Acupuncture in Medicine最新文献

{"title":"Infectious pyogenic sacroiliitis following acupuncture: a series of three cases and review of the literature.","authors":"Yannick Laurent Tchenadoyo Bayala, Ismael Ayouba Tinni, Fulgence Kaboré, Wendlassida Joelle Stéphanie Zabsonré/Tiendrebeogo, Dieu-Donné Ouedraogo","doi":"10.1177/09645284251327200","DOIUrl":"10.1177/09645284251327200","url":null,"abstract":"<p><strong>Background: </strong>Acupuncture is an unusual cause of infectious sacroiliitis. Herein, we report three new cases of pyogenic sacroiliitis deemed to be attributable to acupuncture.Case 1:A 45-year-old male underwent 8 acupuncture sessions. He developed inflammatory pain in the left buttock, fever and tachycardia 11 days after the last session. Examination revealed involvement of the left sacroiliac joint. Magnetic resonance imaging (MRI) of the pelvis was consistent with sacroiliitis and blood cultures were positive for <i>Staphylococcus aureus</i>. The final diagnosis was left sacroiliitis caused by <i>S. aureus</i>. He was treated with lincomycin.Case 2:A 55-year-old female who had undergone 10 acupuncture sessions presented with inflammatory gluteal pain 10 days after the last session. Physical examination revealed signs of sacroiliac involvement, confirmed by MRI of the pelvis. The diagnosis was right sacroiliitis complicated by myositis of the gluteal muscles caused by <i>S. aureus</i>. Treatment consisted of antibiotic therapy with amoxicillin and ofloxacin.Case 3:A 72-year-old female who had undergone 10 acupuncture sessions presented 5 days after the last session for inflammatory gluteal pain. On examination, left unipodal weight-bearing was impossible and the tripod sign was present. MRI and clinical findings were in favor of left sacroiliitis associated with infectious pyogenic spondylodiscitis at L4-L5 and paravertebral abscesses. She received empiric antibiotic treatment with amoxicillin and gentamycin, followed by ofloxacin. On the 14th day, the patient unexpectedly died of pulmonary embolism after developing respiratory distress.</p><p><strong>Conclusion: </strong>This case series highlights the continued need for vigilance in the clinical practice of acupuncture.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"114-119"},"PeriodicalIF":2.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture for polymyositis: a case report.","authors":"Siqi Zhang, Liang Zhou, Guirong Dong, Hongsheng Dong, Chunling Bao","doi":"10.1177/09645284241307657","DOIUrl":"10.1177/09645284241307657","url":null,"abstract":"","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"58-60"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture induces analgesia by regulating spinal synaptic plasticity via the AMPA/NMDA receptor in a model of cervical spondylotic radiculopathy: secondary analysis of an experimental study in rats.","authors":"Tian Wang, Hai-Yan Chen, Pu Yang, Xi Zhang, Sheng-Yong Su","doi":"10.1177/09645284251314189","DOIUrl":"10.1177/09645284251314189","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Cervical spondylotic radiculopathy (CSR) is characterized by neuropathic pain (NP). Although the analgesic effect of electroacupuncture (EA) has been widely recognized in clinical practice, the mechanism of EA in the treatment of CSR remains unknown. We previously reported that 7 days of EA improved behavioral markers of NP, attenuated increases in α-synuclein, synapsin 1 and 2, postsynaptic density (PSD)-95 and growth-associated protein (GAP)-43, and improved ultrastructural changes within synapses in a rat model of CSR. Herein, we present supplemental data from the same cohort of animals examining the timing of behavioral improvement within the first week (through additional measurements at 3 and 5 days into the EA treatment) and new data on the effects of EA on α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) and &lt;i&gt;N&lt;/i&gt;-methyl-d-aspartic acid receptor (NMDAR) levels.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;As previously reported, the rats were divided into four groups at random: normal, sham, CSR and CSR + EA. EA at bilateral LI4 and LR3 was administered once a day for 7 days (20 min each) in the CSR + EA group after the CSR model was established by inserting a fishing line under the laminae. Behavioral assessments were carried out prior to initiation of EA and at 3, 5 and 7 days into the 7-day treatment course. Concentrations ofγ-aminobutyric acid (GABA) and glutamate (Glu) were determined using enzyme-linked immunosorbent assay and ultraviolet colorimetry, respectively, and AMPAR (glutamate receptor (GluR)1 and GluR2 membrane protein) expression was determined using Western blotting. Immunohistochemistry was used to detect the protein expression and average optical density (AOD) of NMDAR1 (NR1), NMDAR2A (NR2A) and NMDAR2B (NR2B). Quantitative reverse transcription-polymerase chain reaction was used to detect the mRNA expression of NR1, NR2A and NR2B. Transmission electron microscopy was used to observe changes in synaptic ultrastructure.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;EA significantly improved the pressure pain threshold (PPT) and mechanical withdrawal threshold (MWT) 5 days into the intervention, although effects were less pronounced than at 7 days (at completion of treatment). However, significant effects on gait scores were not seen prior to 7 days. As previously reported, EA also improved markers of synaptic ultrastructure. In the spinal cord, GluR1 membrane protein expression was decreased, GluR2 membrane protein expression was increased, and the GluR1/GluR2 ratio was decreased. Protein and mRNA expression of NR1, NR2A and NR2B was significantly decreased. GABA concentration was markedly increased, while Glu concentration was markedly decreased.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Evidence of EA analgesia (higher PPT and MWT scores) was seen after 5 days of EA, while positive effects on motor function required 7 days of treatment. The underlying mechanism may be related to inhibition of AMPA","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"38-51"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Involvement of the astroglial glutamate-glutamine cycle in the analgesic effects of electroacupuncture in a rat model of chronic neuropathic pain.","authors":"Hao-Han Zhu, Xing-Ke Song, Jian-Liang Zhang, Jin-Ling Zhang, Pei-Jing Rong, Jun-Ying Wang","doi":"10.1177/09645284241309952","DOIUrl":"10.1177/09645284241309952","url":null,"abstract":"<p><strong>Objective: </strong>Our previous study found that astrocytes are involved in cumulative analgesia; however, the underlying mechanism remains unclear. The aim of this study was to further explore the potential role of astrocytes in the effects of electroacupuncture (EA) on neuropathic pain by focusing on the glutamate-glutamine cycle.</p><p><strong>Methods: </strong>69 male Sprague-Dawley (SD) rats were randomly divided into a normal control group, untreated chronic constriction injury (CCI) model group and EA-treated model (CCI + EA) group. EA was applied bilaterally at ST36 and GB34. Pain thresholds were assessed using behavioral tests and thermal stimuli. We examined the co-expression of glutamate/aspartate transporter (GLAST) via immunofluorescence and measured the expression levels of GLAST, glutamate transporter (GLT)-1 and glutamine synthetase (GS) using Western blotting and polymerase chain reaction (PCR). Glutamate (Glu) and gamma-aminobutyric acid (GABA) levels were detected by high-performance liquid chromatography (HPLC). To validate the impact of GLAST/GLT-1 in the analgesic effect of EA, an additional 30 SD male rats were divided into groups receiving intrathecal saline, GLAST antagonist or GLT-1 antagonist alongside EA.</p><p><strong>Results: </strong>Post-CCI, pain thresholds were decreased, GLAST expression was diminished, and spinal Glu levels were increased. EA treatment reversed these effects, improved pain thresholds and GLAST/GLT-1 expression in astrocytes, and reduced Glu levels. Antagonist administration negated the analgesic effects of EA.</p><p><strong>Conclusion: </strong>Repeated EA administration inhibited CCI-induced chronic neuropathic pain in rats, corresponding to a reversal of decreased expression of GLAST and GLT-1, which may have accelerated the clearance of Glu and thereby reduced its concentration. Regulation of the astroglial glutamate-glutamine cycle is a potential target of EA.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"43 1","pages":"14-25"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture pretreatment at ST36 alleviates acute gastric mucosal lesions induced by water immersion restraint stress through the TRPV1/SP/CGRP/NO pathway in rats.","authors":"Qun Jiang, Mingyan Guo, Lingsong Guo, Qiong Ling, Chuangbo Xie, Xiangyu Li, Gaofeng Zhao, Weifeng Tu","doi":"10.1177/09645284241300177","DOIUrl":"10.1177/09645284241300177","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to determine the impact of electro-acupuncture (EA) pretreatment on the progression of acute gastric mucosal lesions (AGMLs) induced by water immersion restraint stress (WIRS) and explore the related mechanisms including the transient receptor potential vanilloid (TRPV)1 signaling pathways.</p><p><strong>Methods: </strong>Rats treated with EA for 4 days were subjected to WIRS for 6 h. Microscopic lesions, oxidative stress and TRPV1, substance P (SP), calcitonin gene-related peptide (CGRP) and nitric oxide (NO) levels in the dorsal root ganglion (DRG) and gastric tissues were detected.</p><p><strong>Results: </strong>The results indicated the development of AGMLs with a substantial increase of TRPV1/SP in the DRG and TRPV1/SP/MDA (malondialdehyde activity) in the stomach, and a significant decrease in CGRP/NO/SOD (superoxide dismutase) in gastric tissues, using a combination of real-time reverse transcription polymerase chain reaction, Western blotting and enzyme-linked immunosorbent assay.</p><p><strong>Conclusion: </strong>The TRPV1 signaling pathways likely play an important role in the pathogenesis of AGML. In addition, EA pretreatment protected gastric mucosa lesions induced by WIRS by reducing the expression of TRPV1/SP in the DRG and gastric mucosa, as well as up-regulating gastric CGRP/NO. Antioxidant mechanisms are likely to at least partially mediate the protective effects of EA against AGML.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":"43 1","pages":"3-13"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture improves cognitive impairment after subarachnoid hemorrhage in rats through the PI3K/AKT signaling pathway.","authors":"Feng Zhou, Zhenzhi Wang, Kang Xiong, Xiaoman Fu, Hongru Jiang, Meiling Zhang, Qiang Wang, Yuan Wang","doi":"10.1177/09645284251314187","DOIUrl":"10.1177/09645284251314187","url":null,"abstract":"<p><strong>Objective: </strong>Cognitive impairment (CI) is highly prevalent in subarachnoid hemorrhage (SAH) patients. The phosphatidylinositol 3-kinase (PI3K)/AKT pathway plays a critical role in neuronal survival in a variety of central nervous system injuries. This study aimed to determine whether electroacupuncture (EA) at <i>Yintang</i> and LI20 ameliorates SAH-CI in a rat model and to examine whether it modulates the PI3K/AKT pathway by administering a PI3K inhibitor (LY294002) versus dimethyl sulfoxide (DMSO) vehicle.</p><p><strong>Methods: </strong>Notably, 129 male Sprague-Dawley rats were divided into Blank, Sham, SAH and SAH + EA groups (Experiment 1, <i>n</i> = 54) and SAH, SAH + EA, SAH + LY294002, SAH + EA + LY294002 and SAH + EA + DMSO groups (Experiment 2, <i>n</i> = 75). Garcia scoring was used to evaluate neurological function. The moisture content of the rat brain was determined by dry‒wet method. The Morris water maze was used to assess learning and memory function. Pathological changes in neurons in the hippocampus were observed via hematoxylin-eosin (H&E) staining. The number of surviving neurons and the percentage of apoptotic cells in the hippocampus were detected via Nissl and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) staining. The expression of PI3K/AKT pathway-related proteins was detected via Western blotting.</p><p><strong>Results: </strong>The results indicated that EA intervention after SAH reduced brain water content, enhanced Garcia scores, improved neurological function and behavioral markers of CI, and increased the number of surviving neurons in the hippocampus. Moreover, EA significantly increased the expression of AKT, phosphorylated (p)-AKT, PI3K, p-PI3K, glycogen synthase kinase (GSK)-3β, p-GSK-3β and B cell lymphoma (Bcl)-2 proteins, and decreased the expression of Bcl-2-associated X (Bax) and caspase-3. In addition, the effects of EA were abolished by LY294002.</p><p><strong>Conclusion: </strong>EA appeared to improve CI in a rat model of SAH through the activation of the PI3K/AKT pathway.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"26-37"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143063091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Practical and economic challenges of implementing group auricular acupuncture treatment for chronic pain in primary care.","authors":"Iman Majd, Daniel Cherkin, Masa Sasagawa","doi":"10.1177/09645284251314188","DOIUrl":"10.1177/09645284251314188","url":null,"abstract":"<p><strong>Background: </strong>Although growing numbers of patients seek acupuncture for pain management, few acupuncturists with insurance credentialing work in the conventional medical settings. This has resulted in increasing frustration among patients wishing to receive acupuncture in primary care settings as part of their insurance benefits.</p><p><strong>Methods: </strong>A course of eight weekly sessions of group auricular acupuncture (AA) for chronic musculoskeletal pain was implemented in a US primary care clinic and billed to insurance. The process of implementing group AA is described, including patients and researchers' perceptions of their experience. We also examined various hypothetical scenarios for reimbursement based on relative value units (RVUs) based on Centers for Medicare and Medicaid (CMS) billing/coding.</p><p><strong>Results: </strong>Recruitment was greatly limited by COVID-19 requirements for social distancing and administrative hurdles, such that only four patients participated, three of whom attended all eight sessions. Seven additional Medicare patients were excluded due to concerns that acupuncture would not be covered. Participants reported mostly positive experiences with both AA and the group model of care. Based on our hypothetical reimbursement scenarios, in the fee-for-service model, group sessions appear to be economically more viable when staffed by non-physician acupuncturists credentialed for insurance reimbursement. For example, for a group of six patients each receiving acupuncture would be anticipated to generate 3.60 RVUs, whereas a physician seeing three individual patients consecutively for return office visits at CMS Evaluation and Management (E/M) level 3 could generate at least 4.11 RVUs.</p><p><strong>Conclusions: </strong>Offering group AA services in primary care clinics might increase access to acupuncture for patients with chronic pain. Although patients appreciated quicker access to acupuncture through group visits, and the group visit experience itself, logistical and economic barriers remain a challenge for sustainable group-based acupuncture visits.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"52-57"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143021779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-intensity electroacupuncture is superior to low-intensity electroacupuncture for knee osteoarthritis: a meta-analysis of randomized controlled trials.","authors":"Shi-Guo Yuan, Jung Chen, Mei-Xiong Chen, Nan-Sheng Zheng, Zhi-Wei Zhang, Hua-Jun Wang, Jia Li, Ling Li, Yan-Ping Gao","doi":"10.1177/09645284241298718","DOIUrl":"10.1177/09645284241298718","url":null,"abstract":"<p><strong>Background: </strong>Electroacupuncture (EA) has been demonstrated to be efficacious and safe in patients with knee osteoarthritis (KOA), yet the optimal current intensity for pain control in KOA remains unspecified. The present meta-analysis aimed to compare the effects of high-intensity and low-intensity EA in terms of pain relief and functional improvement in KOA.</p><p><strong>Methods: </strong>A thorough and comprehensive literature search for randomized controlled trials (RCTs), all looking at the intensity of EA for KOA, was carried out in PubMed, EMBASE, Cochrane Library, China National Knowledge Infrastructure (CNKI), China Science Journal Citation Report (VIP) and Wanfang database, as well as ClinicalTrials.gov. All databases were searched from their inception until April 2022. Study quality was assessed using the Cochrane risk of bias (RoB)2 tool. Finally, a meta-analysis of all eligible RCTs was performed using Review Manager 5.3.</p><p><strong>Results: </strong>Three studies with 472 individuals were included in the meta-analysis. The pain intensity reductions were significantly different between the high-intensity EA group and low-intensity EA group (mean difference (MD) = -0.22, 95% confidence interval (CI) = -0.26 to -0.18, <i>p</i> < 0.00001). There was no significant difference between the two groups in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores (MD = -3.62, 95% CI = -12.22 to 4.98, <i>p</i> = 0.41). High-intensity EA significantly improved emotional scale (ES) scores compared to low-intensity EA (MD = -0.72, 95% CI = -0.76 to -0.67, <i>p</i> < 0.00001).</p><p><strong>Conclusion: </strong>The findings of this systematic review and meta-analysis indicated that high-intensity EA provides superior pain relief and has a bigger impact on emotional scale scores in patients with KOA.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"303-310"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of acupuncture treatment in post-stroke depression and anxiety disorders: a prospective, randomized, controlled, single-blind study.","authors":"Eser Kalaoğlu, Fatma Nur Kesiktaş, Ömer Faruk Bucak, Mücahit Atasoy, Azad Günderci","doi":"10.1177/09645284241298294","DOIUrl":"10.1177/09645284241298294","url":null,"abstract":"<p><strong>Objective: </strong>Our aim was to examine the effectiveness of acupuncture in post-stroke depression/anxiety disorders and to determine whether it reduces the need for anxiolytic and sedative drug use.</p><p><strong>Methods: </strong>This study included 54 stroke patients with depression and/or anxiety disorder. Patients were randomly assigned to the acupuncture treatment group (n = 27) or the control group (n = 27). A conventional rehabilitation program was applied to all patients and acupuncture was performed twice a week for 4 weeks. Patients were evaluated blindly by a psychiatrist at baseline (week 0), week 4 and week 8, using the Hamilton depression rating scale (HAM-D) and Hamilton anxiety rating scale (HAM-A), and drug doses were adjusted when necessary. The HAM-D and HAM-A scores at week 4 were pre-specified as the two primary outcome measures.</p><p><strong>Results: </strong>Within each group, there was a significant decrease in the mean scores of HAM-D and HAM-A at weeks 4 and 8. No between-group differences in HAM-A or HAM-D scores were seen at 4 weeks but there was a significant decrease in HAM-D scores in favor of the acupuncture group at week 8 (p < 0.025). At week 4, the number of cases whose selective serotonin reuptake inhibitor (SSRI) dose was increased was found to be significantly higher in the control group.</p><p><strong>Conclusion: </strong>While the study was negative with respect to its primary outcomes, the findings with respect to certain secondary outcomes suggests further research is warranted to determine if acupuncture treatment is an effective/safe treatment to alleviate post-stroke depression/anxiety.</p><p><strong>Trial registration number: </strong>NCT04283591 (ClinicalTrials.gov).</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"319-325"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of electroacupuncture on senile osteoporosis in rats.","authors":"Jun Zhou, Jinling Wang, Mengjian Qu, Qian Wang, Liqiong Wang, Sijia Liu, Jing Liu, Guanghua Sun, Peirui Zhong, Xiarong Huang, Danni Liu, Linwei Yin, Chengqi He","doi":"10.1177/09645284241280089","DOIUrl":"10.1177/09645284241280089","url":null,"abstract":"<p><strong>Objectives: </strong>The objectives were to explore the protective effects of electroacupuncture (EA) on senile osteoporosis in aged rats and investigate the underlying mechanisms.</p><p><strong>Methods: </strong>This study included aged (24-month-old; n = 16) and young (3-month-old; n = 8) male Sprague-Dawley rats. Aged rats were further randomized 1:1 to an aged control group (Aged; n = 8) and an EA treatment group (EA; n = 8). The 3-month-old rats served as young controls (Young). EA rats received EA at ST36, SP6, GB34 and SP10 bilaterally for 30 min a day, 5 days a week, for 8 weeks.</p><p><strong>Results: </strong>EA significantly increased serum markers of bone formation in Aged rats. There were no significant differences in serum markers of bone resorption between EA and Aged rats. Deterioration of bone mineral density (BMD) and trabecular bone architecture was observed in the Aged group, while EA significantly increased BMD of the left femur and L5 vertebral body in aged rats. Aging-induced deterioration of trabecular bone architecture was partially reversed in EA rats. Runx2 and Osterix mRNA and protein levels were significantly increased and peroxisome proliferator-activated receptor (PPAR)γ was significantly decreased in bone marrow cells in EA compared with Aged groups. The mRNA and protein levels of core constituents of the Wnt/β-catenin signaling pathway (Wnt3a, low-density lipoprotein receptor-related protein (LRP)5 and β-catenin) were significantly increased and Dickkopf 1 was significantly decreased in bone marrow cells in EA compared with Aged groups.</p><p><strong>Conclusion: </strong>EA may prevent bone loss and deterioration in aged rats by promoting osteogenesis via a mechanism that may involve activation of the Wnt/β-catenin signaling pathway. EA may represent a therapeutic option for senile osteoporosis.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"334-341"},"PeriodicalIF":2.4,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}