Todd Shearer, Melissa Comstock, Rex L Williams, Mark C Johnson, Ewa Cendrowicz, Cathrine Leonowens, Margaret Smith, Todd M Baughman, Caroline J Breitbach, Shinta Cheng, Damian J Green
{"title":"Kinetics of Nirogacestat-Mediated Increases in B-cell Maturation Antigen on Plasma Cells Inform Therapeutic Combinations in Multiple Myeloma.","authors":"Todd Shearer, Melissa Comstock, Rex L Williams, Mark C Johnson, Ewa Cendrowicz, Cathrine Leonowens, Margaret Smith, Todd M Baughman, Caroline J Breitbach, Shinta Cheng, Damian J Green","doi":"10.1158/2767-9764.CRC-24-0075","DOIUrl":"10.1158/2767-9764.CRC-24-0075","url":null,"abstract":"<p><strong>Significance: </strong>GSIs can enhance multiple myeloma therapies targeting BCMA by increasing mbBCMA on plasma cells. In response to the GSI nirogacestat, mbBCMA rapidly and robustly increased in vitro and in vivo. Elucidating nirogacestat's effects on BCMA kinetics will guide potential multiple myeloma dosing strategies.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"3114-3123"},"PeriodicalIF":2.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632591/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yichi Zhang, Marjaana Ojalill, Antonia Boyer, Xiao Lei Chen, Elise Tahon, Gaëtan Thivolle Lioux, Marvin Xia, Maryam Abbas, Halime Meryem Soylu, Douglas B Flieder, Denise C Connolly, Alfredo A Molinolo, Michael T McHale, Dwayne G Stupack, David D Schlaepfer
{"title":"Nuclear Focal Adhesion Kinase Protects against Cisplatin Stress in Ovarian Carcinoma.","authors":"Yichi Zhang, Marjaana Ojalill, Antonia Boyer, Xiao Lei Chen, Elise Tahon, Gaëtan Thivolle Lioux, Marvin Xia, Maryam Abbas, Halime Meryem Soylu, Douglas B Flieder, Denise C Connolly, Alfredo A Molinolo, Michael T McHale, Dwayne G Stupack, David D Schlaepfer","doi":"10.1158/2767-9764.CRC-24-0382","DOIUrl":"10.1158/2767-9764.CRC-24-0382","url":null,"abstract":"<p><strong>Significance: </strong>FAK inhibitors are in combinatorial clinical testing with agents that prevent Ras-Raf-MAPK pathway activation in various cancers. This study suggests that nuclear FAK limits ERK/MAPK activation in supporting HGSOC cell survival to cisplatin stress. Overall, it is likely that targets of FAK-mediated survival signaling may be tumor type- and context-dependent.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"3165-3179"},"PeriodicalIF":2.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11659947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142710432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maj K Kjeldsen, Morten Jørgensen, Dina Sofie B Grønseth, Martin Schønemann-Lund, Gitte-Bettina Nyvang, Charlotte Aaquist Haslund, Anja Oer Knudsen, Anne Krejbjerg Motavaf, Susanne Malander, Maarit Anttila, Gabriel Lindahl, Johanna Mäenpää, Maria Dimoula, Theresa L Werner, Trine Zeeberg Iversen, Sakari Hietanen, Lars Fokdal, Hanna Dahlstrand, Line Bjørge, Michael J Birrer, Mansoor R Mirza, Maria Rossing
{"title":"Beyond HRD Status: Unraveling Genetic Variants Impacting PARP Inhibitor Sensitivity in Advanced Ovarian Cancer.","authors":"Maj K Kjeldsen, Morten Jørgensen, Dina Sofie B Grønseth, Martin Schønemann-Lund, Gitte-Bettina Nyvang, Charlotte Aaquist Haslund, Anja Oer Knudsen, Anne Krejbjerg Motavaf, Susanne Malander, Maarit Anttila, Gabriel Lindahl, Johanna Mäenpää, Maria Dimoula, Theresa L Werner, Trine Zeeberg Iversen, Sakari Hietanen, Lars Fokdal, Hanna Dahlstrand, Line Bjørge, Michael J Birrer, Mansoor R Mirza, Maria Rossing","doi":"10.1158/2767-9764.CRC-24-0294","DOIUrl":"10.1158/2767-9764.CRC-24-0294","url":null,"abstract":"<p><strong>Significance: </strong>The irregular response to PARPi in HRD-positive and -negative tumors highlights the need for identifying additional biomarkers. This study explores the mutational landscape beyond HRD status in AOC, ultimately advancing precision oncology in future clinical practice.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"3190-3200"},"PeriodicalIF":2.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11670052/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142735176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Malcolm F McDonald, Rachel Naomi Curry, Isabella O'Reilly, Brittney Lozzi, Alexis Cervantes, Zhung-Fu Lee, Anna Rosenbaum, Peihao He, Carrie Mohila, Arif O Harmanci, Akdes Serin Harmanci, Benjamin Deneen, Ganesh Rao
{"title":"Tumor Expression of CD83 Reduces Glioma Progression and Is Associated with Reduced Immunosuppression.","authors":"Malcolm F McDonald, Rachel Naomi Curry, Isabella O'Reilly, Brittney Lozzi, Alexis Cervantes, Zhung-Fu Lee, Anna Rosenbaum, Peihao He, Carrie Mohila, Arif O Harmanci, Akdes Serin Harmanci, Benjamin Deneen, Ganesh Rao","doi":"10.1158/2767-9764.CRC-24-0281","DOIUrl":"10.1158/2767-9764.CRC-24-0281","url":null,"abstract":"<p><strong>Significance: </strong>Immunosuppression in malignant glioma remains a barrier to therapeutic development. CD83 overexpression in human and mouse glioma increases survival. CD83+ tumor cells promote signatures related to cytotoxic T cells, enhanced activation of CD8+ T cells, and increased proinflammatory cytokines. These findings suggest that tumor-expressed CD83 could mediate tumor-immune communications.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"3209-3223"},"PeriodicalIF":2.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142735178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zhaoxiang Cai, Rebecca C Poulos, Adel Aref, Phillip J Robinson, Roger R Reddel, Qing Zhong
{"title":"DeePathNet: A Transformer-Based Deep Learning Model Integrating Multiomic Data with Cancer Pathways.","authors":"Zhaoxiang Cai, Rebecca C Poulos, Adel Aref, Phillip J Robinson, Roger R Reddel, Qing Zhong","doi":"10.1158/2767-9764.CRC-24-0285","DOIUrl":"10.1158/2767-9764.CRC-24-0285","url":null,"abstract":"<p><strong>Significance: </strong>DeePathNet integrates cancer-specific biological pathways using transformer-based deep learning for enhanced cancer analysis. It outperforms existing models in predicting drug responses, cancer types, and subtypes. By enabling pathway-level biomarker discovery, DeePathNet represents a significant advancement in cancer research and could lead to more effective treatments.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"3151-3164"},"PeriodicalIF":2.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11652962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Slavica Dimitrieva, Jon M Harrison, Jonathan Chang, Michelle Piquet, Mari Mino-Kenudson, Millicent Gabriel, Vivek Sagar, Heiko Horn, Kasper Lage, Julie Kim, Gang Li, Shaobu Weng, Cynthia Harris, Anupriya S Kulkarni, David T Ting, Motaz Qadan, Peter J Fagenholz, Cristina R Ferrone, Angelo L Grauel, Tyler Laszewski, Alina Raza, Markus Riester, Tim Somerville, Joel P Wagner, Glenn Dranoff, Jeffrey A Engelman, Audrey Kauffmann, Rebecca Leary, Andrew L Warshaw, Keith D Lillemoe, Carlos Fernández-Del Castillo, David A Ruddy, Andrew S Liss, Viviana Cremasco
{"title":"Dynamic Evolution of Fibroblasts Revealed by Single-Cell RNA Sequencing of Human Pancreatic Cancer.","authors":"Slavica Dimitrieva, Jon M Harrison, Jonathan Chang, Michelle Piquet, Mari Mino-Kenudson, Millicent Gabriel, Vivek Sagar, Heiko Horn, Kasper Lage, Julie Kim, Gang Li, Shaobu Weng, Cynthia Harris, Anupriya S Kulkarni, David T Ting, Motaz Qadan, Peter J Fagenholz, Cristina R Ferrone, Angelo L Grauel, Tyler Laszewski, Alina Raza, Markus Riester, Tim Somerville, Joel P Wagner, Glenn Dranoff, Jeffrey A Engelman, Audrey Kauffmann, Rebecca Leary, Andrew L Warshaw, Keith D Lillemoe, Carlos Fernández-Del Castillo, David A Ruddy, Andrew S Liss, Viviana Cremasco","doi":"10.1158/2767-9764.CRC-23-0489","DOIUrl":"10.1158/2767-9764.CRC-23-0489","url":null,"abstract":"<p><strong>Significance: </strong>Pancreatic cancer remains a high unmet medical need. Understanding the interactions between stroma and cancer cells in this disease may unveil new opportunities for therapeutic intervention.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"3049-3066"},"PeriodicalIF":2.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11609929/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anne E Dodson, Sol Shenker, Pamela Sullivan, Sumeet U Nayak, Chris Middleton, Michael McGuire, Edmond Chipumuro, Yuji Mishina, Erica R Tobin, Louise Cadzow, Andrew A Wylie, Dipen Sangurdekar
{"title":"Pan-Cancer Analysis of Homologous Recombination Deficiency in Cell Lines.","authors":"Anne E Dodson, Sol Shenker, Pamela Sullivan, Sumeet U Nayak, Chris Middleton, Michael McGuire, Edmond Chipumuro, Yuji Mishina, Erica R Tobin, Louise Cadzow, Andrew A Wylie, Dipen Sangurdekar","doi":"10.1158/2767-9764.CRC-24-0316","DOIUrl":"10.1158/2767-9764.CRC-24-0316","url":null,"abstract":"<p><strong>Significance: </strong>HRD is common in cancer and can be exploited therapeutically, as it sensitizes cells to DNA-damaging agents. Here, we scored more than 1,300 cancer cell lines for HRD using two different bioinformatic approaches, thereby enabling large-scale analyses that provide insights into the etiology and features of HRD.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"3084-3098"},"PeriodicalIF":2.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11621922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rachel A Francis, Sean Tavtigian, Carolyn Horton, Andreana N Holowatyj
{"title":"Variant of Uncertain Significance Patterns among Patients with Early-Onset Colorectal Cancer.","authors":"Rachel A Francis, Sean Tavtigian, Carolyn Horton, Andreana N Holowatyj","doi":"10.1158/2767-9764.CRC-24-0368","DOIUrl":"10.1158/2767-9764.CRC-24-0368","url":null,"abstract":"<p><strong>Significance: </strong>Among individuals with early-onset colorectal cancer, germline VUS reclassification as well as rates of VUSs in cancer susceptibility genes differed by self-identified race/ethnicity. These findings point to the importance of VUS reclassification as this may alter clinical management and to distinct germline variant spectra among diverse patients with early-onset colorectal cancer.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"309-317"},"PeriodicalIF":2.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11824576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142803697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Identification of ncRNA Biomarkers in Non-Small Cell Lung Cancer to Address Racial Disparities.","authors":"Lu Gao, Pushpa Dhilipkannah, Feng Jiang","doi":"10.1158/2767-9764.CRC-24-0262","DOIUrl":"10.1158/2767-9764.CRC-24-0262","url":null,"abstract":"<p><strong>Significance: </strong>This study identifies ethnicity-related ncRNA biomarkers that differentiate lung cancer in AAs and WAs, offering diagnostic panels with high sensitivity and specificity. These findings provide a promising approach to addressing racial disparities in lung cancer detection and improving early diagnosis across diverse populations.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"3201-3208"},"PeriodicalIF":2.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11675572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Theron Palmer, Michael D Kessler, Xiaoshan M Shao, Archana Balan, Mark Yarchoan, Neeha Zaidi, Tamara Y Lopez-Vidal, Ali M Saeed, Jessica Gore, Nilofer S Azad, Elizabeth M Jaffee, Alexander V Favorov, Valsamo Anagnostou, Rachel Karchin, Daria A Gaykalova, Elana J Fertig, Ludmila Danilova
{"title":"SpliceMutr Enables Pan-Cancer Analysis of Splicing-Derived Neoantigen Burden in Tumors.","authors":"Theron Palmer, Michael D Kessler, Xiaoshan M Shao, Archana Balan, Mark Yarchoan, Neeha Zaidi, Tamara Y Lopez-Vidal, Ali M Saeed, Jessica Gore, Nilofer S Azad, Elizabeth M Jaffee, Alexander V Favorov, Valsamo Anagnostou, Rachel Karchin, Daria A Gaykalova, Elana J Fertig, Ludmila Danilova","doi":"10.1158/2767-9764.CRC-23-0309","DOIUrl":"10.1158/2767-9764.CRC-23-0309","url":null,"abstract":"<p><strong>Significance: </strong>SpliceMutr shows that splicing antigenicity changes in response to ICI therapies and that native modulation of the splicing machinery through mutations increases the contribution of splicing to the neoantigen load of some The Cancer Genome Atlas cancer subtypes. Future studies of the relationship between splicing antigenicity and immune checkpoint inhibitor response pan-cancer are essential to establish the interplay between antigen heterogeneity and immunotherapy regimen on patient response.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"3137-3150"},"PeriodicalIF":2.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11648103/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142523759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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