Clinical nutrition research最新文献_第2页

Dietary intake patterns and nutritional adequacy in older adults with predialysis chronic kidney disease: a comparison by diabetes status. 老年透析前慢性肾病患者的饮食摄入模式和营养充足性：与糖尿病状态的比较

Clinical nutrition research Pub Date : 2026-04-01 Epub Date: 2026-04-30 DOI: 10.7762/cnr.2026.0014

Jeong Eun Kim, Jisoo Kim, Yu-Jin Kwon, Jung Eun Lee, Jung Joo Lee, Ji-Won Lee, Yoo Kyoung Park

{"title":"Dietary intake patterns and nutritional adequacy in older adults with predialysis chronic kidney disease: a comparison by diabetes status.","authors":"Jeong Eun Kim, Jisoo Kim, Yu-Jin Kwon, Jung Eun Lee, Jung Joo Lee, Ji-Won Lee, Yoo Kyoung Park","doi":"10.7762/cnr.2026.0014","DOIUrl":"10.7762/cnr.2026.0014","url":null,"abstract":"Objective: Nutritional management is essential in caring for patients with chronic kidney disease (CKD), older adults at higher risk of malnutrition and comorbidities. However, data on actual dietary intake patterns in older adults with predialysis CKD, especially by diabetes mellitus (DM) status, remain limited.Methods: This cross-sectional study included 106 patients aged ≥65 years with CKD stage G3a or higher, divided into DM (n=67) and non-DM (n=39) groups. Dietary intake was assessed using a single 24-hour recall. Nutrient and food-group intakes were compared with recommended levels.Results: In both groups, energy intake was lower than recommended levels. More than half of the participants exceeded sodium limits, and approximately half consumed excess protein. Patients with DM had significantly higher protein intake and blood urea nitrogen (BUN) levels than those without DM. Most food groups, except protein foods, were consumed below recommended levels.Conclusion: Dietary patterns in older adults with predialysis CKD showed low energy intake, high sodium intake, and relatively high protein intake. Those with DM had higher protein intake and BUN levels, suggesting dietary differences by diabetes status. These findings underscore the need for age-sensitive, individualized nutritional management strategies that consider kidney function and DM status.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"15 2","pages":"108-116"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13176662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147943982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Applying traditional K-foods to official development assistance programs for micronutrient deficiency nutrition support. 将传统k食品应用于官方发展援助项目，以支持微量营养素缺乏症。

Clinical nutrition research Pub Date : 2026-04-01 Epub Date: 2026-04-30 DOI: 10.7762/cnr.2026.0003

Sohye Cho, Jung Min Cho

{"title":"Applying traditional K-foods to official development assistance programs for micronutrient deficiency nutrition support.","authors":"Sohye Cho, Jung Min Cho","doi":"10.7762/cnr.2026.0003","DOIUrl":"10.7762/cnr.2026.0003","url":null,"abstract":"Micronutrient deficiencies are a major public health concern in low- and middle-income countries, where conventional supplementation and fortification programs are often limited by low bioavailability, fragile supply chains, cultural resistance, and poor long-term adherence. This research note proposes a food-based alternative model that leverages selected traditional Korean foods (K-foods)- gim (dried seaweed), kimchi (fermented vegetables), and cheonggukjang (fermented soybean paste)-as culturally adaptable and nutritionally dense components of official development assistance nutrition strategies. These foods provide functionally relevant nutrients, such as iodine, vitamin K2, probiotics, and fermentation-derived bioactive peptides, and offer benefits, including shelf stability, microbial resilience, and decentralized production. Employing a multidisciplinary clinical nutrition framework integrating food composition science, fermentation biology, public health nutrition, and development policy, this note presents a five-step research roadmap encompassing nutrient profiling, safety and stability assessment, cultural acceptability evaluation, community-based efficacy trials, and policy translation. By prioritizing food-based, multinutrient dietary interventions over single-nutrient strategies, the proposed model highlights a scalable and clinically relevant pathway for enhancing micronutrient status in resource-limited settings. This work contributes to emerging discussions on nutrition-sensitive official development assistance and highlights K-foods as potential tools for sustainable, culturally responsive global nutrition interventions.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"15 2","pages":"127-138"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13176659/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147944024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between vitamin D status and triglyceride-glucose index among South Korean adults: a cross-sectional study. 韩国成年人维生素D水平与甘油三酯-葡萄糖指数之间的关系：一项横断面研究。

Clinical nutrition research Pub Date : 2026-04-01 Epub Date: 2026-04-30 DOI: 10.7762/cnr.2026.0013

Sunhye Shin

{"title":"Association between vitamin D status and triglyceride-glucose index among South Korean adults: a cross-sectional study.","authors":"Sunhye Shin","doi":"10.7762/cnr.2026.0013","DOIUrl":"10.7762/cnr.2026.0013","url":null,"abstract":"Objective: Because vitamin D deficiency is associated with diabetes and insulin resistance, and the triglyceride-glucose (TyG) index is a reliable marker of metabolic health, this study aimed to clarify the association between vitamin D status and the TyG index.Methods: A cross-sectional analysis was conducted on 4,819 participants from the 2022 Korea National Health and Nutrition Examination survey, stratified by age and sex. Vitamin D deficiency was defined as blood 25-hydroxyvitamin D3 (25(OH)D3) <20 ng/ mL, and a metabolically unhealthy state as a TyG index of ≥8.82 and ≥8.73 for men and women, respectively.Results: Approximately 46.9% of South Korean adults were vitamin D deficient, and 35.5% were metabolically unhealthy. After adjustment, blood 25(OH)D3 levels were inversely correlated with the TyG index in younger women (β=-0.004, standard error [SE]=0.002, P=0.039), middle-aged men (β=-0.006, SE=0.003, P=0.015), and older men (β=-0.008, SE=0.002, P=0.002). Vitamin D deficiency was associated with a higher risk of a metabolically unhealthy state in middle-aged men (odds ratio [OR], 1.59; 95% confidence interval [CI], 1.11-2.28) and older men (OR, 2.15; 95% CI, 1.31-3.55).Conclusion: These findings suggest that adequate vitamin D status may help maintain a metabolically healthy state, and the TyG index may help identify vitamin D insufficiency or deficiency, particularly in middle-aged and older South Korean men.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"15 2","pages":"101-107"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13176658/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147944007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between vitamin B12 deficiency and supraventricular tachycardia: case series. 维生素B12缺乏与室上性心动过速之间的关系：病例系列。

Clinical nutrition research Pub Date : 2026-04-01 Epub Date: 2026-04-30 DOI: 10.7762/cnr.2026.0005

Ankur Verma, Sofiya Rizvi, Mohammad Saif, Vikrant Chouhan, Sanjay Jaiswal

{"title":"Association between vitamin B12 deficiency and supraventricular tachycardia: case series.","authors":"Ankur Verma, Sofiya Rizvi, Mohammad Saif, Vikrant Chouhan, Sanjay Jaiswal","doi":"10.7762/cnr.2026.0005","DOIUrl":"10.7762/cnr.2026.0005","url":null,"abstract":"The incidence of supraventricular tachycardia (SVT) is approximately 35 cases per 100,000 patients with a prevalence of 2.25 cases per 1,000. This dysrhythmia originates at or above the atrioventricular node and is defined by a narrow complex QRS (<120 msec) at a rate of >100 beats/min. The effects of vitamin B12 deficiency on sympathetic and parasympathetic systems may cause heart rate variability and autonomic dysfunction. In patients with SVT, the underlying mechanism may be further exacerbated by vitamin B12 deficiency or induced by the deficiency. We describe a case series of three patients with no known comorbidity who presented to our department with SVT. Their SVTs were terminated using the modified Valsalva maneuver. All three patients were incidentally found to be severely deficient in vitamin B12 and had hyperhomocysteinemia. They were discharged on medications and dietary advice to increase vitamin B12 levels. Correcting vitamin B12 deficiency and hyperhomocysteinemia could play a preventive role in patients at risk for SVT. Our case series demonstrates a plausible association between vitamin B12 deficiency and SVT occurrence in previously healthy individuals with no known comorbid conditions.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"15 2","pages":"122-126"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13176656/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147943971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between plant-based diet indices and depressive symptoms among South Korean adults: a cross-sectional study using the 2014 and 2016 Korea National Health and Nutrition Examination Surveys. 韩国成年人植物性饮食指数与抑郁症状之间的关系：一项使用2014年和2016年韩国国民健康与营养检查调查的横断面研究

Clinical nutrition research Pub Date : 2026-04-01 Epub Date: 2026-04-30 DOI: 10.7762/cnr.2026.0007

Soohyun Park, Yoon Jung Park

{"title":"Association between plant-based diet indices and depressive symptoms among South Korean adults: a cross-sectional study using the 2014 and 2016 Korea National Health and Nutrition Examination Surveys.","authors":"Soohyun Park, Yoon Jung Park","doi":"10.7762/cnr.2026.0007","DOIUrl":"10.7762/cnr.2026.0007","url":null,"abstract":"Objective: This study investigated the association between plant-based diet indices-overall plant-based diet index (PDI), healthful PDI (hPDI), and unhealthful PDI (uPDI)-and depressive symptoms in South Korean adults.Methods: This cross-sectional study analyzed 5,846 participants (aged 19-64 years) using data from the 2014 and 2016 South Korea National Health and Nutrition Examination Survey. Dietary intake was assessed with a semiquantitative food frequency questionnaire, from which PDIs were derived. Depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9). Survey-weighted linear and logistic regression models were applied to assess associations, adjusting for sociodemographic, lifestyle, and clinical factors.Results: In fully adjusted models, higher overall PDI and hPDI were associated with lower PHQ-9 scores (β=-0.23; 95% confidence interval [CI], -0.41 to -0.04 and β=-0.16; 95% CI, -0.30 to -0.02 per 10-unit increment, respectively), whereas higher uPDI scores were associated with higher PHQ-9 scores (β=0.21; 95% CI, 0.07 to 0.35 per 10-unit increment). For clinical depressive symptoms (PHQ-9 ≥10), each 10-unit increase in overall PDI was associated with a 33% reduction in odds (odds ratio, 0.67; 95% CI, 0.50 to 0.89). Associations for hPDI and uPDI were attenuated and not statistically significant. Subgroup analyses revealed that these associations varied by sex, age, and obesity status.Conclusion: Greater adherence to healthy plant-based foods and lower intake of less healthy plant-based foods were associated with fewer depressive symptoms among South Korean adults. These findings highlight the importance of plant-based food quality, rather than quantity alone, in supporting mental health.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"15 2","pages":"79-90"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13176661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147943967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toward a longevity diet framework: integrating global evidence for healthy aging in the South Korean population. 迈向长寿饮食框架：整合韩国人口健康老龄化的全球证据。

Clinical nutrition research Pub Date : 2026-04-01 Epub Date: 2026-04-30 DOI: 10.7762/cnr.2026.0015

Soyoung Jung, Hae Jin Kang, Mijoo Choi, Yoo Kyoung Park

{"title":"Toward a longevity diet framework: integrating global evidence for healthy aging in the South Korean population.","authors":"Soyoung Jung, Hae Jin Kang, Mijoo Choi, Yoo Kyoung Park","doi":"10.7762/cnr.2026.0015","DOIUrl":"10.7762/cnr.2026.0015","url":null,"abstract":"Objective: As global life expectancy rises, the focus has shifted from longevity alone to healthy aging. Although dietary models such as the Mediterranean, Dietary Approaches to Stop Hypertension (DASH), Mediterranean-DASH Intervention for Neurodegenerative Delay, and EAT-Lancet diets show benefits for specific health outcomes, their direct application to South Korean populations is limited by differences in dietary patterns and cultural practices. This study aimed to develop nutritional criteria for a South Korean-adapted longevity diet framework.Methods: A multiphase development approach was used, including a narrative review of major dietary models and clinical nutrition guidelines to identify key components of a longevity diet. Macronutrient distribution, food group intake, and nutrient-specific recommendations were synthesized into a structured framework. The EAT-Lancet reference diet was adjusted from 2,400 to 2,000 kcal/ day to reflect energy requirements of South Korean adults.Results: The proposed framework comprises six domain-specific recommendations, including macronutrient targets of 50%-65% carbohydrates, 10%-20% protein, and 15%-30% fat, with a 1:1 animal to plant protein ratio. Food group recommendations were tailored to South Korean dietary patterns. The framework addresses weight management, glycemic control, cardiovascular health, cognitive function, muscle function, and skin health. It emphasizes whole grains, dietary fiber, plant-based proteins, and unsaturated fats, while limiting refined carbohydrates, added sugars, and saturated fats.Conclusion: This study presents evidence-based nutritional criteria for a South Korean-adapted longevity diet framework that integrates disease prevention with functional health support to promote healthy aging.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"15 2","pages":"91-100"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13176660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147943994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of oral supplementation with whey protein concentrate and its hydrolysates on blood cholesterol levels and oxidative DNA damage in South Korean male smokers. 口服补充浓缩乳清蛋白及其水解物对韩国男性吸烟者血液胆固醇水平和氧化性DNA损伤的影响。

Clinical nutrition research Pub Date : 2026-01-01 Epub Date: 2026-01-31 DOI: 10.7762/cnr.2026.0001

Ji Yeon Paik, Seung-Min Lee, Eunju Park

{"title":"Effects of oral supplementation with whey protein concentrate and its hydrolysates on blood cholesterol levels and oxidative DNA damage in South Korean male smokers.","authors":"Ji Yeon Paik, Seung-Min Lee, Eunju Park","doi":"10.7762/cnr.2026.0001","DOIUrl":"10.7762/cnr.2026.0001","url":null,"abstract":"Objective: Cigarette smoking leads to oxidative stress and high cholesterolemia, which are key drivers of cardiovascular disease (CVD). Whey is known for its antioxidant and hypolipidemic properties. This study investigated whether whey protein concentrate (WPC) and hydrolysate of WPC (HWPC) can alleviate CVD risk in South Korean smokers by lowering oxidative stress and blood lipids.Methods: A total of 25 male smokers were screened, of which 18 eligible participants (72.0%), randomly assigned to either the WPC (n=9) or the HWPC (n=9) group, completed the 8-week intervention. Before (week 0, baseline) and after the intervention, participants visited the laboratory for blood collection and anthropometric measurements (body weight, height, waist circumference, body fat mass, nutritional intake). Blood samples were analyzed for plasma lipid profiles, plasma fat-soluble antioxidants, and leukocyte oxidative DNA damage using the comet assay.Results: There were no significant differences in anthropometric measurements, dietary food intake, plasma conjugated dienes, total radical-trapping antioxidant potential, and erythrocytes' glutathione peroxidase and catalase activities in both WPC and HWPC groups. However, we observed a significant decrease in the tail moments of leukocytes, low-density lipoprotein cholesterol, atherogenic index, and high coenzyme Q10 levels in both groups. In the WPC group, total cholesterol decreased, while plasma retinol, α-tocopherol, lycopene, α-carotene, and β-carotene increased.Conclusion: WPC or HWPC significantly decreases blood cholesterol levels and oxidative DNA damage and increases plasma fat-soluble antioxidant levels. Thus, WPC or HWPC might be used as oral supplementation to lower the risk for CVD in South Korean male smokers.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"15 1","pages":"25-35"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007808/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dietary management of pediatric patients with kidney disease: recommendations by the Korean Society of Pediatric Nephrology and the Korean Society of Clinical Nutrition. 肾病患儿的饮食管理：韩国儿科肾病学会和韩国临床营养学会的建议

Clinical nutrition research Pub Date : 2026-01-01 Epub Date: 2026-01-31 DOI: 10.7762/cnr.2025.0033

Yo Han Ahn, Hee Gyung Kang, Jiyoung Song, Sangmi Han, Eujin Park, Jin-Soon Suh, Jeong Yeon Kim, Min Ji Park, Keum Hwa Lee, Seon Hee Lim, Kyeong Hun Shin, Hyunji Ko, Hyun Joo Lee, Eunyoung Jeong, Jinsu Kim, Sohyun Park, Eonju Choi, Yuri Seo, Kyooyung Oh, Jin Kyoung Kim, Hyun Kyung Lee

{"title":"Dietary management of pediatric patients with kidney disease: recommendations by the Korean Society of Pediatric Nephrology and the Korean Society of Clinical Nutrition.","authors":"Yo Han Ahn, Hee Gyung Kang, Jiyoung Song, Sangmi Han, Eujin Park, Jin-Soon Suh, Jeong Yeon Kim, Min Ji Park, Keum Hwa Lee, Seon Hee Lim, Kyeong Hun Shin, Hyunji Ko, Hyun Joo Lee, Eunyoung Jeong, Jinsu Kim, Sohyun Park, Eonju Choi, Yuri Seo, Kyooyung Oh, Jin Kyoung Kim, Hyun Kyung Lee","doi":"10.7762/cnr.2025.0033","DOIUrl":"10.7762/cnr.2025.0033","url":null,"abstract":"Pediatric kidney disease has a lower prevalence than other pediatric conditions and has a notably different etiology from kidney diseases occurring in adults. Furthermore, the pediatric population is unique in that they experience ongoing growth and development, distinguishing them from adult patients. Consequently, pediatric patients with kidney disease require a more specialized and meticulous nutritional management plan compared with adult patients. To address this need and promote optimal dietary practices for pediatric patients with kidney disease, pediatric nephrologists from the Korean Society of Pediatric Nephrology and nutritionists from the Korean Society of Clinical Nutrition have collaborated to formulate nutritional guidelines specifically tailored to Korean dietary patterns. These guidelines offer detailed, nutrient-specific recommendations regarding the consumption of energy, protein, calcium, phosphorus, and potassium while providing practical, culturally relevant guidance intended to support both pediatric patients and their caregivers.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"15 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007806/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of propolis supplementation on blood glucose and lipid profiles in individuals with metabolic syndrome and type 2 diabetes: a systematic review and meta-analysis. 蜂胶补充对代谢综合征和2型糖尿病患者血糖和血脂的影响：一项系统综述和荟萃分析

Clinical nutrition research Pub Date : 2026-01-01 Epub Date: 2026-01-31 DOI: 10.7762/cnr.2025.0004

Ezatollah Fazeli Moghadam, Elham Afshari, Leili Khaghani, Parivash Shekarchizadeh-Esfahani

{"title":"Effects of propolis supplementation on blood glucose and lipid profiles in individuals with metabolic syndrome and type 2 diabetes: a systematic review and meta-analysis.","authors":"Ezatollah Fazeli Moghadam, Elham Afshari, Leili Khaghani, Parivash Shekarchizadeh-Esfahani","doi":"10.7762/cnr.2025.0004","DOIUrl":"10.7762/cnr.2025.0004","url":null,"abstract":"Objective: Propolis has been suggested as a complementary therapy for improving glycemic control and lipid metabolism. However, evidence from clinical trials remains inconsistent. This systematic review and meta-analysis aimed to provide a clear and updated assessment of the effects of propolis supplementation on fasting blood sugar (FBS) and lipid profiles in individuals with type 2 diabetes mellitus (T2DM) and metabolic syndrome (MetS).Methods: A comprehensive search was conducted on the PubMed, Scopus, Cochrane Library, and Web of Science databases through December 2024 to identify randomized controlled trials (RCTs) evaluating the impact of propolis supplementation on FBS and lipid parameters. Eligible data were pooled using a random-effects model, and weighted mean differences (WMDs) were calculated as pooled effect sizes.Results: A total of 12 RCTs were included, encompassing 736 participants. Propolis supplementation significantly reduced FBS (WMD, -12.08 mg/dL; 95% confidence interval [CI], -19.13 to -5.04; P=0.001) and triglyceride (TG) levels (WMD, -25.40 mg/dL; 95% CI, -44.21 to -6.59; P=0.008) without significantly affecting the levels of total cholesterol, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol.Conclusion: These findings suggest that propolis supplementation may modestly improve glycemic control and reduce TG levels in individuals with T2DM and MetS. However, the limited number of available studies and relatively small sample sizes highlight the need for large, high-quality RCTs to verify these findings and clarify the metabolic effects of propolis.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"15 1","pages":"45-54"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of meal sequence intervention on blood glucose response in healthy adults: a systematic review. 膳食顺序干预对健康成人血糖反应的影响：一项系统综述

Clinical nutrition research Pub Date : 2026-01-01 Epub Date: 2026-01-31 DOI: 10.7762/cnr.2025.0027

Jinmin Kim, Eun-Hee Jang, Seungmin Lee

{"title":"Effects of meal sequence intervention on blood glucose response in healthy adults: a systematic review.","authors":"Jinmin Kim, Eun-Hee Jang, Seungmin Lee","doi":"10.7762/cnr.2025.0027","DOIUrl":"10.7762/cnr.2025.0027","url":null,"abstract":"Objective: Achieving glycemic control is essential in the prevention and management of metabolic disorders, with several dietary strategies having been proposed. Meal sequence, which is defined as the order of food consumption while maintaining the overall composition and intake, may attenuate postprandial glycemic responses. This systematic review aimed to assess the effects of meal sequences on postprandial glycemic responses in healthy adults and explore its potential as a preventive strategy for glycemic control.Methods: Literature published between January 2015 and March 2025 in PubMed, Cochrane Library, Web of Science, KoreaMed, and RISS was searched using the keywords \"healthy adult,\" \"food order,\" \"meal sequence,\" and \"glucose response.\"Results: Among the 2,442 records identified, one randomized controlled trial, four randomized crossover studies, and one repeated-measures design with a total of 107 participants aged 20-36.7 years met the inclusion criteria. Most of the studies reported that consuming vegetables, fruits, or protein-rich foods before carbohydrate-rich foods reduced postprandial glucose responses and incremental area under the curve compared with mixed or carbohydrate-first meals. These effects were also noted in randomized controlled trials and randomized crossover design.Conclusion: Our findings indicate that adjusting the order of food consumption can effectively mitigate acute postprandial glucose responses in healthy individuals. Further large-scale and long-term randomized controlled trials across diverse populations and standardized protocols are warranted to strengthen the evidence base.","PeriodicalId":72617,"journal":{"name":"Clinical nutrition research","volume":"15 1","pages":"55-63"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13007804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0