults diagnosed with type 2 diabetes. A 12-week randomized clinical trial was conducted on 44 adults aged 30-50 years from Ahvaz, Iran. The participants were divided into education and control groups. The education participants were taught the MyPlate recommendations. Serum levels of fasting blood sugar (FBS), hemoglobin A1c (HbA1c), lipid profiles, and inflammatory markers, including high sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α, and adiponectin, were measured at the baseline and the end of the study. The results showed that serum levels of FBS (p = 0.014) and HbA1c (p < 0.001) decreased significantly in the education group at the end of the study. The serum level of low-density lipoprotein in the education group declined significantly at the end of the study (p = 0.043). Furthermore, the serum level of hs-CRP (p = 0.005) declined significantly while the level of adiponectin (p = 0.035) increased in the education group at the end of the study. The evidence of this study showed that nutrition education using MyPlate recommendations is an effective method for controlling diabetes complications. A longitudinal analysis with a larger sample size is recommended to confirm the evidence of this study.Trial registration: Iranian Registry of Clinical Trials Identifier: IRCT2015031921443N2.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"11 3","pages":"171-182"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f7/30/cnr-11-171.PMC9348908.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40616575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Cerebral Cortex Transcriptome Profiles in Ischemic Stroke and Alzheimer's Disease Models. 缺血性卒中和阿尔茨海默病模型中大脑皮层转录组谱的比较

Clinical nutrition research Pub Date : 2022-07-25 eCollection Date: 2022-07-01 DOI: 10.7762/cnr.2022.11.3.159

Juhyun Song

{"title":"Comparison of Cerebral Cortex Transcriptome Profiles in Ischemic Stroke and Alzheimer's Disease Models.","authors":"Juhyun Song","doi":"10.7762/cnr.2022.11.3.159","DOIUrl":"https://doi.org/10.7762/cnr.2022.11.3.159","url":null,"abstract":"Ischemic stroke and Alzheimer's disease (AD) are representative geriatric diseases with a rapidly increasing prevalence worldwide. Recent studies have reported an association between ischemic stroke neuropathology and AD neuropathology. Ischemic stroke shares some similar characteristics with AD, such as glia activation-induced neuroinflammation, amyloid beta accumulation, and neuronal cell loss, as well as some common risk factors with AD progression. Although there are considerable similarities in neuropathology between ischemic stroke and AD, no studies have ever compared specific genetic changes of brain cortex between ischemic stroke and AD. Therefore, in this study, I compared the cerebral cortex transcriptome profile of 5xFAD mice, an AD mouse model, with those of middle cerebral artery occlusion (MCAO) mice, an ischemic stroke mouse model. The data showed that the expression of many genes with important functional implications in MCAO mouse brain cortex were related to synaptic dysfunction and neuronal cell death in 5xFAD mouse model. In addition, changes in various protein-coding RNAs involved in synaptic plasticity, amyloid beta accumulation, neurogenesis, neuronal differentiation, glial activation, inflammation and neurite outgrowth were observed. The findings could serve as an important basis for further studies to elucidate the pathophysiology of AD in patients with ischemic stroke.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"11 3","pages":"159-170"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/47/e5/cnr-11-159.PMC9348914.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40697008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Effects of Artichoke Supplementation on Liver Enzymes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 补充洋蓟对肝酶的影响:随机对照试验的系统回顾和荟萃分析。

Clinical nutrition research Pub Date : 2022-07-25 eCollection Date: 2022-07-01 DOI: 10.7762/cnr.2022.11.3.228

Mohammad Reza Amini, Fatemeh Sheikhhossein, Alireza Talebyan, Elham Bazshahi, Farhang Djafari, Azita Hekmatdoost

{"title":"Effects of Artichoke Supplementation on Liver Enzymes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Mohammad Reza Amini, Fatemeh Sheikhhossein, Alireza Talebyan, Elham Bazshahi, Farhang Djafari, Azita Hekmatdoost","doi":"10.7762/cnr.2022.11.3.228","DOIUrl":"https://doi.org/10.7762/cnr.2022.11.3.228","url":null,"abstract":"Studies examining the effect of artichoke on liver enzymes have reported inconsistent results. This systematic review and meta-analysis aimed to assess the effects of artichoke administration on the liver enzymes. PubMed, Embase, the Cochrane Library, and Scopus databases were searched for articles published up to January 2022. Standardized mean difference (Hedges' g) were analyzed using a random-effects model. Heterogeneity, publication bias, and sensitivity analysis were assessed for the liver enzymes. Pooled analysis of seven randomized controlled trials (RCTs) suggested that the artichoke administration has an effect on both alanine aminotransferase (ALT) (Hedges' g, -1.08; 95% confidence interval [CI], -1.76 to -0.40; p = 0.002), and aspartate aminotransferase (AST) (Hedges' g, -1.02; 95% CI, -1.76 to -0.28; p = 0.007). Greater effects on ALT were detected in trials that lasted ≤8 weeks. Also, greater effects on AST were detected in trials using > 500 mg artichoke. Overall, this meta-analysis demonstrated artichoke supplementation decreased ALT and AST.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"11 3","pages":"228-239"},"PeriodicalIF":0.0,"publicationDate":"2022-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/cc/9c/cnr-11-228.PMC9348909.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40616576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Walnut (Juglans regia) Leaf Extract on Glycemic Control and Lipid Profile in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Clinical Trials 核桃叶提取物对2型糖尿病患者血糖控制和血脂水平的影响：随机临床试验的系统评价和荟萃分析

Clinical nutrition research Pub Date : 2022-04-01 DOI: 10.7762/cnr.2022.11.2.120

A. Mirzababaei, M. Daneshvar, Faezeh Abaj, E. Daneshzad, Dorsa Hosseininasab, Cain C. T. Clark, K. Mirzaei

{"title":"The Effect of Walnut (Juglans regia) Leaf Extract on Glycemic Control and Lipid Profile in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Clinical Trials","authors":"A. Mirzababaei, M. Daneshvar, Faezeh Abaj, E. Daneshzad, Dorsa Hosseininasab, Cain C. T. Clark, K. Mirzaei","doi":"10.7762/cnr.2022.11.2.120","DOIUrl":"https://doi.org/10.7762/cnr.2022.11.2.120","url":null,"abstract":"Numerous clinical trials have examined the beneficial effects of Juglans regia leaf extract (JRLE) in patients with type 2 diabetes mellitus (T2DM); however, the results of these studies are inconsistent. Therefore, we conducted the current systematic review and meta-analysis to evaluate the effect of JRLE on glycemic control and lipid profile in T2DM patients. We searched online databases including PubMed, Scopus, EMBASE, and Web of Science for randomized controlled clinical trials that examined the effect of JRLE on glycemic and lipid indices in T2DM patients. Data were pooled using both fixed and random-effect models and weighted mean difference (WMD) was considered as the overall effect size. Of the total records, 4 eligible studies, with a total sample size of 195 subjects, were included. The meta-analysis revealed that JRLE supplementation significantly reduces fasting blood glucose (WMD, −18.04; 95% confidence interval [CI], −32.88 mg/dL, −3.21 mg/dL; p = 0.017) and significantly increases fasting insulin level (WMD, 1.93; 95% CI, 0.40 U/L, 3.45 U/L; p = 0.014). Although the overall effect of JRLE supplementation on hemoglobin A1c was not significant, a significant reduction was seen in studies with an intervention duration of > 8 weeks (WMD, −0.64; 95% CI, −1.16%, −0.11%; p = 0.018). Moreover, we also found no significant change in lipid parameters. Our findings revealed a beneficial effect of JRLE supplementation on glycemic indices in T2DM patients, but no significant improvement was found for lipid profile parameters.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"11 1","pages":"120 - 132"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42248375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1