Acupuncture in Medicine最新文献

{"title":"Electroacupuncture alleviates acute myocardial ischemic injury in mice by regulating the β₁ adrenergic receptor and post-receptor protein kinase A signaling pathway.","authors":"Haiyan Zuo, Qiaoyu Qu, Yan Tong, Lei Wang, Xiaoxiao Wang, Shengbing Wu, Meiqi Zhou","doi":"10.1177/09645284241298716","DOIUrl":"10.1177/09645284241298716","url":null,"abstract":"<p><strong>Objective: </strong>To determine the effect of electroacupuncture (EA) on β₁-adrenergic receptor (β₁-AR) and post-receptor protein kinase A (PKA) signaling pathway after acute myocardial ischemia (MI).</p><p><strong>Methods: </strong>An MI model was established by ligating the left anterior descending coronary artery of wild-type (WT) C57/BL and β₁-AR^+/- mice (heterozygous for β₁-AR gene deletion). EA treatment was administered at HT5-HT7 or LU9-LU8. We evaluated cardiac function by measuring ST segment displacement, ischemic area and serum levels of creatine kinase (CK)-MB and lactate dehydrogenase (LDH). Pathological morphology/apoptosis of myocardial tissue were examined using hematoxylin-eosin and terminal deoxynucleotidyl transferase dUTP nick end labeling staining. Norepinephrine (NE) levels in myocardial tissue were detected by ELISA. Levels of β₁ and post-receptor PKA signaling components were evaluated by quantitative reverse transcription polymerase chain reaction (qRT-PCR) and Western blotting.</p><p><strong>Results: </strong>EA stimulation at HT7-HT5 could better regulate the level of β₁-AR in myocardial tissue than that at LU9-LU8. Following EA, the ST segment, serum CK-MB/ LDH and area of myocardial infarction were decreased in WT mice, and the degree of myocardial pathology/apoptosis and expression of cleaved caspase-3 were decreased. Myocardial levels of Gs protein (Gs), adenylate cyclase (AC), cyclic adenosine monophosphate (cAMP), phosphorylated protein kinase A (p-PKA), L-type voltage-gated calcium channel α1C (Cav1.2), serine phosphate 16-phospholamban (p-PLB^s16) and sarcoplasmic reticulum Ca²⁺-adenosine triphosphate (ATP)ase 2a (SERCA2a) increased after EA. However, these effects of EA were not replicated in β₁-AR^+/- mice. Interestingly, myocardial NE content decreased after EA in WT and β₁-AR^+/- mice.</p><p><strong>Conclusion: </strong>EA may enhance cardiac function and reduced MI area/apoptosis by restoring the activity of β₁-AR and post-receptor PKA signaling.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"342-355"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11633077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture in the treatment of cocaine addiction: how does it work?","authors":"Luqiang Sun, Haichuan Wang","doi":"10.1177/09645284241248473","DOIUrl":"10.1177/09645284241248473","url":null,"abstract":"<p><p>Cocaine is a frequently abused and highly addictive drug that damages brain health and imposes substantial social and economic costs. Acupuncture has been used in the treatment of cocaine addiction and has been shown to improve abnormal mental and motor states. This article mainly focuses on the neurobiological mechanisms involving the central nervous system (CNS) and peripheral nervous system (PNS) that underlie the effects of acupuncture in the treatment of cocaine addiction. The central dopamine system is a key player in acupuncture treatment of cocaine addiction; the ventral tegmental area (VTA)-nucleus accumbens (NAc) signaling pathway, which has a modulatory influence on behavior and psychology after chronic use of cocaine, is a significant target of acupuncture action. Moreover, acupuncture alleviates cocaine-induced seizures or acute psychomotor responses through the paraventricular thalamus and the lateral habenula (LHb)-rostromedial tegmental (RMTg) nucleus circuits. The data suggest that acupuncture can impact various cocaine-induced issues via stimulation of diverse brain areas; nevertheless, the interconnection of these brain regions and the PNS mechanisms involved remain unknown. In this review, we also discuss the effects of specific acupuncture protocols on cocaine addiction and note that variations in needling modalities, current intensities and traditional acupuncture point locations have led to different experimental results. Therefore, standardized acupuncture protocols (with respect to stimulation methods, point locations and number of sessions) may become particularly important in future studies.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"251-259"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140847295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture treatment for post-stroke hemianopia: a case report.","authors":"Xueqian Jia, Fu Xu, Erhui Yu, Yihui Liu, Rong Wang, Gongyue Zhou","doi":"10.1177/09645284241277211","DOIUrl":"10.1177/09645284241277211","url":null,"abstract":"","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"295-297"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142152969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture ameliorates senile osteoporosis by promoting bone remodeling and regulating autophagy.","authors":"Jing Liu, Jun Zhou, Jinlin Wang, Xiarong Huang, Mengjian Qu, Ying Liao, Guanghua Sun, Peirui Zhong, Jinqu Tan, Zhilu Sun","doi":"10.1177/09645284241265872","DOIUrl":"10.1177/09645284241265872","url":null,"abstract":"<p><strong>Objectives: </strong>Osteoporosis is widely regarded as a typical aged-related disease caused by impaired bone remodeling. This research was designed to explore the protective effects of electroacupuncture (EA) on senile osteoporosis in a rat model and investigate the underlying mechanisms.</p><p><strong>Methods: </strong>Three-month-old rats were randomly selected as the youth group, and 24-month-old rats were randomly assigned to the elderly and EA groups. Rats in the EA group received 30 min of EA at bilateral SP10, ST36, K13 and GB34 daily, 5 days a week for 8 weeks. Bone mineral density (BMD), microstructure of the bone tissue, bone turnover biomarkers and expression level of autophagy-related proteins were detected.</p><p><strong>Results: </strong>Compared with the elderly group, EA treatment significantly increased BMD of the femur and ameliorated the microstructure. EA treatment increased trabecular bone volume ratio (= bone volume / total volume [BV/TV]) and trabecular number (Tb.N) and decreased trabecular separation (Tb.Sp) in senile osteoporosis rats. Compared with the elderly group, the serum N-terminal telopeptide of type I collagen (NTX1) level in the EA group was lower, and the serum procollagen type I N-terminal propeptide (PINP) concentration was higher. In addition, the expression of Beclin 1, microtubule-associated protein I light chain 3 (LC3B) and P62 was inhibited in the senile osteoporosis rats after EA treatment.</p><p><strong>Conclusions: </strong>EA can effectively alleviate aging-related bone loss and improve the microstructure of bone tissue in senile osteoporosis rats, and the regulation of autophagy might be one of the important mechanisms.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"260-267"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141787038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonsurgical treatment of bilateral vocal fold paralysis: a case study of voice training combined with acupuncture.","authors":"Jing Peng, Mi Zou, Manwa L Ng, Jie Tan, Juan Xiang","doi":"10.1177/09645284241265869","DOIUrl":"10.1177/09645284241265869","url":null,"abstract":"","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"289-291"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141858673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of acupuncture on drinkers with chronic prostatitis / chronic pelvic pain syndrome: secondary analysis of a randomized clinical trial.","authors":"Lili Zhu, Yuanjie Sun, Shiyan Yan, Xiaoxu Liu, Xinlu Wang, Zhishun Liu","doi":"10.1177/09645284241274158","DOIUrl":"10.1177/09645284241274158","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy of acupuncture in drinkers with chronic prostatitis / chronic pelvic pain syndrome (CP/CPPS).</p><p><strong>Methods: </strong>We conducted a secondary analysis of a randomized controlled trial across multiple centers, involving 224 drinkers. Patients received either acupuncture or sham acupuncture treatment. The primary outcome was the proportion of responders, defined as participants who had a reduction of 6 points or more from baseline in the National Institute of Health-Chronic Prostatitis Symptom Index (NIH-CPSI) total score at weeks 8 and 32. Secondary outcomes measures included the Global Response Assessment (GRA), International Prostate Symptom Score (IPSS) and International Index of Erectile Function 5 (IIEF-5).</p><p><strong>Results: </strong>One hundred and twelve drinkers were included in each group (n = 224 in total). The proportion of responders in terms of NIH-CPSI was 58.9% versus 40.3% in the acupuncture group (AG) and sham acupuncture group (SAG), respectively, with a statistically significant difference of 18.6% (<i>p</i> = 0.002) at week 8. Higher proportions of responders with respect to NIH-CPSI (<i>p</i> < 0.001 at week 32) and GRA (<i>p</i> < 0.001 at week 8 and <i>p</i> = 0.01 at week 32) were observed in the AG compared with the SAG. No between-group differences were found in the changes in IPSS at any assessment time point. Changes in IIEF-5 score were significantly higher in the AG than in the SAG at weeks 20 and 32, while the difference was not statistically significant at week 8.</p><p><strong>Conclusion: </strong>Acupuncture appeared to alleviate the symptoms of pain among drinkers with CP/CPPS and improve their quality of life, but had no demonstrable effect on urinary tract symptoms or erectile function among these patients.</p><p><strong>Trial registration number: </strong>NCT03213938 (ClinicalTrials.gov).</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"243-250"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture alleviates sciatic nerve injury and inhibits autophagy in rats.","authors":"Meiling Chen, He Ran Xiong, Yanping Hu, Song Wang, Fan Zhou, Chao Xiang, Xin Zhao","doi":"10.1177/09645284241280074","DOIUrl":"10.1177/09645284241280074","url":null,"abstract":"<p><strong>Background: </strong>Sciatic nerve injury is a common form of peripheral nerve injury (PNI). It has been suggested that electroacupuncture (EA) stimulation at GB30 and ST36 can improve nerve dysfunction post-PNI. Autophagy is an important factor in the regeneration of sciatic nerves and recovery of motor function. Therefore, we investigated the biological effects of EA and examined whether these were mediated by autophagy in sciatic nerve injury.</p><p><strong>Methods: </strong>Mechanical clamping of the sciatic nerve in Sprague-Dawley rats was performed to establish an experimental model of sciatic nerve injury. EA stimulation was administered once daily for 15 min for seven consecutive days beginning 1 week after successful modeling. The recovery of sciatic nerve function was examined via the sciatic functional index (SFI) test. Morphometric analysis was conducted by staining nerve samples with toluidine blue. Autophagy-associated protein levels were measured via Western blotting.</p><p><strong>Results: </strong>EA stimulation at GB30 and ST36 significantly increased the number of myelinated fibers, axonal and fiber diameters, and the thickness of the myelin sheath in our rat model of sciatic nerve injury. In addition, EA stimulation greatly facilitated nerve regeneration following sciatic nerve injury. Moreover, sciatic nerve injury-induced autophagy was inhibited by EA stimulation.</p><p><strong>Conclusion: </strong>EA facilitates recovery of injured sciatic nerves and inhibits autophagy in a rat model.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"268-274"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture inhibits TLR4/NF-κB signaling in the dorsal root ganglion of rats with spared nerve injury.","authors":"Yangyang Xia, Meng Xue, Yalan Sun, Ying Wang, Zhihua Huang, Cheng Huang","doi":"10.1177/09645284241279874","DOIUrl":"10.1177/09645284241279874","url":null,"abstract":"<p><strong>Objective: </strong>Neuropathic pain can be provoked by high mobility group box 1 (HMGB1) activation of toll-like receptor (TLR)4/nuclear factor (NF)-κB signaling in the dorsal root ganglion (DRG). Electroacupuncture (EA) has been reported to effectively alleviate neuropathic pain with few side effects, but its precise mechanism of action remains unknown. The aim of this study was to explore whether 2 Hz EA stimulation suppresses TLR4/NF-κB signaling in the DRG following spared nerve injury (SNI) in a rat model.</p><p><strong>Methods: </strong>In this experiment, SNI rats were given 2 Hz EA once every other day for a total of 21 days. Paw withdrawal threshold (PWT) was measured to assess SNI-induced mechanical hypersensitivity, and western blotting and immunofluorescence staining were used to determine the levels of pain-related signaling molecules and pro-inflammatory mediators in the DRG.</p><p><strong>Results: </strong>SNI up-regulated HMGB1, TLR4, myeloid differentiation factor-88 adaptor protein (MyD88) and NF-κB p65 protein expression in the DRG. In addition, immunofluorescence staining demonstrated that SNI induced higher levels of TLR4 and MyD88 in the DRG. We also demonstrated co-localization of TLR4 and MyD88 with both calcitonin gene-related peptide (CGRP) and isolectin GS-IB4 in the DRG of SNI rats, respectively. Meanwhile, 2 Hz EA stimulation effectively reversed the elevations of HMGB1, TLR4, MyD88 and NF-κB p65 induced by SNI in the DRG, which was coupled with amelioration of SNI-induced mechanical hypersensitivity.</p><p><strong>Conclusions: </strong>The results of this study suggested that inhibition of the TLR4/NF-κB signaling pathway in the DRG by 2 Hz EA might be exploited as a therapeutic option for neuropathic pain.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"275-284"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture for Tourette syndrome in a child: a case report.","authors":"Liya Wu, Sujing Li, Wenwen Yang, Siyue Yang, Xinbo Gu, Hantong Hu, Hong Gao","doi":"10.1177/09645284241277208","DOIUrl":"10.1177/09645284241277208","url":null,"abstract":"","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"292-294"},"PeriodicalIF":2.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motor behavior improvement in naive gerbils by cholinergic receptor activation and acupuncture","authors":"Kelly Zhang, Manoela Gallon Pitta, Gustavo Henrique de Mello Rosa, Lucas Hipolito do Espírito Santo, Josie Resende Torres Silva, Elaine Caldeira de Oliveira Guirro, João Eduardo de Araujo","doi":"10.1177/09645284241277213","DOIUrl":"https://doi.org/10.1177/09645284241277213","url":null,"abstract":"","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"1 1","pages":""},"PeriodicalIF":2.5,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}