Function and mechanism of bispecific antibodies targeting SARS-CoV-2

Cell insight Pub Date : 2024-02-03 DOI:10.1016/j.cellin.2024.100150

Zhaohui Li , Zengyuan Zhang , Steven T. Rosen , Mingye Feng

{"title":"Function and mechanism of bispecific antibodies targeting SARS-CoV-2","authors":"Zhaohui Li , Zengyuan Zhang , Steven T. Rosen , Mingye Feng","doi":"10.1016/j.cellin.2024.100150","DOIUrl":null,"url":null,"abstract":"<div><p>As the dynamic evolution of SARS-CoV-2 led to reduced efficacy in monoclonal neutralizing antibodies and emergence of immune escape, the role of bispecific antibodies becomes crucial in bolstering antiviral activity and suppressing immune evasion. This review extensively assesses a spectrum of representative bispecific antibodies targeting SARS-CoV-2, delving into their characteristics, design formats, mechanisms of action, and associated advantages and limitations. The analysis encompasses factors influencing the selection of parental antibodies and strategies for incorporating added benefits in bispecific antibody design. Furthermore, how different classes of parental antibodies contribute to augmenting the broad-spectrum neutralization capability within bispecific antibodies is discussed. In summary, this review presents analyses and discussions aimed at offering valuable insights for shaping future strategies in bispecific antibody design to effectively confront the challenges posed by SARS-CoV-2 and propel advancements in antiviral therapeutic development.</p></div>","PeriodicalId":72541,"journal":{"name":"Cell insight","volume":"3 2","pages":"Article 100150"},"PeriodicalIF":0.0000,"publicationDate":"2024-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2772892724000051/pdfft?md5=3578145c01d2fd45abb18950a0ae9257&pid=1-s2.0-S2772892724000051-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cell insight","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2772892724000051","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

As the dynamic evolution of SARS-CoV-2 led to reduced efficacy in monoclonal neutralizing antibodies and emergence of immune escape, the role of bispecific antibodies becomes crucial in bolstering antiviral activity and suppressing immune evasion. This review extensively assesses a spectrum of representative bispecific antibodies targeting SARS-CoV-2, delving into their characteristics, design formats, mechanisms of action, and associated advantages and limitations. The analysis encompasses factors influencing the selection of parental antibodies and strategies for incorporating added benefits in bispecific antibody design. Furthermore, how different classes of parental antibodies contribute to augmenting the broad-spectrum neutralization capability within bispecific antibodies is discussed. In summary, this review presents analyses and discussions aimed at offering valuable insights for shaping future strategies in bispecific antibody design to effectively confront the challenges posed by SARS-CoV-2 and propel advancements in antiviral therapeutic development.

查看原文本刊更多论文

针对 SARS-CoV-2 的双特异性抗体的功能和机制

由于 SARS-CoV-2 的动态演化导致单克隆中和抗体的效力降低和免疫逃逸的出现，双特异性抗体在增强抗病毒活性和抑制免疫逃逸方面的作用变得至关重要。本综述广泛评估了一系列具有代表性的针对 SARS-CoV-2 的双特异性抗体，深入探讨了它们的特点、设计形式、作用机制以及相关的优势和局限性。分析包括影响亲代抗体选择的因素，以及在双特异性抗体设计中加入附加优势的策略。此外，还讨论了不同类别的亲代抗体如何有助于增强双特异性抗体的广谱中和能力。总之，本综述进行了分析和讨论，旨在为制定双特异性抗体设计的未来战略提供有价值的见解，以有效应对 SARS-CoV-2 带来的挑战，推动抗病毒疗法开发的进步。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊