Cancer research communications最新文献

{"title":"Clotting Promotes Glioma Growth and Infiltration Through Activation of Focal Adhesion Kinase.","authors":"Lynn M Knowles, Carolin Wolter, Stefan Linsler, Simon Müller, Steffi Urbschat, Ralf Ketter, Andreas Müller, Xiangda Zhou, Bin Qu, Sebastian Senger, Jürgen Geisel, Tim Schmidt, Hermann Eichler, Jan Pilch","doi":"10.1158/2767-9764.CRC-24-0164","DOIUrl":"10.1158/2767-9764.CRC-24-0164","url":null,"abstract":"<p><strong>Significance: </strong>High-grade gliomas are associated with intratumoral thrombosis, tumor cell necrosis, and hemorrhage. The resulting blood clot serves as an adhesive matrix for glioma cell integrins that activate FAK. Knocking down FAK with CRISPR cas9, on the other hand, is highly effective at halting GBM growth in mice.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"3124-3136"},"PeriodicalIF":2.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11638908/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PEG-BCT-100 and Canavanine Synergistically Induce Apoptosis in Arginine Biosynthetic Enzyme-Deficient Pancreatic Cancer.","authors":"Tsz Tung Kwong, Hao Hao Deng, Chi-Hang Wong, Anthony W H Chan, Landon Long Chan, Siu-Ho K Chok, Paul N Cheng, Stephen Chan","doi":"10.1158/2767-9764.CRC-24-0425","DOIUrl":"10.1158/2767-9764.CRC-24-0425","url":null,"abstract":"<p><strong>Significance: </strong>This study investigates the synergistic antitumor effect of PEG-BCT-100, an arginase, in clinical trials, with canavanine in pancreatic cancer, in vitro and in vivo. The treatment induces cancer cell apoptosis while sparing normal fibroblasts. Our findings suggest heightened susceptibility of pancreatic tumors deficient in arginine biosynthesis enzymes ASS1 and OTC.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"3180-3189"},"PeriodicalIF":2.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11695075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142683481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Capicua C1 Domain Is Required for Full Activity of the CIC::DUX4 Fusion Oncoprotein.","authors":"Cuyler Luck, Kyle A Jacobs, Ross A Okimoto","doi":"10.1158/2767-9764.CRC-24-0348","DOIUrl":"10.1158/2767-9764.CRC-24-0348","url":null,"abstract":"<p><strong>Significance: </strong>We show in mammalian settings that the capicua C1 functional domain is a supercharger for CIC::DUX4, a poorly studied fusion oncoprotein which drives a rare sarcoma with dismal outcomes.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"3099-3113"},"PeriodicalIF":2.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11626509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Race and Ethnicity with Genomic Testing at a Comprehensive Cancer Center in North Carolina.","authors":"Clare Meernik, Frances Wang, Yadurshini Raveendran, Michelle F Green, Devon K Check, Hayden B Bosworth, Linda M Sutton, John H Strickler, Tomi F Akinyemiju","doi":"10.1158/2767-9764.CRC-24-0134","DOIUrl":"10.1158/2767-9764.CRC-24-0134","url":null,"abstract":"<p><strong>Significance: </strong>Non-Hispanic Black patients diagnosed with prostate cancer between 2014 and 2019 and treated at a comprehensive cancer center were less likely to use tumor-specific genomic testing compared with non-Hispanic White patients. Disparities in the use of precision oncology technologies should be monitored and addressed to ensure equitable cancer care.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"2968-2975"},"PeriodicalIF":2.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142514006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative Guidance of Pancreatic Cancer Resection Using a Toll-like Receptor 2-Targeted Fluorescence Molecular Imaging Agent.","authors":"Amanda S Huynh, Allison S Cohen, Michael Doligalski, Todd J Casagni, Valerie E Moberg, Xuan Huang, Jennifer Morse, Dominique Abrahams, Mark C Lloyd, Barbara A Centeno, Margaret K Baldwin, Mark L McLaughlin, Josef Vagner, David L Morse","doi":"10.1158/2767-9764.CRC-24-0244","DOIUrl":"10.1158/2767-9764.CRC-24-0244","url":null,"abstract":"<p><p>To increase the achievement of negative R0 surgical margins and increase the low survival rates of pancreatic cancer, improvements in assessing tumor margins during surgical resections are needed. This can be accomplished by using pancreatic cancer-targeted fluorescence molecular imaging agents to intraoperatively detect tumor margins in real time. Because Toll-like receptor 2 (TLR2) is broadly expressed among many cancer types including pancreatic adenocarcinomas, a high-affinity TLR2-targeted fluorescence molecular imaging agent (TLR2L-800) was developed. We investigate the potential for increased survival by employing real-time intraoperative tumor detection in a preclinical orthotopic human pancreatic xenograft tumor model using TLR2L-800. Three cohorts of nude mice bearing orthotopic human pancreatic xenograft tumors were intravenously injected with TLR2L-800. At 24 hours postinjection, one cohort underwent in vivo fluorescence-guided surgical removal of tumors using a real-time fluorescence imaging platform, a second cohort underwent visible light surgery (VLS), and a third cohort did not undergo surgery. A fourth, nontumor-bearing cohort was administered TLR2L-800 with no surgery. At 41 days postsurgery, the survival rates were 53% for the fluorescence-guided surgery (FGS) group and 0% for both the VLS and the tumor-bearing no-surgery group. The overall 200-day survival rate of 35% for the FGS group was significant compared with 0% for the VLS group (P value = 0.0018). This study demonstrates the potential of increasing disease-free survival for patients with pancreatic cancer by increasing the attainment of R0 margins using a novel tumor-targeted lipopeptide ligand-based fluorescence molecular imaging agent, TLR2L-800, during real-time FGS.</p><p><strong>Significance: </strong>Human TLR2 is broadly expressed among pancreatic adenocarcinomas, and the highly specific TLR2L-800 fluorescence molecular imaging agent has potential for use in fluorescence-guided surgery to increase R0 margins and improve patient survival.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"2877-2887"},"PeriodicalIF":2.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142333590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determining the N-Glycan and Collagen/Extracellular Matrix Protein Compositions in a Novel Outcome Cohort of Prostate Cancer Tissue Microarrays Using MALDI-MSI.","authors":"Jordan P Hartig, Kaitlyn Bejar, Lyndsay E A Young, Grace Grimsley, Jennifer R Bethard, Dean A Troyer, Javier Hernandez, Jennifer D Wu, Joseph E Ippolito, Lauren E Ball, Jonathan A L Gelfond, Teresa L Johnson-Pais, Anand S Mehta, Robin J Leach, Peggi M Angel, Richard R Drake","doi":"10.1158/2767-9764.CRC-24-0152","DOIUrl":"10.1158/2767-9764.CRC-24-0152","url":null,"abstract":"<p><strong>Significance: </strong>Using matrix-assisted laser desorption/ionization mass spectrometry imaging techniques on a unique cohort of prostate cancer tissues, we highlighted several molecular characteristics of matrix that have potential to act as early predictors of prostate cancer metastasis.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"3036-3048"},"PeriodicalIF":2.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11600299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142333587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional RNAi Screening Identifies G2/M and Kinetochore Components as Modulators of TNFα/NF-κB Prosurvival Signaling in Head and Neck Squamous Cell Carcinoma.","authors":"Ethan L Morgan, Anthony D Saleh, Shaleeka Cornelius, Sophie G Carlson, Tiffany Toni, Hui Cheng, Jun Jeon, Ramya Viswanathan, Xinping Yang, Christopher Silvin, Paul E Clavijo, Anastasia L Sowers, James B Mitchell, Pinar Ormanoglu, Madhu Lal Nag, Scott E Martin, Zhong Chen, Carter Van Waes","doi":"10.1158/2767-9764.CRC-24-0274","DOIUrl":"10.1158/2767-9764.CRC-24-0274","url":null,"abstract":"<p><strong>Significance: </strong>Here, RNAi library screening reveals that multiple G2/M and kinetochore components, including TTK/monopolar spindle 1, modulate TNFα-induced NF-κB activation, cell survival, and genotoxicity, underscoring their potential importance as therapeutic targets in HNSCC.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"2903-2918"},"PeriodicalIF":2.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11541648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Significance of Comprehensive Metabolic Phenotypes in Cancer Risk: A Japan Multi-Institutional Collaborative Cohort Study.","authors":"Takeshi Watanabe, Tien Van Nguyen, Sakurako Katsuura-Kamano, Kokichi Arisawa, Masashi Ishizu, Taichi Unohara, Keitaro Tanaka, Chisato Shimanoe, Mako Nagayoshi, Takashi Tamura, Yuko Kubo, Yasufumi Kato, Isao Oze, Hidemi Ito, Nobuaki Michihata, Yohko Nakamura, Shiroh Tanoue, Chihaya Koriyama, Sadao Suzuki, Hiroko Nakagawa-Senda, Teruhide Koyama, Satomi Tomida, Kiyonori Kuriki, Naoyuki Takashima, Akiko Harada, Kenji Wakai, Keitaro Matsuo","doi":"10.1158/2767-9764.CRC-24-0249","DOIUrl":"10.1158/2767-9764.CRC-24-0249","url":null,"abstract":"<p><strong>Significance: </strong>The prospective cohort study in a large Japanese population suggested that metabolic phenotypes are important risk factors for total and some site-specific cancers in Japanese adults. Moreover, the risk of each site-specific cancer may differ according to metabolic phenotypes.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"2986-2997"},"PeriodicalIF":2.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11579844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142523760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between Immune-Related Adverse Events and Atezolizumab in Previously Treated Patients with Unresectable Advanced or Recurrent Non-Small Cell Lung Cancer.","authors":"Hidetoshi Hayashi, Makoto Nishio, Hiroaki Akamatsu, Yasushi Goto, Satoru Miura, Akihiko Gemma, Ichiro Yoshino, Toshihiro Misumi, Takashi Kijima, Naoto Takase, Masaki Fujita, Sadatomo Tasaka, Atsuto Mouri, Tetsuro Kondo, Kei Takamura, Yosuke Kawashima, Kazuyoshi Imaizumi, Shunichiro Iwasawa, Shintaro Nakagawa, Tetsuya Mitsudomi","doi":"10.1158/2767-9764.CRC-24-0212","DOIUrl":"10.1158/2767-9764.CRC-24-0212","url":null,"abstract":"<p><strong>Purpose: </strong>Real-world, large-scale studies on the association between immune-related adverse events (irAE) and immune checkpoint inhibitor therapy effectiveness are limited. We evaluated overall survival (OS) and progression-free survival based on the occurrence and grade of irAEs.</p><p><strong>Patients and methods: </strong>We used data from Japanese patients with unresectable advanced or recurrent non-small cell lung cancer (NSCLC) who received atezolizumab and were enrolled in J-TAIL, a multicenter, prospective, single-arm observational study.</p><p><strong>Results: </strong>Among the 1,002 patients, 190 (19.0%) developed irAEs. The most common irAEs were skin disorders (3.8%) of any grade and interstitial lung disease (1.5%) of grade ≥3. Patients who developed irAEs within 4 or 6 weeks of treatment initiation had higher baseline C-reactive protein levels than those without irAEs. OS was longer in patients with irAEs [HR, 0.66; 95% confidence interval (CI), 0.54-0.82], particularly in those with low-grade irAEs (HR, 0.45; 95% CI, 0.33-0.62), than in patients without irAEs. The HR (95% CI) for OS in patients with low-grade and high-grade skin or endocrine disorder-related irAEs was 0.42 (0.28-0.64) and 0.37 (0.15-0.88), respectively. The HR (95% CI) for OS in patients with low-grade and high-grade irAEs other than skin or endocrine disorders was 0.44 (0.30-0.65) and 1.27 (0.96-1.69), respectively.</p><p><strong>Conclusions: </strong>In patients with unresectable advanced or recurrent NSCLC treated with atezolizumab in real-world settings, irAEs are associated with a clinical benefit except in those with high-grade irAEs other than skin and endocrine disorders.</p><p><strong>Significance: </strong>Immune checkpoint inhibitors are useful for treating NSCLC but can cause life-threatening irAEs. This study had a large sample size and stratified the analysis by irAE type and grade. The results suggest that improved management of irAEs may improve the therapeutic effect of atezolizumab.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"2858-2867"},"PeriodicalIF":2.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142402198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High TNF and NF-κB Pathway Dependency Are Associated with AZD5582 Sensitivity in OSCC via CASP8-Dependent Apoptosis.","authors":"Annie Wai Yeeng Chai, Yee Hua Tan, Shiyin Ooi, Pei San Yee, Shi Mun Yee, Howard Lightfoot, Syd Barthorpe, Mathew J Garnett, Sok Ching Cheong","doi":"10.1158/2767-9764.CRC-24-0136","DOIUrl":"10.1158/2767-9764.CRC-24-0136","url":null,"abstract":"<p><strong>Significance: </strong>Mechanistically guided drug repurposing has been made possible by systematically integrating pharmacologic and CRISPR-Cas9 screen data. Our study discovers the biomarker and cell death mechanisms underpinning sensitivity toward AZD5582, an antagonist of the inhibitor of apoptosis family protein. Our findings have important implications for improving future trial design for patients with OSCC using this emerging drug class.</p>","PeriodicalId":72516,"journal":{"name":"Cancer research communications","volume":" ","pages":"2919-2932"},"PeriodicalIF":2.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142367679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}