Clinical nutrition research最新文献_第10页

Clinical nutrition research Pub Date : 2022-01-01 DOI: 10.7762/cnr.2022.11.1.62

A. Ahmadi, M. Eftekhari, Z. Mazloom, M. Masoompour, M. Fararooei, M. Zare, N. Hejazi

{"title":"Health-Related Quality of Life and Nutritional Status Are Related to Dietary Magnesium Intake in Chronic Obstructive Pulmonary Disease: A Cross-Sectional Study","authors":"A. Ahmadi, M. Eftekhari, Z. Mazloom, M. Masoompour, M. Fararooei, M. Zare, N. Hejazi","doi":"10.7762/cnr.2022.11.1.62","DOIUrl":"https://doi.org/10.7762/cnr.2022.11.1.62","url":null,"abstract":"An insufficient intake of magnesium may be associated with the development of chronic obstructive pulmonary disease (COPD). We aimed to determine the relationship between health related quality of life (QoL), anthropometric indices and nutritional status with dietary magnesium intake in COPD patients. Sixty-one COPD patients participated in this cross-sectional study. QoL and nutritional status were assessed. Furthermore, body composition, calf circumference, and muscle strength were measured; equations were used to calculate fat-free mass index, body mass index, and muscle mass value. Dietary magnesium intake was assessed by three 24-hours recalls and magnesium intake was categorized as ≤ 188.08 mg/day (A group) and > 188.08 mg/day (B group). The χ2, independent-sample t-test and Mann-Whitney test were used for statistical analysis. The p values less than 0.05 were considered significant. Of QoL assessments the total and impact mean scores of St. George's respiratory questionnaire in the B group were significantly lower than the means of the A group (p value = 0.007 and 0.005, respectively). The instrumental activity of daily living score was significantly improved in patients with higher consumption of dietary magnesium (p = 0.02). Participants had a significantly lower mean score of patient-generated subjective global assessment in the B group compared to the A group (p = 0.003). Higher intake of dietary magnesium can lead to improve QoL and nutrition status.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"11 1","pages":"62 - 73"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44339293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Association Between Low Carbohydrate Diet and Resting Metabolic Rate in Overweight and Obese Women: A Cross-Sectional Study 低碳水化合物饮食与超重和肥胖女性静息代谢率之间的关系:一项横断面研究

Clinical nutrition research Pub Date : 2022-01-01 DOI: 10.7762/cnr.2022.11.1.50

Seyedeh Forough Sajjadi, A. Mirzababaei, S. Pooyan, Niloufar Rasaei, M. Yekaninejad, Farideh Shiraseb, K. Mirzaei

{"title":"The Association Between Low Carbohydrate Diet and Resting Metabolic Rate in Overweight and Obese Women: A Cross-Sectional Study","authors":"Seyedeh Forough Sajjadi, A. Mirzababaei, S. Pooyan, Niloufar Rasaei, M. Yekaninejad, Farideh Shiraseb, K. Mirzaei","doi":"10.7762/cnr.2022.11.1.50","DOIUrl":"https://doi.org/10.7762/cnr.2022.11.1.50","url":null,"abstract":"Resting metabolic rate (RMR) accounts for most daily energy expenditure. The low carbohydrate diet (LCD) attenuates decreases in RMR. This study aims to investigate the relationship between an LCD and RMR status among overweight and obese women. We enrolled 291 overweight and obese women in this cross-sectional study. Body mass index (BMI), fat mass, fat-free mass, visceral fat, and insulin level were assessed. RMR was measured using indirect calorimetry. LCD score (LCDS) was measured using a validated semi-quantitative food frequency questionnaire. Analysis of variance, independent sample t-test, and Multinomial logistic regression tests were used. Results showed no relationship between LCDS and deviation of normal RMR (DNR) even after adjust for confounders (increased [Inc.] RMR: odds ratio [OR], 0.97; 95% confidence interval [CI], 0.92–1.01; p = 0.20; decreased [Dec.] RMR: OR, 0.97; 95% CI, 0.94–1.00; p = 0.14). Some components of LCDS had no significant association with DNR, such as carbohydrate and Dec. RMR in adjusted model (OR, 1.62; 95% CI, 0.98–1.37; p = 0.08) and monounsaturated fatty acids and Dec. RMR in adjusted model (OR, 0.48; 95% CI, 0.21–1.10, p = 0.08). However, refined grains had a significant association with Inc. RMR in crude model (OR, 0.87; 95% CI, 0.77–0.99, p = 0.04). There is no association between LCDS and RMR status.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"11 1","pages":"50 - 61"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42684607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Risk of Osteoporotic Fractures Among Obese Women Based on Body Mass Index and Waist Circumference: A Nationwide Cohort in South Korea 基于体重指数和腰围的肥胖女性骨质疏松性骨折风险:韩国全国队列研究

Clinical nutrition research Pub Date : 2022-01-01 DOI: 10.7762/cnr.2022.11.1.32

Gyeongsil Lee, Seulggie Choi, Yoosun Cho, Sang Min Park

{"title":"Risk of Osteoporotic Fractures Among Obese Women Based on Body Mass Index and Waist Circumference: A Nationwide Cohort in South Korea","authors":"Gyeongsil Lee, Seulggie Choi, Yoosun Cho, Sang Min Park","doi":"10.7762/cnr.2022.11.1.32","DOIUrl":"https://doi.org/10.7762/cnr.2022.11.1.32","url":null,"abstract":"We evaluated the association between obesity status by body mass index (BMI) or waist circumference (WC) and osteoporotic fracture risk. We collected data of 143,673 women with a mean age of 58.5 years without history of osteoporotic fracture from the Korean National Health Insurance Service Cohort. Participants were divided into four groups according to obesity by BMI and WC, normal BMI/WC (BMI 18.5–24.9 kg/m2 and WC < 85 cm, reference), obese BMI/normal WC (BMI ≥ 25 kg/m2 and WC < 85 cm), normal BMI/obese WC (BMI < 25 kg/m2 and WC ≥ 85 cm), and obese BMI/WC (BMI ≥ 25 kg/m2 and WC < 85cm). Cox proportional hazards regression analyses were performed to obtain hazard ratios (HRs) with 95% confidence intervals (CIs) for the subsequent median 6.0 years, which were adjusted for age, socioeconomic status, lifestyle, morbidity index, and osteoporosis medication. Compared with the normal group, normal BMI/obese WC was associated with a higher osteoporotic fracture risk after multivariable adjustment (HRs [95% CI], 1.13 [1.05–1.21]), and obese BMI/normal WC was associated with a lower osteoporotic fracture risk (0.89 [0.84–0.94]). Obese BMI/normal WC was associated with a lower risk for hip fractures (0.75 [0.57–0.99]). Obese BMI/normal WC was associated with decreased risk of osteoporotic fracture, whereas normal BMI/obese WC was associated with increased risk of osteoporotic fracture compared with the normal group among East Asian women in their late 40s or more.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"11 1","pages":"32 - 41"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42892804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Olive Leaf Extract Supplementation Combined with Calorie-Restricted Diet on Reducing Body Weight and Fat Mass in Obese Women: Result of a Randomized Control Trial. 橄榄叶提取物补充联合卡路里限制饮食对肥胖妇女体重和脂肪质量的降低:一项随机对照试验的结果。

Clinical nutrition research Pub Date : 2021-10-31 eCollection Date: 2021-10-01 DOI: 10.7762/cnr.2021.10.4.314

Fatemeh Haidari, Forough Shayesteh, Majid Mohammad-Shahi, Mohammad-Taha Jalali, Kambiz Ahmadi-Angali

{"title":"Olive Leaf Extract Supplementation Combined with Calorie-Restricted Diet on Reducing Body Weight and Fat Mass in Obese Women: Result of a Randomized Control Trial.","authors":"Fatemeh Haidari, Forough Shayesteh, Majid Mohammad-Shahi, Mohammad-Taha Jalali, Kambiz Ahmadi-Angali","doi":"10.7762/cnr.2021.10.4.314","DOIUrl":"https://doi.org/10.7762/cnr.2021.10.4.314","url":null,"abstract":"The present trial aims to evaluate a supplementation of the olive leaf extract (OLE) in adjunct with a weight loss diet on anthropometric indices, glycemic indices, lipid profile, as well as the level of adipokines, and free fatty acid in obese women. We carried out an 8-week randomized, placebo-controlled, double-blind, parallel-group, clinical trial. The participants were randomly stratified according to age and they were assigned to one of the two study groups: Standard weight loss diet (estimated daily energy requirements minus 500 kcal) + OLE supplementation (n = 35) in intervention group or Standard weight loss diet (estimated daily energy requirements minus 500 kcal) + placebo (n = 35) in placebo group. The study groups were homogeneous regarding the baseline age, height, weight, body mass index (BMI), waist circumferences, married status, and physical activity levels (p > 0.05). The results of analysis of covariance presented significant decreases in BMI, fat mass, and body weight in the OLE group compared to those in the placebo group (p < 0.05). At the end of the study, the serum levels of fasting blood sugar, insulin, low-density lipoprotein cholesterol, total cholesterol, leptin, fatty free acid, and homeostasis model assessment-insulin resistance significantly decreased, and serum levels of high-density lipoprotein cholesterol and adiponectin elevated in the intervention group (p < 0.05). Based on results it seems that the addition of OLE to a hypocaloric diet for 8-week compared with a hypocaloric diet alone may be more effective in modifying obesity and metabolic risk factors.Trial registration: Iranian Registry of Clinical Trials Identifier: IRCT20190129042552N2.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":" ","pages":"314-329"},"PeriodicalIF":0.0,"publicationDate":"2021-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/9a/bd/cnr-10-314.PMC8575641.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39638389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Nutritional Intervention for a Korean Adolescent with Atopic Dermatitis: a Case Report. 营养干预对韩国青少年特应性皮炎:1例报告。

Clinical nutrition research Pub Date : 2021-10-28 eCollection Date: 2021-10-01 DOI: 10.7762/cnr.2021.10.4.364

Sunghee Kim, Sung-Im Lee, Shin-Sook Kang

{"title":"Nutritional Intervention for a Korean Adolescent with Atopic Dermatitis: a Case Report.","authors":"Sunghee Kim, Sung-Im Lee, Shin-Sook Kang","doi":"10.7762/cnr.2021.10.4.364","DOIUrl":"https://doi.org/10.7762/cnr.2021.10.4.364","url":null,"abstract":"Atopic dermatitis (AD) is a common inflammatory skin disease in children worldwide but can affect individuals of all ages. Patients and parents of pediatric patients tend to restrict too much food because they think this aggravates or causes AD. However, there is a risk of nutrient deficiency owing to a lack of balanced diet. Herein, nutritional counseling was conducted to improve the eating habits of a patient with AD, promote nutritionally balanced meals, and consequently observe changes in the severity of AD. This report discusses the case of a 15-year-old male patient with AD who did not receive nutritional counseling previously but regularly ate breakfast and consumed fruits, beans, vegetables, and milk more frequently after counseling. His vegetable consumption increased from less than one plate a day before counseling to more than eight plates a day after counseling. This change was reflected in the nutritional quotient for adolescents (NQ-A) score. After consultation, eating habits improved, as indicated by a 1.2-, 2.4-, and 1.5-fold increase in NQ-A, diversity category, and balance category scores, respectively. The intake of protein, dietary fiber, vitamin A, vitamin D, vitamin K, vitamin C, niacin, calcium, potassium, magnesium, and water was inadequate before consultation and improved after consultation. The eating habits and severity of AD also improved after nutritional counseling. However, this result was not tested in a tightly controlled environment. It was difficult to conclude that only the eating habits affected the severity. Therefore, further research is needed.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":" ","pages":"364-370"},"PeriodicalIF":0.0,"publicationDate":"2021-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f0/b0/cnr-10-364.PMC8575648.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39638391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary Intake of Polyphenols and the Risk of Breast Cancer: a Case-Control Study. 饮食摄入多酚与乳腺癌风险:一项病例对照研究。

Clinical nutrition research Pub Date : 2021-10-28 eCollection Date: 2021-10-01 DOI: 10.7762/cnr.2021.10.4.330

Alireza Bahrami, Elham Makiabadi, Saba Jalali, Zeinab Heidari, Mojan Assadi, Bahram Rashidkhani

{"title":"Dietary Intake of Polyphenols and the Risk of Breast Cancer: a Case-Control Study.","authors":"Alireza Bahrami, Elham Makiabadi, Saba Jalali, Zeinab Heidari, Mojan Assadi, Bahram Rashidkhani","doi":"10.7762/cnr.2021.10.4.330","DOIUrl":"https://doi.org/10.7762/cnr.2021.10.4.330","url":null,"abstract":"Despite mounting evidence that dietary polyphenols might have a protective role against the risk of breast cancer (BC), few studies have assessed the relationship between intake of polyphenol classes and subclasses with BC. Thus, we examined the relationship between dietary polyphenol classes and individual polyphenol subclasses and the risk of BC. Overall, 134 newly diagnosed BC patients and 267 healthy hospitalized controls were studied. Dietary intake was assessed using a validated 168-item food frequency questionnaire (FFQ). To estimate dietary intake of polyphenols, polyphenol content (flavonoids, lignans, stilbenes and phenolic acids) of 80 food items were derived from an updated version of the phenol explorer database containing information on the effects of food processing on polyphenol content. The dietary polyphenol intake was calculated by matching the subjects' food consumption data with our polyphenol content database. Multivariate logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Controls had higher intake of total polyphenol (marginally significant; p = 0.07), hydroxycinnamic acid (marginally significant; p = 0.05) and lignan (p = 0.01). After adjusting for potential confounders, high consumption of lignans (highest vs. lowest tertile: OR, 0.51; 95% CI, 0.26-0.97; p for trend = 0.04) associated with decreased risk of BC. There was no significant relationship between intake of other polyphenols and risk of BC. Our findings suggest that high lignan intake is associated with a reduced risk of BC.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":" ","pages":"330-340"},"PeriodicalIF":0.0,"publicationDate":"2021-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e6/c1/cnr-10-330.PMC8575644.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39638390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The Association of Dietary Total Antioxidant Capacity with Inflammatory Biomarkers and Anthropometric Indices in Patients Who Candidate for Coronary Artery Bypass Graft Surgery: a Cross-sectional Study. 冠状动脉搭桥手术患者饮食总抗氧化能力与炎症生物标志物和人体测量指标的关系:一项横断面研究

Clinical nutrition research Pub Date : 2021-10-28 eCollection Date: 2021-10-01 DOI: 10.7762/cnr.2021.10.4.353

Zahra Mohammadi, Hadi Abdollahzad, Shahab Rezaeian, Feridoun Sabzi, Nazanin Tafteh

{"title":"The Association of Dietary Total Antioxidant Capacity with Inflammatory Biomarkers and Anthropometric Indices in Patients Who Candidate for Coronary Artery Bypass Graft Surgery: a Cross-sectional Study.","authors":"Zahra Mohammadi, Hadi Abdollahzad, Shahab Rezaeian, Feridoun Sabzi, Nazanin Tafteh","doi":"10.7762/cnr.2021.10.4.353","DOIUrl":"https://doi.org/10.7762/cnr.2021.10.4.353","url":null,"abstract":"Antioxidant compounds can attenuate inflammation and delay degenerative processes especially in the cardiovascular system. This study aimed to determine the relationship between dietary total antioxidant capacity (DTAC) and serum biomarkers in patients undergoing coronary artery bypass graft surgery. In this cross-sectional study, 146 patients who had referred to Imam Ali Hospital in Kermanshah were recruited and demographic, anthropometric, physical activity and dietary data were collected. Fasting blood glucose (FBG), serum levels of lipid profile, inflammatory markers (interleukin [IL]-17, intercellular and vascular cell adhesion molecules [ICAM, VCAM]), and total antioxidant capacity (TAC) were also measured. A regression model adjusted for confounding variables presented that the coefficients of ICAM and VCAM (ng/dL) in the third tertile of DTAC were lower than those in the first tertile (β = -417.2, 95% confidence interval [CI] = -509.9 to -324.5, p < 0.001; β = -293.2, 95% CI = -334.3, -252.1, p < 0.001, respectively). The β of serum TAC (ng/dL) in the third tertile was 0.86 (95% CI = 0.77, 0.95, p < 0.001) higher than that in the first tertile. DTAC had no statistically significant relationship with lipid profile, FBG, and IL-17 levels, and anthropometric indices. In this study DTAC was associated with increased serum TAC and decreased cell adhesion molecules. Therefore, diet antioxidants may be beneficial in attenuating of inflammation in coronary artery diseases.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":" ","pages":"353-363"},"PeriodicalIF":0.0,"publicationDate":"2021-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/17/73/cnr-10-353.PMC8575643.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39638392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Effects of Calcium Fortified Beverage Intake on Insulin Sensitivity and Antioxidant Metabolism in Healthy Elderly. 钙强化饮料摄入对健康老年人胰岛素敏感性和抗氧化代谢的影响

Clinical nutrition research Pub Date : 2021-10-28 eCollection Date: 2021-10-01 DOI: 10.7762/cnr.2021.10.4.303

Seonjeong Kim, Eunju Park, Jae-Hee Park

{"title":"Effects of Calcium Fortified Beverage Intake on Insulin Sensitivity and Antioxidant Metabolism in Healthy Elderly.","authors":"Seonjeong Kim, Eunju Park, Jae-Hee Park","doi":"10.7762/cnr.2021.10.4.303","DOIUrl":"https://doi.org/10.7762/cnr.2021.10.4.303","url":null,"abstract":"Calcium, one of the most important nutrients, determines the quality of life of the elderly. It has been reported that 7 out of 10 people over the age of 60 have insufficient calcium intake. The purpose of this study was to evaluate the effect of calcium fortified beverage (CFB) intake on insulin sensitivity and antioxidant metabolism in healthy elderly. A crossover clinical trial was performed and antioxidant status of healthy elderly (age above 65 years, n = 8) was analyzed. Subjects did not take CFB for 0-3 weeks. They then took it for 3-6 weeks. CFB supplementation decreased insulin levels (Δ3-6 weeks: 1.19 ± 0.65 μ IU/mL → Δ0-3 weeks: -0.58 ± 0.38 μ IU/mL). Increasing degree of fasting blood glucose level was suppressed by intake of CFB, although the suppression was not statistically significant. Except for insulin, there were no significant differences in results of biochemical analysis between 0-3 weeks and 3-6 weeks. Catalase activity was significantly increased by CFB supplementation (Δ3-6 weeks: 3.50 ± 5.30 K g/Hb) compared to the no CFB supplementation period (Δ0-3 weeks: -12.48 ± 4.37 K g/Hb). However, the activity of superoxide dismutase and glutathione-peroxidase were not significantly different between 0-3 weeks and 3-6 weeks. H2O2-induced DNA oxidative damage was also decreased significantly by CFB supplementation. Taken together, these results indicate that CFB has beneficial effect on insulin sensitivity and some antioxidant enzymes in healthy elderly.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":" ","pages":"303-313"},"PeriodicalIF":0.0,"publicationDate":"2021-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/ea/80/cnr-10-303.PMC8575645.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39638388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Direct-to-Consumer Genetic Testing in Korea: Current Status and Significance in Clinical Nutrition. 韩国直接面向消费者的基因检测:临床营养的现状和意义。

Clinical nutrition research Pub Date : 2021-10-22 eCollection Date: 2021-10-01 DOI: 10.7762/cnr.2021.10.4.279

Ga Young Lee, Sung Nim Han

{"title":"Direct-to-Consumer Genetic Testing in Korea: Current Status and Significance in Clinical Nutrition.","authors":"Ga Young Lee, Sung Nim Han","doi":"10.7762/cnr.2021.10.4.279","DOIUrl":"https://doi.org/10.7762/cnr.2021.10.4.279","url":null,"abstract":"Direct-to-consumer genetic testing (DTC-GT) provides a means for consumers to gain insights into their genetic background and how it relates to their health without the involvement of medical institutions. In Korea, DTC-GT was introduced in 2016 in accordance with the legislation on Paragraph (3) 2 of Article 50 of the Bioethics and Safety Act. Only 12 genetic test items involving 46 genes were approved at first, but the approved items were expanded to 70 in November 2020. However, the genetic test items of DTC-GT services in Korea are still restricted to the wellness area, and access to disease risk related information is only permitted to medical institutions. Further, studies revealing the relationship between genotype differences and responses to nutrients, food components, or nutritional status are increasing, and this association appears to be robust for some genes. This strong association between genetic variations and nutrition suggests that DTC-GT can be used as an important tool by clinical nutritionists to gain insights into an individual's genetic susceptibilities and provide guidance on nutritional counseling and meal planning based on the patient's genetic information. This review summarized the history and current status of DTC-GT and investigated the relationship between genetic variations with associated phenotypic traits to clarify further the importance of DTC-GT in the field of clinical nutrition.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":" ","pages":"279-291"},"PeriodicalIF":0.0,"publicationDate":"2021-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f3/4f/cnr-10-279.PMC8575646.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39638386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Irisin Acts via the PGC-1α and BDNF Pathway to Improve Depression-like Behavior. 鸢尾素通过PGC-1α和BDNF通路改善抑郁样行为

Clinical nutrition research Pub Date : 2021-10-20 eCollection Date: 2021-10-01 DOI: 10.7762/cnr.2021.10.4.292

Danbi Jo, Juhyun Song

{"title":"Irisin Acts via the PGC-1α and BDNF Pathway to Improve Depression-like Behavior.","authors":"Danbi Jo, Juhyun Song","doi":"10.7762/cnr.2021.10.4.292","DOIUrl":"https://doi.org/10.7762/cnr.2021.10.4.292","url":null,"abstract":"Depression is the most prevalent psychiatric disorder experienced by the world's population. Mechanisms associated with depression-like behavior have not been fully investigated. Among the therapeutic solution for depression, exercise is considered an important regulator attenuating depressive neuropathology. Exercise has been reported to boost the secretion of myokines such as irisin and myostatin in skeletal muscles. Myokines secreted during exercise are involved in various cellular responses including the endocrine and autocrine systems. Especially, irisin as a cleaved version of fibronectin domain-containing protein 5 has multiple functions such as white fat-browning, energy expenditure increase, anti-inflammatory effects, and mitochondrial function improvement in both systemic circulation and central nervous system. Furthermore, irisin activates energy metabolism-related signaling peroxisome proliferator-activated receptor-gamma coactivator-1 alpha and memory formation-related signaling brain-derived neurotrophic factor involved in depression. However, the role and mechanism of irisin in depression disorder is not obvious until now. Here, we review recent evidences regarding the therapeutic effect of irisin in depression disorder. We suggest that irisin is a key molecule that suppresses several neuropathological mechanisms involved in depression.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":" ","pages":"292-302"},"PeriodicalIF":0.0,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/20/04/cnr-10-292.PMC8575642.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39638387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10