Acupuncture in Medicine最新文献

{"title":"Rapidly progressive spinal epidural abscess with purulent meningitis following acupuncture: a case report.","authors":"Tao Cong, Zhihao Han, Yuanyuan Liu","doi":"10.1177/09645284261421948","DOIUrl":"10.1177/09645284261421948","url":null,"abstract":"","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"180-182"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146199960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture for post-stroke equinovarus: a case report.","authors":"Jinyuan Shi, Rui Lv, Yongqing Pan, Fuyan Chen","doi":"10.1177/09645284261421951","DOIUrl":"10.1177/09645284261421951","url":null,"abstract":"","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"177-179"},"PeriodicalIF":2.6,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146199977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture regulates gut microbiota and metabolites in a rat model of chronic migraine.","authors":"Hao Zheng, Zhe Wang, Shi-Jie Wei, Li-Xia Huang, Meng Han, Yu-Kuan Zhang, Wen-Jun Bai, Jing Han","doi":"10.1177/09645284261423204","DOIUrl":"10.1177/09645284261423204","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to investigate the effects of acupuncture on a rat model of chronic migraine (CM) and explore the underlying mechanism of action from the perspective of the gut-brain axis.</p><p><strong>Methods: </strong>A total of 24 male Sprague-Dawley (SD) rats were randomly allocated into control, model and acupuncture groups (<i>n</i> = 8 each). The CM model was established by intraperitoneal injection of nitroglycerin (NTG). Acupuncture was administered at GV20 and bilateral PC6/LR3/ST36 for rats in the acupuncture group once a day for 9 days. Enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of 5-hydroxytryptamine (5-HT), calcitonin gene-related peptide (CGRP) and vasoactive intestinal peptide (VIP) in plasma. A combination of 16S rDNA sequencing and liquid chromatography-mass spectrometry (LC-MS) metabolomics was adopted to investigate the role of the gut-brain axis in migraine chronification and the effect of acupuncture on CM.</p><p><strong>Results: </strong>Acupuncture treatment significantly attenuated hyperalgesia in CM model rats and regulated serum levels of brain-gut peptides, including 5-HT, CGRP and VIP. Furthermore, the gut microbial community structure and metabolic profile changed in CM rats and acupuncture impacted the changes. Notably, acupuncture modulated 10 gut microbial genera and 13 fecal metabolites.</p><p><strong>Conclusion: </strong>These findings suggest that the gut-brain axis may play an important role in the chronification of migraine, and the regulation of gut microbiota and metabolites may be one of the mechanisms underlying the analgesic effect of acupuncture in CM.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"138-156"},"PeriodicalIF":2.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture inhibits the NLRP3/caspase-1/ASC signaling pathway in a mouse model of inflammatory bowel disease.","authors":"Lv Jia, Sihui Cao, Lin Chen, Zuqiang Li, Penghui Lu, Qiong Liu, Mi Liu","doi":"10.1177/09645284261423205","DOIUrl":"10.1177/09645284261423205","url":null,"abstract":"<p><strong>Objective: </strong>Intestinal inflammatory responses are a key pathological feature of inflammatory bowel disease (IBD) and the nucleotide oligomerization domain (NOD)-like receptor protein 3/cysteine aspartate protease-1/apoptosis-associated speck-like protein (NLRP3/caspase-1/ASC) signaling pathway plays a key role in mediating these responses. The aim of this study was to investigate how electroacupuncture (EA) affects inflammation-related protein levels, including NLRP3, caspase-1 and ASC, in a mouse model of IBD and explore the underlying mechanisms of action.</p><p><strong>Methods: </strong>Forty-eight mice were randomly assigned to control, model, EA and NLRP3 inhibitor groups. IBD was induced using dextran sodium sulfate (DSS). After 1 week of EA treatment, fecal occult blood tests were performed and disease activity index (DAI) scores were recorded. In addition, hematoxylin-eosin staining was performed to evaluate the histopathological changes in the colon. Serum interleukin (IL)-1β, IL-18 and tumor necrosis factor (TNF)-α levels were measured using enzyme-linked immunosorbent assay, and protein expression of NLRP3, caspase-1, ASC, gasdermin D (GSDMD), N-terminal GSDMD (N-GSDMD), IL-1β and IL-18 in colonic tissues was assessed using Western blotting.</p><p><strong>Results: </strong>IBD resulted in alterations in general condition and colonic morphology, a significant increase in serum IL-1β, IL-18 and TNF-α levels, and a significant increase in protein expression of NLRP3, caspase-1, ASC, GSDMD, N-GSDMD, IL-1β and IL-18 in the colonic tissues (<i>p</i> < 0.01 or <i>p</i> < 0.001). EA and NLRP3 inhibition reversed these pathological changes and reduced the expression of inflammatory proteins induced by intestinal inflammatory responses (<i>p</i> < 0.05 or <i>p</i> < 0.01).</p><p><strong>Conclusion: </strong>The NLRP3/caspase-1/ASC signaling pathway appears to play a role in mediating the therapeutic effects of EA in IBD.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"157-166"},"PeriodicalIF":2.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147484291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and safety of electroacupuncture in patients with upper limb spasticity after brain injury: a randomized controlled trial.","authors":"Zhenguo Wu, Ganglin Chen, Xianrui Hu, Jing He","doi":"10.1177/09645284261433566","DOIUrl":"10.1177/09645284261433566","url":null,"abstract":"<p><strong>Objective: </strong>To explore the effectiveness and safety of electroacupuncture (EA) as an adjunct to conventional rehabilitation (CR) in patients with upper limb spasticity after brain injury.</p><p><strong>Methods: </strong>This study was a single-blind, prospective, two-group parallel randomized controlled trial. Eligible patients were randomly divided into an intervention group and a control group. Participants in the control group received CR only, whereas those in the intervention group received CR supplemented with EA, administered five times weekly for 2 weeks. Modified Ashworth scale (MAS), shear modulus of biceps brachii muscle (BBM), Fugl-Meyer motor scale (FMMS), Barthel index (BI) and safety were assessed at baseline and after 2 weeks of treatment.</p><p><strong>Results: </strong>A total of 64 patients were randomized, with 58 included in the final (per protocol) analysis. The baseline data of the two groups were comparable. Following the 2-week treatment period, improvements were observed in both groups compared to baseline. However, no significant differences were noted between the two groups in MAS (<i>Z</i> = -1.692, <i>p</i> = 0.091), BBM shear modulus short axis of 0° elbow flexion (mean difference (MD) -1.079, 95% confidence interval (CI) -2.786 to 0.628), long axis of 0° elbow flexion (MD -0.499, 95% CI -1.699 to 0.700), short axis of 90° elbow flexion (MD -0.005, 95% CI -0.933 to 0.923), long axis of 90° elbow flexion (MD -0.845, 95% CI -1.355 to 1.113), FMMS (MD -0.890, 95% CI -2.243 to 0.462) or BI (MD 0.024, 95% CI -2.955 to 3.002) scores. One participant reported an itchy sensation at the acupuncture site, with no other adverse events observed during or after the trial.</p><p><strong>Conclusion: </strong>EA was not effective when added to CR as a 2-week intervention for upper limb spasticity after brain injury, but appears to be a safe intervention in this population.</p><p><strong>Trial registration number: </strong>ChiCTR2200060819 (Chinese Clinical Trial Registry).</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"125-137"},"PeriodicalIF":2.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147872910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cholinergic neurons in the dorsal nucleus of the vagus nerve are involved in the mechanism of action of electroacupuncture at HT7 in a mouse model of chronic heart failure.","authors":"Shi-Yue Wang, Hao-Sheng Wu, Sheng-Bing Wu, Meiqi Zhou","doi":"10.1177/09645284261424260","DOIUrl":"10.1177/09645284261424260","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the role and mechanism of the dorsal motor nucleus of the vagus nerve (DMV) in the effects of electroacupuncture (EA) at HT7 in a mouse model of chronic heart failure (CHF).</p><p><strong>Methods: </strong>A CHF model was established in male C57 mice by ligating the anterior descended branch of the left coronary artery. In part I of the experiment, mice were randomly divided into Control, untreated model (CHF) and EA-treated model (CHF + EA) groups (n = 6 each). In part II, mice were randomly divided into the following groups (n = 6 each): EA-treated model group (CHF + EA); EA-treated model group receiving cholinergic neuron promoter chemogenetic activating virus encoding human M4 muscarinic (hM4) receptor (hM4D) and clozapine-N-oxide (CNO) (CHF + hM4D + CNO + EA); EA-treated model group additionally receiving \"empty\" virus encoding enhanced green fluorescence protein (EGFP) and CNO (CHF + EFGP + CNO + EA); EA-treated model group receiving hM4D only (CHF + hM4D + EA); and EA-treated model group receiving CNO only (CHF + CNO + EA). All mice except those in the Control and CHF groups were treated with bilateral EA at HT7 (frequency 2 Hz, intensity 2mA, pulse width 0.2 ms ± 20%) once a day (20 min each time) for 7 days. Left ventricular ejection fraction (LVEF), left ventricular fractional shortening (LVFS), scar area and serum inflammatory factor levels were evaluated using a Doppler ultrasound imaging system, Masson staining, ELISA and other methods.</p><p><strong>Results: </strong>Compared with the Control group, LVEF/LVFS in the CHF group decreased (<i>p</i> < 0.001), the scar area was larger, atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP) and interleukin (IL)-6 levels increased significantly, and acetylcholine (ACh) decreased significantly (<i>p</i> < 0.001) in the CHF group. Compared with the CHF group, LVEF/LVFS increased (<i>p</i> < 0.001), scar area was smaller, ANP, BNP and IL-6 decreased significantly and ACh increased significantly (<i>p</i> < 0.001) in the CHF + EA group. Compared with the CHF + EA group, the CHF + hM4D + CNO + EA group exhibited a decrease in LVEF/LVFS (<i>p</i> < 0.001), a larger scar area, a significant increase in ANP, BNP and IL-6, and a significant decrease in ACh (<i>p</i> < 0.001),while there was no significant difference in each index between the CHF + CNO + EA and CHF + hM4D + EA groups (<i>p</i> > 0.05). Compared with the CHF + hM4D + CNO + EA group, the CHF + EGFP + CNO + EA exhibited an increase in LVEF/LVFS (<i>p</i> < 0.001), a smaller scar area, a significant decrease in ANP, BNP and IL-6, and a significant increase in ACh (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Electroacupuncture at (HT7) may activate DMV^Ach and reduce myocardial fibrosis, thereby improving CHF, in a mouse model.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"167-176"},"PeriodicalIF":2.7,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of manual acupuncture on microglial polarization and the Sirt1/NF-κB pathway in a rat model of post-stroke depression.","authors":"Menghan Li, Xinming Yang, Dawei Ran, Yi Shu, Yu Wang, Shizhe Deng, Jiaxiao Zhou, Lei Shi, Yuzheng Du","doi":"10.1177/09645284261423203","DOIUrl":"10.1177/09645284261423203","url":null,"abstract":"<p><strong>Background: </strong>In the treatment of post-stroke depression (PSD), acupuncture has emerged as a therapeutic option; however, the exact mechanisms underlying its efficacy remain unclear. Prior research suggests acupuncture may improve PSD symptoms by regulating M1/M2 microglial polarization, reducing the release of inflammatory factors and inflammatory-associated damage.</p><p><strong>Objective: </strong>The aim of the present study was to explore whether manual acupuncture (MA) can mediate microglial polarization via the silence information regulator/nuclear factor κB (Sirt1/NF-κB) pathway, thereby reducing inflammatory responses in the brains of rats exhibiting PSD and improving depressive behavior.</p><p><strong>Methods: </strong>Thirty male rats were divided into a middle cerebral artery occlusion (MCAO) group, PSD group, PSD + MA group, PSD + MA + Sirt1 inhibitor group, and PSD + MA + NS (normal saline) group. Acupuncture was applied 6 days a week for 4 weeks at GV26, GV20 and bilateral PC6 and SP6. In the PSD + MA + Sirt1 inhibitor group, nicotinamide (NAM), a specific inhibitor of Sirt1, was slowly injected into the frontal lobe with a stereotactic injector 1 h before acupuncture. Behavioral tests were conducted after modeling and intervention, including the sucrose preference test (SPT) and open field test (OFT), and body weight was monitored. Following the tests, specimens of the dorsolateral frontal lobe were taken to evaluate molecular markers. Immunofluorescence staining was employed to determine the expression levels of M1 microglial markers CD16/Iba1 and M2 microglial markers CD206/Iba1 in the dorsolateral prefrontal cortex. mRNA expression of CD16/intrinsic nitric oxide synthase (iNOS) and CD206/arginase (Arg)-1 was detected by q-RT-PCR. Western blot analysis was used to quantify protein expression of Sirt1, total p65 and phosphorylated p65 (p-p65) proteins. Interleukin (IL)-1β, IL-6, IL-10 and tumor necrosis factor (TNF)-α levels were quantified using ELISA.</p><p><strong>Results: </strong>Depression-like behavior of PSD model rats was reduced by MA. Acupuncture promoted transformation of microglia from M1 to M2 in the prefrontal lobe, thereby decreasing expression of pro-inflammatory factors (IL-1β, IL-6 and TNF-α) and increasing expression of anti-inflammatory IL-10 after PSD. In addition, expression of Sirt1 in the prefrontal lobe increased following MA, while expression of p65/p-p65 was reduced, indicating activation of the Sirt1/NF-κB pathway. These findings suggest that M1 to M2 microglial polarization was closely related to Sirt1/NF-κB pathway activation following MA.</p><p><strong>Conclusion: </strong>MA promoted the transformation of microglia from M1 to M2 in the prefrontal lobe of PSD rats, reduces the inflammatory response and improves depression-like behavior in rats. These effects were associated with activation of the Sirt/NF-κB pathway.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"100-112"},"PeriodicalIF":2.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147324319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture at ST25 combined with metformin improves intestinal function via the JAK/STAT pathway in a rat model of diabetes.","authors":"Xu Qian, Ke Pei, Yongwei Jiang, Bin Xu, Wei Wu","doi":"10.1177/09645284251410578","DOIUrl":"10.1177/09645284251410578","url":null,"abstract":"<p><strong>Background: </strong>Metformin (Met) is a first-line pharmacological treatment for type 2 diabetes mellitus (T2DM). The potential effect of combining electroacupuncture (EA) at ST25 (<i>Tianshu</i>) with Met in ameliorating intestinal injury remains largely unexplored.</p><p><strong>Methods: </strong>We established wild-type (Control) and diabetic model groups that remained untreated (Model), received EA only (EA), received Met treatment only (Met) or received EA combined with Met (EA + Met), and compared markers of intestinal injury and insulin resistance, as well as effects on signal transducer and activator of transcription (STAT) proteins and microRNAs.</p><p><strong>Results: </strong>EA and Met treatment (alone and in combination) had positive effects on fasting plasma glucose, fasting insulin levels, Homeostatic Model Assessment-insulin resistance (HOMA-IR) indices and stool number, while fecal water content was positively impacted by EA treatment (with or without concurrent Met) but not Met alone. Hematoxylin-eosin staining demonstrated that both EA alone and EA in combination with Met appeared to repair intestinal damage in the jejunum, ileum and colon. In addition, enzyme-linked immunosorbent assay revealed that serum interleukin 10 levels were restored in all treatment groups. Furthermore, quantitative real-time polymerase chain reaction (PCR) analysis revealed that EA at ST25 resulted in the activation of <i>STAT5A</i> in the jejunum, as well as <i>STAT5A</i>, <i>STAT5B</i> and <i>STAT6</i> in the ileum. Notably, in the EA + Met group, there was a specific enhancement of <i>STAT2</i>, <i>STAT3</i> and <i>STAT5B</i> in the colon, indicating segment-specific activation within distinct regions of the intestine.</p><p><strong>Conclusion: </strong>EA at ST25 may ameliorate intestinal injury via the Janus kinase (Jak)/STAT signaling pathway and is closely related to jejunal and ileal segments. These findings provide a theoretical basis for EA combined with medication.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"65-79"},"PeriodicalIF":2.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146049533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical epidural suppurative infection following acupuncture treatment of neck pain: a case report.","authors":"Yuan Zhou, Kejie Ji, Qiwang He, Qing Yu, Haiju Sun, Xiang Shi, Hongming Pan","doi":"10.1177/09645284251414148","DOIUrl":"10.1177/09645284251414148","url":null,"abstract":"","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"113-116"},"PeriodicalIF":2.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146049565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of electroacupuncture on the micturition reflex and urethral closure in a rat model of stress urinary incontinence: the role of spinal 5-HT_2C receptor mediated signaling.","authors":"Biao Chen, Lili Liu, Jun Dai, Xiyuan Dong, Huiping Zhang, Yuan Chen","doi":"10.1177/09645284261415902","DOIUrl":"10.1177/09645284261415902","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to evaluate the therapeutic effect of electroacupuncture (EA) in a rat model of stress urinary incontinence (SUI) induced by vaginal distension (VD). The potential mechanisms underlying this process were also explored.</p><p><strong>Methods: </strong>Virgin Sprague-Dawley rats underwent VD (to model SUI) or a sham operation, followed by EA or no treatment. Cystometry and leak point pressure (LPP) testing were employed to demonstrate the impact of EA on the micturition reflex and urethral closure function. mRNA expression of α_1A and α_1D adrenoceptors and 5-hydroxytryptamine (5-HT)_2C and 5-HT_2A receptors were examined in spinal segments using real-time qRT-PCR, Western blotting and immunohistochemistry (IHC). The individual role of 5-HT_2A and 5-HT_2C receptors were distinguished with selective antagonists (MDL 100907 and SB 242084, respectively).</p><p><strong>Results: </strong>EA treatment successfully reversed the decrease of LPP induced by VD without any significant effect on the micturition reflex in this rat model of SUI. VD did not change bladder basic pressure (BP), voided volume or bladder contraction. Multiple approaches including qRT-PCR, Western blotting and IHC revealed over-expression of 5-HT_2C and 5-HT_2A receptors but not α_1A or α_1D adrenoceptors in the L6-S2 spinal cord of these rats. Administration of the 5-HT_2C antagonist (SB 242084) largely eliminated EA-mediated mitigation of the decrease in LLP caused by VD, while the 5-HT_2A antagonist (MDL 100907) had no effect under these conditions.</p><p><strong>Conclusion: </strong>EA improves impaired urethral closure capacity induced by VD in female rats, and it appears that the 5-HT_2C receptor plays a critical role in this effect. It is reasonable to speculate that EA represents a promising treatment for SUI caused by childbirth trauma.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"90-99"},"PeriodicalIF":2.7,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146163492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}