ADMET and DMPK最新文献

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Recent advances in nanomaterials-based electrochemical sensors for tramadol analysis. 基于纳米材料的曲马多电化学传感器研究进展。
IF 2.5
ADMET and DMPK Pub Date : 2023-01-01 DOI: 10.5599/admet.1593
Farideh Mousazadeh, Yar-Mohammad Baghelani, Shamsi Rahimi
{"title":"Recent advances in nanomaterials-based electrochemical sensors for tramadol analysis.","authors":"Farideh Mousazadeh,&nbsp;Yar-Mohammad Baghelani,&nbsp;Shamsi Rahimi","doi":"10.5599/admet.1593","DOIUrl":"https://doi.org/10.5599/admet.1593","url":null,"abstract":"<p><p>Tramadol is a centrally-acting analgesic used for treating moderate to severe acute and chronic pain. Pain is an unpleasant sensation that occurs most commonly as a result of tissue injury. Tramadol possesses agonist actions at the μ-opioid receptor and effects reuptake at the noradrenergic and serotonergic systems. In the last years, several analytical procedures have been published in the literature for the determination of tramadol from pharmaceutical formulations and biological matrices. Electrochemical methods have attracted tremendous attention for the quantification of this drug owing to their demonstrated potential for quick response, real-time measurements, elevated selectivity and sensitivity. In this review, we highlighted the recent advances and applications of nanomaterials-based electrochemical sensors for the analysis and detection of tramadol, which is extremely important for the indication of effective diagnoses and for quality control analyses in order to protect human health. Also, the main challenges in developing nanomaterials-based electrochemical sensors for the determination of tramadol will be discussed. At last, this review offers prospects for the future research and development needed for modified electrode sensing technology for the detection of tramadol.</p>","PeriodicalId":7259,"journal":{"name":"ADMET and DMPK","volume":"11 2","pages":"117-134"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9656513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and biological evaluation of coumarin-quinone hybrids as multifunctional bioactive agents. 香豆素-醌类多功能生物活性化合物的合成及生物学评价。
IF 2.5
ADMET and DMPK Pub Date : 2023-01-01 DOI: 10.5599/admet.1468
Anees Pangal, Khursheed Ahmed
{"title":"Synthesis and biological evaluation of coumarin-quinone hybrids as multifunctional bioactive agents.","authors":"Anees Pangal,&nbsp;Khursheed Ahmed","doi":"10.5599/admet.1468","DOIUrl":"https://doi.org/10.5599/admet.1468","url":null,"abstract":"<p><p>We report the synthesis, structural characterization and pharmaceutical activity of four coumarin-quinone hybrids. The compounds were significantly active against <i>Staphylococcus aureus</i>, <i>Pseudomonas aeoginosa</i> and <i>Candida albicans</i>. Promising antioxidant activity was observed when compared to ascorbic acid. Two compounds, DTBSB and DTBSN, also showed commendable <i>in vitro</i> antiproliferative activities against the cells of human cancer cell lines MCF-7, MDA-MB-231, COLO-205, HT-29 and A549 along with appreciable tumor selectivity with distinct selectivity index. Molecular docking studies using cyclooxygenase-2 (PDB ID: 6COX) revealed strong binding affinities for the COX-2 active site. Moreover, ADMET properties of the synthesized compounds were determined using the pKCSM and SwissADME online tools and all the compounds had accurate pharmacokinetic profiles. Hence, the new coumarin-quinone hybrids DTBSB and DTBSN can be considered for optimization and lead development.</p>","PeriodicalId":7259,"journal":{"name":"ADMET and DMPK","volume":"11 1","pages":"81-96"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9260631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determination of salicylic acid content in pharmaceuticals using chitosan@Fe3O4/CPE electrode detected by SWV technique. SWV技术检测chitosan@Fe3O4/CPE电极测定药品中水杨酸含量。
IF 2.5
ADMET and DMPK Pub Date : 2023-01-01 DOI: 10.5599/admet.1682
Sudarut Pitakrut, Phetlada Sanchayanukun, Sasithorn Muncharoen
{"title":"Determination of salicylic acid content in pharmaceuticals using chitosan@Fe<sub>3</sub>O<sub>4</sub>/CPE electrode detected by SWV technique.","authors":"Sudarut Pitakrut,&nbsp;Phetlada Sanchayanukun,&nbsp;Sasithorn Muncharoen","doi":"10.5599/admet.1682","DOIUrl":"https://doi.org/10.5599/admet.1682","url":null,"abstract":"<p><p>Chitosan-coated magnetite nanoparticles (Chitosan@Fe<sub>3</sub>O<sub>4</sub>) were used to modify the carbon paste electrode (Chitosan@Fe<sub>3</sub>O<sub>4</sub>/CPE) to enhance sensitivity for salicylic acid (SA) analysis using square wave voltammetry (SWV). The performance and behaviour of the purposed electrodes were investigated using cyclic voltammetry (CV). The results showed that the mixed behaviour process was observed. Furthermore, parameters affecting SWV were also studied. It was discovered that the optimum conditions were a two-linearity range of SA determination, 1-100 and 100-400 μM. The limit of detection (LOD) and the limit of quantitation (LOQ) for SA are 0.57 μM and 0.90 μM, respectively. The proposed electrodes were successfully used to determine SA in applications employing pharmaceutical samples.</p>","PeriodicalId":7259,"journal":{"name":"ADMET and DMPK","volume":"11 2","pages":"175-184"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10029921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Voltammetric determination of vitamin B6 in the presence of vitamin C based on zinc ferrite nano-particles modified screen-printed graphite electrode. 铁酸锌纳米颗粒修饰网印石墨电极伏安法测定维生素B6。
IF 2.5
ADMET and DMPK Pub Date : 2023-01-01 DOI: 10.5599/admet.1702
Peyman Mohammadzadeh Jahani, Maedeh Jafari, Sayed Ali Ahmadi
{"title":"Voltammetric determination of vitamin B6 in the presence of vitamin C based on zinc ferrite nano-particles modified screen-printed graphite electrode.","authors":"Peyman Mohammadzadeh Jahani,&nbsp;Maedeh Jafari,&nbsp;Sayed Ali Ahmadi","doi":"10.5599/admet.1702","DOIUrl":"https://doi.org/10.5599/admet.1702","url":null,"abstract":"<p><p>The zinc ferrite nano-particles (ZnFe<sub>2</sub>O<sub>4</sub>) modified screen-printed graphite electrode (ZnFe<sub>2</sub>O<sub>4</sub>/SPGE) was used for the voltammetric determination of vitamin B<sub>6</sub> in real samples, using differential pulse voltammetry (DPV). It has been found that the oxidation of vitamin B<sub>6</sub> at the surface of such an electrode occurs at a potential about 150 mV less positive compared to an unmodified screen-printed graphite electrode. After optimization, a vitamin B6 sensor with a linear range from 0.8 to 585.0 μM and a detection limit of 0.17 μM. The ZnFe<sub>2</sub>O<sub>4</sub>/SPGE sensor exhibits good resolution between the voltammetric peaks of vitamin B<sub>6</sub> and vitamin C, making it suitable for detecting vitamin B<sub>6</sub> in the presence of vitamin C in real samples.</p>","PeriodicalId":7259,"journal":{"name":"ADMET and DMPK","volume":"11 2","pages":"251-261"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10029923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Use of Azospirillum baldaniorum cells in quercetin detection. 氮螺旋菌细胞在槲皮素检测中的应用。
IF 2.5
ADMET and DMPK Pub Date : 2023-01-01 DOI: 10.5599/admet.1661
Matvey V Kanevskiy, Irina S Kosheleva, Vladislav O Menukhov, Elizaveta S Zhdanova, Svetlana V Borisova, Gennady L Burygin, Svetlana A Konnova, Victor D Bunin, Olga I Guliy
{"title":"Use of <i>Azospirillum baldaniorum</i> cells in quercetin detection.","authors":"Matvey V Kanevskiy,&nbsp;Irina S Kosheleva,&nbsp;Vladislav O Menukhov,&nbsp;Elizaveta S Zhdanova,&nbsp;Svetlana V Borisova,&nbsp;Gennady L Burygin,&nbsp;Svetlana A Konnova,&nbsp;Victor D Bunin,&nbsp;Olga I Guliy","doi":"10.5599/admet.1661","DOIUrl":"https://doi.org/10.5599/admet.1661","url":null,"abstract":"<p><p>The possibility of detection and determination of flavonoids by using microbial cells was shown for the first time using the quercetin - <i>Azospirillum baldaniorum</i> Sp245 model system. The activity of the flavonoids quercetin, rutin and naringenin toward <i>A. baldaniorum</i> Sp245 was evaluated. It was found that when the quercetin concentration ranged from 50 to 100 μM, the number of bacterial cells decreased. Rutin and naringenin did not affect bacterial numbers. Quercetin at 100 μM increased bacterial impedance by 60 %. Under the effect of quercetin, the magnitude of the electro-optical signal from cells decreased by 75 %, as compared with the no-quercetin control. Our data show the possibility of developing sensor-based systems for the detection and determination of flavonoids.</p>","PeriodicalId":7259,"journal":{"name":"ADMET and DMPK","volume":"11 2","pages":"277-291"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262226/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10012558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electronic tongue for determining the limit of detection of human pathogenic bacteria. 测定人类致病菌检出限的电子舌。
IF 2.5
ADMET and DMPK Pub Date : 2023-01-01 DOI: 10.5599/admet.1650
Aya Abu Rumaila, Basima Abu Rumaila, Wafa Masoud, Antonio Ruiz-Canales, Nawaf Abu-Khalaf
{"title":"Electronic tongue for determining the limit of detection of human pathogenic bacteria.","authors":"Aya Abu Rumaila,&nbsp;Basima Abu Rumaila,&nbsp;Wafa Masoud,&nbsp;Antonio Ruiz-Canales,&nbsp;Nawaf Abu-Khalaf","doi":"10.5599/admet.1650","DOIUrl":"https://doi.org/10.5599/admet.1650","url":null,"abstract":"<p><p>The Electronic tongue (ET) has been used as a diagnostic technique in the medical sector. It is composed of a multisensor array set with high cross-sensitivity and low selectivity characteristics. The research investigated using Astree II Alpha MOS ET to determine the limit of early detection and diagnosis of food-borne human pathogenic bacteria and to recognize unknown bacterial samples relying on pre-stored models. <i>Staphylococcus aureus</i> (ATCC 25923) and <i>Escherichia coli</i> (ATCC25922) were proliferated in nutrient broth (NB) medium with original inoculum (approximately 107*10<sup>5</sup> CFU/mL). They were diluted up to 10<sup>-14</sup> and the dilutions ranging from 10<sup>-14</sup> to 10<sup>-4</sup> were measured using ET. The partial least square (PLS) regression model detected the limit of detection (LOD) of the concentration that was monitored to grow the bacteria with different incubation periods (from 4 to 24 h). The measured data were analysed by principal component analysis (PCA) and followed by projecting unknown bacterial samples (at specific concentrations and time of incubation) to examine the recognition ability of the ET. Astree II ET was able to track bacterial proliferation and metabolic changes in the media at very low concentrations (between the dilutions 10<sup>-11</sup> and 10<sup>-10</sup> for both bacteria). <i>S.aureus</i> was detected after 6 h incubation period and between 6 and 8 h for <i>E.coli</i>. After creating the strains' models, ET was also able to classify unknown samples according to their foot-printing characteristics in the media (<i>S.aureus</i>, <i>E.coli</i> or neither of them). The results considered ET a powerful potentiometric tool for the early identification of food-borne microorganisms in their native state within a complex system to save patients' lives.</p>","PeriodicalId":7259,"journal":{"name":"ADMET and DMPK","volume":"11 2","pages":"237-250"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262229/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10029916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Electrochemical sensor for determination of butylated hydroxyanisole in real samples using glassy carbon electrode modified by [Co(HL)2Cl2] nano-complex. 用[Co(HL)2Cl2]纳米配合物修饰的玻碳电极电化学传感器测定样品中丁基化羟基茴香醚。
IF 2.5
ADMET and DMPK Pub Date : 2023-01-01 DOI: 10.5599/admet.1703
Mahbubeh Fazli, Niloufar Akbarzadeh-T
{"title":"Electrochemical sensor for determination of butylated hydroxyanisole in real samples using glassy carbon electrode modified by [Co(HL)2Cl2] nano-complex.","authors":"Mahbubeh Fazli,&nbsp;Niloufar Akbarzadeh-T","doi":"10.5599/admet.1703","DOIUrl":"https://doi.org/10.5599/admet.1703","url":null,"abstract":"<p><p>A new mononuclear Co(II) complex with the formula [Co(HL)2Cl2] (<b>1</b>) (HL= N-(2-hydroxy-1-naphthylidene)-2-methyl aniline) has been synthesized and characterized by Fourier transform infrared spectroscopy, UV-Vis, elemental analysis and single crystal X-ray structure analysis. Single crystals of the complex [Co(HL)2Cl2] (<b>1</b>) were obtained through slow evaporation of an acetonitrile solution at room temperature. The crystal structure analysis revealed that the two Schiff base ligands create a tetrahedral geometry via oxygen atoms and two chloride atoms. The nano-size of [Co(HL)2Cl2] (<b>2</b>) have been synthesized by the sonochemical process. Characterization of nanoparticles (<b>2</b>) was carried out via X-ray powder diffraction (XRD), scanning electron microscopy (SEM), UV-Vis, and FT-IR spectroscopy. The average sample size synthesized via the sonochemical method was approximately 56 nm. In this work, a simple sensor based on a glassy carbon electrode modified with [Co(HL)2Cl2] nano-complex was developed ([Co(HL)2Cl2] nano-complex/GCE) for convenient and fast electrochemical detection of butylated hydroxyanisole (BHA). The modified electrode offers considerably improved voltammetric sensitivity toward BHA compared to the bare electrode. Applying linear differential pulse voltammetry, a good linear relationship of the oxidation peak current with respect to concentrations of BHA across the range of 0.5-150 μM and a detection limit of 0.12 μM was achieved. The [Co(HL)2Cl2] nano-complex/GCE sensor was applied to the determination of BHA in real samples successfully.</p>","PeriodicalId":7259,"journal":{"name":"ADMET and DMPK","volume":"11 2","pages":"185-199"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10262221/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10029917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges, current status and emerging strategies in the development of rapidly dissolving FDM 3D-printed tablets: An overview and commentary. 快速溶解FDM 3d打印片剂发展的挑战、现状和新兴策略:概述和评论。
IF 2.5
ADMET and DMPK Pub Date : 2023-01-01 DOI: 10.5599/admet.1622
Abu T M Serajuddin
{"title":"Challenges, current status and emerging strategies in the development of rapidly dissolving FDM 3D-printed tablets: An overview and commentary.","authors":"Abu T M Serajuddin","doi":"10.5599/admet.1622","DOIUrl":"https://doi.org/10.5599/admet.1622","url":null,"abstract":"<p><p>Since the approval of a 3D-printed tablet by the FDA in 2015 for marketing, there has been a great interest in 3D printing in the pharmaceutical field for the development of personalized and on-demand medications. Among various 3D printing methods explored for the development of oral solid dosage form like tablet, the fused deposition modeling (FDM) 3D-printing, where the drug-polymer mixtures are first converted into filaments by hot melt extrusion (HME) and then the filaments are printed into tablets using 3D printers by applying computer-aided design principles, has emerged as the most attractive option. However, no FDM 3D-printed tablets have yet been marketed as the technology faces many challenges, such as limited availability of pharmaceutical-grade polymers that can be printed into tablets, low drug-polymer miscibility, the need for high temperature for HME and 3D-printing, and slow drug release rates from tablets. These challenges are discussed in this article with a special focus on drug release rates since FDM 3D-printing usually leads to the preparation of slow-release tablets while the rapid release from dosage forms is often desired for optimal therapeutic outcomes of new drug candidates. Pros and cons of various strategies for the development of rapidly dissolving FDM 3D-printed tablets reported in the literature are reviewed. Finally, two case studies on emerging strategies for the development of rapidly dissolving FDM 3D-printed tablets are presented, where one outlines a systematic approach for formulating rapidly dissolving tablets, and the other describes a novel strategy to increase dissolution rates of drugs from FDM 3D-printed tablets, which at the same time can also increase drug-polymer miscibility and printability of tablets and lower processing temperatures. Thus, this overview and commentary discusses various issues involving the formulation of rapidly dissolving FDM 3D-printed tablets and provides guidance for the development of commercially viable products.</p>","PeriodicalId":7259,"journal":{"name":"ADMET and DMPK","volume":"11 1","pages":"33-55"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9260632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Pharmaceutical and pharmacokinetic evaluation of a newly formulated multiparticulate matrix of levodopa and carbidopa. 新配制的左旋多巴和卡比多巴多颗粒基质的药理学和药代动力学评价。
IF 2.5
ADMET and DMPK Pub Date : 2023-01-01 DOI: 10.5599/admet.1474
Emelia Priscilla Imbeah, Ofosua Adi-Dako, Benoit Banga N'guessan, Kennedy Kwami Edem Kukuia, Benedicta Obenewaa Dankyi, Ismaila Adams, Ebenezer Ofori-Attah, Regina Appiah-Opong, Seth Kwabena Amponsah
{"title":"Pharmaceutical and pharmacokinetic evaluation of a newly formulated multiparticulate matrix of levodopa and carbidopa.","authors":"Emelia Priscilla Imbeah,&nbsp;Ofosua Adi-Dako,&nbsp;Benoit Banga N'guessan,&nbsp;Kennedy Kwami Edem Kukuia,&nbsp;Benedicta Obenewaa Dankyi,&nbsp;Ismaila Adams,&nbsp;Ebenezer Ofori-Attah,&nbsp;Regina Appiah-Opong,&nbsp;Seth Kwabena Amponsah","doi":"10.5599/admet.1474","DOIUrl":"https://doi.org/10.5599/admet.1474","url":null,"abstract":"<p><p>Levodopa is routinely co-administered with carbidopa in the management of Parkinson's disease. Although the aforementioned combination therapy is effective, there may be fluctuating plasma levels of levodopa after oral administration. We formulated and evaluated the kinetic characteristics of the chitosan-pectin-based multiparticulate matrix of levodopa and carbidopa. Pectin was extracted from the cocoa husk, and the chitosan-pectin-based matrix was prepared by wet granulation. Formulations were evaluated for drug-excipient compatibility, drug content, precompression properties and in vitro release. For pharmacokinetic evaluation, rats were put into groups and administered either chitosan-pectin based matrix of levodopa/carbidopa, Sinemet<sup>®</sup> CR or levodopa/carbidopa immediate release powder. Rats were administered the different formulations of levodopa/carbidopa (20/5 mg/kg) per os every 12 hours. The pharmacokinetic parameters of levodopa were estimated for the various treatment groups. The percentage content of levodopa and carbidopa in the various formulations was within the acceptance criteria. The AUC<sub>0-24</sub> for levodopa/carbidopa multiparticulate matrix (Formulation 3: 484.98 ± 18.70 μg.hr/mL); Formulation 4: 535.60 ± 33.04 μg.hr/mL), and C<sub>max</sub> (Formulation 3: 36.28 ± 1.52 μg/mL; Formulation 4: 34.80 ± 2.19 μg/mL) were higher than Sinemet<sup>®</sup> CR (AUC<sub>0-24</sub> 262.84 ± 16.73 μg.hr/mL and C<sub>max</sub> 30.62 ± 3.37 μg/mL). The <i>t</i> <sub>1/2</sub> of the new formulation was longer compared to Sinemet<sup>®</sup> CR.</p>","PeriodicalId":7259,"journal":{"name":"ADMET and DMPK","volume":"11 1","pages":"97-115"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9260633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of in vitro two-dimensional (2D) and three-dimensional (3D) cell culture systems for ADME-Tox screening in drug discovery and development: a comprehensive review. 体外二维(2D)和三维(3D)细胞培养系统用于ADME-Tox筛选在药物发现和开发中的作用:全面回顾。
IF 2.5
ADMET and DMPK Pub Date : 2023-01-01 DOI: 10.5599/admet.1513
Venkatesh Chunduri, Srinivas Maddi
{"title":"Role of in vitro two-dimensional (2D) and three-dimensional (3D) cell culture systems for ADME-Tox screening in drug discovery and development: a comprehensive review.","authors":"Venkatesh Chunduri,&nbsp;Srinivas Maddi","doi":"10.5599/admet.1513","DOIUrl":"https://doi.org/10.5599/admet.1513","url":null,"abstract":"<p><p>Drug discovery and development have become a very time-consuming and expensive process. Preclinical animal models have become the gold standard for studying drug pharmacokinetic and toxicity parameters. However, the involvement of a huge number of animal subjects and inter-species pathophysiological variations between animals and humans has provoked a lot of debate, particularly because of ethical concerns. Although many efforts are being established by biotech and pharmaceutical companies for screening new chemical entities <i>in vitro</i> before preclinical trials, failures during clinical trials are still involved. Currently, a large number of two- dimensional (2D) in vitro assays have been developed and are being developed by researchers for the screening of compounds. Although these assays are helpful in screening a huge library of compounds and have shown perception, there is a significant lack in predicting human Absorption, Distribution, Metabolism, Excretion and Toxicology (ADME-Tox). As a result, these assays cannot completely replace animal models. The recent inventions in three-dimensional (3D) cell culture-based assays like organoids and micro-physiological systems have shown great potential alternative tools for predicting the compound pharmacokinetic and pharmacodynamic fate in humans. In this comprehensive review, we have summarized some of the most commonly used 2D in vitro assays and emphasized the achievements in next-generation 3D cell culture-based systems for predicting the compound ADME-Tox.</p>","PeriodicalId":7259,"journal":{"name":"ADMET and DMPK","volume":"11 1","pages":"1-32"},"PeriodicalIF":2.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9909725/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9260636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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