ADMET and DMPK最新文献

{"title":"Anti-inflammatory activities of flavonoid derivates.","authors":"Ysrafil Ysrafil,&nbsp;Zulfiayu Sapiun,&nbsp;Nangsih Sulastri Slamet,&nbsp;Fihrina Mohamad,&nbsp;Hartati Hartati,&nbsp;Sukmawati A Damiti,&nbsp;Francisca Diana Alexandra,&nbsp;Sudarman Rahman,&nbsp;Sri Masyeni,&nbsp;Harapan Harapan,&nbsp;Sukamto S Mamada,&nbsp;Talha Bin Emran,&nbsp;Firzan Nainu","doi":"10.5599/admet.1918","DOIUrl":"10.5599/admet.1918","url":null,"abstract":"<p><strong>Background and purpose: </strong>Flavonoids are a group of phytochemicals found abundantly in various plants. Scientific evidence has revealed that flavonoids display potential biological activities, including their ability to alleviate inflammation. This activity is closely related to their action in blocking the inflammatory cascade and inhibiting the production of pro-inflammatory factors. However, as flavonoids typically have poor bioavailability and pharmacokinetic profile, it is quite challenging to establish these compounds as a drug. Nevertheless, progressive advancements in drug delivery systems, particularly in nanotechnology, have shown promising approaches to overcome such challenges.</p><p><strong>Review approach: </strong>This narrative review provides an overview of scientific knowledge about the mechanism of action of flavonoids in the mitigation of inflammatory reaction prior to delivering a comprehensive discussion about the opportunity of the nanotechnology-based delivery system in the preparation of the flavonoid-based drug.</p><p><strong>Key results: </strong>Various studies conducted in silico, in vitro, in vivo, and clinical trials have deciphered that the anti-inflammatory activities of flavonoids are closely linked to their ability to modulate various biochemical mediators, enzymes, and signalling pathways involved in the inflammatory processes. This compound could be encapsulated in nanotechnology platforms to increase the solubility, bioavailability, and pharmacological activity of flavonoids as well as reduce the toxic effects of these compounds.</p><p><strong>Conclusion: </strong>In Summary, we conclude that flavonoids and their derivates have given promising results in their development as new anti-inflammatory drug candidates, especially if they formulate in nanoparticles.</p>","PeriodicalId":7259,"journal":{"name":"ADMET and DMPK","volume":"11 3","pages":"331-359"},"PeriodicalIF":2.5,"publicationDate":"2023-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567070/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41187990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a highly sensitive voltammetric sensor for the detection of folic acid by using MoS₂ and ionic liquid-modified carbon paste electrode.","authors":"Hadi Soltani Nejad,&nbsp;Fariba Garkani Nejad,&nbsp;Hadi Beitollahi","doi":"10.5599/admet.1823","DOIUrl":"10.5599/admet.1823","url":null,"abstract":"<p><strong>Background and purpose: </strong>Sensitive analytical determination of folic acid is important in clinical laboratories due to its versatile biological functions.</p><p><strong>Experimental approach: </strong>A simple folic acid sensor was successfully fabricated based on two-dimensional transition metal dichalcogenide MoS₂ modified carbon ionic liquid paste electrode (MoS₂-CILPE). The electrochemical properties of the fabricated electrode were investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV), and chronoamperometry.</p><p><strong>Key results: </strong>The fabricated sensor displayed excellent electroactivity towards folic acid using CV. Under optimal conditions (0.1 M PBS (pH 7.0)), the DPV oxidation peak current was proportional to folic acid concentration in the range from 5.0 μM to 100.0 μM with an estimated limit of detection of 1.0 μM and limit of quantification of 5.0 μM.</p><p><strong>Conclusion: </strong>The ability of the sensor for routine analyses was demonstrated by the detection of folic acid present in folic acid tablets and urine samples with appreciable recovery values.</p>","PeriodicalId":7259,"journal":{"name":"ADMET and DMPK","volume":"11 3","pages":"361-371"},"PeriodicalIF":2.5,"publicationDate":"2023-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41187991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dissolution-permeation of hot-melt extruded amorphous solid dispersion comprising an experimental grade of HPMCAS.","authors":"Hironori Tanaka,&nbsp;Tetsuya Miyano,&nbsp;Hiroshi Ueda","doi":"10.5599/admet.1586","DOIUrl":"10.5599/admet.1586","url":null,"abstract":"<p><strong>Background and purpose: </strong>Physicochemical properties of an amorphous solid dispersion (ASD) comprising an experimental grade of hydroxypropyl methylcellulose acetate succinate (HPMCAS-MX) with lower glass transition temperature have been previously investigated. This study aimed to evaluate applicability of HPMCAS-MX to hot-melt extrusion (HME) and dissolution-permeation performance of prepared ASDs using MicroFLUX.</p><p><strong>Review approach: </strong>A physical mixture of indomethacin (IMC) and HPMCAS-MX or -MG (a commercial grade with higher transition temperature) at 20:80 weight ratio was hot-melt extruded to prepare an ASD (IMC-MX and IMC-MG, respectively). The dissolution-permeation performance and the stability of the ASDs were measured.</p><p><strong>Key results: </strong>A torque reduction at 120 °C implied that IMC-MX transformed into an amorphous state at this temperature, but IMC-MG required around 170 °C. This result was supported by Raman mapping of the the HME samples. IMC-MG and IMC-MX remained in an amorphous state at 40 °C for three months. The initial dissolution rate and solubility of the ASDs were higher than that of crystalline IMC. The apparent permeability of IMC from IMC-MX and IMC-MG was comparable but was approximately two-fold higher than that from crystalline IMC.</p><p><strong>Conclusion: </strong>HPMCAS-MX enabled HME process at a lower temperature and improved the dissolution-permeation performance of indomethacin.</p>","PeriodicalId":7259,"journal":{"name":"ADMET and DMPK","volume":"11 3","pages":"373-385"},"PeriodicalIF":2.5,"publicationDate":"2023-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41187992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preparation of self-assembly silica redox nanoparticles to improve drug encapsulation and suppress the adverse effect of doxorubicin.","authors":"Minh-Dat Quoc Tang, Nhu-Thuy Trinh, Dung Vu, Thu-Ha Thi Nguyen, Hung Thanh Dong, Toi Van Vo, Long Binh Vong","doi":"10.5599/admet.1845","DOIUrl":"10.5599/admet.1845","url":null,"abstract":"<p><strong>Background and purpose: </strong>The utilization of doxorubicin (DOX) in clinal trials is also challenging owing to its adverse effects, including low oral bioavailability, generation of reactive oxygen species (ROS), cardiotoxicity, and epithelial barrier damage. Recently, scavenging of ROS reduced the cytotoxicity of DOX, suggesting a new approach for using DOX as an anticancer treatment. Thus, in this study, non-silica and silica redox nanoparticles (denoted as RNP^N and siRNP, respectively) with ROS scavenging features have been designed to encapsulate DOX and reduce its cytotoxicity.</p><p><strong>Experimental approach: </strong>DOX-loaded RNP^N (DOX@RNP^N) and DOX-loaded siRNP (DOX@siRNP) were prepared by co-dissolving DOX with RNP^N and siRNP, respectively. The size and stability of nanoparticles were characterized by the dynamic light scattering system. Additionally, encapsulation efficiency, loading capacity, and release profile of DOX@RNP^N and DOX@siRNP were identified by measuring the absorbance of DOX. Finally, the cytotoxicity of DOX@RNP^N and DOX@siRNP against normal murine fibroblast cells (L929), human hepatocellular carcinoma cells (HepG2), and human breast cancer cells (MCF-7) were also investigated.</p><p><strong>Key results: </strong>The obtained result showed that RNP^N exhibited a pH-sensitive character while silanol moieties improved the stability of siRNP in physiological conditions. DOX@RNP^N and DOX@siRNP were formed at several tens of nanometers in diameter with narrow distribution. Moreover, DOX@siRNP stabilized under different pH buffers, especially gastric pH, and improved encapsulation of DOX owing to the addition of silanol groups. DOX@RNP^N and DOX@siRNP maintained anticancer activity of DOX against HepG2, and MCF-7 cells, while their cytotoxicity on L929 cells was significantly reduced compared to free DOX treatment.</p><p><strong>Conclusion: </strong>DOX@RNP^N and DOX@siRNP could effectively suppress the adverse effect of DOX, suggesting the potential to become promising nanomedicines for cancer treatments.</p>","PeriodicalId":7259,"journal":{"name":"ADMET and DMPK","volume":"1 1","pages":"551-560"},"PeriodicalIF":2.5,"publicationDate":"2023-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10626516/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41797602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green synthesis, characterization and biological activities of silver nanoparticles synthesized from Neolamarkia cadamba","authors":"Maheswari Juluri, Reshma Anjum Mohammed, S. Mohan, Narasimha Golla, S. Krishna, Kishori Battini","doi":"10.5599/admet.1793","DOIUrl":"https://doi.org/10.5599/admet.1793","url":null,"abstract":"Background and purpose: Metal nanoparticles are essential due to their unique catalytic, electrical, magnetic, and optical characteristics, as well as their prospective use in sensing, catalysis, and biological research. In recent years, researchers have focused on developing cost-effective and eco-friendly biogenic practices using the green synthesis of metal nanoparticles (AgNP). Experimental approach: In the present study, the aqueous extracts prepared from the leaf, stem, bark, and flower of Neolamarkia cadamba were used for the synthesis of silver nanoparticles. Synthesized silver nanoparticles were characterized using UV-Visible spectroscopy, zeta potential, dynamic light scattering, scanning electron microscope (SEM), and EDAX. Key results: The current study showed absorption of synthesized AgNPs at 425, 423, 410, and 400 nm. Dynamic light scattering of AgNPs Showed size distribution of AgNPs synthesized from leaf, stem, and flower aqueous extracts ranges from 80-200 nm and AgNPs prepared from bark extract ranges from 100-700 nm. Zeta-potential of the biosynthesized AgNPs was found as a sharp peak at -23.1 mV for the leaf, -27.0 mV for the stem, -34.1 mV for the bark, and -20.2 mV for the flower. Silver nanoparticles and crude extracts of Neolamarkia cadamba showed effective antibacterial, antifungal, and antioxidant activities. Conclusion: Silver nanoparticles have substantial antibacterial activity against Gram-positive bacteria and also exhibit the utmost antifungal activity against Aspergillus niger. The study concludes that the green synthesis of silver nanoparticles from N. cadamba leaf, stem, bark, and flower extract is a reliable and eco-friendly technique.","PeriodicalId":7259,"journal":{"name":"ADMET and DMPK","volume":" ","pages":""},"PeriodicalIF":2.5,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45439831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anomalous salting-out, self-association and p<i>K</i>_a effects in the practically-insoluble bromothymol blue.","authors":"Alex Avdeef","doi":"10.5599/admet.1822","DOIUrl":"10.5599/admet.1822","url":null,"abstract":"<p><strong>Background and purpose: </strong>The widely-used and practically insoluble diprotic acidic dye, bromothymol blue (BTB), is a neutral molecule in strongly acidic aqueous solutions. The Schill (1964) extensive solubility-pH measurement of bromothymol blue in 0.1 and 1.0 M NaCl solutions, with pH adjusted with HCl from 0.0 to 5.4, featured several unusual findings. The data suggest that the difference in solubility of the neutral-form molecule in 1M NaCl is more than 0.7 log unit lower than the solubility in pure water. This could be considered as uncharacteristically high for a salting-out effect. Also, the study reported two apparent values of p<i>K</i>_a1, 1.48 and 1.00, in 0.1 M and 1.0 M NaCl solutions, respectively. The only other measured value found for pK_a1 in the literature is -0.66 (Gupta and Cadwallader, 1968).</p><p><strong>Experimental approach: </strong>It was reasoned that the there can be only a single p<i>K</i>_a1 for BTB. Also, it was hypothesized that salting-out alone might not account for such a large difference in solubility observed at the two levels of salt. A generalized mass action approach incorporating activity corrections for charged species using the Stokes-Robinson hydration equation and for neutral species using the Setschenow equation, was selected to analyze the Schill solubility-pH data to seek a rationalization of these unusual results.</p><p><strong>Key results: </strong>BTB reveals complex speciation chemistry in saturated aqueous solutions which had been poorly understood for many years. The appearance of two different values of pK_a1 at different levels of NaCl and the anomalously high value of the empirical salting-out constant could be rationalized to normal values by invoking the formation of a very stable neutral dimer (log <i>K</i>₂ = 10.0 ± 0.1 M^-1). A 'normal' salting-out constant, 0.25 M^-1 was then derived. It was also possible to estimate the 'self-interaction' constant. The data analysis in the present study critically depended on the p<i>K</i>_a1 = -0.66 reported by Gupta and Cadwallader.</p><p><strong>Conclusion: </strong>A more reasonable salting-out constant and a consistent single value for p<i>K</i>_a1 have been determined by considering a self-interacting (aggregation) model involving an uncharged form of the molecule, which is likely a zwitterion, as suggested by literature spectrophotometric studies.</p>","PeriodicalId":7259,"journal":{"name":"ADMET and DMPK","volume":"11 3","pages":"419-432"},"PeriodicalIF":2.5,"publicationDate":"2023-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10567066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41187989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent advances in electrochemical determination of anticancer drug 5-fluorouracil.","authors":"Totka Dodevska, Dobrin Hadzhiev, Ivan Shterev","doi":"10.5599/admet.1711","DOIUrl":"10.5599/admet.1711","url":null,"abstract":"<p><p>Reliable, rapid, highly selective and sensitive analytical methods for the determination of antineoplastic agent 5-fluorouracil (5-FU) in human body fluids (blood serum/plasma and urine) are required to improve the chemotherapy regimen to reduce its toxicity and improve efficacy. Nowadays, electrochemical techniques provide a powerful analytical tool for 5-FU detection systems. This comprehensive review covers the advances in the development of electrochemical sensors for the quantitative determination of 5-FU, mainly focused on original studies reported from 2015 to date. We have summarized recent trends in the electrochemical sensor systems applied for the analysis of 5-FU in pharmaceutical formulations and biological samples, and critically evaluated the key performance metrics of these sensors (limit of detection, linear range, stability and recovery). Challenges and future outlooks in this field have also been discussed.</p>","PeriodicalId":7259,"journal":{"name":"ADMET and DMPK","volume":"11 2","pages":"135-150"},"PeriodicalIF":3.4,"publicationDate":"2023-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262222/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10029919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An electrochemical sensing platform based on a modified carbon paste electrode with graphene/Co₃O₄ nanocomposite for sensitive propranolol determination.","authors":"Parisa Karami-Kolmoti, Reza Zaimbashi","doi":"10.5599/admet.1705","DOIUrl":"10.5599/admet.1705","url":null,"abstract":"<p><p>A simple and sensitive method for the determination of propranolol using a modified carbon paste electrode with graphene/Co₃O₄ nanocomposite was presented. The electrochemical measurements of propranolol are studied using differential pulse voltammetry, cyclic voltammetry and chronoamperometry. The graphene/Co₃O₄ nanocomposite exhibits excellent catalytic activity towards the electrochemical oxidation of propranolol in phosphate buffer solution of pH 7.0. The graphene/Co₃O₄ nanocomposite facilitates the determination of propranolol in the concentration range 1.0-300.0 μM and a detection limit and sensitivity of 0.3 μM. and 0.1275 μA/μM were achieved.</p>","PeriodicalId":7259,"journal":{"name":"ADMET and DMPK","volume":"11 2","pages":"227-236"},"PeriodicalIF":3.4,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262224/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10029922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Voltammetric determination of hydrochlorothiazide at a modified carbon paste electrode with polypyrrole nanotubes.","authors":"Arefeh Mohammadnavaz,&nbsp;Fariba Garkani-Nejad","doi":"10.5599/admet.1706","DOIUrl":"10.5599/admet.1706","url":null,"abstract":"<p><p>In this paper, the electrochemical behavior of hydrochlorothiazide (HCTZ) is described using carbon paste electrodes modified with polypyrrole nanotubes (PPy-NTs/CPEs) at pH value 7. Experiments revealed that the presence of HCTZ greatly impacts the electrochemical behavior of modified CPEs. The synthesized PPy-NTs were utilized as a sensing material for the electrochemical detection of HCTZ and were investigated by cyclic voltammetry (CV), differential pulse voltammetry (DPV) and chronoamperometry. The key experiment conditions, including supporting electrolyte and electrolyte pH, were studied and optimized. Under optimized conditions, the prepared sensor displayed the linear relationships for the concentrations of HCTZ from 5.0 to 400.0 μM (R² = 0.9984). The detection limit of the PPy-NTs/CPEs sensor was found to be 1.5 μM using the DPV method. The PPy-NTs is highly selective, stable and sensitive for the determination of HCT. Therefore, we believe the newly prepared PPy-NTs material can be useful for different electrochemical applications.</p>","PeriodicalId":7259,"journal":{"name":"ADMET and DMPK","volume":"11 2","pages":"293-302"},"PeriodicalIF":2.5,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262231/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10029920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The optimization of electrochemical immunosensors to detect epithelial sodium channel as a biomarker of hypertension.","authors":"Tias F H Lestari,&nbsp;Riyanto Setiyono,&nbsp;Nina Tristina,&nbsp;Yulia Sofiatin,&nbsp;Yeni Wahyuni Hartati","doi":"10.5599/admet.1629","DOIUrl":"10.5599/admet.1629","url":null,"abstract":"<p><p>The epithelial sodium channel (ENaC) is a transmembrane protein that regulates the balance of sodium salt levels in the body through its expression in various tissues. The increase in sodium salt in the body is related to the expression of ENaC, thereby increasing blood pressure. Therefore, overexpression of the ENaC protein can be used as a biomarker for hypertension. The detection of ENaC protein using anti-ENaC in the biosensor system has been optimized with the Box-Behnken experimental design. The steps carried out in this research are screen-printed carbon electrode modification with gold nanoparticles, then anti-ENaC was immobilized using cysteamine and glutaraldehyde. Optimum conditions of the experiment, such as anti-ENaC concentration, glutaraldehyde incubation time, and anti-ENaC incubation time, were optimized using the Box-Behnken experimental design to determine the factors that influence the increase in immunosensor current response and the optimum conditions obtained were then applied to variations in ENaC protein concentrations. The optimum experimental conditions for anti-ENaC concentration were 2.5 μg/mL, the glutaraldehyde incubation time was 30 minutes, and the anti-ENaC incubation time was 90 minutes. The developed electrochemical immunosensor has a detection limit of 0.0372 ng/mL and a quantification limit of 0.124 ng/mL for the ENaC protein concentration range of 0.09375 to 1.0 ng/mL. Thus, the immunosensor generated from this study can be used to measure the concentration of normal urine samples and those of patients with hypertension.</p>","PeriodicalId":7259,"journal":{"name":"ADMET and DMPK","volume":"11 2","pages":"211-226"},"PeriodicalIF":2.5,"publicationDate":"2023-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262218/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9656517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}