Cell insight最新文献_第6页

Transcripts derived from the neocortical enhancer of Ctnnb1 promote the enhancer-promoter interaction and maintain Ctnnb1 transcription 源自 Ctnnb1 新皮质增强子的转录本促进增强子与启动子之间的相互作用并维持 Ctnnb1 的转录

Cell insight Pub Date : 2025-02-01 Epub Date: 2024-10-11 DOI: 10.1016/j.cellin.2024.100212

Chen Zhao , Liang Wang , Junbao Wang, Kuan Tian, Xiaojiao Hua, Fangyu Wang, Yan Zhou

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APC orchestrates microtubule dynamics by acting as a positive regulator of KIF2A and a negative regulator of CLASPs APC 通过充当 KIF2A 的正调控因子和 CLASPs 的负调控因子来协调微管动力学

Cell insight Pub Date : 2025-02-01 Epub Date: 2024-10-11 DOI: 10.1016/j.cellin.2024.100210

Yong Wang , Xinping Liu , Zheng Liu , Shasha Hua , Kai Jiang

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Cover 封面

Cell insight Pub Date : 2025-02-01 Epub Date: 2025-01-29 DOI: 10.1016/S2772-8927(25)00004-5

引用次数: 0

Roles of core fucosylation modification in immune system and diseases 核心岩藻糖基化修饰在免疫系统和疾病中的作用

Cell insight Pub Date : 2025-02-01 Epub Date: 2024-10-09 DOI: 10.1016/j.cellin.2024.100211

Qiu Pan , Xiao-Lian Zhang

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The cell autonomous and non-autonomous roles of itaconate in immune response 衣康酸在免疫应答中的细胞自主和非自主作用。

Cell insight Pub Date : 2025-02-01 Epub Date: 2024-11-22 DOI: 10.1016/j.cellin.2024.100224

Chao Chen , Xinjian Li

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Spontaneous and environment induced genomic alterations in yeast model 酵母模型中自发和环境诱导的基因组变化

Cell insight Pub Date : 2025-02-01 Epub Date: 2024-09-26 DOI: 10.1016/j.cellin.2024.100209

Ke-Jing Li , Lei Qi , Ying-Xuan Zhu , Min He , Qian Xiang , Dao-Qiong Zheng

{"title":"Spontaneous and environment induced genomic alterations in yeast model","authors":"Ke-Jing Li , Lei Qi , Ying-Xuan Zhu , Min He , Qian Xiang , Dao-Qiong Zheng","doi":"10.1016/j.cellin.2024.100209","DOIUrl":"10.1016/j.cellin.2024.100209","url":null,"abstract":"<div><div>While genomic alterations are fundamental to biological evolution, enabling adaptation and diversity, they can also result in detrimental outcomes, such as the development of genetic diseases including cancer. The budding yeast <em>Saccharomyces cerevisiae</em> serves as an exemplary model for investigating the mechanisms behind various genomic alterations, including point mutations, chromosomal rearrangements, and whole-chromosome aneuploidy. In this review, we highlight the application of genetic screening systems to assess the mutagenic effects of physical and chemical agents efficiently. Additionally, we discuss the utilization of high-throughput sequencing technologies to uncover comprehensive genomic alterations and rare genetic events. We provide a detailed summary of the features of genomic alterations and discuss the genetic mechanisms driving these changes under both spontaneous and stress-induced conditions. Given the high conservation of DNA replication and repair machinery across different organisms, the insights gained from studies on yeast offer valuable perspectives for understanding the delicate balance between genome plasticity and integrity in other species.</div></div>","PeriodicalId":72541,"journal":{"name":"Cell insight","volume":"4 1","pages":"Article 100209"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142705407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Just a SNP away: The future of in vivo massively parallel reporter assay 只差一个 SNP体内大规模并行报告分析的未来

Cell insight Pub Date : 2025-02-01 Epub Date: 2024-10-10 DOI: 10.1016/j.cellin.2024.100214

Katherine N. Degner , Jessica L. Bell , Sean D. Jones , Hyejung Won

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Progress in photoreceptor replacement therapy for retinal degenerative diseases 视网膜退行性疾病的光感受器替代治疗进展。

Cell insight Pub Date : 2025-02-01 Epub Date: 2024-11-28 DOI: 10.1016/j.cellin.2024.100223

Yuxin Du , Yin Shen

引用次数: 0

Phase-separated chromatin compartments: Orchestrating gene expression through condensation 相分离的染色质区室：通过凝集协调基因表达

Cell insight Pub Date : 2024-12-01 Epub Date: 2024-10-12 DOI: 10.1016/j.cellin.2024.100213

Xin Li , Chengzhi Liu , Zhichao Lei , Huan Chen , Liang Wang

{"title":"Phase-separated chromatin compartments: Orchestrating gene expression through condensation","authors":"Xin Li , Chengzhi Liu , Zhichao Lei , Huan Chen , Liang Wang","doi":"10.1016/j.cellin.2024.100213","DOIUrl":"10.1016/j.cellin.2024.100213","url":null,"abstract":"<div><div>Eukaryotic genomes are organized into distinct chromatin compartments, some of which exhibit properties of biomolecular condensates. These condensates primarily form due to chromatin-associated proteins/complexes (CAPs). CAPs play a crucial role in gene expression, functioning as either transcriptional repressors or activators. Phase separation, a well-established biophysical phenomenon, is a key driver of chromatin condensate formation by CAPs. Notably, multivalent CAPs with the ability to engage in diverse interactions promote chromatin compaction, leading to the formation of transcriptionally repressed compartments. Conversely, interactions between intrinsically disordered region (IDR)-containing transcriptional regulators, mediated by their multivalent IDRs, lead to the formation of protein-rich, transcriptionally active droplets on decondensed genomic regions. Interestingly, both repressive heterochromatin and activating euchromatin condensates exhibit spontaneous phase separation and selectively enrich components with concordant transcriptional functions. This review delves into the mechanisms by which transcriptionally repressive CAPs orchestrate the formation of repressed chromatin domains. We further explore how a diverse array of transcription-related CAPs or core histone variants, via phase separation, influence gene expression by inducing erroneous transcription events, regulating expression levels, and facilitating the interconversion of transcriptionally repressed and active regions.</div></div>","PeriodicalId":72541,"journal":{"name":"Cell insight","volume":"3 6","pages":"Article 100213"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142532224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights into mosquito-borne arbovirus receptors 对蚊媒虫媒病毒受体的认识

Cell insight Pub Date : 2024-12-01 Epub Date: 2024-08-24 DOI: 10.1016/j.cellin.2024.100196

Jianying Liu , Yixin Quan , Hua Tong , Yibin Zhu , Xiaolu Shi , Yang Liu , Gong Cheng

{"title":"Insights into mosquito-borne arbovirus receptors","authors":"Jianying Liu , Yixin Quan , Hua Tong , Yibin Zhu , Xiaolu Shi , Yang Liu , Gong Cheng","doi":"10.1016/j.cellin.2024.100196","DOIUrl":"10.1016/j.cellin.2024.100196","url":null,"abstract":"<div><div>The increasing global prevalence of mosquito-borne viruses has emerged as a significant threat to human health and life. Identifying receptors for these viruses is crucial for improving our knowledge of viral pathogenesis and developing effective antiviral strategies. The widespread application of CRISPR-Cas9 screening have led to the discovery of many mosquito-borne virus receptors. The revealed structures of virus-receptor complexes also provide important information for understanding their interaction mechanisms. This review provides a comprehensive summary of both conventional and novel approaches for identifying new viral receptors and the putative entry factors of the most prevalent mosquito-borne viruses within the <em>Flaviviridae</em>, <em>Togaviridae</em>, and <em>Bunyavirales</em>. At the same time, we emphasize the common receptors utilized by these viruses for entry into both vertebrate hosts and mosquito vectors. We discuss promising avenues for developing anti-mosquito-borne viral strategies that target these receptors. Notably, targeting universal receptors of specific mosquito-borne viruses in both vertebrates and mosquitoes offers dual benefits for disease prevention. Additionally, the widespread use of AI-based machine learning and protein structure prediction will accelerate the identification of new viral receptors and provide new avenues for antiviral drug discovery.</div></div>","PeriodicalId":72541,"journal":{"name":"Cell insight","volume":"3 6","pages":"Article 100196"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772892724000518/pdfft?md5=b58af911ce662736b3c07a46c56b3b91&pid=1-s2.0-S2772892724000518-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142314994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0