Clinical nutrition research最新文献_第7页

Lipocalin-2 Secreted by the Liver Regulates Neuronal Cell Function Through AKT-Dependent Signaling in Hepatic Encephalopathy Mouse Model. 肝性脑病小鼠模型中肝脏分泌的脂钙素-2通过akt依赖性信号调节神经元细胞功能

Clinical nutrition research Pub Date : 2023-04-01 DOI: 10.7762/cnr.2023.12.2.154

Danbi Jo, Yoon Seok Jung, Juhyun Song

{"title":"Lipocalin-2 Secreted by the Liver Regulates Neuronal Cell Function Through AKT-Dependent Signaling in Hepatic Encephalopathy Mouse Model.","authors":"Danbi Jo, Yoon Seok Jung, Juhyun Song","doi":"10.7762/cnr.2023.12.2.154","DOIUrl":"https://doi.org/10.7762/cnr.2023.12.2.154","url":null,"abstract":"Hepatic encephalopathy (HE) associated with liver failure is accompanied by hyperammonemia, severe inflammation, depression, anxiety, and memory deficits as well as liver injury. Recent studies have focused on the liver-brain-inflammation axis to identify a therapeutic solution for patients with HE. Lipocalin-2 is an inflammation-related glycoprotein that is secreted by various organs and is involved in cellular mechanisms including iron homeostasis, glucose metabolism, cell death, neurite outgrowth, and neurogenesis. In this study, we investigated that the roles of lipocalin-2 both in the brain cortex of mice with HE and in Neuro-2a (N2A) cells. We detected elevated levels of lipocalin-2 both in the plasma and liver in a bile duct ligation mouse model of HE. We confirmed changes in cytokine expression, such as interleukin-1β, cyclooxygenase 2 expression, and iron metabolism related to gene expression through AKT-mediated signaling both in the brain cortex of mice with HE and N2A cells. Our data showed negative effects of hepatic lipocalin-2 on cell survival, iron homeostasis, and neurite outgrowth in N2A cells. Thus, we suggest that regulation of lipocalin-2 in the brain in HE may be a critical therapeutic approach to alleviate neuropathological problems focused on the liver-brain axis.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"12 2","pages":"154-167"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/96/01/cnr-12-154.PMC10193436.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9874641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Some Vitamins in Respiratory-related Viral Infections: A Narrative Review. 某些维生素在呼吸道相关病毒感染中的作用：叙述性综述。

Clinical nutrition research Pub Date : 2023-01-31 eCollection Date: 2023-01-01 DOI: 10.7762/cnr.2023.12.1.77

Jae-Hee Park, Yunjung Lee, Mijoo Choi, Eunju Park

{"title":"The Role of Some Vitamins in Respiratory-related Viral Infections: A Narrative Review.","authors":"Jae-Hee Park, Yunjung Lee, Mijoo Choi, Eunju Park","doi":"10.7762/cnr.2023.12.1.77","DOIUrl":"10.7762/cnr.2023.12.1.77","url":null,"abstract":"This study aimed to find out the effect of vitamins on respiratory-related viral infections, including coronavirus disease 2019 (COVID-19), through the literature reviews. From January 2000 to June 2021, the studies (cohort studies, cross-sectional studies, case-control studies, randomized control trials) related to vitamins (vitamin A, D, E, C, B6, folate, and B12) and COVID-19/severe acute respiratory syndrome/Middle East respiratory syndrome/cold/influenza were selected from the PubMed, Embase, and Cochrane libraries and analyzed. The relationship between vitamins and virus-related respiratory diseases was identified. Through the review, 39 studies were selected on vitamin D, one study on vitamin E, 11 studies on vitamin C, and 3 studies on folate. Regarding COVID-19, 18 studies on vitamin D, 4 studies on vitamin C, and 2 studies on folate showed significant effects of the intake of these nutrients in preventing COVID-19. Regarding colds and influenza, 3 studies on vitamin D, 1 study on vitamin E, 3 studies on vitamin C, and 1 study on folate demonstrated that the intake of these nutrients significantly prevents these diseases. Therefore, this review suggested the intake of vitamins D, E, C, and folate is important for preventing respiratory diseases related to viruses, such as COVID-19, colds, and influenza. The relationship between these nutrients and virus-related respiratory diseases should be continuously monitored in the future.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"12 1","pages":"77-89"},"PeriodicalIF":0.0,"publicationDate":"2023-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/5c/18/cnr-12-77.PMC9900078.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10727524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nutrition Intervention in a Gastric Cancer Patient With Gastrectomy for 12 Months: A Case Report. 1例胃癌切除术后12个月的营养干预。

Clinical nutrition research Pub Date : 2023-01-01 DOI: 10.7762/cnr.2023.12.1.1

So Young Youn, Bo Eun Kim, Eun Mee Kim

引用次数: 0

The Effects of Blackcurrant and Raspberry Consumption on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 黑加仑和覆盆子食用对血压的影响:随机对照试验的系统回顾和荟萃分析。

Clinical nutrition research Pub Date : 2023-01-01 DOI: 10.7762/cnr.2023.12.1.54

Ali Nikparast, Fatemeh Sheikhhossein, Mohammad Reza Amini, Sogand Tavakoli, Azita Hekmatdoost

{"title":"The Effects of Blackcurrant and Raspberry Consumption on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Ali Nikparast, Fatemeh Sheikhhossein, Mohammad Reza Amini, Sogand Tavakoli, Azita Hekmatdoost","doi":"10.7762/cnr.2023.12.1.54","DOIUrl":"https://doi.org/10.7762/cnr.2023.12.1.54","url":null,"abstract":"A systematic review and meta-analysis were designed to summarize studies conducted on the effects of raspberry and blackcurrant consumption on blood pressure (BP). Eligible studies were detected by searching numerous five online databases including PubMed, Scopus, Web of Science, Cochrane Library, and Google Scholar, until December 17, 2022. We pooled the mean difference and its 95% confidence interval (CI) by applying a random-effects model. Overall, the impact of raspberry and blackcurrant on BP was reported in ten randomized controlled trials (RCTs) (420 subjects). Pooled analysis of six clinical trials revealed that raspberry consumption has no significant reduction in systolic blood pressure (SBP) (weighted mean differences [WMDs], -1.42; 95% CI, -3.27 to 0.87; p = 0.224) and diastolic blood pressure (DBP) (WMD, -0.53; 95% CI, -1.77 to 0.71; p = 0.401), in comparison with placebo. Moreover, pooled analysis of four clinical trials indicated that blackcurrant consumption did not reduce SBP (WMD, -1.46; 95% CI, -6.62 to 3.7; p = 0.579), and DBP (WMD, -2.09; 95% CI, -4.38 to 0.20; p = 0.07). Raspberry and blackcurrant consumption elicited no significant reductions in BP. More accurate RCTs are required to clarify the impact of raspberry and blackcurrant intake on BP.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"12 1","pages":"54-64"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ca/7b/cnr-12-54.PMC9900079.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10727523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Positive Interaction Between CG, CC Genotypes of Cryptochrome Circadian Clocks 1, and Energy-Adjusted Dietary Inflammatory Index on High Sensitivity C-Reactive Protein Level in Women With Central Obesity. CG、CC基因型隐色素昼夜节律时钟1与能量调节饮食炎症指数对中枢性肥胖女性高敏c反应蛋白水平的正相互作用

Clinical nutrition research Pub Date : 2023-01-01 DOI: 10.7762/cnr.2023.12.1.7

Elaheh Asgari, Farideh Shiraseb, Atieh Mirzababaei, Hadith Tangestani, Khadijeh Mirzaei

{"title":"Positive Interaction Between CG, CC Genotypes of Cryptochrome Circadian Clocks 1, and Energy-Adjusted Dietary Inflammatory Index on High Sensitivity C-Reactive Protein Level in Women With Central Obesity.","authors":"Elaheh Asgari, Farideh Shiraseb, Atieh Mirzababaei, Hadith Tangestani, Khadijeh Mirzaei","doi":"10.7762/cnr.2023.12.1.7","DOIUrl":"https://doi.org/10.7762/cnr.2023.12.1.7","url":null,"abstract":"Creating a complex balance between dietary composition, circadian rhythm, and the hemostasis control of energy is important for managing diseases. Therefore, we aimed to determine the interaction between cryptochrome circadian clocks 1 polymorphism and energy-adjusted dietary inflammatory index (E-DII) on high-sensitivity C-reactive protein in women with central obesity. This cross-sectional study recruited 220 Iranian women aged 18-45 with central obesity. The 147-item semi-quantitative food frequency questionnaire was used to assess the dietary intakes, and the E-DII score was calculated. Anthropometric and biochemical measurements were determined. By polymerase chain response-restricted length polymorphism method, cryptochrome circadian clocks 1 polymorphism was assigned. Participants were categorized into three groups based on the E-DII score, then categorized according to cryptochrome circadian clocks 1 genotypes. The mean and standard deviation of age, BMI, and high-sensitivity C-reactive protein (hs-CRP) were 35.61 ± 9.57 years, 30.97 ± 4.16 kg/m2, and 4.82 ± 5.16 mg/dL, respectively. The interaction of the CG genotype and E-DII score had a significant association with higher hs-CRP level compared to GG genotype as the reference group (β, 1.19; 95% CI, 0.11-2.27; p value, 0.03). There was a marginally significant association between the interaction of the CC genotype and the E-DII score with higher hs-CRP level compared to the GG genotype as the reference group (β, 0.85; 95% CI, -0.15 to 1.86; p value, 0.05). There is probably positive interaction between CG, CC genotypes of cryptochrome circadian clocks 1, and E-DII score on the high-sensitivity C-reactive protein level in women with central obesity.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"12 1","pages":"7-20"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/88/a3/cnr-12-7.PMC9900074.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10735567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association Between Protein Intake From Different Animal and Plant Origins and the Risk of Non-Alcoholic Fatty Liver Disease: A Case-Control Study. 来自不同动植物来源的蛋白质摄入与非酒精性脂肪性肝病风险之间的关系:一项病例对照研究

Clinical nutrition research Pub Date : 2023-01-01 DOI: 10.7762/cnr.2023.12.1.29

Yasaman Khazaei, Narges Dehghanseresht, Sara Ebrahimi Mousavi, Matin Nazari, Shekoufeh Salamat, Omid Asbaghi, Anahita Mansoori

{"title":"Association Between Protein Intake From Different Animal and Plant Origins and the Risk of Non-Alcoholic Fatty Liver Disease: A Case-Control Study.","authors":"Yasaman Khazaei, Narges Dehghanseresht, Sara Ebrahimi Mousavi, Matin Nazari, Shekoufeh Salamat, Omid Asbaghi, Anahita Mansoori","doi":"10.7762/cnr.2023.12.1.29","DOIUrl":"https://doi.org/10.7762/cnr.2023.12.1.29","url":null,"abstract":"Previous studies have frequently reviewed how different macronutrients affect liver health. Still, no study centered around protein intake and the non-alcoholic fatty liver disease (NAFLD) risk relationship. This study aimed to examine the association between the consumption of total and different sources of protein and NAFLD risk. We allocated 243 eligible subjects to the case and control groups, including 121 incidence cases of NAFLD, and 122 healthy controls. Two groups were matched in age, body mass index, and sex. We evaluated the usual food intake of participants using FFQ. Binary logistic regression was conducted to estimate the risk of NAFLD in relation to different sources of protein intake. The age of participants was 42.7 years on average, and 53.1% were male. We found Higher intake of protein in total (odds ratio [OR], 0.24; 95% confidence interval [CI], 0.11-0.52) was significantly associated with a lower risk of NAFLD, despite adjusting for multiple confounders. in detail, higher tendency to the vegetables (OR, 0.28; 95% CI, 0.13-0.59), grains (OR, 0.24; 95% CI, 0.11-0.52), and nuts (OR, 0.25; 95% CI, 0.12-0.52) as the main sources of protein, were remarkably correlated with lower NAFLD risk. In contrary, increased intake of meat protein (OR, 3.15; 95% CI, 1.46-6.81) was positively associated with a higher risk. Totally, more calorie intake from proteins was inversely associated with lower NAFLD risk. This was more likely when the protein sources were selected less from meats and more from plants. Accordingly, increasing the consumption of proteins, particularly from plants, may be a good recommendation to manage and prevent NAFLD.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"12 1","pages":"29-39"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/2d/7a/cnr-12-29.PMC9900076.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10735572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Bitter Taste Receptor TAS2R38 Genetic Variation (rs10246939), Dietary Nutrient Intake, and Bio-Clinical Parameters in Koreans. 韩国人苦味受体TAS2R38遗传变异(rs10246939)、膳食营养摄入和生物临床参数

Clinical nutrition research Pub Date : 2023-01-01 DOI: 10.7762/cnr.2023.12.1.40

Benish, Jeong-Hwa Choi

{"title":"Bitter Taste Receptor TAS2R38 Genetic Variation (rs10246939), Dietary Nutrient Intake, and Bio-Clinical Parameters in Koreans.","authors":"Benish, Jeong-Hwa Choi","doi":"10.7762/cnr.2023.12.1.40","DOIUrl":"https://doi.org/10.7762/cnr.2023.12.1.40","url":null,"abstract":"Differential bitterness perception associated with genetic polymorphism in the bitter taste receptor gene taste 2 receptor member 38 (TAS2R38) may influence an individual's food preferences, nutrition consumption, and eventually chronic nutrition-related disorders including cardiovascular disease. Therefore, the effect of genetic variations on nutritional intake and clinical markers needs to be elaborated for health and disease prevention. In this study, we conducted sex-stratified analysis to examine the association between genetic variant TAS2R38 rs10246939 A > G with daily nutritional intake, blood pressure, and lipid parameters in Korean adults (males = 1,311 and females = 2,191). We used the data from the Multi Rural Communities Cohort, Korean Genome and Epidemiology Study. Findings suggested that the genetic variant TAS2R38 rs10246939 was associated with dietary intake of micronutrients including calcium (adjusted p = 0.007), phosphorous (adjusted p = 0.016), potassium (adjusted p = 0.022), vitamin C (adjusted p = 0.009), and vitamin E (adjusted p = 0.005) in females. However, this genetic variant did not influence blood glucose, lipid profile parameters, and other blood pressure markers. These may suggest that this genetic variation is associated with nutritional intake, but its clinical effect was not found. More studies are needed to explore whether TAS2R38 genotype may be a potential predictive marker for the risk of metabolic diseases via modulation of dietary intake.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"12 1","pages":"40-53"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0a/21/cnr-12-40.PMC9900072.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10735569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Obesity Surgery on Serum Uric Acid in People With Severe Obesity: A Retrospective Study. 肥胖手术对严重肥胖患者血清尿酸的影响:一项回顾性研究

Clinical nutrition research Pub Date : 2023-01-01 DOI: 10.7762/cnr.2023.12.1.21

Leila Vafa, Masoud Amini, Hooman Kamran, Ladan Aghakhani, Seyed Vahid Hosseini, Zahra Mohammadi, Neda Haghighat

{"title":"The Impact of Obesity Surgery on Serum Uric Acid in People With Severe Obesity: A Retrospective Study.","authors":"Leila Vafa, Masoud Amini, Hooman Kamran, Ladan Aghakhani, Seyed Vahid Hosseini, Zahra Mohammadi, Neda Haghighat","doi":"10.7762/cnr.2023.12.1.21","DOIUrl":"https://doi.org/10.7762/cnr.2023.12.1.21","url":null,"abstract":"Studies indicate an association between hyperuricemia (HUA) and metabolic syndrome risk factors. On the other hand, obesity is a major modifiable and independent risk factor for HUA and gout. However, evidence concerning the effects of bariatric surgery on serum uric acid levels is limited and not completely clarified. This retrospective study was carried out with 41 patients who underwent sleeve gastrectomy (n = 26) and Roux-en-Y gastric bypass (n = 15) from September 2019 to October 2021. Anthropometric, clinical, and biochemical data, including uric acid blood urea nitrogen and creatinine fasting blood sugar (FBS), serum triglyceride (TG), and serum cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), were measured preoperatively and postoperative 3, 6 and 12 months. From baseline to 6 and 12 months, bariatric surgery resulted in a significant decrease in serum uric acid of patients with severe obesity (p < 0.001). The decreases in serum FBS, TG, and cholesterol of patients were significant during 6 and 12 months of follow-up (p < 0.05). However, the HDL increase of patients was not statistically significant in 6 and 12 months (p > 0.05). Besides, although patients' serum level of LDL decreased significantly during the 6 months of follow-up (p = 0.007), it was not significant after 12 months (p = 0.092). Bariatric surgery significantly reduces serum uric acid levels. Therefore, it may be an effective supplementary therapy for lowering serum uric acid concentrations in morbidly obese patients.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"12 1","pages":"21-28"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/55/04/cnr-12-21.PMC9900075.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10744628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Tart Cherry Juice Consumption on Body Composition and Anthropometric Measures: A Systematic Review and Meta-Analysis of Randomized Controlled Trials. 饮用酸樱桃汁对身体成分和人体测量的影响:随机对照试验的系统回顾和荟萃分析。

Clinical nutrition research Pub Date : 2023-01-01 DOI: 10.7762/cnr.2023.12.1.65

Mohammad Reza Amini, Nastaran Payandeh, Fatemeh Sheikhhossein, Hossein Shahinfar, Sanaz Pourreza, Azita Hekmatdoost

{"title":"Effect of Tart Cherry Juice Consumption on Body Composition and Anthropometric Measures: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Mohammad Reza Amini, Nastaran Payandeh, Fatemeh Sheikhhossein, Hossein Shahinfar, Sanaz Pourreza, Azita Hekmatdoost","doi":"10.7762/cnr.2023.12.1.65","DOIUrl":"https://doi.org/10.7762/cnr.2023.12.1.65","url":null,"abstract":"The present systematic review and meta-analysis were accomplished to understand the effects of tart cherry juice consumption on body composition and anthropometric measures. Five databases were searched using relevant keywords from inception to January 2022. All clinical trials investigating the effect of tart cherry juice consumption on body weight (BW), body mass index (BMI), waist circumference (WC), fat mass (FM), fat-free mass (FFM), and percentage body fat (PBF) were included. Out of 441 citations, 6 trials that enrolled 126 subjects were included. Tart cherry juice consumption significantly did not reduce BW (weighted mean difference [WMD], -0.4 kg; 95% confidence interval [CI], -3.25 to 2.46; p = 0.789; GRADE = low), BMI (WMD, -0.07 kg/m2; 95% CI, -0.89 to 0.74; p = 0.857; GRADE = low), FM (WMD, 0.21 kg; 95% CI, -1.83 to 2.25; p = 0.837; GRADE = low), FFM (WMD, -0.12 kg; 95% CI, -2.47 to 2.27; p = 0.919; GRADE = low), WC (WMD, 1.69 cm; 95% CI, -1.88 to 5.27; p = 0.353; GRADE = low), and PBF (WMD, 0.18%; 95% CI, -1.81 to -2.17; p = 0.858; GRADE = low). Overall, these data suggest that tart cherry juice consumption has no significant effect on BW, BMI, FM, FFM, WC, and PBF.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"12 1","pages":"65-76"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/7e/4c/cnr-12-65.PMC9900077.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10735571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Green Coffee Supplementation on Lipid Profile, Glycemic Indices, Inflammatory Biomarkers and Anthropometric Indices in Iranian Women With Polycystic Ovary Syndrome: A Randomized Clinical Trial. 补充绿咖啡对伊朗多囊卵巢综合征妇女血脂、血糖指数、炎症生物标志物和人体测量指标的影响:一项随机临床试验

Clinical nutrition research Pub Date : 2022-10-28 eCollection Date: 2022-10-01 DOI: 10.7762/cnr.2022.11.4.241

Mehrnoush Meshkani, Ahmad Saedisomeolia, Mirsaeed Yekaninejad, Seyed Ahmad Mousavi, Azam Ildarabadi, Marzieh Vahid-Dastjerdi

{"title":"The Effect of Green Coffee Supplementation on Lipid Profile, Glycemic Indices, Inflammatory Biomarkers and Anthropometric Indices in Iranian Women With Polycystic Ovary Syndrome: A Randomized Clinical Trial.","authors":"Mehrnoush Meshkani, Ahmad Saedisomeolia, Mirsaeed Yekaninejad, Seyed Ahmad Mousavi, Azam Ildarabadi, Marzieh Vahid-Dastjerdi","doi":"10.7762/cnr.2022.11.4.241","DOIUrl":"https://doi.org/10.7762/cnr.2022.11.4.241","url":null,"abstract":"Polycystic ovary syndrome (PCOS) is a heterogeneous clinical syndrome. Recent studies examine different strategies to modulate its related complications. Chlorogenic acid, as a bioactive component of green coffee (GC), is known to have great health benefits. The present study aimed to determine the effect of GC on lipid profile, glycemic indices, and inflammatory biomarkers. Forty-four PCOS patients were enrolled in this randomized clinical trial of whom 34 have completed the study protocol. The intervention group (n = 17) received 400 mg of GC supplements, while the placebo group (n = 17) received the same amount of starch for six weeks. Then, glycemic indices, lipid profiles, and inflammatory parameters were measured. After the intervention period, no significant difference was shown in fasting blood sugar, insulin level, Homeostasis model assessment of insulin resistance index, low-density lipoprotein, high-density lipoprotein, Interleukin 6 or 10 between supplementation and placebo groups. However, cholesterol and triglyceride serum levels decreased significantly in the intervention group (p < 0.05). This research confirmed that GC supplements might improve some lipid profiles in women with PCOS. However, more detailed studies with larger sample sizes are required to prove the effectiveness of this supplement.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"11 4","pages":"241-254"},"PeriodicalIF":0.0,"publicationDate":"2022-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c4/5a/cnr-11-241.PMC9633971.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40687684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2